JPS6185388A - 新規化合物，その製法及びそれを含む医薬組成物 - Google Patents

新規化合物，その製法及びそれを含む医薬組成物

Info

Publication number
JPS6185388A
JPS6185388A JP60207693A JP20769385A JPS6185388A JP S6185388 A JPS6185388 A JP S6185388A JP 60207693 A JP60207693 A JP 60207693A JP 20769385 A JP20769385 A JP 20769385A JP S6185388 A JPS6185388 A JP S6185388A
Authority
JP
Japan
Prior art keywords
formula
amino
purine
compound
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP60207693A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0586792B2 (OSRAM
Inventor
マイケル・レイモンド・ハーンデン
リチヤード・ルイス・ジヤーベスト
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848423833A external-priority patent/GB8423833D0/en
Priority claimed from GB858510331A external-priority patent/GB8510331D0/en
Priority claimed from GB858520618A external-priority patent/GB8520618D0/en
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of JPS6185388A publication Critical patent/JPS6185388A/ja
Publication of JPH0586792B2 publication Critical patent/JPH0586792B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/007—Esters of unsaturated alcohols having the esterified hydroxy group bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP60207693A 1984-09-20 1985-09-19 新規化合物，その製法及びそれを含む医薬組成物 Granted JPS6185388A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB848423833A GB8423833D0 (en) 1984-09-20 1984-09-20 Compounds
GB8423833 1984-09-20
GB8510331 1985-04-23
GB858510331A GB8510331D0 (en) 1985-04-23 1985-04-23 Compounds
GB858520618A GB8520618D0 (en) 1985-08-16 1985-08-16 Compounds
GB8520618 1985-08-16
PCT/GB1986/000153 WO1987005604A1 (en) 1984-09-20 1986-03-17 2-aminopurine derivatives and process for their preparation

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP5130044A Division JPH0826021B2 (ja) 1984-09-20 1993-05-07 新規化合物、その製法及びそれを含む医薬組成物

Publications (2)

Publication Number Publication Date
JPS6185388A true JPS6185388A (ja) 1986-04-30
JPH0586792B2 JPH0586792B2 (OSRAM) 1993-12-14

Family

ID=27262464

Family Applications (2)

Application Number Title Priority Date Filing Date
JP60207693A Granted JPS6185388A (ja) 1984-09-20 1985-09-19 新規化合物，その製法及びそれを含む医薬組成物
JP5130044A Expired - Lifetime JPH0826021B2 (ja) 1984-09-20 1993-05-07 新規化合物、その製法及びそれを含む医薬組成物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP5130044A Expired - Lifetime JPH0826021B2 (ja) 1984-09-20 1993-05-07 新規化合物、その製法及びそれを含む医薬組成物

Country Status (24)

Country Link
EP (1) EP0182024B1 (OSRAM)
JP (2) JPS6185388A (OSRAM)
KR (1) KR930006349B1 (OSRAM)
AT (1) AT389118B (OSRAM)
AU (1) AU589371B2 (OSRAM)
BG (1) BG61493B2 (OSRAM)
CA (1) CA1262899A (OSRAM)
CY (1) CY1747A (OSRAM)
CZ (1) CZ283721B6 (OSRAM)
DE (1) DE3582399D1 (OSRAM)
DK (1) DK167019B1 (OSRAM)
ES (1) ES8703876A1 (OSRAM)
FI (1) FI87564C (OSRAM)
GR (1) GR852272B (OSRAM)
HK (1) HK128693A (OSRAM)
HU (1) HU198934B (OSRAM)
IE (1) IE58141B1 (OSRAM)
MX (1) MX165116B (OSRAM)
MY (1) MY102473A (OSRAM)
NL (1) NL960006I2 (OSRAM)
NO (1) NO167572C (OSRAM)
NZ (1) NZ213528A (OSRAM)
PT (1) PT81160B (OSRAM)
WO (1) WO1987005604A1 (OSRAM)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0259583A (ja) * 1988-07-23 1990-02-28 Beecham Group Plc 化合物の新規な製造方法
JP2007297412A (ja) * 1995-03-07 2007-11-15 Novartis Internatl Pharmaceutical Ltd ヒト・ヘルペスウイルス−８の治療に対するペンシクロビルの使用
JP2009091362A (ja) * 1996-01-16 2009-04-30 Novartis Internatl Pharmaceutical Ltd 高含量ファムシクロビル錠剤
JP2019504000A (ja) * 2015-12-08 2019-02-14 レトロフィン， インコーポレイテッド 神経性障害の処置のための環式ホスフェートおよび環式ホスホロアミデート

