|
US4677112A
(en)
*
|
1984-02-02 |
1987-06-30 |
Warner-Lambert Company |
1,2,3,4-tetrahydro-2-oxo-8-quinolineacetic and -propanoic acids and derivatives as cognition activators
|
|
US4687776A
(en)
*
|
1986-10-24 |
1987-08-18 |
Warner-Lambert Company |
Drug stabilization
|
|
ATE184793T1
(de)
*
|
1993-10-21 |
1999-10-15 |
Otsuka Pharma Co Ltd |
Die verwendung von carbostyrilderivaten zur herstellung eines arzneimittels zur hemmung der produktion von interleukin-8
|
|
GB9405019D0
(en)
*
|
1994-03-15 |
1994-04-27 |
Smithkline Beecham Plc |
Novel compounds
|
|
DK1393721T3
(da)
|
1997-03-20 |
2009-03-30 |
Schering Corp |
Doseringsform af pulveragglomerater
|
|
US20010031244A1
(en)
|
1997-06-13 |
2001-10-18 |
Chiesi Farmaceutici S.P.A. |
Pharmaceutical aerosol composition
|
|
DZ2947A1
(fr)
*
|
1998-11-25 |
2004-03-15 |
Chiesi Farma Spa |
Inhalateur à compteur de dose sous pression.
|
|
US6315985B1
(en)
*
|
1999-06-18 |
2001-11-13 |
3M Innovative Properties Company |
C-17/21 OH 20-ketosteroid solution aerosol products with enhanced chemical stability
|
|
US7214687B2
(en)
*
|
1999-07-14 |
2007-05-08 |
Almirall Ag |
Quinuclidine derivatives and medicinal compositions containing the same
|
|
ES2165768B1
(es)
|
1999-07-14 |
2003-04-01 |
Almirall Prodesfarma Sa |
Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
|
|
IT1317720B1
(it)
*
|
2000-01-07 |
2003-07-15 |
Chiesi Farma Spa |
Dispositivo per la somministrazione di aerosol dosati pressurizzati inpropellenti idrofluoroalcani.
|
|
IT1318514B1
(it)
*
|
2000-05-12 |
2003-08-27 |
Chiesi Farma Spa |
Formulazioni contenenti un farmaco glucocorticosteroide per iltrattamento di patologie broncopolmonari.
|
|
CN1213732C
(zh)
*
|
2000-05-22 |
2005-08-10 |
奇斯药制品公司 |
用于加压计量吸入器的稳定药用溶液制剂
|
|
AR028948A1
(es)
*
|
2000-06-20 |
2003-05-28 |
Astrazeneca Ab |
Compuestos novedosos
|
|
ATE267591T1
(de)
*
|
2001-07-02 |
2004-06-15 |
Chiesi Farma Spa |
Optimierte tobramycin-formulierung zur aerosolbildung
|
|
US20030229058A1
(en)
|
2001-11-13 |
2003-12-11 |
Moran Edmund J. |
Aryl aniline beta2 adrenergic receptor agonists
|
|
TWI249515B
(en)
|
2001-11-13 |
2006-02-21 |
Theravance Inc |
Aryl aniline beta2 adrenergic receptor agonists
|
|
US6653323B2
(en)
|
2001-11-13 |
2003-11-25 |
Theravance, Inc. |
Aryl aniline β2 adrenergic receptor agonists
|
|
NZ535018A
(en)
*
|
2002-03-01 |
2007-02-23 |
Chiesi Farmaceutici S |
Pharmaceutical aerosol formulation containing formoterol, and its method of production
|
|
JP2005527618A
(ja)
|
2002-05-28 |
2005-09-15 |
セラヴァンス インコーポレーテッド |
アルコキシアリールβ2アドレナリン作動性レセプターアゴニスト
|
|
US20050025718A1
(en)
*
|
2003-07-31 |
2005-02-03 |
Boehringer Ingelheim International Gmbh |
Medicaments for inhalation comprising an anticholinergic and a betamimetic
|
|
EP1651224B1
(en)
*
|
2003-07-31 |
2011-10-05 |
Boehringer Ingelheim International GmbH |
Medicaments for inhalation comprising an anticholinergic and a betamimetic
|
|
EP1654001A2
(en)
*
|
2003-08-05 |
2006-05-10 |
Boehringer Ingelheim International GmbH |
Medicaments for inhalation comprising steroids and a betamimetic
|
|
US20050059643A1
(en)
*
|
2003-08-05 |
2005-03-17 |
