JPS59193888A - フロ−（３，４−ｃ）−ピリジン誘導体、その製造法及びそれを含有する医薬 - Google Patents

フロ−（３，４−ｃ）−ピリジン誘導体、その製造法及びそれを含有する医薬

Info

Publication number
JPS59193888A
JPS59193888A JP59066853A JP6685384A JPS59193888A JP S59193888 A JPS59193888 A JP S59193888A JP 59066853 A JP59066853 A JP 59066853A JP 6685384 A JP6685384 A JP 6685384A JP S59193888 A JPS59193888 A JP S59193888A
Authority
JP
Japan
Prior art keywords
group
carbon atoms
alkoxy
groups
carbon
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP59066853A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0556353B2 (enrdf_load_stackoverflow
Inventor
アンドレ・エサヌ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ipsen Pharma SAS
Original Assignee
Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB838327815A external-priority patent/GB8327815D0/en
Application filed by Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS filed Critical Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Publication of JPS59193888A publication Critical patent/JPS59193888A/ja
Publication of JPH0556353B2 publication Critical patent/JPH0556353B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Hydrogenated Pyridines (AREA)
JP59066853A 1983-04-05 1984-04-05 フロ−（３，４−ｃ）−ピリジン誘導体、その製造法及びそれを含有する医薬 Granted JPS59193888A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB8309165 1983-04-05
GB8309165 1983-04-05
GB8327815 1983-10-18
GB838327815A GB8327815D0 (en) 1983-10-18 1983-10-18 Furo-(3 4-c)-pyridine derivatives

Publications (2)

Publication Number Publication Date
JPS59193888A true JPS59193888A (ja) 1984-11-02
JPH0556353B2 JPH0556353B2 (enrdf_load_stackoverflow) 1993-08-19

Family

ID=26285725

Family Applications (1)

Application Number Title Priority Date Filing Date
JP59066853A Granted JPS59193888A (ja) 1983-04-05 1984-04-05 フロ−（３，４−ｃ）−ピリジン誘導体、その製造法及びそれを含有する医薬

Country Status (29)

Country Link
US (1) US4581363A (enrdf_load_stackoverflow)
JP (1) JPS59193888A (enrdf_load_stackoverflow)
KR (1) KR900005518B1 (enrdf_load_stackoverflow)
AU (1) AU582113B2 (enrdf_load_stackoverflow)
CA (1) CA1257269A (enrdf_load_stackoverflow)
CH (1) CH660191A5 (enrdf_load_stackoverflow)
DE (1) DE3412885C2 (enrdf_load_stackoverflow)
DK (1) DK157931C (enrdf_load_stackoverflow)
DZ (1) DZ629A1 (enrdf_load_stackoverflow)
EG (1) EG18150A (enrdf_load_stackoverflow)
ES (1) ES8601998A1 (enrdf_load_stackoverflow)
FI (1) FI76804C (enrdf_load_stackoverflow)
FR (2) FR2543829B1 (enrdf_load_stackoverflow)
GR (1) GR79577B (enrdf_load_stackoverflow)
HK (1) HK11187A (enrdf_load_stackoverflow)
IE (1) IE57424B1 (enrdf_load_stackoverflow)
IL (1) IL71243A (enrdf_load_stackoverflow)
IN (1) IN160104B (enrdf_load_stackoverflow)
IT (1) IT1173770B (enrdf_load_stackoverflow)
LU (1) LU85262A1 (enrdf_load_stackoverflow)
MA (1) MA20084A1 (enrdf_load_stackoverflow)
MX (1) MX167397B (enrdf_load_stackoverflow)
MY (1) MY8600664A (enrdf_load_stackoverflow)
NL (1) NL190328C (enrdf_load_stackoverflow)
NO (1) NO161802C (enrdf_load_stackoverflow)
NZ (1) NZ207552A (enrdf_load_stackoverflow)
OA (1) OA07699A (enrdf_load_stackoverflow)
PT (1) PT78361B (enrdf_load_stackoverflow)
SE (1) SE458362B (enrdf_load_stackoverflow)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02504394A (ja) * 1988-04-06 1990-12-13 ソシエテ・ド・コンセイユ・ド・ルシエルシエ・エ・ダアツプリカーシヨン・シヤンテイフイツク・（エス．セー．エール．アー．エス） フロ〔３，４‐ｃ〕ピリジン鏡像体の立体特異的製造方法、かくして得られた化合物及びこれの製薬組成物

