JPH11510837A - 薬物送達のための制御された放出薬剤および組織処置薬剤としての使用のためのマルチブロック生分解性ヒドロゲル - Google Patents

薬物送達のための制御された放出薬剤および組織処置薬剤としての使用のためのマルチブロック生分解性ヒドロゲル

Info

Publication number
JPH11510837A
JPH11510837A JP9507762A JP50776297A JPH11510837A JP H11510837 A JPH11510837 A JP H11510837A JP 9507762 A JP9507762 A JP 9507762A JP 50776297 A JP50776297 A JP 50776297A JP H11510837 A JPH11510837 A JP H11510837A
Authority
JP
Japan
Prior art keywords
macromer
hydrophobic
gel
group
block
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP9507762A
Other languages
English (en)
Japanese (ja)
Other versions
JPH11510837A5 (enExample
Inventor
ピー． パサク，チャンドラシェカー
ピー． バルマン，シクハ
フィルブルック，シー．マイケル
ソーニー，アマルプリート
ジェイ． コウリー，アーサー
ゼット． アビラ，ルイス
ティー． キエラス，マーク
Original Assignee
フォーカル，インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by フォーカル，インコーポレイテッド filed Critical フォーカル，インコーポレイテッド
Publication of JPH11510837A publication Critical patent/JPH11510837A/ja
Publication of JPH11510837A5 publication Critical patent/JPH11510837A5/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1274—Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases or cochleates; Sponge phases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/58—Adhesives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/60—Liquid-swellable gel-forming materials, e.g. super-absorbents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0031—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0042—Materials resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/046—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C08L71/02—Polyalkylene oxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/13—Burn treatment
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S524/00—Synthetic resins or natural rubbers -- part of the class 520 series
    • Y10S524/916—Hydrogel compositions
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S525/00—Synthetic resins or natural rubbers -- part of the class 520 series
    • Y10S525/941—Polymer mixture containing block copolymer is mixed or reacted with chemical treating agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Organic Chemistry (AREA)
  • Surgery (AREA)
  • Dispersion Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polyethers (AREA)
JP9507762A 1995-07-28 1996-07-26 薬物送達のための制御された放出薬剤および組織処置薬剤としての使用のためのマルチブロック生分解性ヒドロゲル Withdrawn JPH11510837A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US172395P 1995-07-28 1995-07-28
US60/001,723 1995-07-28
PCT/US1996/012285 WO1997005185A2 (en) 1995-07-28 1996-07-26 Multiblock biodegradable hydrogels for use as controlled release agents for drugs delivery and tissue treatment agents

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2005293028A Division JP2006097031A (ja) 1995-07-28 2005-10-05 薬物送達のための制御された放出薬剤および組織処置薬剤としての使用のためのマルチブロック生分解性ヒドロゲル

Publications (2)

Publication Number Publication Date
JPH11510837A true JPH11510837A (ja) 1999-09-21
JPH11510837A5 JPH11510837A5 (enExample) 2004-08-26

Family

ID=21697509

Family Applications (2)

Application Number Title Priority Date Filing Date
JP9507762A Withdrawn JPH11510837A (ja) 1995-07-28 1996-07-26 薬物送達のための制御された放出薬剤および組織処置薬剤としての使用のためのマルチブロック生分解性ヒドロゲル
JP2005293028A Withdrawn JP2006097031A (ja) 1995-07-28 2005-10-05 薬物送達のための制御された放出薬剤および組織処置薬剤としての使用のためのマルチブロック生分解性ヒドロゲル

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2005293028A Withdrawn JP2006097031A (ja) 1995-07-28 2005-10-05 薬物送達のための制御された放出薬剤および組織処置薬剤としての使用のためのマルチブロック生分解性ヒドロゲル

Country Status (7)

Country Link
US (5) US6201065B1 (enExample)
EP (1) EP0842209B1 (enExample)
JP (2) JPH11510837A (enExample)
AT (1) ATE342295T1 (enExample)
CA (1) CA2228118A1 (enExample)
DE (1) DE69636626T2 (enExample)
WO (1) WO1997005185A2 (enExample)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001514931A (ja) * 1997-08-18 2001-09-18 ボストン サイエンティフィック リミテッド 移植可能なプロテーゼ用の生体溶解吸収性組成物
JP2003527172A (ja) * 2000-03-13 2003-09-16 バイオキュア・インコーポレーテッド 組織増量及び被覆用組成物
JP2005534732A (ja) * 2002-06-14 2005-11-17 ポリメーレクスペール エス アー 熱感応性ポリマー及びそのポリマーから得られた熱可逆性ゲル
JP2006504451A (ja) * 2002-08-22 2006-02-09 フレセニウス メディカル ケア ドイチェランド ゲーエムベーハー ポリマー支持体表面にハイドロゲル形成ポリマーを固定化するための方法
JP2008106269A (ja) * 2006-09-29 2008-05-08 Nof Corp 生分解性ポリオキシアルキレン誘導体の製造方法
JP2009261931A (ja) * 2008-04-23 2009-11-12 Tyco Healthcare Group Lp 生体吸収性外科用組成物
JP2010500917A (ja) * 2006-06-15 2010-01-14 マイクロベンション， インコーポレイテッド 膨張性ポリマーで構成される塞栓形成デバイス
JP2011507637A (ja) * 2007-12-21 2011-03-10 マイクロベンション， インコーポレイテッド 生物医学的使用のためのハイドロゲルフィラメント
JP2016509610A (ja) * 2012-12-17 2016-03-31 シーカー，マティアス 鎖延長されたポロキサマー、生物材料を含むそれから形成された熱可逆性ハイドロゲルおよびその医学的適用
WO2016143647A1 (ja) * 2015-03-10 2016-09-15 国立大学法人 東京大学 ゲル前駆体クラスターを用いた低濃度ゲルの製造方法、及び当該製造方法により得られるゲル
WO2020027016A1 (ja) * 2018-07-31 2020-02-06 国立大学法人 東京大学 スポンジ様の多孔体構造を有する高分子ゲル