Boehringer Ingelheim International Gmbh |
Medicaments for inhalation comprising a steroid and a betamimetic
|
|
TW200526547A
(en)
|
2003-09-22 |
2005-08-16 |
Theravance Inc |
Amino-substituted ethylamino β2 adrenergic receptor agonists
|
|
SE0303179D0
(sv)
*
|
2003-11-26 |
2003-11-26 |
Astrazeneca Ab |
Novel compounds
|
|
TW200531692A
(en)
|
2004-01-12 |
2005-10-01 |
Theravance Inc |
Aryl aniline derivatives as β2 adrenergic receptor agonists
|
|
IL177103A0
(en)
*
|
2004-02-27 |
2006-12-10 |
Chiesi Farma Spa |
Stable pharmaceutical solution formulations for pressurized metered dose inhalers
|
|
EP1595531A1
(en)
*
|
2004-05-13 |
2005-11-16 |
CHIESI FARMACEUTICI S.p.A. |
Stable pharmaceutical solution formulations for pressurized metered dose inhalers
|
|
WO2005092861A1
(en)
*
|
2004-03-11 |
2005-10-06 |
Pfizer Limited |
Quinolinone derivatives pharmaceutical compositions containing them and their use
|
|
EP1574501A1
(en)
*
|
2004-03-11 |
2005-09-14 |
Pfizer Limited |
Quinolinone derivatives, pharmaceutical compositions containing them and their use
|
|
PE20060159A1
(es)
*
|
2004-03-24 |
2006-04-04 |
Chiesi Farma Spa |
Monoclorhidrato de 8-hidroxi-5-[(1r)-1-hidroxi-2-{[(1r)-2-(4-metoxifenil)-1-metiletil]amino}etil]-2-(1h)-quinolinona en forma cristalina y el proceso para su preparacion
|
|
US7307076B2
(en)
*
|
2004-05-13 |
2007-12-11 |
Boehringer Ingelheim International Gmbh |
Beta agonists for the treatment of respiratory diseases
|
|
ES2257152B1
(es)
*
|
2004-05-31 |
2007-07-01 |
Laboratorios Almirall S.A. |
Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos.
|
|
RU2006146042A
(ru)
|
2004-06-03 |
2008-07-20 |
Тереванс |
Диаминные агонисты 2-адренергических рецепторов
|
|
EP1778638A1
(en)
|
2004-07-21 |
2007-05-02 |
Theravance, Inc. |
Diaryl ether beta2 adrenergic receptor agonists
|
|
EP1786762A2
(en)
|
2004-09-10 |
2007-05-23 |
Theravance, Inc. |
Amidine substituted aryl aniline compounds
|
|
JP2008534611A
(ja)
|
2005-03-30 |
2008-08-28 |
シェーリング コーポレイション |
抗コリン作用薬、コルチコステロイドおよび長時間作用性βアゴニストを合わせる薬物および方法
|
|
ES2265276B1
(es)
|
2005-05-20 |
2008-02-01 |
Laboratorios Almirall S.A. |
Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor beta2 adrenergico.
|
|
CA2609429A1
(en)
*
|
2005-05-31 |
2006-12-07 |
Boehringer Ingelheim International Gmbh |
Medicament containing a betamimetic in conjunction with an anticholinergic and a pde iv inhibitor
|
|
ES2332290T3
(es)
*
|
2005-08-01 |
2010-02-01 |
Chiesi Farmaceutici S.P.A. |
Formulaciones farmaceuticas que comprenden un agonista de beta2 de accion prolongada para su administracion mediante nebulizacion.
|
|
TW200738634A
(en)
*
|
2005-08-02 |
2007-10-16 |
Astrazeneca Ab |
New salt
|
|
CA2620281A1
(en)
*
|
2005-08-26 |
2007-03-01 |
Astrazeneca Ab |
A combination of compounds, which can be used in the treatment of respiratory diseases, especially chronic obstructive pulmonary disease (copd) and asthma
|
|
GB0601951D0
(en)
|
2006-01-31 |
2006-03-15 |
Novartis Ag |
Organic compounds
|
|
WO2008008021A1
(en)
*
|
2006-07-14 |
2008-01-17 |
Astrazeneca Ab |
Inhalation system and delivery device for the administration of a drug in the form of dry powder.
