JPS58124778A - ５，６，７−トリノル−４，８−インタ−ｍ−フエニレンＰＧＩ↓２誘導体 - Google Patents

５，６，７−トリノル−４，８−インタ−ｍ−フエニレンＰＧＩ↓２誘導体

Info

Publication number
JPS58124778A
JPS58124778A JP57006150A JP615082A JPS58124778A JP S58124778 A JPS58124778 A JP S58124778A JP 57006150 A JP57006150 A JP 57006150A JP 615082 A JP615082 A JP 615082A JP S58124778 A JPS58124778 A JP S58124778A
Authority
JP
Japan
Prior art keywords
methyl
acid
phenylene
added
inter
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP57006150A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0153672B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html
Inventor
Kiyotaka Ono
大野　清隆
Hiroshi Nagase
博 長瀬
Kazuhisa Matsumoto
和久 松本
Shintarou Nishio
西尾　伸大郎
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toray Industries Inc
Original Assignee
Toray Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11630492&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JPS58124778(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Toray Industries Inc filed Critical Toray Industries Inc
Priority to JP57006150A priority Critical patent/JPS58124778A/ja
Priority to ZA83328A priority patent/ZA83328B/xx
Priority to EP83100449A priority patent/EP0084856B2/en
Priority to DE8383100449T priority patent/DE3367774D1/de
Priority to AT83100449T priority patent/ATE23716T1/de
Priority to US06/459,226 priority patent/US4474802A/en
Priority to AU10609/83A priority patent/AU556348B2/en
Priority to CA000419895A priority patent/CA1226280A/en
Publication of JPS58124778A publication Critical patent/JPS58124778A/ja
Publication of JPH0153672B2 publication Critical patent/JPH0153672B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/09—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis
    • C07C29/12—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis of esters of mineral acids
    • C07C29/124—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis of esters of mineral acids of halides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/56—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by isomerisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4015—Esters of acyclic unsaturated acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
JP57006150A 1982-01-20 1982-01-20 ５，６，７−トリノル−４，８−インタ−ｍ−フエニレンＰＧＩ↓２誘導体 Granted JPS58124778A (ja)

Priority Applications (8)

Application Number Priority Date Filing Date Title
JP57006150A JPS58124778A (ja) 1982-01-20 1982-01-20 ５，６，７−トリノル−４，８−インタ−ｍ−フエニレンＰＧＩ↓２誘導体
ZA83328A ZA83328B (en) 1982-01-20 1983-01-18 5,6,7-trinor-4,8-itner-m-phenylene prostaglandin i2 derivative
AU10609/83A AU556348B2 (en) 1982-01-20 1983-01-19 5,6,7-trinor-4,8-inter-m-phenylene prostaglandin i2 derivatives
AT83100449T ATE23716T1 (de) 1982-01-20 1983-01-19 5,6,7-trinor-4,8-inter-m-phenylen-prostaglandin i2-derivate.
DE8383100449T DE3367774D1 (de) 1982-01-20 1983-01-19 5,6,7-trinor-4, 8-inter-m-phenylene prostaglandin i2 derivatives
EP83100449A EP0084856B2 (en) 1982-01-20 1983-01-19 5,6,7-Trinor-4, 8-inter-m-phenylene prostaglandin I2 derivatives
US06/459,226 US4474802A (en) 1982-01-20 1983-01-19 5,6,7-Trinor-4,8-inter-m-phenylene prostaglandin I2 derivatives useful in anti-ulcer, hypotensive and platelet aggregation inhibiting compositions
CA000419895A CA1226280A (en) 1982-01-20 1983-01-20 5,6,7-trinor-4,8-inter-m-phenylene prostaglandin i.sub.2 derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP57006150A JPS58124778A (ja) 1982-01-20 1982-01-20 ５，６，７−トリノル−４，８−インタ−ｍ−フエニレンＰＧＩ↓２誘導体

Publications (2)

Publication Number Publication Date
JPS58124778A true JPS58124778A (ja) 1983-07-25
JPH0153672B2 JPH0153672B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1989-11-15

Family

ID=11630492

Family Applications (1)

Application Number Title Priority Date Filing Date
JP57006150A Granted JPS58124778A (ja) 1982-01-20 1982-01-20 ５，６，７−トリノル−４，８−インタ−ｍ−フエニレンＰＧＩ↓２誘導体

Country Status (8)

