AR048339A1 - Monoclorhidrato de 8- hidroxi-5-((1r)) -1- hidroxi-2- (((1r)-2 ( 4-metoxifenil) -1- metiletil) amino ) eti l) -2 (1h) - quinolinona en form acristalina y el proceso para su preparacion - Google Patents
Monoclorhidrato de 8- hidroxi-5-((1r)) -1- hidroxi-2- (((1r)-2 ( 4-metoxifenil) -1- metiletil) amino ) eti l) -2 (1h) - quinolinona en form acristalina y el proceso para su preparacionInfo
- Publication number
- AR048339A1 AR048339A1 ARP050101185A ARP050101185A AR048339A1 AR 048339 A1 AR048339 A1 AR 048339A1 AR P050101185 A ARP050101185 A AR P050101185A AR P050101185 A ARP050101185 A AR P050101185A AR 048339 A1 AR048339 A1 AR 048339A1
- Authority
- AR
- Argentina
- Prior art keywords
- hydroxi
- amino
- preparation
- quinolinone
- monoclorhydrate
- Prior art date
Links
- -1 AMINO Chemical class 0.000 title 1
- SYCWERNQGSKYAG-QVRIGTRMSA-N hydron;8-hydroxy-5-[(1r)-1-hydroxy-2-[[(2r)-1-(4-methoxyphenyl)propan-2-yl]amino]ethyl]-1h-quinolin-2-one;chloride Chemical compound Cl.C1=CC(OC)=CC=C1C[C@@H](C)NC[C@H](O)C1=CC=C(O)C2=C1C=CC(=O)N2 SYCWERNQGSKYAG-QVRIGTRMSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/48—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
- C07D215/26—Alcohols; Ethers thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/58—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
- C07D215/60—N-oxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Abstract
Monoclorihidrato de 8-hidroxi-5-[(1R)-1-hidroxi-2-{[(1R)-2-(4-metoxifenil)-1-metiletil]amino}etil]-2(1H)-quinolinona de formula (I) en forma cristalina, provisto de características apropiadas para ser usado en la preparacion de composiciones farmacéuticas para inhalacion en combinacion con vehículos apropiados.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04007045 | 2004-03-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR048339A1 true AR048339A1 (es) | 2006-04-19 |
Family
ID=34963779
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP050101185A AR048339A1 (es) | 2004-03-24 | 2005-03-23 | Monoclorhidrato de 8- hidroxi-5-((1r)) -1- hidroxi-2- (((1r)-2 ( 4-metoxifenil) -1- metiletil) amino ) eti l) -2 (1h) - quinolinona en form acristalina y el proceso para su preparacion |
Country Status (30)
Country | Link |
---|---|
US (1) | US20070197586A1 (es) |
EP (1) | EP1729773B1 (es) |
JP (1) | JP2007530489A (es) |
KR (1) | KR20070001946A (es) |
CN (2) | CN101812017A (es) |
AR (1) | AR048339A1 (es) |
AT (1) | ATE399552T1 (es) |
AU (1) | AU2005224032A1 (es) |
BR (1) | BRPI0508213A (es) |
CA (1) | CA2560650A1 (es) |
CY (1) | CY1108323T1 (es) |
DE (1) | DE602005007871D1 (es) |
DK (1) | DK1729773T3 (es) |
EA (1) | EA010128B1 (es) |
ES (1) | ES2309739T3 (es) |
HR (1) | HRP20080495T3 (es) |
IL (1) | IL178227A0 (es) |
MA (1) | MA28549B1 (es) |
MX (1) | MXPA06010515A (es) |
NO (1) | NO20064274L (es) |
NZ (1) | NZ550010A (es) |
PE (1) | PE20060159A1 (es) |
PL (1) | PL1729773T3 (es) |