|
|
KR20090030347A
(ko)
|
2006-07-19 |
2009-03-24 |
아스트라제네카 아베 |
신규 트리시클릭 스피로피페리딘 화합물, 이들의 합성 및 이들의 케모킨 수용체 활성의 조절제로서의 용도
|
|
ES2298049B1
(es)
*
|
2006-07-21 |
2009-10-20 |
Laboratorios Almirall S.A. |
Procedimiento para fabricar bromuro de 3(r)-(2-hidroxi-2,2-ditien-2-ilacetoxi)-1-(3-fenoxipropil)-1-azoniabiciclo (2.2.2) octano.
|
|
CA2667962A1
(en)
|
2006-10-30 |
2008-05-08 |
Novartis Ag |
Heterocyclic compounds as antiinflammatory agents
|
|
TW200825084A
(en)
*
|
2006-11-14 |
2008-06-16 |
Astrazeneca Ab |
New compounds 521
|
|
BRPI0721039A2
(pt)
|
2006-12-19 |
2014-07-29 |
Astrazeneca Ab |
" derivados de quinuclidinol como antagonistas de receptores muscarínicos ".
|
|
EP1953143A1
(en)
|
2007-01-30 |
2008-08-06 |
CHIESI FARMACEUTICI S.p.A. |
Process for the preparation of 8-hydroxy-5-[(1R)-1-hydroxy-2[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]-2(1H)-quinolinone monohydrochloride
|
|
ES2306595B1
(es)
|
2007-02-09 |
2009-09-11 |
Laboratorios Almirall S.A. |
Sal de napadisilato de 5-(2-((6-(2,2-difluoro-2-feniletoxi)hexil)amino)-1-hidroxietil)-8-hidroxiquinolin-2(1h)-ona como agonista del receptor adrenergico beta2.
|
|
US20100056565A1
(en)
*
|
2007-02-15 |
2010-03-04 |
Argenta Discovery Limited |
Heterocyclic Derivatives as M3 Muscarinic Receptors
|
|
JP2010520188A
(ja)
*
|
2007-02-28 |
2010-06-10 |
シプラ・リミテッド |
カルモテロールの異性体を調製する方法
|
|
CA2608561A1
(en)
*
|
2007-10-29 |
2009-04-29 |
Carl Paluszkiewicz |
Motorcycle wind deflector accessory support
|
|
ES2320961B1
(es)
|
2007-11-28 |
2010-03-17 |
Laboratorios Almirall, S.A. |
Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor adrenergico beta2.
|
|
CN101910153B
(zh)
|
2008-01-11 |
2014-01-22 |
诺华股份有限公司 |
作为激酶抑制剂的嘧啶类
|
|
EP2100599A1
(en)
|
2008-03-13 |
2009-09-16 |
Laboratorios Almirall, S.A. |
Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
|
|
EP2100598A1
(en)
|
2008-03-13 |
2009-09-16 |
Laboratorios Almirall, S.A. |
Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
|
|
EP2116536A1
(en)
*
|
2008-05-07 |
2009-11-11 |
CHIESI FARMACEUTICI S.p.A. |
Crystal form of 8-hydroxy-5-[(1r)-1-hydroxy-2-[[(1r)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]-2(1h)- quinolinone monohydrochloride
|
|
EP2116537A1
(en)
*
|
2008-05-07 |
2009-11-11 |
CHIESI FARMACEUTICI S.p.A. |
Polymorph of 8-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]-2(1H)-quinolinone monohydrochloride
|
|
EP2300464A1
(en)
*
|
2008-05-13 |
2011-03-30 |
AstraZeneca AB |
Quinuclidine derivatives as muscarinic m3 receptor antagonists
|
|
WO2009139708A1
(en)
*
|
2008-05-13 |
2009-11-19 |
Astrazeneca Ab |
PHARMACEUTICAL PRODUCT COMPRISING A MUSCARINIC RECEPTOR ANTAGONIST AND A β2-ADRENOCEPTOR AGONIST
|
|
MX2010012492A
(es)
|
2008-05-27 |
2010-12-21 |
Astrazeneca Ab |
Derivados de fenoxipiridinilamida y su uso en el tratamiento de estados de enfermedad mediados por fosfodiesterasa 4.
