UA86221C2 - 8-hydroxy-5-[(1r)-1-hydroxy-2[[(1r)-2-(4-methoxyphenyl)-1-methyl ethyl]amino]ethyl]-2-(1h)-quinolinone monohydrochloride - Google Patents
8-hydroxy-5-[(1r)-1-hydroxy-2[[(1r)-2-(4-methoxyphenyl)-1-methyl ethyl]amino]ethyl]-2-(1h)-quinolinone monohydrochloride Download PDFInfo
- Publication number
- UA86221C2 UA86221C2 UAA200609448A UAA200609448A UA86221C2 UA 86221 C2 UA86221 C2 UA 86221C2 UA A200609448 A UAA200609448 A UA A200609448A UA A200609448 A UAA200609448 A UA A200609448A UA 86221 C2 UA86221 C2 UA 86221C2
- Authority
- UA
- Ukraine
- Prior art keywords
- hydroxy
- ethyl
- methoxyphenyl
- ethanol
- amino
- Prior art date
Links
- SYCWERNQGSKYAG-QVRIGTRMSA-N hydron;8-hydroxy-5-[(1r)-1-hydroxy-2-[[(2r)-1-(4-methoxyphenyl)propan-2-yl]amino]ethyl]-1h-quinolin-2-one;chloride Chemical compound Cl.C1=CC(OC)=CC=C1C[C@@H](C)NC[C@H](O)C1=CC=C(O)C2=C1C=CC(=O)N2 SYCWERNQGSKYAG-QVRIGTRMSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract description 11
- 238000002360 preparation method Methods 0.000 abstract description 3
- 239000000969 carrier Substances 0.000 abstract description 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 38
- 150000001875 compounds Chemical class 0.000 description 17
- 239000002904 solvent Substances 0.000 description 11
- 239000000203 mixture Substances 0.000 description 10
- 239000000725 suspension Substances 0.000 description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 8
- ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 description 7
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 238000000354 decomposition reaction Methods 0.000 description 4
- 238000000113 differential scanning calorimetry Methods 0.000 description 4
- 239000012535 impurity Substances 0.000 description 4
- 238000002844 melting Methods 0.000 description 4
- 230000008018 melting Effects 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 238000005406 washing Methods 0.000 description 4
- 238000005515 capillary zone electrophoresis Methods 0.000 description 3
- 238000002425 crystallisation Methods 0.000 description 3
- 230000008025 crystallization Effects 0.000 description 3
- 238000004821 distillation Methods 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 238000000227 grinding Methods 0.000 description 3
- 238000004128 high performance liquid chromatography Methods 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 238000000634 powder X-ray diffraction Methods 0.000 description 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 3
- 238000001953 recrystallisation Methods 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- 238000009903 catalytic hydrogenation reaction Methods 0.000 description 2
- 239000012043 crude product Substances 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- 238000007605 air drying Methods 0.000 description 1
- 125000005606 carbostyryl group Chemical group 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical group O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 1
- DQYBDCGIPTYXML-UHFFFAOYSA-N ethoxyethane;hydrate Chemical compound O.CCOCC DQYBDCGIPTYXML-UHFFFAOYSA-N 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 239000012456 homogeneous solution Substances 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/48—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