PT (1) | PT1729773E (es) |
RS (1) | RS50602B (es) |
SI (1) | SI1729773T1 (es) |
TN (1) | TNSN06249A1 (es) |
UA (1) | UA86221C2 (es) |
WO (1) | WO2005089760A1 (es) |
ZA (1) | ZA200607907B (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1953143A1 (en) * | 2007-01-30 | 2008-08-06 | CHIESI FARMACEUTICI S.p.A. | Process for the preparation of 8-hydroxy-5-[(1R)-1-hydroxy-2[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]-2(1H)-quinolinone monohydrochloride |
EP2116537A1 (en) * | 2008-05-07 | 2009-11-11 | CHIESI FARMACEUTICI S.p.A. | Polymorph of 8-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]-2(1H)-quinolinone monohydrochloride |
EP2116536A1 (en) | 2008-05-07 | 2009-11-11 | CHIESI FARMACEUTICI S.p.A. | Crystal form of 8-hydroxy-5-[(1r)-1-hydroxy-2-[[(1r)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]-2(1h)- quinolinone monohydrochloride |
WO2011015289A1 (en) | 2009-08-04 | 2011-02-10 | Chiesi Farmaceutici S.P.A. | 8-hydroxy-5-[(1r)-1-hydroxy-2-[[(1r)-2-(4-methoxyphenyl)-1-methylethyl] amino]ethyl]-2(1h)-quinolinone hemi-fumarate |
EP2360147A1 (en) | 2010-02-22 | 2011-08-24 | CHIESI FARMACEUTICI S.p.A. | Process for preparing crystalline particles of a salt of 8-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino] ethyl]-2(1H)-quinolinone (carmoterol) |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8334494D0 (en) * | 1983-12-24 | 1984-02-01 | Tanabe Seiyaku Co | Carbostyril derivatives |
GB9603237D0 (en) * | 1996-02-16 | 1996-04-17 | Sandoz Ltd | Organic compounds |
SE9700135D0 (sv) * | 1997-01-20 | 1997-01-20 | Astra Ab | New formulation |
WO2005013945A2 (en) * | 2003-08-05 | 2005-02-17 | Boehringer Ingelheim International Gmbh | Medicaments for inhalation comprising steroids and a betamimetic |
EP1953143A1 (en) * | 2007-01-30 | 2008-08-06 | CHIESI FARMACEUTICI S.p.A. | Process for the preparation of 8-hydroxy-5-[(1R)-1-hydroxy-2[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]-2(1H)-quinolinone monohydrochloride |
EP2116537A1 (en) * | 2008-05-07 | 2009-11-11 | CHIESI FARMACEUTICI S.p.A. | Polymorph of 8-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]-2(1H)-quinolinone monohydrochloride |
EP2116536A1 (en) * | 2008-05-07 | 2009-11-11 | CHIESI FARMACEUTICI S.p.A. | Crystal form of 8-hydroxy-5-[(1r)-1-hydroxy-2-[[(1r)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]-2(1h)- quinolinone monohydrochloride |
-
2005
- 2005-03-23 AR ARP050101185A patent/AR048339A1/es not_active Application Discontinuation
- 2005-03-23 PE PE2005000338A patent/PE20060159A1/es not_active Application Discontinuation
- 2005-03-24 EP EP05730069A patent/EP1729773B1/en active Active
- 2005-03-24 UA UAA200609448A patent/UA86221C2/uk unknown
- 2005-03-24 ES ES05730069T patent/ES2309739T3/es active Active
- 2005-03-24 NZ NZ550010A patent/NZ550010A/en unknown
- 2005-03-24 CA CA002560650A patent/CA2560650A1/en not_active Abandoned