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8406538D0 (sv) 1984-12-21 1984-12-21 Astra Laekemedel Ab Novel derivatives of purine
GB8628826D0 (en) * 1986-12-02 1987-01-07 Beecham Group Plc Pharmaceutical products
ES2098219T3 (es) * 1987-08-01 1997-05-01 Beecham Group Plc Compuestos de purina y su preparacion.
US5175288A (en) * 1987-08-01 1992-12-29 Beecham Group P.L.C. Process for preparing purine derivatives and intermediates thereof
GB8817270D0 (en) * 1988-07-20 1988-08-24 Beecham Group Plc Novel process
GB8822236D0 (en) * 1988-09-21 1988-10-26 Beecham Group Plc Chemical process
JPH02247191A (ja) * 1989-02-02 1990-10-02 Merck & Co Inc 抗レトロウイルス剤としてのプリンおよびピリミジン非環状ヌクレオシドの環状モノホスフエート類
CA2009109A1 (en) * 1989-02-02 1990-08-02 John Hannah Antiviral acyclonucleosides and acyclonucleotides
GB8904855D0 (en) * 1989-03-03 1989-04-12 Beecham Group Plc Pharmaceutical treatment
GB8922076D0 (en) * 1989-09-28 1989-11-15 Beecham Group Plc Novel process
GB9004647D0 (en) * 1990-03-01 1990-04-25 Beecham Group Plc Pharmaceuticals
GB9102127D0 (en) * 1991-01-31 1991-03-13 Smithkline Beecham Plc Pharmaceuticals
GB9201961D0 (en) 1992-01-30 1992-03-18 Smithkline Beecham Plc Pharmaceuticals
GB9326177D0 (en) * 1993-12-22 1994-02-23 Smithkline Beecham Plc Pharmaceuticals
IL111138A (en) * 1993-10-05 1997-04-15 Smithkline Beecham Plc Pharmaceutical compositions comprising penciclovir and/or its bioprecursor and/or its derivatives for the treatment and prophylaxis of post-herpetic neuralgia
US6124304A (en) * 1993-10-05 2000-09-26 Smithkline Beecham Plc Penciclovir for the treatment of zoster associated pain
GB9323404D0 (en) * 1993-11-12 1994-01-05 Smithkline Beecham Plc Pharmaceuticals
US6683084B1 (en) 1993-11-12 2004-01-27 Novartis International Pharmaceutical Ltd. Use of 2-amino purine derivatives for the treatment and prophylaxis of human herpes virus 6 infections
GB9323403D0 (en) * 1993-11-12 1994-01-05 Smithkline Beecham Plc Pharmaceuticals
GB9402161D0 (en) * 1994-02-04 1994-03-30 Wellcome Found Chloropyrimidine intermediates
GB9407698D0 (en) 1994-04-19 1994-06-15 Smithkline Beecham Plc Pharmaceuticals
DE4420751A1 (de) * 1994-06-15 1995-12-21 Basf Ag Verfahren zur Herstellung von enantiomerenreinen Lactamen
US5736549A (en) * 1994-10-05 1998-04-07 Chiroscience Limited Hypoxanthine and guanine compounds
RU2181049C2 (ru) * 1994-12-12 2002-04-10 Новартис Интернэшнл Фармасьютикал Лтд. Использование аминопуриновых противовирусных соединений для лечения и профилактики латентных инфекций, вызванных вирусом герпеса
US7279483B2 (en) 1996-02-07 2007-10-09 Novartis Ag Famciclovir monohydrate
DE69706833T2 (de) * 1996-02-07 2002-04-11 Novartis International Pharmaceutical Ltd., Hamilton Pharmazeutische zusammensetzungen enthaltend famciclovir monohydrat
GB9615276D0 (en) * 1996-07-20 1996-09-04 Smithkline Beecham Plc Pharmaceuticals
GR1002949B (el) * 1996-07-20 1998-07-29 Smithkline Beecham P.L.C. Φαρμακα
GB9615253D0 (en) * 1996-07-20 1996-09-04 Smithkline Beecham Plc Pharmaceuticals
CA2251481A1 (en) * 1997-11-12 1999-05-12 Junichi Yasuoka Purine derivatives having cyclopropane ring
GB9807116D0 (en) * 1998-04-02 1998-06-03 Smithkline Beecham Plc Novel process
SI20022A (sl) * 1998-07-29 2000-02-29 Kemijski inštitut Alkilno substituirani purinovi derivati in njihova priprava
EP2316468A1 (en) 2002-02-22 2011-05-04 Shire LLC Delivery system and methods for protecting and administering dextroamphetamine
EP1532151A2 (en) 2002-08-26 2005-05-25 Teva Pharmaceutical Industries Limited Crystalline solid famciclovir forms i, ii, iii and preparation thereof
US20040224917A1 (en) 2003-01-14 2004-11-11 Gilead Sciences, Inc. Compositions and methods for combination antiviral therapy
AU2006230269A1 (en) 2005-03-30 2006-10-05 Novartis Ag Penciclovir or famciclovir for the treatment of recurrent genital herpes with a one-day application
GB2426247A (en) * 2005-05-20 2006-11-22 Arrow Int Ltd Methods of preparing purine derivatives such as famciclovir
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
TWI375560B (en) 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
WO2017029298A1 (en) 2015-08-17 2017-02-23 Sanovel Ilac Sanayi Ve Ticaret A.S. A topical antiviral composition
US20230218644A1 (en) 2020-04-16 2023-07-13 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5989682A (ja) * 1982-10-14 1984-05-23 ザ・ウエルカム・フアウンデ−シヨン プリン誘導体

