JPS5283379A - Synthesis of carbostyril derivatives - Google Patents

Synthesis of carbostyril derivatives

Info

Publication number
JPS5283379A
JPS5283379A JP15714075A JP15714075A JPS5283379A JP S5283379 A JPS5283379 A JP S5283379A JP 15714075 A JP15714075 A JP 15714075A JP 15714075 A JP15714075 A JP 15714075A JP S5283379 A JPS5283379 A JP S5283379A
Authority
JP
Japan
Prior art keywords
alkyl
carbostyril derivatives
synthesis
formula
bond
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP15714075A
Other languages
Japanese (ja)
Other versions
JPS5913510B2 (en
Inventor
Shiro Yoshizaki
Shigeharu Tamada
Kazuyuki Nakagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP50157140A priority Critical patent/JPS5913510B2/en
Publication of JPS5283379A publication Critical patent/JPS5283379A/en
Publication of JPS5913510B2 publication Critical patent/JPS5913510B2/en
Expired legal-status Critical Current

Links

Landscapes

  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PURPOSE: 5-(α-Substd. aminoalkanoyl- carbostyril derivatives of formula I (R1 is H, 1W4C alkyl, aralkyl bearing 1W4C alkyl; R2 is H, 1W3C alkyl; A is 1W4C alkyleneoxy, satd. bond; B is phenyl, radical of formula III, IV, or V; dotted line at 3, 4-bond represents satd. or double bond) and 5- [(2-substd. amino-1-hydroxy) alkyl] carbostyril derivatives of formula II; for example, 5-[(1-methyl-2-phenylethyl) amnioacetyl] -8-hydroxycarbostyril hydrochloride.
COPYRIGHT: (C)1977,JPO&Japio
JP50157140A 1975-12-26 1975-12-26 Calbostyril Yudou Tainoseizohou Expired JPS5913510B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP50157140A JPS5913510B2 (en) 1975-12-26 1975-12-26 Calbostyril Yudou Tainoseizohou

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP50157140A JPS5913510B2 (en) 1975-12-26 1975-12-26 Calbostyril Yudou Tainoseizohou

Publications (2)

Publication Number Publication Date
JPS5283379A true JPS5283379A (en) 1977-07-12
JPS5913510B2 JPS5913510B2 (en) 1984-03-30

Family

ID=15643057

Family Applications (1)

Application Number Title Priority Date Filing Date
JP50157140A Expired JPS5913510B2 (en) 1975-12-26 1975-12-26 Calbostyril Yudou Tainoseizohou

Country Status (1)

Country Link
JP (1) JPS5913510B2 (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57154129A (en) * 1981-03-16 1982-09-22 Otsuka Pharmaceut Co Ltd Cardiotonic drug
JPS60208965A (en) * 1983-12-24 1985-10-21 Tanabe Seiyaku Co Ltd Novel carbostyril derivative and its preparation
US6653323B2 (en) 2001-11-13 2003-11-25 Theravance, Inc. Aryl aniline β2 adrenergic receptor agonists
US6670376B1 (en) 2001-11-13 2003-12-30 Theravance, Inc. Aryl aniline β2 adrenergic receptor agonists
US7399863B2 (en) 2003-09-22 2008-07-15 Theravance, Inc. Amino-substituted ethylamino β2 adrenergic receptor agonists
US7402673B2 (en) 2004-06-03 2008-07-22 Theravance, Inc. Diamine β2 adrenergic receptor agonists
US7566785B2 (en) 2004-09-10 2009-07-28 Theravance, Inc. Amidine substituted aryl aniline compounds
US7582765B2 (en) 2003-05-08 2009-09-01 Theravance, Inc. Aryl aniline β2 adrenergic receptor agonists
US7622467B2 (en) 2004-01-12 2009-11-24 Theravance, Inc. Aryl aniline derivatives as β2 adrenergic receptor agonists

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0453380Y2 (en) * 1985-05-28 1992-12-15

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57154129A (en) * 1981-03-16 1982-09-22 Otsuka Pharmaceut Co Ltd Cardiotonic drug
JPH0153248B2 (en) * 1981-03-16 1989-11-13 Otsuka Pharma Co Ltd
JPS60208965A (en) * 1983-12-24 1985-10-21 Tanabe Seiyaku Co Ltd Novel carbostyril derivative and its preparation
JPS6354362A (en) * 1983-12-24 1988-03-08 Tanabe Seiyaku Co Ltd Carbostyril compound
USRE33024E (en) * 1983-12-24 1989-08-15 Tanabe Seiyaku Co. Ltd. Bronchodilating 8-hydroxy-5-(1R)-1-hydroxy-2-(N-((1R)-2-(p-methoxyphenyl)-1-methylethyl)-amino)ethyl) carbostyril and intermediates thereof
JPH0446950B2 (en) * 1983-12-24 1992-07-31 Tanabe Seiyaku Co
US6949568B2 (en) 2001-11-13 2005-09-27 Theravance, Inc. Aryl aniline β2 adrenergic receptor agonists
US6670376B1 (en) 2001-11-13 2003-12-30 Theravance, Inc. Aryl aniline β2 adrenergic receptor agonists
US6653323B2 (en) 2001-11-13 2003-11-25 Theravance, Inc. Aryl aniline β2 adrenergic receptor agonists
US7125892B2 (en) 2001-11-13 2006-10-24 Theravance, Inc. Aryl aniline β2 adrenergic receptor agonists
US7582765B2 (en) 2003-05-08 2009-09-01 Theravance, Inc. Aryl aniline β2 adrenergic receptor agonists
US7399863B2 (en) 2003-09-22 2008-07-15 Theravance, Inc. Amino-substituted ethylamino β2 adrenergic receptor agonists
US7964730B2 (en) 2003-09-22 2011-06-21 Theravance, Inc. Amino-substituted ethylamino β2 adrenergic receptor agonists
US7622467B2 (en) 2004-01-12 2009-11-24 Theravance, Inc. Aryl aniline derivatives as β2 adrenergic receptor agonists
US7994165B2 (en) 2004-01-12 2011-08-09 Theravance, Inc. Aryl aniline derivatives as β2 adrenergic receptor agonists
US7402673B2 (en) 2004-06-03 2008-07-22 Theravance, Inc. Diamine β2 adrenergic receptor agonists
US7566785B2 (en) 2004-09-10 2009-07-28 Theravance, Inc. Amidine substituted aryl aniline compounds

Also Published As

Publication number Publication date
JPS5913510B2 (en) 1984-03-30

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