Families Citing this family (277)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9306038A (pt) * 1992-02-28 1998-01-13 Univ Texas Hidrogéis biodegradáveis fotopolimerizáveis como materiais de contato de tecidos e condutores de liberação controlada
US6201065B1 (en) * 1995-07-28 2001-03-13 Focal, Inc. Multiblock biodegradable hydrogels for drug delivery and tissue treatment
US6696499B1 (en) * 1996-07-11 2004-02-24 Life Medical Sciences, Inc. Methods and compositions for reducing or eliminating post-surgical adhesion formation
WO1998012274A1 (en) 1996-09-23 1998-03-26 Chandrashekar Pathak Methods and devices for preparing protein concentrates
US20090324721A1 (en) * 1996-09-23 2009-12-31 Jack Kennedy Hydrogels Suitable For Use In Polyp Removal
US7009034B2 (en) * 1996-09-23 2006-03-07 Incept, Llc Biocompatible crosslinked polymers
US8003705B2 (en) * 1996-09-23 2011-08-23 Incept Llc Biocompatible hydrogels made with small molecule precursors
DE19640092A1 (de) * 1996-09-28 1998-04-16 Beiersdorf Ag Strukturen mit Lipid-Doppelmembranen, in deren lipophilen Bereich längerkettige Moleküle eintauchen oder durch hydrophobe Wechselwirkungen an solche Moleküle angedockt sind
US6039757A (en) * 1997-03-12 2000-03-21 Cardiosynopsis, Inc. In situ formed fenestrated stent
JP2001516261A (ja) 1997-03-20 2001-09-25 フォーカル・インコーポレーテッド 生物分解性の組織開創器
US6211249B1 (en) * 1997-07-11 2001-04-03 Life Medical Sciences, Inc. Polyester polyether block copolymers
US5837752A (en) * 1997-07-17 1998-11-17 Massachusetts Institute Of Technology Semi-interpenetrating polymer networks
EP1512395A1 (en) * 1997-07-18 2005-03-09 Azopax Therapeutics LLC Biodegradable macromers for the controlled release of biologically active substances
US6153211A (en) * 1997-07-18 2000-11-28 Infimed, Inc. Biodegradable macromers for the controlled release of biologically active substances
ES2211033T3 (es) 1998-01-07 2004-07-01 Debio Recherche Pharmaceutique S.A. Acrilatos de polietilenglicol heterobifuncionales degradables y geles y conjugados derivados de dichos acrilatos.
US6872384B1 (en) 1998-02-23 2005-03-29 Life Medical Sciences, Inc. Treatment of trauma
US6367929B1 (en) 1998-03-02 2002-04-09 Johnson & Johnson Vision Care, Inc. Hydrogel with internal wetting agent
WO1999059638A2 (en) * 1998-05-15 1999-11-25 Chiron Corporation Compositions and methods for the delivery of nucleic acid molecules
JP2002521140A (ja) * 1998-07-31 2002-07-16 ファースト ウォーター リミテッド 生体接着剤組成物および該組成物を含有する生体医用電極
US6632457B1 (en) * 1998-08-14 2003-10-14 Incept Llc Composite hydrogel drug delivery systems
US6514534B1 (en) * 1998-08-14 2003-02-04 Incept Llc Methods for forming regional tissue adherent barriers and drug delivery systems
US6152943A (en) * 1998-08-14 2000-11-28 Incept Llc Methods and apparatus for intraluminal deposition of hydrogels
US6818018B1 (en) 1998-08-14 2004-11-16 Incept Llc In situ polymerizable hydrogels
US7790192B2 (en) 1998-08-14 2010-09-07 Accessclosure, Inc. Apparatus and methods for sealing a vascular puncture
US7347850B2 (en) * 1998-08-14 2008-03-25 Incept Llc Adhesion barriers applicable by minimally invasive surgery and methods of use thereof
AU2707500A (en) 1998-12-04 2000-06-26 Incept Llc Biocompatible crosslinked polymers
US20080114092A1 (en) * 1998-12-04 2008-05-15 Incept Llc Adhesion barriers applicable by minimally invasive surgery and methods of use thereof
DE69922050T2 (de) 1999-02-05 2005-11-10 The Regents Of The University Of California, Oakland Thermoreversibles polymer für intralumenalimplantate
JP2002537069A (ja) 1999-02-23 2002-11-05 ファーソン メジカル インク． 損傷の治療方法
DK1168934T3 (da) * 1999-04-12 2008-05-13 Cornell Res Foundation Inc Hydrogeldannende system med hydrofobe og hydrofile komponenter
US6716445B2 (en) 1999-04-12 2004-04-06 Cornell Research Foundation, Inc. Hydrogel entrapping therapeutic agent and stent with coating comprising this
WO2000069942A1 (en) * 1999-05-19 2000-11-23 University Of Utah Research Foundation Stabilization and acoustic activation of polymeric micelles for drug delivery
US6579951B1 (en) * 1999-06-08 2003-06-17 Life Medical Sciences, Inc. Chain-extended or crosslinked polyethylene oxide/polypropylene oxide/polyethylene oxide block polymer with optional polyester blocks
US6589998B1 (en) 1999-06-11 2003-07-08 Cytyc Health Corporation Gel composition for filling a breast milk duct prior to surgical excision of the duct or other breast tissue
BR0013695A (pt) * 1999-09-01 2002-07-16 Rhodia Chimie Sa Copolìmero em blocos, processos de preparação dos mesmos, e, de controle de equilìbrio hidrófilo/ hidrófobo, e utilização de copolìmeros em blocos
JP2003514650A (ja) 1999-11-15 2003-04-22 バイオキュア・インコーポレーテッド 応答性ポリマー性中空粒子
US6710126B1 (en) 1999-11-15 2004-03-23 Bio Cure, Inc. Degradable poly(vinyl alcohol) hydrogels
AU4902901A (en) * 1999-11-15 2001-06-25 Biocure, Inc. Degradable poly(vinyl alcohol) hydrogels
WO2001041735A2 (en) * 1999-12-07 2001-06-14 Amgen Inc. Thermosensitive biodegradable hydrogels based on low molecular weight pluronics
US6652883B2 (en) 2000-03-13 2003-11-25 Biocure, Inc. Tissue bulking and coating compositions
AU2001245660B2 (en) 2000-03-13 2006-06-15 Biocompatibles Uk Limited Embolic compositions
AU2001252914A1 (en) * 2000-03-14 2001-09-24 Alnis Bioscience, Inc. Cryoprotective system
CA2402546C (en) * 2000-03-15 2009-06-02 Yu-Ling Cheng Environment responsive gelling copolymer
US7160931B2 (en) * 2000-03-15 2007-01-09 Yu-Ling Cheng Thermally reversible implant and filler
US7193007B2 (en) 2000-03-15 2007-03-20 Yu-Ling Cheng Environment responsive gelling copolymer
WO2001091784A1 (en) * 2000-05-26 2001-12-06 C.T.P. Cable Technology Procurement Ag Means for maintenance and/or correction of glucose concentration in blood
ATE325144T1 (de) * 2000-05-29 2006-06-15 Bio Merieux Biokompatible polymere für die bindung von biologischen liganden
US8313504B2 (en) * 2000-09-18 2012-11-20 Cordis Corporation Foam matrix embolization device
US20040018228A1 (en) * 2000-11-06 2004-01-29 Afmedica, Inc. Compositions and methods for reducing scar tissue formation
FR2819416B1 (fr) 2001-01-15 2004-12-17 Oreal Composition moussante tehrmogelifiante et mousse obtenue
KR100496396B1 (ko) * 2001-02-28 2005-06-20 다이니혼 잉키 가가쿠 고교 가부시키가이샤 흡수성 재료
US6949251B2 (en) * 2001-03-02 2005-09-27 Stryker Corporation Porous β-tricalcium phosphate granules for regeneration of bone tissue
US6529759B1 (en) * 2001-03-08 2003-03-04 Electrical Geodesics, Inc. Method for mapping internal body tissue
US20020192286A1 (en) * 2001-03-27 2002-12-19 Macromed, Incorporated Biodegradable triblock copolymers as solubilizing agents for drugs and method of use thereof
US20040185101A1 (en) * 2001-03-27 2004-09-23 Macromed, Incorporated. Biodegradable triblock copolymers as solubilizing agents for drugs and method of use thereof