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4735950A (en) * 1983-04-05 1988-04-05 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S) Furo-(3,4-C)-pyridine derivatives and therapeutic composition containing the same
GB8427218D0 (en) * 1984-10-27 1984-12-05 Scras Pyridine derivatives
DE3990349T1 (de) * 1988-04-06 1990-04-26 Scras Stereospezifisches verfahren zur herstellung von enantiomeren von furo(3,4-c)pyridin, so erhaltene verbindungen und therapeutische zusammensetzungen auf basis dieser verbindungen
GB8917168D0 (en) * 1989-07-27 1989-09-13 Scras Asymmetric synthesis of furo(3,4-c)pyridine derivatives
US5130252A (en) * 1990-05-14 1992-07-14 Synthetech, Inc. Resolution of furopyridine enantiomers and synthetic precursors thereof
US6043259A (en) * 1998-07-09 2000-03-28 Medicure Inc. Treatment of cardiovascular and related pathologies
NZ514567A (en) 1999-03-08 2002-11-26 Medicure Inc Pyridoxal analogues for vitamin B-6 disorders
EP1196171A2 (en) * 1999-07-13 2002-04-17 Medicure Inc. Use of pyridoxin derivatives for the treatment of diabetes and related complications
AU783855B2 (en) * 1999-08-24 2005-12-15 Medicure International Inc. Compositions for the treatment of cardiovascular diseases containing pyridoxal compounds and cardiovascular compounds
US7442689B2 (en) * 2000-02-29 2008-10-28 Medicure International Inc. Cardioprotective phosphonates and malonates
ATE293119T1 (de) 2000-02-29 2005-04-15 Medicure Int Inc Cardioprotektive phosphonate
WO2001072309A2 (en) 2000-03-28 2001-10-04 Medicure International Inc. Treatment of cerebrovascular disease
US6897228B2 (en) * 2000-07-07 2005-05-24 Medicure International Inc. Pyridoxine and pyridoxal analogues: new uses
US6548519B1 (en) 2001-07-06 2003-04-15 Medicure International Inc. Pyridoxine and pyridoxal analogues: novel uses
CA2414188A1 (en) 2000-07-07 2002-01-17 Medicure International Inc. Pyridoxine and pyridoxal analogues: cardiovascular therapeutics
US20040121988A1 (en) * 2001-03-28 2004-06-24 Medicure International Inc. Treatment of cerebrovascular disease
US20040186077A1 (en) * 2003-03-17 2004-09-23 Medicure International Inc. Novel heteroaryl phosphonates as cardioprotective agents
CN101014357A (zh) * 2004-07-07 2007-08-08 麦迪库瑞国际公司 利用血小板聚集药物的组合疗法
US20070060549A1 (en) * 2004-08-10 2007-03-15 Friesen Albert D Combination therapies employing ace inhibitors and uses thereof for the treatment of diabetic disorders
AU2005304220A1 (en) * 2004-10-28 2006-05-18 Medicure International Inc. Dual antiplatelet/anticoagulant pyridoxine analogs
US20060094749A1 (en) * 2004-10-28 2006-05-04 Medicure International Inc. Substituted pyridoxines as anti-platelet agents
US7459468B2 (en) * 2004-10-28 2008-12-02 Medicure International, Inc. Aryl sulfonic pyridoxines as antiplatelet agents
US20070149485A1 (en) * 2005-11-28 2007-06-28 Medicure International, Inc. Selected dosage for the treatment of cardiovascular and related pathologies

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54109996A (en) * 1977-11-25 1979-08-29 Scras Pridine derivative*manufacture thereof and kidney protection and diuretic composition containing said derivative
JPS57150688A (en) * 1981-02-10 1982-09-17 Do Konseiyu Do Rushierushie E Furo(3,4-c)pyridine derivative, manufacture and medicinal composition containing same

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2008582B (en) * 1977-11-25 1982-04-28 Scras Pyridine derivative

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54109996A (en) * 1977-11-25 1979-08-29 Scras Pridine derivative*manufacture thereof and kidney protection and diuretic composition containing said derivative
JPS57150688A (en) * 1981-02-10 1982-09-17 Do Konseiyu Do Rushierushie E Furo(3,4-c)pyridine derivative, manufacture and medicinal composition containing same

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02504394A (ja) * 1988-04-06 1990-12-13 ソシエテ・ド・コンセイユ・ド・ルシエルシエ・エ・ダアツプリカーシヨン・シヤンテイフイツク・（エス．セー．エール．アー．エス） フロ〔３，４‐ｃ〕ピリジン鏡像体の立体特異的製造方法、かくして得られた化合物及びこれの製薬組成物

Also Published As

Publication number Publication date
FI76804C (fi) 1988-12-12
NZ207552A (en) 1986-05-09
MY8600664A (en) 1986-12-31
IT8420396A0 (it) 1984-04-05
IL71243A (en) 1987-12-20
DZ629A1 (fr) 2004-09-13
IN160104B (enrdf_load_stackoverflow) 1987-06-27
FR2543829B1 (fr) 1986-11-21
EG18150A (en) 1992-08-30
SE8401841L (sv) 1984-10-06
DK157931C (da) 1990-08-27
JPH0556353B2 (enrdf_load_stackoverflow) 1993-08-19
FI841273L (fi) 1984-10-06
IT1173770B (it) 1987-06-24
CH660191A5 (fr) 1987-03-31
ES531285A0 (es) 1985-11-01
KR900005518B1 (ko) 1990-07-30
FR2543956A1 (fr) 1984-10-12
IE57424B1 (en) 1992-09-09
AU2640184A (en) 1984-10-11
AU582113B2 (en) 1989-03-16
KR840008651A (ko) 1984-12-17
NO161802C (no) 1989-09-27
FR2543956B1 (fr) 1986-07-04
CA1257269A (en) 1989-07-11
DE3412885A1 (de) 1984-10-11
MA20084A1 (fr) 1984-12-31
OA07699A (fr) 1985-08-30
FI841273A0 (fi) 1984-03-30
SE458362B (sv) 1989-03-20
SE8401841D0 (sv) 1984-04-03
IE840826L (en) 1984-10-05
MX167397B (es) 1993-03-22
IL71243A0 (en) 1984-06-29
PT78361A (en) 1984-05-01
DK178084A (da) 1984-10-06
GR79577B (enrdf_load_stackoverflow) 1984-10-30
DK178084D0 (da) 1984-04-04
NO161802B (no) 1989-06-19
HK11187A (en) 1987-02-13
PT78361B (en) 1986-05-28
NL190328B (nl) 1993-08-16
FR2543829A1 (fr) 1984-10-12
FI76804B (fi) 1988-08-31
ES8601998A1 (es) 1985-11-01
DE3412885C2 (de) 1990-10-04
NL8401013A (nl) 1984-11-01
DK157931B (da) 1990-03-05
LU85262A1 (fr) 1984-10-24
US4581363A (en) 1986-04-08
NO841322L (no) 1984-10-08
NL190328C (nl) 1994-01-17

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