- C07D215/26—Alcohols; Ethers thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/58—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
- C07D215/60—N-oxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04007045 | 2004-03-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA86221C2 true UA86221C2 (en) | 2009-04-10 |
Family
ID=34963779
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200609448A UA86221C2 (en) | 2004-03-24 | 2005-03-24 | 8-hydroxy-5-[(1r)-1-hydroxy-2[[(1r)-2-(4-methoxyphenyl)-1-methyl ethyl]amino]ethyl]-2-(1h)-quinolinone monohydrochloride |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US20070197586A1 (es) |
| EP (1) | EP1729773B1 (es) |
| JP (1) | JP2007530489A (es) |
| KR (1) | KR20070001946A (es) |
| CN (2) | CN1929840B (es) |
| AR (1) | AR048339A1 (es) |
| AT (1) | ATE399552T1 (es) |
| AU (1) | AU2005224032A1 (es) |
| BR (1) | BRPI0508213A (es) |
| CA (1) | CA2560650A1 (es) |
| CY (1) | CY1108323T1 (es) |
| DE (1) | DE602005007871D1 (es) |
| DK (1) | DK1729773T3 (es) |
| EA (1) | EA010128B1 (es) |
| ES (1) | ES2309739T3 (es) |
| HR (1) | HRP20080495T3 (es) |
| IL (1) | IL178227A0 (es) |
| MA (1) | MA28549B1 (es) |
| MX (1) | MXPA06010515A (es) |
| NO (1) | NO20064274L (es) |
| NZ (1) | NZ550010A (es) |
| PE (1) | PE20060159A1 (es) |
| PL (1) | PL1729773T3 (es) |
| PT (1) | PT1729773E (es) |
| RS (1) | RS50602B (es) |
| SI (1) | SI1729773T1 (es) |
| TN (1) | TNSN06249A1 (es) |
| UA (1) | UA86221C2 (es) |
| WO (1) | WO2005089760A1 (es) |
| ZA (1) | ZA200607907B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1953143A1 (en) * | 2007-01-30 | 2008-08-06 | CHIESI FARMACEUTICI S.p.A. | Process for the preparation of 8-hydroxy-5-[(1R)-1-hydroxy-2[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]-2(1H)-quinolinone monohydrochloride |
| EP2116537A1 (en) * | 2008-05-07 | 2009-11-11 | CHIESI FARMACEUTICI S.p.A. | Polymorph of 8-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]-2(1H)-quinolinone monohydrochloride |
| EP2116536A1 (en) * | 2008-05-07 | 2009-11-11 | CHIESI FARMACEUTICI S.p.A. | Crystal form of 8-hydroxy-5-[(1r)-1-hydroxy-2-[[(1r)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]-2(1h)- quinolinone monohydrochloride |
| WO2011015289A1 (en) | 2009-08-04 | 2011-02-10 | Chiesi Farmaceutici S.P.A. | 8-hydroxy-5-[(1r)-1-hydroxy-2-[[(1r)-2-(4-methoxyphenyl)-1-methylethyl] amino]ethyl]-2(1h)-quinolinone hemi-fumarate |
| EP2360147A1 (en) | 2010-02-22 | 2011-08-24 | CHIESI FARMACEUTICI S.p.A. | Process for preparing crystalline particles of a salt of 8-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino] ethyl]-2(1H)-quinolinone (carmoterol) |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8334494D0 (en) * | 1983-12-24 | 1984-02-01 | Tanabe Seiyaku Co | Carbostyril derivatives |
| GB9603237D0 (en) * | 1996-02-16 | 1996-04-17 | Sandoz Ltd | Organic compounds |
| SE9700135D0 (sv) * | 1997-01-20 | 1997-01-20 | Astra Ab | New formulation |
| EP1654001A2 (en) * | 2003-08-05 | 2006-05-10 | Boehringer Ingelheim International GmbH | Medicaments for inhalation comprising steroids and a betamimetic |