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU577303B2 (en) * 1983-08-18 1988-09-22 Novartis International Pharmaceutical Ltd 9-substituted-2-amino purines
EP0141927B1 (en) * 1983-08-18 1991-10-30 Beecham Group Plc Antiviral guanine derivatives
EP0152316B1 (en) * 1984-01-26 1989-07-26 Merck & Co. Inc. Substituted butyl guanines and their utilization in antiviral compositions

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5989682A (ja) * 1982-10-14 1984-05-23 ザ・ウエルカム・フアウンデ−シヨン プリン誘導体

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0259583A (ja) * 1988-07-23 1990-02-28 Beecham Group Plc 化合物の新規な製造方法
JP2007297412A (ja) * 1995-03-07 2007-11-15 Novartis Internatl Pharmaceutical Ltd ヒト・ヘルペスウイルス−８の治療に対するペンシクロビルの使用
JP2009091362A (ja) * 1996-01-16 2009-04-30 Novartis Internatl Pharmaceutical Ltd 高含量ファムシクロビル錠剤
JP2019504000A (ja) * 2015-12-08 2019-02-14 レトロフィン， インコーポレイテッド 神経性障害の処置のための環式ホスフェートおよび環式ホスホロアミデート

Also Published As

Publication number Publication date
PT81160B (pt) 1988-01-22
KR930006349B1 (ko) 1993-07-14
HU198934B (en) 1989-12-28
AU4756085A (en) 1986-03-27
NZ213528A (en) 1989-03-29
DK424685D0 (da) 1985-09-18
FI87564C (fi) 1993-01-25
FI875059A0 (fi) 1987-11-16
CA1262899A (en) 1989-11-14
HK128693A (en) 1993-11-26
ES8703876A1 (es) 1987-03-01
NO167572C (no) 1991-11-20
ES547128A0 (es) 1987-03-01
DE3582399D1 (de) 1991-05-08
NO167572B (no) 1991-08-12
FI87564B (fi) 1992-10-15
AT389118B (de) 1989-10-25
NL960006I1 (nl) 1996-09-02
EP0182024A2 (en) 1986-05-28
JPH0826021B2 (ja) 1996-03-13
BG61493B2 (bg) 1997-09-30
NO874764L (no) 1987-11-16
WO1987005604A1 (en) 1987-09-24
CY1747A (en) 1994-06-03
JPH0625241A (ja) 1994-02-01
ATA904286A (de) 1989-03-15
EP0182024B1 (en) 1991-04-03
MX165116B (es) 1992-10-27
DK167019B1 (da) 1993-08-16
JPH0586792B2 (OSRAM) 1993-12-14
NL960006I2 (nl) 1996-09-02
CZ283721B6 (cs) 1998-06-17
HUT47576A (en) 1989-03-28
FI875059L (fi) 1987-11-16
MY102473A (en) 1992-06-30
NO874764D0 (no) 1987-11-16
GR852272B (OSRAM) 1986-01-21
IE852307L (en) 1986-03-20
DK424685A (da) 1986-03-21
IE58141B1 (en) 1993-07-14
PT81160A (en) 1985-10-01
EP0182024A3 (en) 1989-03-08
AU589371B2 (en) 1989-10-12
CS391591A3 (en) 1992-05-13

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