US20040022853A1 (en) * 2001-04-26 2004-02-05 Control Delivery Systems, Inc. Polymer-based, sustained release drug delivery system
AU2002259045B2 (en) * 2001-04-26 2008-05-22 Psivida Us Inc. Sustained release drug delivery system containing codrugs
EP2319430B1 (en) 2001-05-29 2013-11-13 Microvention, Inc. Vascular embolization device and method of manufacture
US6939564B2 (en) * 2001-06-08 2005-09-06 Labopharm, Inc. Water-soluble stabilized self-assembled polyelectrolytes
US6730772B2 (en) 2001-06-22 2004-05-04 Venkatram P. Shastri Degradable polymers from derivatized ring-opened epoxides
KR100566911B1 (ko) 2001-06-25 2006-04-03 주식회사 삼양사 약물 전달체용 음이온기-함유 양친성 블록 공중합체 및 그의 양이온성 약물과의 복합체
WO2003006043A1 (en) * 2001-07-10 2003-01-23 Massachusetts Institute Of Technology Surfactant peptide nanostructures, and uses thereof
FR2829494B1 (fr) * 2001-07-13 2005-10-28 Rhodia Chimie Sa Compositions aqueuses comprenant un microgel chimique associe a un polymere pontant, preparation et utilisation
WO2003008480A1 (en) * 2001-07-14 2003-01-30 Samyang Corporation Positively charged amphiphilic block copolymer as drug carrier and complex thereof with negatively charged drug
US7572288B2 (en) 2001-07-20 2009-08-11 Microvention, Inc. Aneurysm treatment device and method of use
US8252040B2 (en) 2001-07-20 2012-08-28 Microvention, Inc. Aneurysm treatment device and method of use
US8715312B2 (en) * 2001-07-20 2014-05-06 Microvention, Inc. Aneurysm treatment device and method of use
US20030082235A1 (en) * 2001-08-13 2003-05-01 Yissum Research Development Company Of The Hebrew University Of Jerusalem Novel reverse thermo-sensitive block copolymers
US20080063620A1 (en) * 2001-08-13 2008-03-13 Yissum Research Development Company Of The Hebrew University Of Jerusalem Novel reverse thermo-sensitive block copolymers
IN2014DN10834A (enExample) * 2001-09-17 2015-09-04 Psivida Inc
US7223282B1 (en) * 2001-09-27 2007-05-29 Advanced Cardiovascular Systems, Inc. Remote activation of an implantable device
US6592899B2 (en) 2001-10-03 2003-07-15 Macromed Incorporated PLA/PLGA oligomers combined with block copolymers for enhancing solubility of a drug in water
US7842498B2 (en) 2001-11-08 2010-11-30 Bio-Rad Laboratories, Inc. Hydrophobic surface chip
US7491690B2 (en) * 2001-11-14 2009-02-17 Northwestern University Self-assembly and mineralization of peptide-amphiphile nanofibers
WO2003042300A1 (en) * 2001-11-15 2003-05-22 Biomatera Inc. Method for preparing gels
US7205337B2 (en) * 2001-12-21 2007-04-17 Isotis Orthobiologics, Inc. End-capped polymers and compositions containing such compounds
US7241813B2 (en) * 2001-12-21 2007-07-10 Isotis Orthobiologics, Inc. End-capped polymers and compositions containing such compounds
AU2003215280A1 (en) * 2002-02-15 2003-09-09 Northwestern University Self-assembly of peptide-amphiphile nanofibers under physiological conditions
US20060239961A1 (en) * 2002-02-15 2006-10-26 Nektar Therapeutics Al, Corporation Hydrolytically degradable alkylene oxide based polymers
AU2003216379A1 (en) * 2002-02-22 2003-09-09 Control Delivery Systems, Inc. Method for treating otic disorders
US8298606B2 (en) * 2002-03-08 2012-10-30 The Regents Of The University Of California Methods and compositions for stabilizing the myocardium
US7985601B2 (en) * 2002-03-08 2011-07-26 The Regents Of The University Of California Tunable, semi-interpenetrating polymer networks (sIPNS) for medicine and biotechnology
US7018655B2 (en) 2002-03-18 2006-03-28 Labopharm, Inc. Amphiphilic diblock, triblock and star-block copolymers and their pharmaceutical compositions
US20030180348A1 (en) * 2002-03-22 2003-09-25 Levinson R. Saul Transcellular drug delivery system
AU2003225516A1 (en) * 2002-03-26 2003-10-08 Yissum Research Development Company Of The Hebrew University Of Jerusalem Responsive biomedical composites
US7005143B2 (en) * 2002-04-12 2006-02-28 3M Innovative Properties Company Gel materials, medical articles, and methods
US20030203032A1 (en) * 2002-04-25 2003-10-30 Schultz Clyde L. Growth factor delivery system for the healing of wounds and the prevention of inflammation and disease
WO2003090662A2 (en) * 2002-04-25 2003-11-06 Rapidheal, Inc. Growth factor delivery system for the healing of wounds and the prevention of inflammation and disease
US20030204180A1 (en) * 2002-04-30 2003-10-30 Kimberly-Clark Worldwide, Inc. Temperature responsive delivery systems
US6923961B2 (en) * 2002-04-30 2005-08-02 Fziomed, Inc. Chemically activated carboxypolysaccharides and methods for use to inhibit adhesion formation and promote hemostasis
US8273366B2 (en) * 2002-06-05 2012-09-25 University Of Florida Research Foundation, Incorporated Ophthalmic drug delivery system
US7649023B2 (en) 2002-06-11 2010-01-19 Novartis Ag Biodegradable block copolymeric compositions for drug delivery
US7160551B2 (en) * 2002-07-09 2007-01-09 The Board Of Trustees Of The University Of Illinois Injectable system for controlled drug delivery
JP2006500978A (ja) * 2002-08-20 2006-01-12 イグザクテック・インコーポレイテッド 骨成長誘導物質の運搬および送達用組成物、およびその組成物の製造および適用方法
US7534761B1 (en) 2002-08-21 2009-05-19 North Western University Charged peptide-amphiphile solutions and self-assembled peptide nanofiber networks formed therefrom
US8673333B2 (en) * 2002-09-25 2014-03-18 The Johns Hopkins University Cross-linked polymer matrices, and methods of making and using same
US7862831B2 (en) * 2002-10-09 2011-01-04 Synthasome, Inc. Method and material for enhanced tissue-biomaterial integration
GB0222522D0 (en) 2002-09-27 2002-11-06 Controlled Therapeutics Sct Water-swellable polymers
US20050069572A1 (en) * 2002-10-09 2005-03-31 Jennifer Elisseeff Multi-layered polymerizing hydrogels for tissue regeneration
US6800663B2 (en) * 2002-10-18 2004-10-05 Alkermes Controlled Therapeutics Inc. Ii, Crosslinked hydrogel copolymers
US7554021B2 (en) 2002-11-12 2009-06-30 Northwestern University Composition and method for self-assembly and mineralization of peptide amphiphiles
WO2004044012A1 (en) * 2002-11-12 2004-05-27 The Polymer Technology Group Incorporated Control of polymer surface molecular architecture via amphipathic endgroups
AU2003298647A1 (en) 2002-11-14 2004-06-15 Claussen, Randal, C. Synthesis and self-assembly of abc triblock bola peptide
ES2624353T3 (es) 2002-11-15 2017-07-13 Idenix Pharmaceuticals Llc 2'-Metil nucleósidos en combinación con interferón y mutación de Flaviviridae
US7223826B2 (en) * 2003-01-30 2007-05-29 3M Innovative Properties Company Amide-functional polymers, compositions, and methods
US20040185013A1 (en) * 2003-01-30 2004-09-23 Burgio Paul A. Dental whitening compositions and methods
US20040151691A1 (en) * 2003-01-30 2004-08-05 Oxman Joel D. Hardenable thermally responsive compositions