| EP1953143A1 (en) * | 2007-01-30 | 2008-08-06 | CHIESI FARMACEUTICI S.p.A. | Process for the preparation of 8-hydroxy-5-[(1R)-1-hydroxy-2[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]-2(1H)-quinolinone monohydrochloride |
| EP2116537A1 (en) * | 2008-05-07 | 2009-11-11 | CHIESI FARMACEUTICI S.p.A. | Polymorph of 8-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]-2(1H)-quinolinone monohydrochloride |
| EP2116536A1 (en) * | 2008-05-07 | 2009-11-11 | CHIESI FARMACEUTICI S.p.A. | Crystal form of 8-hydroxy-5-[(1r)-1-hydroxy-2-[[(1r)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]-2(1h)- quinolinone monohydrochloride |
-
2005
- 2005-03-23 AR ARP050101185A patent/AR048339A1/es not_active Application Discontinuation
- 2005-03-23 PE PE2005000338A patent/PE20060159A1/es not_active Application Discontinuation
- 2005-03-24 RS RSP-2008/0393A patent/RS50602B/sr unknown
- 2005-03-24 JP JP2007504359A patent/JP2007530489A/ja not_active Withdrawn
- 2005-03-24 CN CN2005800076387A patent/CN1929840B/zh not_active Expired - Fee Related
- 2005-03-24 EP EP05730069A patent/EP1729773B1/en active Active
- 2005-03-24 CN CN200910173473A patent/CN101812017A/zh active Pending
- 2005-03-24 CA CA002560650A patent/CA2560650A1/en not_active Abandoned
- 2005-03-24 DE DE602005007871T patent/DE602005007871D1/de active Active
- 2005-03-24 WO PCT/EP2005/003144 patent/WO2005089760A1/en active Application Filing
- 2005-03-24 KR KR1020067015966A patent/KR20070001946A/ko not_active Application Discontinuation
- 2005-03-24 AT AT05730069T patent/ATE399552T1/de not_active IP Right Cessation
- 2005-03-24 PL PL05730069T patent/PL1729773T3/pl unknown
- 2005-03-24 BR BRPI0508213-7A patent/BRPI0508213A/pt not_active IP Right Cessation
- 2005-03-24 MX MXPA06010515A patent/MXPA06010515A/es active IP Right Grant
- 2005-03-24 SI SI200530320T patent/SI1729773T1/sl unknown
- 2005-03-24 US US10/593,571 patent/US20070197586A1/en not_active Abandoned
- 2005-03-24 UA UAA200609448A patent/UA86221C2/uk unknown
- 2005-03-24 NZ NZ550010A patent/NZ550010A/en unknown
- 2005-03-24 ES ES05730069T patent/ES2309739T3/es active Active
- 2005-03-24 EA EA200601531A patent/EA010128B1/ru not_active IP Right Cessation
- 2005-03-24 PT PT05730069T patent/PT1729773E/pt unknown
- 2005-03-24 AU AU2005224032A patent/AU2005224032A1/en not_active Abandoned
- 2005-03-24 DK DK05730069T patent/DK1729773T3/da active
-
2006
- 2006-08-04 TN TNP2006000249A patent/TNSN06249A1/en unknown
- 2006-09-21 NO NO20064274A patent/NO20064274L/no not_active Application Discontinuation
- 2006-09-21 ZA ZA2006/07907A patent/ZA200607907B/en unknown
- 2006-09-21 IL IL178227A patent/IL178227A0/en not_active IP Right Cessation
- 2006-10-23 MA MA29409A patent/MA28549B1/fr unknown
-
2008
- 2008-09-04 CY CY20081100962T patent/CY1108323T1/el unknown
- 2008-10-01 HR HR20080495T patent/HRP20080495T3/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RS50602B (sr) | 2010-05-07 |
| ZA200607907B (en) | 2008-04-30 |
| CN101812017A (zh) | 2010-08-25 |
| AR048339A1 (es) | 2006-04-19 |
| US20070197586A1 (en) | 2007-08-23 |
| NO20064274L (no) | 2006-10-13 |
| EP1729773B1 (en) | 2008-07-02 |
| CN1929840A (zh) | 2007-03-14 |
| EP1729773A1 (en) | 2006-12-13 |
| KR20070001946A (ko) | 2007-01-04 |
| EA010128B1 (ru) | 2008-06-30 |
| DE602005007871D1 (de) | 2008-08-14 |
| ATE399552T1 (de) | 2008-07-15 |