|
|
GB0814729D0
(en)
*
|
2008-08-12 |
2008-09-17 |
Argenta Discovery Ltd |
New combination
|
|
WO2010067102A1
(en)
|
2008-12-09 |
2010-06-17 |
Astrazeneca Ab |
Diazaspiro [5.5] undecane derivatives and related compounds as muscarinic-receptor antagonists and beta-adrenoreceptor agonists for the treatment of pulmonary disorders
|
|
UY32297A
(es)
|
2008-12-22 |
2010-05-31 |
Almirall Sa |
Sal mesilato de 5-(2-{[6-(2,2-difluoro-2-fenilitoxi) hexil]amino}-1-hidroxietil)-8-hidroxiquinolin-2( 1h)-ona como agonista del receptor b(beta)2 acrenérgico
|
|
EP2228368A1
(en)
|
2009-03-12 |
2010-09-15 |
Almirall, S.A. |
Process for manufacturing 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one
|
|
WO2011015289A1
(en)
|
2009-08-04 |
2011-02-10 |
Chiesi Farmaceutici S.P.A. |
8-hydroxy-5-[(1r)-1-hydroxy-2-[[(1r)-2-(4-methoxyphenyl)-1-methylethyl] amino]ethyl]-2(1h)-quinolinone hemi-fumarate
|
|
WO2011061527A1
(en)
|
2009-11-17 |
2011-05-26 |
Astrazeneca Ab |
Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases
|
|
EP2360147A1
(en)
|
2010-02-22 |
2011-08-24 |
CHIESI FARMACEUTICI S.p.A. |
Process for preparing crystalline particles of a salt of 8-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino] ethyl]-2(1H)-quinolinone (carmoterol)
|
|
EP2563364A1
(en)
|
2010-04-26 |
2013-03-06 |
Mahmut Bilgic |
Combination of carmoterol and fluticasone for use in the treatment respiratory diseases
|
|
WO2011136752A1
(en)
|
2010-04-26 |
2011-11-03 |
Mahmut Bilgic |
Combined pharmaceutical composition comprising carmoterol and ciclesonide for the treatment of respiratory diseases
|
|
WO2011136754A1
(en)
|
2010-04-26 |
2011-11-03 |
Mahmut Bilgic |
A medicament developed for the treatment of respiratory diseases
|
|
UY33597A
(es)
|
2010-09-09 |
2012-04-30 |
Irm Llc |
Compuestos y composiciones como inhibidores de la trk
|
|
WO2012034095A1
(en)
|
2010-09-09 |
2012-03-15 |
Irm Llc |
Compounds and compositions as trk inhibitors
|
|
GB201016912D0
(en)
|
2010-10-07 |
2010-11-24 |
Astrazeneca Ab |
Novel combination
|
|
GB2484977A
(en)
*
|
2010-10-29 |
2012-05-02 |
Biocopea Ltd |
Treatment of a Th-1 mediated disease
|
|
SG192795A1
(en)
|
2011-02-25 |
2013-09-30 |
Irm Llc |
Compounds and compositions as trk inhibitors
|
|
EP2510928A1
(en)
|
2011-04-15 |
2012-10-17 |
Almirall, S.A. |
Aclidinium for use in improving the quality of sleep in respiratory patients
|
|
WO2013011999A1
(ja)
*
|
2011-07-20 |
2013-01-24 |
株式会社カネカ |
光学活性2-メチルプロリン誘導体の製造法
|
|
EP2578570A1
(en)
|
2011-10-07 |
2013-04-10 |
Almirall, S.A. |
Novel process for preparing 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1(r)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one via novel intermediates of synthesis.
|
|
WO2013077830A1
(en)
|
2011-11-25 |
2013-05-30 |
Mahmut Bilgic |
Synergistilly active combinations of roflumilast and carmoterol
|
|
EP2641900A1
(en)
|
2012-03-20 |
2013-09-25 |
Almirall, S.A. |
Novel polymorphic Crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one, heminapadisylate as agonist of the ß2 adrenergic receptor.
|
|
CZ306252B6
(cs)
*
|
2013-03-15 |
2016-10-26 |
Zentiva, K.S. |
Způsob přípravy 5-[(R)-2-(5,6-diethylindan-2-ylamino)-1-hydroxyethyl]-8-hydroxy-(1H)-chinolin-2-onu (indacaterolu)
|