CN1446833A (zh) * 2003-02-08 2003-10-08 复旦大学 一种温敏性可降解微凝胶及其制备方法
MXPA05008483A (es) * 2003-02-11 2006-03-10 Univ Northwestern Metodos y materiales para revestimientos de superficie nanocristalinos y union de nanofibras de anfililos peptidicos sobre las mismas.
CN1794980A (zh) * 2003-03-24 2006-06-28 生物领域医疗公司 利用逆向热敏聚合物的暂时栓塞
US20050074497A1 (en) * 2003-04-09 2005-04-07 Schultz Clyde L. Hydrogels used to deliver medicaments to the eye for the treatment of posterior segment diseases
US20050255144A1 (en) * 2003-04-09 2005-11-17 Directcontact Llc Methods and articles for the delivery of medicaments to the eye for the treatment of posterior segment diseases
US9216106B2 (en) 2003-04-09 2015-12-22 Directcontact Llc Device and method for the delivery of drugs for the treatment of posterior segment disease
FR2854071B1 (fr) * 2003-04-25 2009-01-30 Ethypharm Sa Procede de dispersion de substances hydrosolubles ou hydrophiles dans un fluide a pression supercritique
US20070110784A1 (en) * 2003-05-02 2007-05-17 Rimon Therapeutics Ltd. Thermally reversible implant
US20040249119A1 (en) * 2003-06-05 2004-12-09 Fox Martin Edward Novel mPEG propionaldehyde precursor
AU2004257132B2 (en) 2003-07-18 2008-02-21 Agency For Science, Technology And Research Thermosensitive polymers for therapeutic use and methods of preparation
FR2862652B1 (fr) * 2003-11-24 2006-04-28 Rescoll Soc Procede d'obtention d'un gel thermoreversible a structure tridimensionnelle controlee et gel obtenu
GB2408510B (en) * 2003-11-28 2008-05-14 Ind Tech Res Inst Thermosensitive biodegradable copolymer
KR20070004561A (ko) * 2003-12-05 2007-01-09 노오쓰웨스턴 유니버시티 분지형 펩티드 친양매성 화합물들, 그들의 관련된 에피토프화합물들 및 자가조립된 구조들
ES2380340T3 (es) * 2003-12-05 2012-05-10 Northwestern University Anfífilos peptídicos auto-ensamblantes y métodos relacionados para la administración de factores de crecimiento
US8048450B2 (en) * 2003-12-09 2011-11-01 University Of North Texas Aqueous dispersion of hydrogel nanoparticles with inverse thermoreversible gelation
GB0329654D0 (en) * 2003-12-23 2004-01-28 Smith & Nephew Tunable segmented polyacetal
US20050238678A1 (en) * 2004-03-05 2005-10-27 Janos Borbely Hydrogels from biopolymers
DE102004019504A1 (de) * 2004-04-22 2005-11-10 Celanese Ventures Gmbh Neue Hydrogele auf Basis von Polyvinylalkoholen und Polyvinylalkohol-Copolymeren
US7758654B2 (en) 2004-05-20 2010-07-20 Kensey Nash Corporation Anti-adhesion device
US20050281866A1 (en) * 2004-05-24 2005-12-22 Genzyme Corporation Adherent polymeric compositions
ATE489058T1 (de) * 2004-06-29 2010-12-15 Inc Biocure Bandscheiben-nucleus-pulposus-implantat
GB0417401D0 (en) 2004-08-05 2004-09-08 Controlled Therapeutics Sct Stabilised prostaglandin composition
EP1804824B1 (en) 2004-09-29 2017-01-04 Icahn School of Medicine at Mount Sinai Fsh and fsh receptor modulator compositions and methods for inhibiting osteoclastic bone resorption and bone loss in osteoporosis
WO2006052790A2 (en) 2004-11-05 2006-05-18 The Children's Hospital Of Philadelphia Biodegradable linkers for molecular therapies
BRPI0518582A2 (pt) * 2004-11-24 2008-11-25 Therakine Corp implante para liberaÇço de medicamento intra-ocular
US8128952B2 (en) * 2005-01-12 2012-03-06 Clemson University Research Foundation Ligand-mediated controlled drug delivery
US20060247165A1 (en) * 2005-01-21 2006-11-02 Stupp Samuel I Methods and compositions for encapsulation of cells
EP1846505B1 (en) * 2005-02-09 2015-11-11 Covidien LP Synthetic sealants
WO2006089119A2 (en) * 2005-02-18 2006-08-24 Cartilix, Inc. Biological adhesive
EP1853917A4 (en) * 2005-03-04 2008-09-10 Univ Northwestern ANGIOGENIC HEPARIN BINDING EPITOPES, PEPTIDE AMPHIPHILES, SELF-ASSEMBLED COMPOSITIONS AND METHODS OF USE THEREOF
CA2603116A1 (en) * 2005-03-29 2006-10-05 The Regents Of The University Of California Controlling stem cell destiny with tunable network
US20060222596A1 (en) 2005-04-01 2006-10-05 Trivascular, Inc. Non-degradable, low swelling, water soluble radiopaque hydrogel polymer
US20060224095A1 (en) * 2005-04-05 2006-10-05 University Of New Hampshire Biocompatible polymeric vesicles self assembled from triblock copolymers
US8414907B2 (en) 2005-04-28 2013-04-09 Warsaw Orthopedic, Inc. Coatings on medical implants to guide soft tissue healing
US9119901B2 (en) 2005-04-28 2015-09-01 Warsaw Orthopedic, Inc. Surface treatments for promoting selective tissue attachment to medical impants
WO2006124889A1 (en) * 2005-05-12 2006-11-23 Clopay Plastic Products Company, Inc. Elastomeric films with brittle nonblocking skins
GB0515625D0 (en) * 2005-07-29 2005-09-07 Univ Manchester Hydrogel particle
WO2007016622A2 (en) * 2005-08-02 2007-02-08 Wright Medical Technolody, Inc. Gel composition for inhibiting cellular adhesion
US20070036842A1 (en) * 2005-08-15 2007-02-15 Concordia Manufacturing Llc Non-woven scaffold for tissue engineering
US7691946B2 (en) * 2005-09-30 2010-04-06 The United States Of America As Represented By The Secretary Of Agriculture Soy-based thermosensitive hydrogels for controlled release systems
US20070110788A1 (en) * 2005-11-14 2007-05-17 Hissong James B Injectable formulation capable of forming a drug-releasing device
US7432069B2 (en) * 2005-12-05 2008-10-07 Sontra Medical Corporation Biocompatible chemically crosslinked hydrogels for glucose sensing
US20070149641A1 (en) * 2005-12-28 2007-06-28 Goupil Dennis W Injectable bone cement
WO2007089103A1 (en) * 2006-02-01 2007-08-09 Samyang Corporation Composition for inhibiting adhesion
US8795709B2 (en) 2006-03-29 2014-08-05 Incept Llc Superabsorbent, freeze dried hydrogels for medical applications
US8747870B2 (en) 2006-04-20 2014-06-10 University Of Utah Research Foundation Polymeric compositions and methods of making and using thereof
CA2649915A1 (en) * 2006-04-20 2007-11-01 University Of Utah Research Foundation Polymeric compositions and methods of making and using thereof
JP6075930B2 (ja) 2006-04-24 2017-02-08 インセプト エルエルシー タンパク質架橋剤、架橋方法及びその用途
WO2007127785A2 (en) * 2006-04-25 2007-11-08 William Marsh Rice University Novel injectable macromonomers for the fabrication of hydrogels
US7872068B2 (en) * 2006-05-30 2011-01-18 Incept Llc Materials formable in situ within a medical device
US8273933B2 (en) * 2006-06-14 2012-09-25 Hewlett-Packard Development Company, L.P. Functionalized latex polymer and method of forming the same
KR100773029B1 (ko) * 2006-06-16 2007-11-05 이화여자대학교 산학협력단 수용성 미셀을 형성하는 생분해성 고리형 삼합체 포스파젠-탁솔 컨쥬게이트 항암제 및 이의 제조방법
JP2009540965A (ja) * 2006-06-21 2009-11-26 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 非結合管腔を接合するための組成物および方法
US8608760B2 (en) * 2006-06-21 2013-12-17 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for joining non-conjoined lumens
US8197499B2 (en) * 2006-06-21 2012-06-12 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for joining non-conjoined lumens
