JPS5921693A - 抗菌性ペネム誘導体 - Google Patents

抗菌性ペネム誘導体

Info

Publication number
JPS5921693A
JPS5921693A JP58122479A JP12247983A JPS5921693A JP S5921693 A JPS5921693 A JP S5921693A JP 58122479 A JP58122479 A JP 58122479A JP 12247983 A JP12247983 A JP 12247983A JP S5921693 A JPS5921693 A JP S5921693A
Authority
JP
Japan
Prior art keywords
group
compound
formula
groups
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP58122479A
Other languages
English (en)
Japanese (ja)
Inventor
マイクル・デイビツド・クツク
バリ−・クライブ・ロス
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis UK Holdings Ltd
Original Assignee
Hoechst UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst UK Ltd filed Critical Hoechst UK Ltd
Publication of JPS5921693A publication Critical patent/JPS5921693A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/86—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with only atoms other than nitrogen atoms directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)
JP58122479A 1982-07-08 1983-07-07 抗菌性ペネム誘導体 Pending JPS5921693A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8219745 1982-07-08
GB8219745 1982-07-08

Publications (1)

Publication Number Publication Date
JPS5921693A true JPS5921693A (ja) 1984-02-03

Family

ID=10531540

Family Applications (1)

Application Number Title Priority Date Filing Date
JP58122479A Pending JPS5921693A (ja) 1982-07-08 1983-07-07 抗菌性ペネム誘導体

Country Status (22)

Country Link
US (1) US4738959A (enExample)
EP (1) EP0099059B1 (enExample)
JP (1) JPS5921693A (enExample)
KR (1) KR900007181B1 (enExample)
AT (1) ATE35270T1 (enExample)
AU (1) AU567103B2 (enExample)
CA (1) CA1227194A (enExample)
DE (1) DE3377132D1 (enExample)
DK (1) DK314483A (enExample)
ES (3) ES8504203A1 (enExample)
FI (1) FI77662C (enExample)
GB (2) GB2122619B (enExample)
GR (1) GR78890B (enExample)
HU (3) HU193460B (enExample)
IE (1) IE55581B1 (enExample)
IL (1) IL69174A0 (enExample)
MA (1) MA19842A1 (enExample)
NO (3) NO832487L (enExample)
NZ (1) NZ204829A (enExample)
PH (1) PH23148A (enExample)
PT (1) PT76996B (enExample)
ZA (1) ZA834955B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61236785A (ja) * 1985-04-15 1986-10-22 Sankyo Co Ltd アゼチジノン誘導体
JPS62179860A (ja) * 1986-01-31 1987-08-07 Sintokogio Ltd 低圧鋳造装置

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE28648T1 (de) * 1982-03-26 1987-08-15 Hoechst Uk Ltd 7-oxo-4-thia-1-azabicyclo(3,2,0)heptan-derivate
GB2197865B (en) * 1984-06-29 1989-05-17 Hoechst Uk Ltd Azetidinone derivatives
GB8416565D0 (en) * 1984-06-29 1984-08-01 Hoechst Uk Ltd Antibacterial derivatives
GB2197864B (en) * 1984-06-29 1989-05-17 Hoechst Uk Ltd Antibacterial 7-oxo-4-thia-1-azabicyclo(3.2.0)-hept-2-ene derivatives
GB2164334B (en) * 1984-09-10 1988-08-03 Hoechst Uk Ltd Antibacterial 7-oxo-4-thia-1-azabicyclo 3,2,0 hept-2-ene derivativess
US4868296A (en) * 1985-10-29 1989-09-19 Pfizer Inc. 6-(1-carbamoyl-1-hydroxymethyl) penicillanic acid derivatives
US4797394A (en) * 1985-10-29 1989-01-10 Pfizer Inc. 6-(1-carbamoyl-1-hydroxymethyl)penicillanic acid derivatives

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4301074A (en) * 1977-11-17 1981-11-17 Merck & Co., Inc. 6-(1'-Hydroxyethyl)-2-substituted-pen-2-em-3-carboxylic acid
US4168314A (en) * 1977-11-17 1979-09-18 Merck & Co., Inc. 6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid
EP0003960B1 (de) * 1978-02-02 1983-06-29 Ciba-Geigy Ag 6-Substituierte Thia-Azaverbindungen, ihre Herstellung und diese enthaltende pharmazeutische Präparate
JPS5625110A (en) * 1978-12-18 1981-03-10 Bristol Myers Co Antibacterial
JPS56115788A (en) * 1980-02-19 1981-09-11 Sankyo Co Ltd Azetidinone derivative and its preparation
US4395418A (en) * 1980-06-06 1983-07-26 Sankyo Company Limited Penem-3-carboxylic acid derivatives
GB2083462B (en) * 1980-08-16 1984-05-02 Beecham Group Ltd 2-thiopenem derivatives
US4431658A (en) * 1981-02-02 1984-02-14 Schering Corporation Aza penem compounds
US4347183A (en) * 1981-02-02 1982-08-31 Schering Corporation Process for the synthesis of penems and carbapenems
EP0185651A1 (en) * 1981-07-08 1986-06-25 Hoechst Uk Limited Intermediates for the production of antibacterial penem derivates
ES8305366A1 (es) * 1981-07-08 1983-04-01 Hoechst Uk Ltd "procedimiento para la preparacion de derivados de penem".

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61236785A (ja) * 1985-04-15 1986-10-22 Sankyo Co Ltd アゼチジノン誘導体
JPS62179860A (ja) * 1986-01-31 1987-08-07 Sintokogio Ltd 低圧鋳造装置

Also Published As

Publication number Publication date
GR78890B (enExample) 1984-10-02
IE55581B1 (en) 1990-11-07
HUT40622A (en) 1987-01-28
EP0099059B1 (en) 1988-06-22
PH23148A (en) 1989-05-11
NO842960L (no) 1984-01-09
GB8318513D0 (en) 1983-08-10
ES8601875A1 (es) 1985-11-01
ES523890A0 (es) 1985-04-01
ES539160A0 (es) 1985-11-01
DE3377132D1 (en) 1988-07-28
GB2160865A (en) 1986-01-02
EP0099059A1 (en) 1984-01-25
IE831592L (en) 1984-01-08
FI77662B (fi) 1988-12-30
ES8504203A1 (es) 1985-04-01
ES8602013A1 (es) 1985-11-01
MA19842A1 (fr) 1984-04-01
GB8515248D0 (en) 1985-07-17
HU193460B (en) 1987-10-28
ES539161A0 (es) 1985-11-01
PT76996B (en) 1986-03-12
DK314483D0 (da) 1983-07-07
CA1227194A (en) 1987-09-22
FI832479L (fi) 1984-01-09
AU1665383A (en) 1984-01-12
ATE35270T1 (de) 1988-07-15
GB2122619A (en) 1984-01-18
KR900007181B1 (ko) 1990-09-29
HU193459B (en) 1987-10-28
GB2122619B (en) 1986-01-08
AU567103B2 (en) 1987-11-12
NZ204829A (en) 1986-07-11
FI77662C (fi) 1989-04-10
US4738959A (en) 1988-04-19
GB2160865B (en) 1986-11-26
DK314483A (da) 1984-01-09
NO832487L (no) 1984-01-09
FI832479A0 (fi) 1983-07-06
HU192819B (en) 1987-07-28
ZA834955B (en) 1984-03-28
IL69174A0 (en) 1983-11-30
PT76996A (en) 1983-08-01
KR840005453A (ko) 1984-11-12
NO841108L (no) 1984-01-09

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