JPS6010718B2 - メイタンシノ−ル，メイタナシンおよびメイタンシノ−ル・プロピオネ−トの製造法 - Google Patents

メイタンシノ−ル，メイタナシンおよびメイタンシノ−ル・プロピオネ−トの製造法

Info

Publication number
JPS6010718B2
JPS6010718B2 JP52037167A JP3716777A JPS6010718B2 JP S6010718 B2 JPS6010718 B2 JP S6010718B2 JP 52037167 A JP52037167 A JP 52037167A JP 3716777 A JP3716777 A JP 3716777A JP S6010718 B2 JPS6010718 B2 JP S6010718B2
Authority
JP
Japan
Prior art keywords
maytansinol
ethyl acetate
propionate
culture
methanol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP52037167A
Other languages
English (en)
Japanese (ja)
Other versions
JPS53121998A (en
Inventor
栄治 東出
満子 浅井
清一 谷田
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Priority to JP52037167A priority Critical patent/JPS6010718B2/ja
Priority to US05/811,442 priority patent/US4151042A/en
Priority to AU29073/77A priority patent/AU507869B2/en
Priority to SU772533351A priority patent/SU938746A3/ru
Priority to FR7730340A priority patent/FR2385798A1/fr
Priority to YU02437/77A priority patent/YU243777A/xx
Priority to CS776677A priority patent/CS214881B2/cs
Priority to HU77TA1458A priority patent/HU177391B/hu
Priority to SE7711543A priority patent/SE7711543L/
Priority to NL7711273A priority patent/NL7711273A/xx
Priority to CH1260477A priority patent/CH631740A5/de
Priority to AT736377A priority patent/AT362058B/de
Priority to GB42821/77A priority patent/GB1554395A/en
Priority to CA288,732A priority patent/CA1092999A/en
Priority to DE2746253A priority patent/DE2746253C2/de
Priority to ES463206A priority patent/ES463206A1/es
Priority to IE2100/77A priority patent/IE45888B1/en
Priority to DK458977A priority patent/DK143570C/da
Priority to PL1977201539A priority patent/PL108863B1/pl
Priority to PT67853A priority patent/PT67853B/pt
Priority to IT21819/78A priority patent/IT1094003B/it
Publication of JPS53121998A publication Critical patent/JPS53121998A/ja
Publication of JPS6010718B2 publication Critical patent/JPS6010718B2/ja
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP52037167A 1977-03-31 1977-03-31 メイタンシノ−ル，メイタナシンおよびメイタンシノ−ル・プロピオネ−トの製造法 Expired JPS6010718B2 (ja)

Priority Applications (21)

Application Number Priority Date Filing Date Title
JP52037167A JPS6010718B2 (ja) 1977-03-31 1977-03-31 メイタンシノ−ル，メイタナシンおよびメイタンシノ−ル・プロピオネ−トの製造法
US05/811,442 US4151042A (en) 1977-03-31 1977-06-29 Method for producing maytansinol and its derivatives
AU29073/77A AU507869B2 (en) 1977-03-31 1977-09-23 Microbiological production of maytansinol and its derivatives
SU772533351A SU938746A3 (ru) 1977-03-31 1977-10-07 Способ получени алкалоидов метанзинола, метанацина и пропионата метанзинола
FR7730340A FR2385798A1 (fr) 1977-03-31 1977-10-07 Procede de production de maytansinol et de ses derives par voie microbiologique
YU02437/77A YU243777A (en) 1977-03-31 1977-10-10 Process for producing maytansinol and derivatives thereof
CS776677A CS214881B2 (en) 1977-03-31 1977-10-13 Method of making the maytanacine or maytanasinol propionate
HU77TA1458A HU177391B (en) 1977-03-31 1977-10-13 Process for producing maytanzinol and derivatives
SE7711543A SE7711543L (sv) 1977-03-31 1977-10-13 Forfarande for framstellning av maytansinol, maytanacin eller maytansinolpropionat
NL7711273A NL7711273A (nl) 1977-03-31 1977-10-13 Werkwijze ter bereiding van maytansinol en de- rivaten daarvan.
CH1260477A CH631740A5 (en) 1977-03-31 1977-10-14 Process for the preparation of maytansinol and its derivatives
AT736377A AT362058B (de) 1977-03-31 1977-10-14 Verfahren zur herstellung der antibiotika maytansinol, maytanacin und maytansinol- propionat
GB42821/77A GB1554395A (en) 1977-03-31 1977-10-14 Method for producing maytansinol and its derivatives
CA288,732A CA1092999A (en) 1977-03-31 1977-10-14 Method for producing maytansinol and its derivatives
DE2746253A DE2746253C2 (de) 1977-03-31 1977-10-14 Verfahren zur Herstellung von Maytansinol und dessen Derivaten
ES463206A ES463206A1 (es) 1977-03-31 1977-10-14 Un metodo para preparar maytansinol, maytanacina o propiona-to de maytansinol.
IE2100/77A IE45888B1 (en) 1977-03-31 1977-10-14 Method for producing maytansinol and its derivatives
DK458977A DK143570C (da) 1977-03-31 1977-10-14 Fremgangsmaade til fremstilling af maytansinol,maytanacin og/eller maytansinolpropionat
PL1977201539A PL108863B1 (en) 1977-03-31 1977-10-15 Method of producing maytansinol and derivatives thereof
PT67853A PT67853B (en) 1977-03-31 1978-03-30 Method for producing maytansinol and its derivatives
IT21819/78A IT1094003B (it) 1977-03-31 1978-03-30 Procedimento per produrre maitansinol e suoi derivati