US8974542B2 (en) 2006-06-27 2015-03-10 University of Pittsburgh—of the Commonwealth System of Higher Education Biodegradable elastomeric patch for treating cardiac or cardiovascular conditions
GB0613333D0 (en) 2006-07-05 2006-08-16 Controlled Therapeutics Sct Hydrophilic polyurethane compositions
GB0613638D0 (en) * 2006-07-08 2006-08-16 Controlled Therapeutics Sct Polyurethane elastomers
US20080160065A1 (en) * 2006-07-12 2008-07-03 Janet Anne Halliday Drug delivery polymer with hydrochloride salt of clindamycin
EP3009477B1 (en) 2006-07-20 2024-01-24 Orbusneich Medical Pte. Ltd Bioabsorbable polymeric composition for a medical device
WO2008033497A1 (en) * 2006-09-14 2008-03-20 The Research Foundation Of State University Of New York Nanostructured smart gel for time release drug delivery
CA2699184A1 (en) * 2006-09-22 2008-03-27 Labopharm Inc. Compositions and methods for ph targeted drug delivery
US8889791B2 (en) * 2006-10-10 2014-11-18 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Thermoresponsive, biodegradable, elastomeric material
GB0620685D0 (en) * 2006-10-18 2006-11-29 Controlled Therapeutics Sct Bioresorbable polymers
EP2073754A4 (en) 2006-10-20 2012-09-26 Orbusneich Medical Inc BIOABSORBABLE POLYMER COMPOSITION AND MEDICAL DEVICE BACKGROUND
US7959942B2 (en) 2006-10-20 2011-06-14 Orbusneich Medical, Inc. Bioabsorbable medical device with coating
US20080102123A1 (en) * 2006-10-27 2008-05-01 Schachter Deborah M Self-gelling tunable drug delivery system
EP1917971A1 (en) 2006-10-27 2008-05-07 Société de Conseils de Recherches et d'Applications Scientifiques ( S.C.R.A.S.) Substained release formulations comprising very low molecular weight polymers
WO2008060557A2 (en) * 2006-11-14 2008-05-22 The Trustees Of The University Of Pennsylvania Efficient nuclear delivery of antisense oligonucleotides
JP2010519183A (ja) * 2007-02-06 2010-06-03 インセプト エルエルシー 生理溶液の溶出のためのタンパク質の沈殿を用いる重合
CA2678873C (en) 2007-02-19 2016-10-25 Plurogen Therapeutics, Inc. Compositions for treating biofilms and methods for using same
US20090227689A1 (en) * 2007-03-05 2009-09-10 Bennett Steven L Low-Swelling Biocompatible Hydrogels
US20090227981A1 (en) * 2007-03-05 2009-09-10 Bennett Steven L Low-Swelling Biocompatible Hydrogels
US20080279764A1 (en) * 2007-03-09 2008-11-13 Anthony Manganaro Method and composition for treating cancer
US8076295B2 (en) * 2007-04-17 2011-12-13 Nanotope, Inc. Peptide amphiphiles having improved solubility and methods of using same
KR100838809B1 (ko) * 2007-05-03 2008-06-17 성균관대학교산학협력단 겔강도가 우수한 온도 및 피에치 민감성 블록 공중합체 및이의 제조방법과 이를 이용한 약물전달체
US8133553B2 (en) 2007-06-18 2012-03-13 Zimmer, Inc. Process for forming a ceramic layer
US8309521B2 (en) 2007-06-19 2012-11-13 Zimmer, Inc. Spacer with a coating thereon for use with an implant device
US9023094B2 (en) * 2007-06-25 2015-05-05 Microvention, Inc. Self-expanding prosthesis
US9125807B2 (en) 2007-07-09 2015-09-08 Incept Llc Adhesive hydrogels for ophthalmic drug delivery
US8480651B2 (en) * 2007-08-02 2013-07-09 Covidien Lp Cannula system
EP2184978A2 (de) * 2007-08-02 2010-05-19 Basf Se Wirkstoffe enthaltende polymernetzwerke, verfahren zu deren herstellung sowie deren verwendung
US8067028B2 (en) * 2007-08-13 2011-11-29 Confluent Surgical Inc. Drug delivery device
US8608049B2 (en) 2007-10-10 2013-12-17 Zimmer, Inc. Method for bonding a tantalum structure to a cobalt-alloy substrate
US8629314B2 (en) 2007-12-18 2014-01-14 Ethicon, Inc. Surgical barriers having adhesion inhibiting properties
US8299316B2 (en) 2007-12-18 2012-10-30 Ethicon, Inc. Hemostatic device
US8172861B2 (en) * 2007-12-20 2012-05-08 Tautona Group, L.P. Compositions and methods for joining non-conjoined lumens
US8486528B2 (en) * 2008-01-22 2013-07-16 Gwangju Institute Of Science And Technology Temperature-sensitive nano-carriers
JP2011521896A (ja) 2008-04-15 2011-07-28 サーコード コーポレイション 免疫関連障害に対する局部治療に使用するための局所ｌｆａ−１アンタゴニスト
US11969501B2 (en) 2008-04-21 2024-04-30 Dompé Farmaceutici S.P.A. Auris formulations for treating otic diseases and conditions
EP2278999B1 (en) 2008-04-21 2025-01-29 Dompé farmaceutici S.p.A. Auris formulations for treating otic diseases and conditions
MX2010012397A (es) 2008-05-14 2011-03-15 Otonomy Inc Star Composiciones de corticosteroides de liberacion controlada y metodos para el tratamiento de transtornos oticos.
WO2010011466A2 (en) 2008-06-27 2010-01-28 Otonomy, Inc. Controlled-release cns modulating compositions and methods for the treatment of otic disorders
US8496957B2 (en) * 2008-07-21 2013-07-30 Otonomy, Inc Controlled release auris sensory cell modulator compositions and methods for the treatment of otic disorders
US8784870B2 (en) * 2008-07-21 2014-07-22 Otonomy, Inc. Controlled release compositions for modulating free-radical induced damage and methods of use thereof
AU2009274137B2 (en) * 2008-07-21 2013-10-31 Otonomy, Inc. Controlled release antimicrobial compositions and methods for the treatment of otic disorders
US8318817B2 (en) 2008-07-21 2012-11-27 Otonomy, Inc. Controlled release antimicrobial compositions and methods for the treatment of otic disorders
US8993068B2 (en) 2008-11-04 2015-03-31 The Trustees Of Columbia University In The City Of New York Heterobifunctional polymers and methods for layer-by-layer construction of multilayer films
US8563037B2 (en) * 2009-02-06 2013-10-22 Tautona Group, L.P. Compositions and methods for joining non-conjoined lumens
EP2396070B1 (en) 2009-02-12 2024-12-04 Incept Llc Drug delivery through hydrogel plugs
EP2419116A1 (en) * 2009-04-13 2012-02-22 North Western University Novel peptide-based scaffolds for cartilage regeneration and methods for their use
US10639396B2 (en) 2015-06-11 2020-05-05 Microvention, Inc. Polymers
BRPI1014645B1 (pt) 2009-04-30 2020-07-07 Technip France método e sistema para compartilhar linhas de amarração
US9463004B2 (en) 2009-05-04 2016-10-11 Incept, Llc. Biomaterials for track and puncture closure
CA2762770C (en) 2009-05-19 2017-09-05 Plurogen Therapeutics, Inc. Surface active agent compositions and methods for enhancing oxygenation, reducing bacteria and improving wound healing
US20090298953A1 (en) * 2009-07-09 2009-12-03 Iran Polymer And Petrochemical Institute Drug delivery system and method of making the same
KR20120090052A (ko) 2009-09-24 2012-08-16 마이크로벤션, 인코포레이티드 생물 의학적 사용을 위한 주사가능한 히드로겔 필라멘트
US20110077216A1 (en) * 2009-09-30 2011-03-31 Massachusetts Institute Of Technology Compositions and methods for the treatment of atherosclerosis and other related diseases
EP2485768A1 (en) 2009-10-07 2012-08-15 Sanford-Burnham Medical Research Institute Methods and compositions related to clot-binding lipid compounds
