JPS60208965A - 新規カルボスチリル誘導体及びその製法 - Google Patents

新規カルボスチリル誘導体及びその製法

Info

Publication number
JPS60208965A
JPS60208965A JP59271603A JP27160384A JPS60208965A JP S60208965 A JPS60208965 A JP S60208965A JP 59271603 A JP59271603 A JP 59271603A JP 27160384 A JP27160384 A JP 27160384A JP S60208965 A JPS60208965 A JP S60208965A
Authority
JP
Japan
Prior art keywords
compound
isomer
hydroxy
methoxyphenyl
methylethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP59271603A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0446950B2 (enExample
Inventor
Takeo Iwakuma
岩隈　建男
Akira Tsunashima
綱島　朗
Ichiro Ikezawa
池沢　一郎
Takeyuki Takaichi
高市　雄之
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Pharma Corp
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Publication of JPS60208965A publication Critical patent/JPS60208965A/ja
Publication of JPH0446950B2 publication Critical patent/JPH0446950B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/58—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
    • C07D215/60—N-oxides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP59271603A 1983-12-24 1984-12-21 新規カルボスチリル誘導体及びその製法 Granted JPS60208965A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8334494 1983-12-24
GB838334494A GB8334494D0 (en) 1983-12-24 1983-12-24 Carbostyril derivatives

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP62132886A Division JPS6354362A (ja) 1983-12-24 1987-05-28 カルボスチリル化合物

Publications (2)

Publication Number Publication Date
JPS60208965A true JPS60208965A (ja) 1985-10-21
JPH0446950B2 JPH0446950B2 (enExample) 1992-07-31

Family

ID=10553866

Family Applications (2)

Application Number Title Priority Date Filing Date
JP59271603A Granted JPS60208965A (ja) 1983-12-24 1984-12-21 新規カルボスチリル誘導体及びその製法
JP62132886A Pending JPS6354362A (ja) 1983-12-24 1987-05-28 カルボスチリル化合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP62132886A Pending JPS6354362A (ja) 1983-12-24 1987-05-28 カルボスチリル化合物

Country Status (10)

Country Link
US (2) US4579854A (enExample)
EP (1) EP0147719B1 (enExample)
JP (2) JPS60208965A (enExample)
AT (1) ATE44954T1 (enExample)
CA (1) CA1258859A (enExample)
DE (1) DE3479119D1 (enExample)
GB (1) GB8334494D0 (enExample)
HK (1) HK89790A (enExample)
MY (1) MY101891A (enExample)
SG (1) SG75290G (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007500676A (ja) * 2003-07-31 2007-01-18 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 抗コリン作用薬とベータ受容体刺激薬を含む吸入用薬剤
JP2010516803A (ja) * 2007-01-30 2010-05-20 シエシー ファルマセウティチィ ソシエタ ペル アチオニ ８−ヒドロキシ−５−［（１ｒ）−１−ヒドロキシ−２［［（１ｒ）−２−（４−メトキシフェニル）−１−メチルエチル］アミノ］エチル］−２（１ｈ）−キノリノン・一塩酸塩の製造方法
JP2010520188A (ja) * 2007-02-28 2010-06-10 シプラ・リミテッド カルモテロールの異性体を調製する方法

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US4677112A (en) * 1984-02-02 1987-06-30 Warner-Lambert Company 1,2,3,4-tetrahydro-2-oxo-8-quinolineacetic and -propanoic acids and derivatives as cognition activators
US4687776A (en) * 1986-10-24 1987-08-18 Warner-Lambert Company Drug stabilization
WO1995011026A1 (en) * 1993-10-21 1995-04-27 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivative for inhibiting production of interleukin-8
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US20010031244A1 (en) 1997-06-13 2001-10-18 Chiesi Farmaceutici S.P.A. Pharmaceutical aerosol composition
DZ2947A1 (fr) * 1998-11-25 2004-03-15 Chiesi Farma Spa Inhalateur à compteur de dose sous pression.
US6315985B1 (en) * 1999-06-18 2001-11-13 3M Innovative Properties Company C-17/21 OH 20-ketosteroid solution aerosol products with enhanced chemical stability
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US20030229058A1 (en) 2001-11-13 2003-12-11 Moran Edmund J. Aryl aniline beta2 adrenergic receptor agonists
SI3494995T1 (sl) * 2002-03-01 2020-08-31 Chiesi Farmaceutici S.P.A. Superfina formulacija formoterola
EP1507754A1 (en) 2002-05-28 2005-02-23 Theravance, Inc. Alkoxy aryl beta-2 adrenergic receptor agonists
US20050025718A1 (en) * 2003-07-31 2005-02-03 Boehringer Ingelheim International Gmbh Medicaments for inhalation comprising an anticholinergic and a betamimetic
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EP2563364A1 (en) 2010-04-26 2013-03-06 Mahmut Bilgic Combination of carmoterol and fluticasone for use in the treatment respiratory diseases
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JPS5156464A (ja) * 1974-11-11 1976-05-18 Otsuka Pharma Co Ltd Karubosuchirirujudotaino seizoho
JPS52283A (en) * 1975-06-23 1977-01-05 Otsuka Pharmaceut Co Ltd Process for preparation of carbostyril derivatives
JPS5283379A (en) * 1975-12-26 1977-07-12 Otsuka Pharmaceut Co Ltd Synthesis of carbostyril derivatives

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JPS609713B2 (ja) * 1976-10-08 1985-03-12 大塚製薬株式会社 カルボスチリル誘導体
JPS5913510A (ja) * 1982-07-14 1984-01-24 Kotobuki Sangyo Kk 冷却誘導案内装置

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
JPS5156464A (ja) * 1974-11-11 1976-05-18 Otsuka Pharma Co Ltd Karubosuchirirujudotaino seizoho
JPS52283A (en) * 1975-06-23 1977-01-05 Otsuka Pharmaceut Co Ltd Process for preparation of carbostyril derivatives
JPS5283379A (en) * 1975-12-26 1977-07-12 Otsuka Pharmaceut Co Ltd Synthesis of carbostyril derivatives

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007500676A (ja) * 2003-07-31 2007-01-18 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 抗コリン作用薬とベータ受容体刺激薬を含む吸入用薬剤
JP2010516803A (ja) * 2007-01-30 2010-05-20 シエシー ファルマセウティチィ ソシエタ ペル アチオニ ８−ヒドロキシ−５−［（１ｒ）−１−ヒドロキシ−２［［（１ｒ）−２−（４−メトキシフェニル）−１−メチルエチル］アミノ］エチル］−２（１ｈ）−キノリノン・一塩酸塩の製造方法
JP2010520188A (ja) * 2007-02-28 2010-06-10 シプラ・リミテッド カルモテロールの異性体を調製する方法

Also Published As

Publication number Publication date
CA1259074C (enExample) 1989-09-05
MY101891A (en) 1992-02-15
SG75290G (en) 1990-11-23
CA1258859A (en) 1989-08-29
ATE44954T1 (de) 1989-08-15
EP0147719B1 (en) 1989-07-26
DE3479119D1 (en) 1989-08-31
JPS6354362A (ja) 1988-03-08
USRE33024E (en) 1989-08-15
EP0147719A3 (en) 1986-06-25
JPH0446950B2 (enExample) 1992-07-31
HK89790A (en) 1990-11-09
GB8334494D0 (en) 1984-02-01
US4579854A (en) 1986-04-01
EP0147719A2 (en) 1985-07-10

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