Country Link
US (1) US4474802A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0084856B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS58124778A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE23716T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU556348B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1226280A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3367774D1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA83328B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02262519A (ja) * 1989-03-31 1990-10-25 Kaken Pharmaceut Co Ltd 糖尿病性神経障害治療剤
WO1993007876A1 (fr) * 1991-10-25 1993-04-29 Toray Industries, Inc. Remede contre les maladies hepatiques
WO1994006785A1 (fr) * 1992-09-18 1994-03-31 Toray Industries, Inc. Nouveau derive d'acide sulfonique et son usage medicinal
WO1994008584A1 (en) * 1991-04-11 1994-04-28 Toray Industries, Inc. Inhibitor for metastasis of malignant tumor
JPH07126161A (ja) * 1993-10-29 1995-05-16 Toray Ind Inc 心不全治療剤
JPH07238046A (ja) * 1994-02-24 1995-09-12 Nissan Chem Ind Ltd フェニル置換ヒドロキシシクロペンテノン類、ペンタノン類及びフェニル置換プロスタグランジンｉ２類中間体並びにその製造法及び光学分割法
US5496850A (en) * 1991-04-11 1996-03-05 Toray Industries, Inc. Antimetastasis agent of malignant tumors
WO1996026721A1 (en) * 1995-02-27 1996-09-06 Toray Industries, Inc. Remedy for pulmonary heart
WO1998037895A1 (fr) * 1997-02-27 1998-09-03 Toray Industries, Inc. Medicaments permettant d'ameliorer la circulation pulmonaire
WO1998040073A1 (fr) * 1997-03-13 1998-09-17 Toray Industries, Inc. Medicament pour traiter les lesions vasculaires diabetiques
WO1998041210A1 (fr) * 1997-03-14 1998-09-24 Toray Industries, Inc. Preparation de derive de prostaglandine i a liberation prolongee
US5854281A (en) * 1994-11-17 1998-12-29 Toray Industries, Inc. Preparation for percutaneous absorption
WO1999033490A1 (fr) 1997-12-26 1999-07-08 Yamanouchi Pharmaceutical Co., Ltd. Compositions medicinales a liberation prolongee
WO2000009135A1 (fr) * 1998-08-14 2000-02-24 Toray Industries, Inc. Agents de protection des cellules péridermiques
WO2000009161A1 (fr) * 1998-08-12 2000-02-24 Toray Industries, Inc. Agents qui regulent la production de l'inhibiteur 1 des activateurs du plasminogene
JP2003055368A (ja) * 2001-07-30 2003-02-26 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt ケミカルプロセス
JP2003113189A (ja) * 2001-10-05 2003-04-18 Nichiko Pharmaceutical Co Ltd シクロペンタベンゾフラン誘導体の製造方法及びその製造原料となる新規化合物
JP2005538976A (ja) * 2002-07-08 2005-12-22 ジョンソン、マッセイ、パブリック、リミテッド、カンパニー ベンゾプロスタサイクリン中間体、及びそれらの製造方法
JPWO2005000316A1 (ja) * 2003-06-25 2006-07-27 有限会社 循環器研究所 性交機能改善用外用製剤
JP2014522811A (ja) * 2011-06-16 2014-09-08 ラング バイオテクノロジー インコーポレーテッド ベラプロストの製造方法
US9546145B2 (en) 2003-05-09 2017-01-17 Toray Industries, Inc. Combination therapy for the treatment of chronic renal failure with an angiotensin II receptor antagonist and beraprost
JP2019163300A (ja) * 2012-07-19 2019-09-26 ケイマン ケミカル カンパニー， インコーポレーテッド Ｅｐ４介在性骨関連疾患及び病態用ジフルオロラクタム組成物
JP2020083893A (ja) * 2018-11-26 2020-06-04 チャイロゲート インターナショナル インク．Ｃｈｉｒｏｇａｔｅ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃ． ベラプロスト−３１４ｄ結晶形及びその調製方法
WO2023276983A1 (ja) * 2021-06-28 2023-01-05 大内新興化学工業株式会社 ベラプロストまたは光学活性体の合成中間体およびその製造方法

Families Citing this family (37)