AU2010313530B2 (en) * 2009-10-26 2015-12-17 Microvention, Inc. Embolization device constructed from expansile polymer
EP2498764B1 (en) 2009-11-09 2017-09-06 Spotlight Technology Partners LLC Fragmented hydrogels
CN106913902A (zh) 2009-11-09 2017-07-04 聚光灯技术合伙有限责任公司 多糖基水凝胶
JP5653449B2 (ja) 2009-12-01 2015-01-14 株式会社ブリヂストン 変性ゴム組成物およびその調製方法
EP3960215B1 (en) 2009-12-15 2024-10-16 Incept, LLC Implants and biodegradable fiducial markers
EP2521587B1 (en) * 2010-01-08 2020-04-08 Wake Forest University Health Sciences Delivery system
US8835395B2 (en) 2010-03-10 2014-09-16 Kansas State University Research Foundation Protein peptide hydrogels
US20110223156A1 (en) * 2010-03-11 2011-09-15 Raibekas Andrei A Reversible gel protein formulation
US8551531B2 (en) 2010-04-12 2013-10-08 The Curators Of The University Of Missouri Pentablock polymers
EP2569342B1 (en) 2010-05-11 2022-01-26 Howmedica Osteonics Corp. Organophosphorous, multivalent metal compounds,&polymer adhesive interpenetrating network compositions&methods
US9232805B2 (en) 2010-06-29 2016-01-12 Biocure, Inc. In-situ forming hydrogel wound dressings containing antimicrobial agents
WO2012024390A2 (en) 2010-08-17 2012-02-23 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Biohybrid composite scaffold
US8961501B2 (en) 2010-09-17 2015-02-24 Incept, Llc Method for applying flowable hydrogels to a cornea
US8911712B2 (en) * 2010-10-04 2014-12-16 Church & Dwight, Co., Inc. Multi-purposed dentifrice
EP2683328B1 (en) 2011-03-07 2017-11-08 Wake Forest University Health Sciences Delivery system
US9006345B2 (en) 2011-03-25 2015-04-14 The Trustees Of Columbia University In The City Of New York Heterotrifunctional molecules and methods for the synthesis of dendrimeric materials
AU2012235634B2 (en) 2011-03-28 2017-05-25 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Sustained-release injectable formulation
WO2012145431A2 (en) 2011-04-18 2012-10-26 Microvention, Inc. Embolic devices
CN106729771A (zh) 2011-04-21 2017-05-31 加利福尼亚大学董事会 官能化磁性纳米颗粒及在淀粉样沉积物和神经原纤维缠结成像中用途
EP2707077B1 (en) 2011-05-11 2017-10-04 Microvention, Inc. Device for occluding a lumen
US8765189B2 (en) 2011-05-13 2014-07-01 Howmedica Osteonic Corp. Organophosphorous and multivalent metal compound compositions and methods
WO2012162637A2 (en) 2011-05-26 2012-11-29 Kansas State University Research Foundation Vaccine adjuvants from self-assembling peptides
US10226417B2 (en) 2011-09-16 2019-03-12 Peter Jarrett Drug delivery systems and applications
EP2766407B1 (en) * 2011-10-12 2018-06-27 The Curators Of The University Of Missouri Pentablock polymers
US8936784B2 (en) 2011-10-17 2015-01-20 Poly-Med, Inc. Absorbable in situ gel-forming system, method of making and use thereof
CA2852386C (en) * 2011-10-17 2019-05-21 Poly-Med, Inc. Absorbable in situ gel-forming system, method of making and use thereof
US20130101547A1 (en) 2011-10-19 2013-04-25 Allergan, Inc. Thermoresponsive compositions for dermatological use and methods thereof
EP2785184B1 (en) 2011-11-30 2020-06-10 Emory University Compositions comprising jak inhibitors and haart drugs for use in the prevention or treatment of hiv
US9011884B2 (en) 2012-04-18 2015-04-21 Microvention, Inc. Embolic devices
US9205175B2 (en) 2012-07-27 2015-12-08 Drexel University Thermosensitive and crosslinkable polymer composite for three-dimensional soft tissue scaffold printing
US9395468B2 (en) 2012-08-27 2016-07-19 Ocular Dynamics, Llc Contact lens with a hydrophilic layer
US8633296B1 (en) 2012-09-12 2014-01-21 International Business Machines Corporation Composite hydrogels for delivery of biologically active materials
US9707323B2 (en) 2012-11-12 2017-07-18 Warsaw Orthopedic, Inc. Devices and methods for inhibiting adhesion formation
US9474767B2 (en) 2012-11-12 2016-10-25 Warsaw Orthopedic, Inc. Compositions and methods for inhibiting bone growth
US9421221B2 (en) 2012-11-12 2016-08-23 Warsaw Orthopedic, Inc. Compositions and methods for inhibiting adhesion formation
EP2970421A4 (en) * 2013-03-14 2016-11-02 Genzyme Corp HEAT-SENSITIVE COMPOSITIONS FOR BONE GROWTH
WO2014186669A1 (en) 2013-05-16 2014-11-20 The Curators Of The University Of Missouri Drug loading pentablock polymers
EA201690323A1 (ru) 2013-08-27 2016-07-29 Отономи, Инк. Способы лечения заболеваний уха у детей
US9566296B2 (en) 2013-11-08 2017-02-14 Warsaw Orthopedic, Inc. Multi-layered anti-adhesion device
CA2930552C (en) 2013-11-15 2022-12-13 Ocular Dynamics, Llc Contact lens with a hydrophilic layer
CN111620830A (zh) 2014-03-14 2020-09-04 北卡罗来纳大学教堂山分校 用于抑制雄性生育力的小分子
WO2015153996A1 (en) 2014-04-03 2015-10-08 Micro Vention, Inc. Embolic devices
CN110433326A (zh) 2014-04-29 2019-11-12 微仙美国有限公司 包含活性剂的聚合物
WO2015167751A1 (en) 2014-04-29 2015-11-05 Microvention, Inc. Polymers
CA2970010A1 (en) 2014-12-09 2016-06-16 Karen Havenstrite Medical device coating with a biocompatible layer
AU2016209327A1 (en) 2015-01-20 2017-08-10 Plurogen Therapeutics, Llc Compositions and methods of treating microbes
EP4279064A3 (en) 2015-05-12 2024-02-28 Incept, LLC Drug delivery from hydrogels
EP3331547A4 (en) * 2015-08-05 2019-08-21 Children's Medical Center Corporation COMPOSITIONS WITH PERMEATION PROMOTERS FOR ACTIVE INJECTION
US20170173209A1 (en) * 2015-12-18 2017-06-22 Rousseau Research, Inc. Wound closure compositions and method
US9868870B2 (en) 2016-03-16 2018-01-16 International Business Machines Corporation Hydrogel compositions for direct-write printing applications
EP3512513A4 (en) 2016-09-16 2020-04-15 Otonomy, Inc. OTIC GEL FORMULATIONS FOR THE TREATMENT OF EXTERNAL OTITIS
US11911532B2 (en) 2017-03-29 2024-02-27 The Regents Of The University Of Colorado, A Body Corporate Reverse thermal gels and their use as vascular embolic repair agents
US10457772B2 (en) 2017-09-08 2019-10-29 International Business Machines Corporation Preparation of robust polythioaminal carriers
SE541313C2 (en) * 2017-10-13 2019-06-25 Amferia Ab Amphiphilic antimicrobial hydrogel
CN109400816B (zh) * 2018-08-24 2020-10-30 哈尔滨工业大学 一种可紫外光固化的变色凝胶树脂及其合成方法和凝胶的变色、褪色方法
CA3111385A1 (en) 2018-09-06 2020-03-12 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Sustained-release injectable antibiotical formulation
WO2020076578A1 (en) 2018-10-09 2020-04-16 University Of Rochester Treatment of vulvovaginal disorders
KR20230053614A (ko) * 2020-07-31 2023-04-21 메사추세츠 인스티튜트 오브 테크놀로지 고체 형태의 폴리펩티드를 포함하는 조성물 및 관련 방법
DE102020125546A1 (de) * 2020-09-30 2022-03-31 Leibniz-Institut Für Neue Materialien Gemeinnützige Gesellschaft Mit Beschränkter Haftung Neuartige Hydrogele
WO2023220717A2 (en) * 2022-05-12 2023-11-16 The General Hospital Corporation Nanoparticle doped polyethylene glycol based gels and medical devices for drug delivery
AU2024220563A1 (en) 2023-02-16 2025-08-14 University Of Rochester Improving glymphatic-lymphatic efflux