- 2005-03-24 KR KR1020067015966A patent/KR20070001946A/ko not_active Application Discontinuation
- 2005-03-24 AT AT05730069T patent/ATE399552T1/de not_active IP Right Cessation
- 2005-03-24 DK DK05730069T patent/DK1729773T3/da active
- 2005-03-24 EA EA200601531A patent/EA010128B1/ru not_active IP Right Cessation
- 2005-03-24 RS RSP-2008/0393A patent/RS50602B/sr unknown
- 2005-03-24 MX MXPA06010515A patent/MXPA06010515A/es active IP Right Grant
- 2005-03-24 BR BRPI0508213-7A patent/BRPI0508213A/pt not_active IP Right Cessation
- 2005-03-24 PT PT05730069T patent/PT1729773E/pt unknown
- 2005-03-24 PL PL05730069T patent/PL1729773T3/pl unknown
- 2005-03-24 CN CN200910173473A patent/CN101812017A/zh active Pending
- 2005-03-24 DE DE602005007871T patent/DE602005007871D1/de active Active
- 2005-03-24 AU AU2005224032A patent/AU2005224032A1/en not_active Abandoned
- 2005-03-24 US US10/593,571 patent/US20070197586A1/en not_active Abandoned
- 2005-03-24 CN CN2005800076387A patent/CN1929840B/zh not_active Expired - Fee Related
- 2005-03-24 JP JP2007504359A patent/JP2007530489A/ja not_active Withdrawn
- 2005-03-24 WO PCT/EP2005/003144 patent/WO2005089760A1/en active Application Filing
- 2005-03-24 SI SI200530320T patent/SI1729773T1/sl unknown
-
2006
- 2006-08-04 TN TNP2006000249A patent/TNSN06249A1/en unknown
- 2006-09-21 IL IL178227A patent/IL178227A0/en not_active IP Right Cessation
- 2006-09-21 ZA ZA2006/07907A patent/ZA200607907B/en unknown
- 2006-09-21 NO NO20064274A patent/NO20064274L/no not_active Application Discontinuation
- 2006-10-23 MA MA29409A patent/MA28549B1/fr unknown
-
2008
- 2008-09-04 CY CY20081100962T patent/CY1108323T1/el unknown
- 2008-10-01 HR HR20080495T patent/HRP20080495T3/xx unknown
Also Published As
Publication number | Publication date |
---|---|
CN101812017A (zh) | 2010-08-25 |
CN1929840B (zh) | 2010-12-08 |
NZ550010A (en) | 2010-08-27 |
PL1729773T3 (pl) | 2008-12-31 |
DK1729773T3 (da) | 2008-10-20 |
AU2005224032A1 (en) | 2005-09-29 |
JP2007530489A (ja) | 2007-11-01 |
NO20064274L (no) | 2006-10-13 |
TNSN06249A1 (en) | 2007-12-03 |
MA28549B1 (fr) | 2007-04-03 |
MXPA06010515A (es) | 2007-03-30 |
UA86221C2 (en) | 2009-04-10 |
EA200601531A1 (ru) | 2007-04-27 |
CY1108323T1 (el) | 2014-02-12 |
PT1729773E (pt) | 2008-09-29 |
ATE399552T1 (de) | 2008-07-15 |
WO2005089760A1 (en) | 2005-09-29 |
BRPI0508213A (pt) | 2007-07-17 |
CA2560650A1 (en) | 2005-09-29 |
HRP20080495T3 (en) | 2008-11-30 |
US20070197586A1 (en) | 2007-08-23 |
ZA200607907B (en) | 2008-04-30 |
CN1929840A (zh) | 2007-03-14 |
KR20070001946A (ko) | 2007-01-04 |
EP1729773B1 (en) | 2008-07-02 |
ES2309739T3 (es) | 2008-12-16 |
RS50602B (sr) | 2010-05-07 |
IL178227A0 (en) | 2006-12-31 |
EP1729773A1 (en) | 2006-12-13 |
DE602005007871D1 (de) | 2008-08-14 |
PE20060159A1 (es) | 2006-04-04 |
EA010128B1 (ru) | 2008-06-30 |
SI1729773T1 (sl) | 2008-10-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |