JPS5993093A - 変形されたインターロイキン―２及びその製造方法 - Google Patents
変形されたインターロイキン―２及びその製造方法Info
- Publication number
- JPS5993093A JPS5993093A JP58195931A JP19593183A JPS5993093A JP S5993093 A JPS5993093 A JP S5993093A JP 58195931 A JP58195931 A JP 58195931A JP 19593183 A JP19593183 A JP 19593183A JP S5993093 A JPS5993093 A JP S5993093A
- Authority
- JP
- Japan
- Prior art keywords
- protein
- cysteine
- ifn
- cysteine residue
- mutin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43515482A | 1982-10-19 | 1982-10-19 | |
| US435154 | 1982-10-19 | ||
| US486162 | 1983-04-15 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5993093A true JPS5993093A (ja) | 1984-05-29 |
| JPS6357440B2 JPS6357440B2 (enrdf_load_stackoverflow) | 1988-11-11 |
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Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP58195931A Granted JPS5993093A (ja) | 1982-10-19 | 1983-10-19 | 変形されたインターロイキン―２及びその製造方法 |
| JP18730384A Granted JPS6128384A (ja) | 1982-10-19 | 1984-09-08 | 変形されたインターフェロン―βをコードするＤＮＡ、このＤＮＡを含有するプラスミド及びこのプラスミドにより形質転換された大腸菌 |
| JP18730484A Pending JPS6128394A (ja) | 1982-10-19 | 1984-09-08 | 部位特定突然変異用オリゴヌクレオチド |
| JP18730284A Granted JPS6128393A (ja) | 1982-10-19 | 1984-09-08 | 変形されたインターロイキン―２をコードするｄｎａ、このｄｎａを含有するプラスミド及びこのプラスミドにより形質転換された大腸菌 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP18730384A Granted JPS6128384A (ja) | 1982-10-19 | 1984-09-08 | 変形されたインターフェロン―βをコードするＤＮＡ、このＤＮＡを含有するプラスミド及びこのプラスミドにより形質転換された大腸菌 |
| JP18730484A Pending JPS6128394A (ja) | 1982-10-19 | 1984-09-08 | 部位特定突然変異用オリゴヌクレオチド |
| JP18730284A Granted JPS6128393A (ja) | 1982-10-19 | 1984-09-08 | 変形されたインターロイキン―２をコードするｄｎａ、このｄｎａを含有するプラスミド及びこのプラスミドにより形質転換された大腸菌 |
Country Status (4)
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|---|---|
| JP (4) | JPS5993093A (enrdf_load_stackoverflow) |
| IL (1) | IL90047A (enrdf_load_stackoverflow) |
| IN (1) | IN161992B (enrdf_load_stackoverflow) |
| ZA (1) | ZA837789B (enrdf_load_stackoverflow) |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0176299A2 (en) | 1984-09-26 | 1986-04-02 | Takeda Chemical Industries, Ltd. | Mutual separation of proteins |
| JPS61140600A (ja) * | 1984-12-06 | 1986-06-27 | シタス コーポレイシヨン | 蛋白質の酸化方法 |
| JPS6224A (ja) * | 1985-04-22 | 1987-01-06 | ジエネンテク，インコ−ポレイテツド | 新規なヒト組織プラスミノゲン活性化因子突然変異体 |
| JPS62500631A (ja) * | 1984-10-15 | 1987-03-19 | カイロン コーポレイション | ヒト腫瘍壊死因子 |
| JPS62130684A (ja) * | 1985-08-23 | 1987-06-12 | Toyo Jozo Co Ltd | ポリペプチドおよびその製法 |
| JPS62174022A (ja) * | 1984-12-21 | 1987-07-30 | Otsuka Pharmaceut Co Ltd | 抗腫瘍活性物質およびその製造法 |
| JPH02276590A (ja) * | 1989-02-17 | 1990-11-13 | Merck & Co Inc | タンパク質抗ガン剤 |
| JPH0866194A (ja) * | 1984-10-15 | 1996-03-12 | Cetus Corp | ヒト腫瘍壊死因子ミューテインをコードする遺伝子 |
| JPH08245695A (ja) * | 1984-12-21 | 1996-09-24 | Otsuka Pharmaceut Co Ltd | 抗腫瘍活性物質 |
| US6207798B1 (en) | 1989-08-03 | 2001-03-27 | Merck & Co., Inc. | Modified PE40 toxin fusion proteins |
| JP2004538275A (ja) * | 2001-07-09 | 2004-12-24 | シエーリング アクチエンゲゼルシャフト | ヒトインターフェロン−β配合物 |