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1595369C3 (de) * 1966-12-15 1973-10-04 Badische Anilin- & Soda-Fabrik Ag, 6700 Ludwigshafen Derivate von Blockcopolymerisaten des Äthylenoxids und des 1,2-Propylends und Verfahren zu deren Herstellung
DE2536121A1 (de) 1974-08-19 1976-03-04 Basf Wyandotte Corp Oberflaechenaktive block-polyoxyalkylencopolymere
US3931337A (en) 1974-08-19 1976-01-06 Basf Wyandotte Corporation Multi-block polyacetal copolymer surfactants
US4189609A (en) 1974-08-19 1980-02-19 Basf Wyandotte Corporation Multi-block coupled polyoxyalkylene copolymer surfactants
US3954886A (en) 1974-11-22 1976-05-04 Basf Wyandotte Corporation Alkali stable polyoxyethylene acetal surfactants
US3931148A (en) 1974-12-23 1976-01-06 Basf Wyandotte Corporation Hydroxyalkylamino glycosides and process of preparation
US4178434A (en) 1978-01-03 1979-12-11 Basf Wyandotte Corporation Amine-coupled polyepichlorohydrin and polyamines derived therefrom
US4191820A (en) 1978-01-03 1980-03-04 Basf Wyandotte Corporation Process for preparing polyalkylene polyamine polyethers
US4281199A (en) 1978-06-03 1981-07-28 Basf Wyandotte Corporation Polyalkylene polyamine ether derivatives of polyoxyalkylene compounds
US4261704A (en) 1979-06-22 1981-04-14 Basf Wyandotte Corporation Polyoxyalkylene polyamine detergent compositions
US4287078A (en) 1980-01-28 1981-09-01 Basf Wyandotte Corporation Surfactants derived from the reaction product of polyoxyalkylene polyols and polyglycidyl ethers and glycol-based antifreeze using same
US4314000A (en) 1980-11-03 1982-02-02 Basf Wyandotte Corporation Fiber lubricants yielding low residues upon oxidation
US4504418A (en) 1981-01-09 1985-03-12 Basf Wyandotte Corporation Non-ionic surface-active agents coupled with carbonates or carboxylic esters
US4408084A (en) 1981-01-09 1983-10-04 Basf Wyandotte Corporation Non-ionic surfactants containing acetal groups
US4519950A (en) 1981-01-16 1985-05-28 Basf Wyandotte Corporation Acetal group-containing non-ionic surfactants
ATE37983T1 (de) 1982-04-22 1988-11-15 Ici Plc Mittel mit verzoegerter freigabe.
US4452973A (en) * 1982-11-12 1984-06-05 American Cyanamid Company Poly(glycolic acid)/poly(oxyethylene) triblock copolymers and method of manufacturing the same
US4888176A (en) 1984-05-21 1989-12-19 Massachusetts Institute Of Technology Controlled drug delivery high molecular weight polyanhydrides
US4757128A (en) 1986-08-01 1988-07-12 Massachusetts Institute Of Technology High molecular weight polyanhydride and preparation thereof
US4818542A (en) 1983-11-14 1989-04-04 The University Of Kentucky Research Foundation Porous microspheres for drug delivery and methods for making same
US4741337A (en) 1985-07-17 1988-05-03 Ethicon, Inc. Surgical fastener made from glycolide-rich polymer blends
US5160745A (en) 1986-05-16 1992-11-03 The University Of Kentucky Research Foundation Biodegradable microspheres as a carrier for macromolecules
US4716203A (en) * 1986-09-05 1987-12-29 American Cyanamid Company Diblock and triblock copolymers
IT1198449B (it) 1986-10-13 1988-12-21 F I D I Farmaceutici Italiani Esteri di alcoli polivalenti di acido ialuronico
US4789724A (en) 1986-10-17 1988-12-06 Massachusetts Institute Of Technology Preparation of anhydride copolymers
IL82834A (en) 1987-06-09 1990-11-05 Yissum Res Dev Co Biodegradable polymeric materials based on polyether glycols,processes for the preparation thereof and surgical artiicles made therefrom
US4857311A (en) 1987-07-31 1989-08-15 Massachusetts Institute Of Technology Polyanhydrides with improved hydrolytic degradation properties
US5296627A (en) 1988-06-20 1994-03-22 Ppg Industries, Inc. Ethylenically unsaturated poly(alkyleneoxy) surfactants
US5213580A (en) 1988-08-24 1993-05-25 Endoluminal Therapeutics, Inc. Biodegradable polymeric endoluminal sealing process
US5328471A (en) 1990-02-26 1994-07-12 Endoluminal Therapeutics, Inc. Method and apparatus for treatment of focal disease in hollow tubular organs and other tissue lumens
US4938763B1 (en) 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
US4987744A (en) 1990-01-26 1991-01-29 Union Carbide Industrial Gases Technology Corporation Cryogenic distillation with unbalanced heat pump
US5078994A (en) 1990-04-12 1992-01-07 Eastman Kodak Company Microgel drug delivery system
CA2080224A1 (en) 1990-04-18 1991-10-19 Jindrich Kopecek Colonic-targeted oral drug-dosage forms based on crosslinked hydrogels containing azobonds and exhibiting ph-dependent swelling
US5219564A (en) 1990-07-06 1993-06-15 Enzon, Inc. Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon
US5145518A (en) 1990-06-27 1992-09-08 Xerox Corporation Inks containing block copolymer micelles
US5512091A (en) 1990-08-13 1996-04-30 Steiner; Carol A. Associative polymer hydrogels
US5410016A (en) 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
CA2101773A1 (en) 1991-01-31 1992-08-01 Toyoichi Tanaka Interpenetrating-polymer network phase-transition gels
GB9112267D0 (en) 1991-06-07 1991-07-24 Biocompatibles Ltd Polymeric coating
CA2087125A1 (en) * 1992-01-23 1993-07-24 Mridula Nair Chemically fixed micelles
US5417983A (en) 1992-02-19 1995-05-23 Sagami Chemical Research Center Drug release controlling material responsive to changes in temperature
SE468771B (sv) 1992-02-26 1993-03-15 Perstorp Ab Dendritisk makromolekyl av polyestertyp, foerfarande foer framstaellning daerav samt anvaendning daerav
BR9306038A (pt) 1992-02-28 1998-01-13 Univ Texas Hidrogéis biodegradáveis fotopolimerizáveis como materiais de contato de tecidos e condutores de liberação controlada
US5573934A (en) * 1992-04-20 1996-11-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
KR940003548U (ko) 1992-08-14 1994-02-21 김형술 세탁물 건조기
DE69414558T2 (de) 1993-03-23 1999-07-15 Focal, Inc., Lexington, Mass. Gerät und methode für den lokalen auftrag von polymermaterial auf gewebe
TW272976B (enExample) 1993-08-06 1996-03-21 Ciba Geigy Ag
US5525657A (en) 1994-10-11 1996-06-11 Basf Corporation Latex composition employing specifically defined ethylene oxide/propylene oxide block copolymer surfactant and hydrophobic defoaming agent
US6201065B1 (en) * 1995-07-28 2001-03-13 Focal, Inc. Multiblock biodegradable hydrogels for drug delivery and tissue treatment
US5702717A (en) 1995-10-25 1997-12-30 Macromed, Inc. Thermosensitive biodegradable polymers based on poly(ether-ester)block copolymers
WO2004075569A2 (en) 2003-02-19 2004-09-02 Fujitsu Limited Packet scheduling