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Publication number Priority date Publication date Assignee Title
CA1275287C (en) * 1986-01-24 1990-10-16 Kiyotaka Ohno 2,5,6,7-tetranor-4,8-inter-m-phanylene pgi derivatives
US4880939A (en) * 1986-12-11 1989-11-14 Toray Industries 2,5,6,7-tetranor-18,18,19,19-tetradehydro-4,8-inter-m-phenylene PGI2 derivatives
ATE105555T1 (de) * 1989-02-27 1994-05-15 Toray Industries Verfahren zur herstellung von 5,6,7, -trinor4,8,-inter-m-phenylen pgi,2 abkoemmlingen.
KR960016542B1 (ko) * 1989-03-14 1996-12-14 토레이 가부시기가이샤 2,5,6,7-테트라놀-4,8-인터-m-페닐렌 PGI₂유도체, 이것의 제조 방법 및 이를 함유하는 약제
DE4104607A1 (de) * 1991-02-12 1992-08-13 Schering Ag Prostacyclin- und carbacyclinderivate als mittel zur behandlung von fiebrigen erkrankungen
US5233059A (en) * 1991-07-25 1993-08-03 Iowa State University Research Foundation, Inc. Synthesis of benzoprostacyclins using palladium catalysis
US5169959A (en) * 1991-09-23 1992-12-08 Iowa State University Research Foundation, Inc. Free radical-catalyzed synthesis of benzoprostacyclins
JP3102141B2 (ja) * 1992-05-29 2000-10-23 東レ株式会社 養毛育毛剤
ATE149838T1 (de) * 1992-08-07 1997-03-15 Schering Ag Verwendung von prostanderivaten zur herstellung eines arzneimittels zur behandlung der chronischen polyarthritis
DE4226615C1 (de) * 1992-08-07 1994-05-19 Schering Ag Verwendung von Prostan-Derivaten zur Behandlung von chronischer Polyarthritis
CZ168896A3 (en) * 1995-06-27 1997-01-15 Egyt Gyogyszervegyeszeti Gyar Oxaindene derivatives and process for preparing thereof
DE19530884C2 (de) * 1995-08-11 1997-07-31 Schering Ag Verwendung von Prostan-Derivaten sowie deren Kombination mit Antibiotika zur Behandlung von bakteriellen Meningitis
US6232343B1 (en) 1996-05-07 2001-05-15 Toray Industries, Inc. Ophthalmic preparations
WO1998011899A1 (fr) * 1996-09-17 1998-03-26 Toray Industries, Inc. Agent de potentialisation de la fonction plaquettaire et procede de traitement du dysfonctionnement plaquettaire
US6653345B2 (en) 1997-09-16 2003-11-25 Toray Industries, Inc. C-C chemokine synthesis inhibitor
JP4019481B2 (ja) 1998-01-23 2007-12-12 ソニー株式会社 情報処理装置および方法、情報処理システム、並びに提供媒体
US20030092760A1 (en) * 2001-03-12 2003-05-15 Toray Industries, Inc. Therapeutic agent for renal failure
AU2006267613B2 (en) 2005-07-08 2011-08-11 Toray Industries, Inc. Therapeutic agent and treatment method for ameliorating uremia
JP5424291B2 (ja) * 2006-03-03 2014-02-26 独立行政法人国立循環器病研究センター 骨髄細胞の動員剤および動員方法
JP5271272B2 (ja) 2006-11-16 2013-08-21 ジェンムス ファーマ インコーポレイティド Ａ型インフルエンザウィルス感染の治療のための薬剤としてのｅｐ２およびｅｐ４作動薬
BRPI0917661B8 (pt) 2008-08-13 2021-05-25 Actelion Pharmaceuticals Ltd produto, composição farmacêutica e uso da combinação de macitentan com um composto que é dotado de propriedades agonistas do receptor de prostaciclina
US20120190637A1 (en) 2009-10-14 2012-07-26 Gemmus Pharma, Inc. Combination therapy treatment for viral infections
TWI513462B (zh) 2009-11-13 2015-12-21 Toray Industries 糖尿病之治療或預防藥
CN103509044A (zh) * 2012-06-21 2014-01-15 上海天伟生物制药有限公司 贝前列素钠中间体及其制备方法
CN103242274B (zh) * 2013-05-22 2014-11-05 孙威 一种贝前列素钠化合物及其制备方法
MX375926B (es) 2013-08-09 2025-03-07 Ardelyx Inc Compuestos y metodos para inhibir el transporte de fosfato.
US9765047B2 (en) 2015-08-12 2017-09-19 United Therapeutics Corporation Process for making beraprost
CN106632372B (zh) * 2016-09-26 2019-04-02 上海北卡医药技术有限公司 一种中间体及其制备方法和用途
JP2020502121A (ja) 2016-12-14 2020-01-23 レスピラ セラピューティクス インコーポレイテッドＲｅｓｐｉｒａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． 肺高血圧症および他の肺障害の処置のための方法および組成物
CN107325122B (zh) * 2017-01-06 2020-05-01 常州博海威医药科技股份有限公司 制备贝前列腺素的新中间体及其制备方法
BR112020001748A2 (pt) 2017-07-27 2020-07-21 Allergan, Inc. agonistas de receptor de prostaciclina para redução de gordura corporal
CN109305986B (zh) * 2018-11-13 2021-02-19 济南康和医药科技有限公司 一种贝前列素钠中间体的合成方法
EP3972599A1 (en) 2019-05-21 2022-03-30 Ardelyx, Inc. Combination for lowering serum phosphate in a patient
CN110746450A (zh) * 2019-09-17 2020-02-04 济南康和医药科技有限公司 一种贝前列素钠关键中间体的合成方法
CN112569181B (zh) * 2019-09-27 2023-03-21 中国科学院上海高等研究院 一种快速增溶肾上腺素的方法
CA3167058A1 (en) 2020-02-12 2021-08-19 Cytoagents, Inc. Compositions and methods for treating coronavirus infections
TW202317089A (zh) 2021-06-16 2023-05-01 日商東麗股份有限公司 罹患慢性腎臟病的貓的治療方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2734791A1 (de) * 1977-07-29 1979-02-15 Schering Ag Neue prostaglandin-i tief 2 -derivate und verfahren zu ihrer herstellung
JPS5931510B2 (ja) * 1979-09-03 1984-08-02 東レ株式会社 ５，６，７−トリノル−４，８−インタ−ｍ−フエニレンＰＧＩ↓２誘導体
JPS57144276A (en) * 1981-03-03 1982-09-06 Toray Ind Inc 5,6,7-trinor-4,8-inter-m-phenylene pgi2 derivative