| JP2007530419A (ja) * | 2003-07-11 | 2007-11-01 | バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト | 改良組換えヒトインターフェロン−β−１ｂポリペプチド |
| JP2023528582A (ja) * | 2020-04-29 | 2023-07-05 | ジェノファーム インク． | インターフェロンβ変異体と抗体が融合された組換えタンパク質およびそれを含む薬学的組成物 |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ226543A (en) * | 1987-10-22 | 1992-02-25 | Merck & Co Inc | Recombinant mutant acidic fibroblast growth factor |
| IL93723A (en) * | 1989-03-22 | 1997-02-18 | Merck & Co Inc | Cystein modified truncated pseudomonas exotoxin A |
| JPH0751621A (ja) * | 1993-08-12 | 1995-02-28 | Kansei Kogyo Kk | 静電吸着による管内面更生工法 |
-
1983
- 1983-10-14 IL IL90047A patent/IL90047A/xx not_active IP Right Cessation
- 1983-10-19 JP JP58195931A patent/JPS5993093A/ja active Granted
- 1983-10-19 IN IN1282/CAL/83A patent/IN161992B/en unknown
- 1983-10-19 ZA ZA837789A patent/ZA837789B/xx unknown
-
1984
- 1984-09-08 JP JP18730384A patent/JPS6128384A/ja active Granted
- 1984-09-08 JP JP18730484A patent/JPS6128394A/ja active Pending
- 1984-09-08 JP JP18730284A patent/JPS6128393A/ja active Granted
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0176299A2 (en) | 1984-09-26 | 1986-04-02 | Takeda Chemical Industries, Ltd. | Mutual separation of proteins |
| JPH0866194A (ja) * | 1984-10-15 | 1996-03-12 | Cetus Corp | ヒト腫瘍壊死因子ミューテインをコードする遺伝子 |
| JPS62500631A (ja) * | 1984-10-15 | 1987-03-19 | カイロン コーポレイション | ヒト腫瘍壊死因子 |
| JPS61140600A (ja) * | 1984-12-06 | 1986-06-27 | シタス コーポレイシヨン | 蛋白質の酸化方法 |
| JPH08245695A (ja) * | 1984-12-21 | 1996-09-24 | Otsuka Pharmaceut Co Ltd | 抗腫瘍活性物質 |
| JPS62174022A (ja) * | 1984-12-21 | 1987-07-30 | Otsuka Pharmaceut Co Ltd | 抗腫瘍活性物質およびその製造法 |
| JPH06277071A (ja) * | 1985-04-22 | 1994-10-04 | Genentech Inc | 新規なヒト組織プラスミノゲン活性化因子突然変異体 |
| JPS6224A (ja) * | 1985-04-22 | 1987-01-06 | ジエネンテク，インコ−ポレイテツド | 新規なヒト組織プラスミノゲン活性化因子突然変異体 |
| JPS62130684A (ja) * | 1985-08-23 | 1987-06-12 | Toyo Jozo Co Ltd | ポリペプチドおよびその製法 |
| JPH02276590A (ja) * | 1989-02-17 | 1990-11-13 | Merck & Co Inc | タンパク質抗ガン剤 |
| US6207798B1 (en) | 1989-08-03 | 2001-03-27 | Merck & Co., Inc. | Modified PE40 toxin fusion proteins |
| JP2004538275A (ja) * | 2001-07-09 | 2004-12-24 | シエーリング アクチエンゲゼルシャフト | ヒトインターフェロン−β配合物 |
| JP2007530419A (ja) * | 2003-07-11 | 2007-11-01 | バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト | 改良組換えヒトインターフェロン−β−１ｂポリペプチド |
| JP2023528582A (ja) * | 2020-04-29 | 2023-07-05 | ジェノファーム インク． | インターフェロンβ変異体と抗体が融合された組換えタンパク質およびそれを含む薬学的組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0380475B2 (enrdf_load_stackoverflow) | 1991-12-25 |
| IL90047A (en) | 1992-12-01 |
| ZA837789B (en) | 1984-11-28 |
| JPS6128384A (ja) | 1986-02-08 |
| JPS6357440B2 (enrdf_load_stackoverflow) | 1988-11-11 |
| JPS6128393A (ja) | 1986-02-08 |
| IN161992B (enrdf_load_stackoverflow) | 1988-03-12 |
| JPS6128394A (ja) | 1986-02-08 |
| JPH057996B2 (enrdf_load_stackoverflow) | 1993-01-29 |
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