| ES2309739T3 (es) | 2008-12-16 |
| AU2005224032A1 (en) | 2005-09-29 |
| TNSN06249A1 (en) | 2007-12-03 |
| HRP20080495T3 (en) | 2008-11-30 |
| PE20060159A1 (es) | 2006-04-04 |
| IL178227A0 (en) | 2006-12-31 |
| MXPA06010515A (es) | 2007-03-30 |
| CA2560650A1 (en) | 2005-09-29 |
| CN1929840B (zh) | 2010-12-08 |
| PT1729773E (pt) | 2008-09-29 |
| EA200601531A1 (ru) | 2007-04-27 |
| BRPI0508213A (pt) | 2007-07-17 |
| JP2007530489A (ja) | 2007-11-01 |
| PL1729773T3 (pl) | 2008-12-31 |
| CY1108323T1 (el) | 2014-02-12 |
| SI1729773T1 (sl) | 2008-10-31 |
| DK1729773T3 (da) | 2008-10-20 |
| WO2005089760A1 (en) | 2005-09-29 |
| NZ550010A (en) | 2010-08-27 |
| MA28549B1 (fr) | 2007-04-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR101076929B1 (ko) | 아드레날린 수용체 작용제로서 유용한5-[(ｒ)-2-(5,6-디에틸-인단-2-일아미노)-1-하이드록시-에틸]-8-하이드록시-(1ｈ)-퀴놀린-2-온 염의 제조방법 | |
| JP5267643B2 (ja) | ピタバスタチンカルシウム塩の保存方法 | |
| CZ349498A3 (cs) | Trihydrát methansulfonátu 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)-ethyl)-6-chlor-1,3-dihydro-2H-indol-2-onu, farmaceutická kompozice na jeho bázi a způsob léčení psychotických poruch | |
| UA86221C2 (en) | 8-hydroxy-5-[(1r)-1-hydroxy-2[[(1r)-2-(4-methoxyphenyl)-1-methyl ethyl]amino]ethyl]-2-(1h)-quinolinone monohydrochloride | |
| EP0252823A1 (fr) | Nouveaux dérivés du 1H, 3H-pyrrolo [1,2-c] thiazole, leur préparation et les compositions pharmaceutiques qui les contiennent | |
| US20130345418A1 (en) | Process for purification of aprepitant | |
| JP2024500665A (ja) | ２－ヒドロキシ－５－［２－（４－（トリフルオロメチルフェニル）エチルアミノ）］安息香酸結晶形およびこの製造方法 | |
| EP2825525A1 (en) | New polymorphic form of a long-acting beta-2 adrenoceptor agonist | |
| WO2003027106A1 (en) | Process for the preparation of crystalline polymorph ii of lamivudine | |
| CA2068429C (en) | Process for the purification of 7-chloroquinoline-8-carboxylic acids | |
| CA1148552A (en) | Preparation of germaazaspirodiones and germaazaspiranes | |
| KR100870847B1 (ko) | Ｎ-(1(ｓ)-에톡시카르보닐-3-페닐프로필)-ｌ-알라닌의정제 방법 | |
| KR880001235B1 (ko) | 결정성 무수 소듐 19-데옥시아글리콘 디아네마이신의 제조 방법 | |
| CA2989364C (en) | Process for the preparation of enclomiphene citrate having needle shaped crystal habit. | |
| AU2013204129B2 (en) | Crystal Form of Quinoline Compound and Process for its Production | |
| WO2008135966A1 (en) | Process for the purification of optically impure 2-(2-(3(s)-(3-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-hydroxy-propyl)phenyl-2-propanol | |
| WO1999052935A1 (fr) | Formes cristallines du 1s-[1alpha (2s*,3r*),9alpha]-6, 10-dioxo-n- (2-ethoxy-5 -oxo-tetrahydro-3 -furanyl) -9-[[(1-isoquinolyl) carbonyl]-amino] octahydro-6h -piridazino[1, 2-a][1,2] diazepine-1- carboxamide | |
| WO2016142173A1 (en) | 4-(2-methyl-1h-imidazol-1-yl)-2,2-diphenylbutanenitrile solid form | |
| FR2664595A1 (fr) | Nouveaux derives de benzonaphtyridine-1,8, leur preparation et les compositions qui les contiennent. | |
| FR2653663A1 (en) | Novel benzo[1,8]naphthyridine derivatives, their preparation and compositions containing them | |
| CH294895A (fr) | Procédé de préparation d'une nouvelle oxazoline thérapeutiquement active. | |
| MXPA06007477A (es) | Preparacion de clorhidrato de r-5-(2-(2 -(2-etoxifenoxietilamino) propil)-2- metoxibencenosulfonamida de alta pureza quimica |