Cited By (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02262519A (ja) * 1989-03-31 1990-10-25 Kaken Pharmaceut Co Ltd 糖尿病性神経障害治療剤
WO1994008584A1 (en) * 1991-04-11 1994-04-28 Toray Industries, Inc. Inhibitor for metastasis of malignant tumor
US5496850A (en) * 1991-04-11 1996-03-05 Toray Industries, Inc. Antimetastasis agent of malignant tumors
WO1993007876A1 (fr) * 1991-10-25 1993-04-29 Toray Industries, Inc. Remede contre les maladies hepatiques
WO1994006785A1 (fr) * 1992-09-18 1994-03-31 Toray Industries, Inc. Nouveau derive d'acide sulfonique et son usage medicinal
JPH07126161A (ja) * 1993-10-29 1995-05-16 Toray Ind Inc 心不全治療剤
JPH07238046A (ja) * 1994-02-24 1995-09-12 Nissan Chem Ind Ltd フェニル置換ヒドロキシシクロペンテノン類、ペンタノン類及びフェニル置換プロスタグランジンｉ２類中間体並びにその製造法及び光学分割法
JP4024852B2 (ja) * 1994-11-17 2007-12-19 東レ株式会社 「経皮吸収製剤」
US5854281A (en) * 1994-11-17 1998-12-29 Toray Industries, Inc. Preparation for percutaneous absorption
WO1996026721A1 (en) * 1995-02-27 1996-09-06 Toray Industries, Inc. Remedy for pulmonary heart
WO1998037895A1 (fr) * 1997-02-27 1998-09-03 Toray Industries, Inc. Medicaments permettant d'ameliorer la circulation pulmonaire
WO1998040073A1 (fr) * 1997-03-13 1998-09-17 Toray Industries, Inc. Medicament pour traiter les lesions vasculaires diabetiques
WO1998041210A1 (fr) * 1997-03-14 1998-09-24 Toray Industries, Inc. Preparation de derive de prostaglandine i a liberation prolongee
US6656502B1 (en) 1997-03-14 2003-12-02 Toray Industries, Inc. Sustained-release prostaglandin I derivative preparation
JP3744941B2 (ja) * 1997-03-14 2006-02-15 東レ株式会社 プロスタグランジンｉ誘導体徐放性製剤
WO1999033490A1 (fr) 1997-12-26 1999-07-08 Yamanouchi Pharmaceutical Co., Ltd. Compositions medicinales a liberation prolongee
WO2000009161A1 (fr) * 1998-08-12 2000-02-24 Toray Industries, Inc. Agents qui regulent la production de l'inhibiteur 1 des activateurs du plasminogene
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DE3367774D1 (de) 1987-01-08
CA1226280A (en) 1987-09-01
US4474802A (en) 1984-10-02
EP0084856B1 (en) 1986-11-20
ATE23716T1 (de) 1986-12-15
EP0084856A1 (en) 1983-08-03
AU1060983A (en) 1983-07-28
ZA83328B (en) 1983-10-26
JPH0153672B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1989-11-15
AU556348B2 (en) 1986-10-30
EP0084856B2 (en) 1994-05-04

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