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP52037167A JPS6010718B2 (ja) 1977-03-31 1977-03-31 メイタンシノ−ル，メイタナシンおよびメイタンシノ−ル・プロピオネ−トの製造法

Publications (2)

Publication Number Publication Date
JPS53121998A JPS53121998A (en) 1978-10-24
JPS6010718B2 true JPS6010718B2 (ja) 1985-03-19

Family

ID=12490032

Family Applications (1)

Application Number Title Priority Date Filing Date
JP52037167A Expired JPS6010718B2 (ja) 1977-03-31 1977-03-31 メイタンシノ−ル，メイタナシンおよびメイタンシノ−ル・プロピオネ−トの製造法

Country Status (20)

Country Link
JP (1) JPS6010718B2 ( )
AT (1) AT362058B ( )
AU (1) AU507869B2 ( )
CA (1) CA1092999A ( )
CH (1) CH631740A5 ( )
CS (1) CS214881B2 ( )
DE (1) DE2746253C2 ( )
DK (1) DK143570C ( )
ES (1) ES463206A1 ( )
FR (1) FR2385798A1 ( )
GB (1) GB1554395A ( )
HU (1) HU177391B ( )
IE (1) IE45888B1 ( )
IT (1) IT1094003B ( )
NL (1) NL7711273A ( )
PL (1) PL108863B1 ( )
PT (1) PT67853B ( )
SE (1) SE7711543L ( )
SU (1) SU938746A3 ( )
YU (1) YU243777A ( )

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6016236B2 (ja) * 1977-11-18 1985-04-24 武田薬品工業株式会社 抗生物質ｃ―１５００３ ｐ―３の製造法
JPS6010720B2 (ja) * 1977-11-18 1985-03-19 武田薬品工業株式会社 抗生物質ｃ―１５００３ ｐ―４の製造法
JPS55162791A (en) * 1979-06-05 1980-12-18 Takeda Chem Ind Ltd Antibiotic c-15003pnd and its preparation
EP0028683A1 (en) * 1979-09-21 1981-05-20 Takeda Chemical Industries, Ltd. Antibiotic C-15003 PHO and production thereof
US6573074B2 (en) * 2000-04-12 2003-06-03 Smithkline Beecham Plc Methods for ansamitocin production
US6333410B1 (en) 2000-08-18 2001-12-25 Immunogen, Inc. Process for the preparation and purification of thiol-containing maytansinoids
US7432088B2 (en) 2003-05-08 2008-10-07 Immunogen Inc. Methods for the production of ansamitocins
CN116239607B (zh) * 2023-01-04 2024-04-09 山东大学 一种美登素衍生物及其生物合成方法与应用

Also Published As

Publication number Publication date
IE45888L (en) 1978-09-30
ATA736377A (de) 1980-09-15
PL201539A1 (pl) 1978-09-25
PT67853A (en) 1978-04-01
AU2907377A (en) 1979-03-29
CH631740A5 (en) 1982-08-31
AU507869B2 (en) 1980-02-28
SE7711543L (sv) 1978-10-01
SU938746A3 (ru) 1982-06-23
DK458977A (da) 1978-10-01
IT1094003B (it) 1985-07-26
YU243777A (en) 1982-06-30
CA1092999A (en) 1981-01-06
DK143570B (da) 1981-09-07
DE2746253A1 (de) 1978-10-05
GB1554395A (en) 1979-10-17
PL108863B1 (en) 1980-05-31
FR2385798A1 (fr) 1978-10-27
IE45888B1 (en) 1982-12-29
FR2385798B1 ( ) 1980-04-25
ES463206A1 (es) 1978-08-16
CS214881B2 (en) 1982-06-25
JPS53121998A (en) 1978-10-24
DE2746253C2 (de) 1986-08-21
PT67853B (en) 1980-05-05
NL7711273A (nl) 1978-10-03
IT7821819A0 (it) 1978-03-30
DK143570C (da) 1982-02-08
AT362058B (de) 1981-04-27
HU177391B (en) 1981-09-28

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