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001514931A (ja) * 1997-08-18 2001-09-18 ボストン サイエンティフィック リミテッド 移植可能なプロテーゼ用の生体溶解吸収性組成物
JP2003527172A (ja) * 2000-03-13 2003-09-16 バイオキュア・インコーポレーテッド 組織増量及び被覆用組成物
JP2005534732A (ja) * 2002-06-14 2005-11-17 ポリメーレクスペール エス アー 熱感応性ポリマー及びそのポリマーから得られた熱可逆性ゲル
JP2006504451A (ja) * 2002-08-22 2006-02-09 フレセニウス メディカル ケア ドイチェランド ゲーエムベーハー ポリマー支持体表面にハイドロゲル形成ポリマーを固定化するための方法
JP2010500917A (ja) * 2006-06-15 2010-01-14 マイクロベンション， インコーポレイテッド 膨張性ポリマーで構成される塞栓形成デバイス
JP2013236948A (ja) * 2006-06-15 2013-11-28 Microvention Inc 膨張性ポリマーで構成される塞栓形成デバイス
JP2008106269A (ja) * 2006-09-29 2008-05-08 Nof Corp 生分解性ポリオキシアルキレン誘導体の製造方法
JP2011507637A (ja) * 2007-12-21 2011-03-10 マイクロベンション， インコーポレイテッド 生物医学的使用のためのハイドロゲルフィラメント
JP2009261931A (ja) * 2008-04-23 2009-11-12 Tyco Healthcare Group Lp 生体吸収性外科用組成物
JP2016509610A (ja) * 2012-12-17 2016-03-31 シーカー，マティアス 鎖延長されたポロキサマー、生物材料を含むそれから形成された熱可逆性ハイドロゲルおよびその医学的適用
WO2016143647A1 (ja) * 2015-03-10 2016-09-15 国立大学法人 東京大学 ゲル前駆体クラスターを用いた低濃度ゲルの製造方法、及び当該製造方法により得られるゲル
JPWO2016143647A1 (ja) * 2015-03-10 2017-12-21 国立大学法人 東京大学 ゲル前駆体クラスターを用いた低濃度ゲルの製造方法、及び当該製造方法により得られるゲル
US10550225B2 (en) 2015-03-10 2020-02-04 The University Of Tokyo Process for producing low-concentration gel using gel-precursor clusters, and gel obtained by said production process
WO2020027016A1 (ja) * 2018-07-31 2020-02-06 国立大学法人 東京大学 スポンジ様の多孔体構造を有する高分子ゲル
JPWO2020027016A1 (ja) * 2018-07-31 2021-08-10 国立大学法人 東京大学 スポンジ様の多孔体構造を有する高分子ゲル
US12227642B2 (en) 2018-07-31 2025-02-18 The University Of Tokyo Polymer gel having sponge-like porous structure

Also Published As

Publication number Publication date
ATE342295T1 (de) 2006-11-15
DE69636626D1 (de) 2006-11-23
EP0842209B1 (en) 2006-10-11
DE69636626T2 (de) 2007-08-30
US20050238722A1 (en) 2005-10-27
US6923986B2 (en) 2005-08-02
US7250177B2 (en) 2007-07-31
US6201065B1 (en) 2001-03-13
CA2228118A1 (en) 1997-02-13
US6639014B2 (en) 2003-10-28
EP0842209A2 (en) 1998-05-20
JP2006097031A (ja) 2006-04-13
WO1997005185A2 (en) 1997-02-13
MX9801706A (es) 1998-05-31
US20040072961A1 (en) 2004-04-15
US20020151650A1 (en) 2002-10-17
US6410645B1 (en) 2002-06-25
WO1997005185A3 (en) 1997-03-13

Similar Documents

Publication Publication Date Title
JPH11510837A (ja) 薬物送達のための制御された放出薬剤および組織処置薬剤としての使用のためのマルチブロック生分解性ヒドロゲル
Li et al. Towards the development of polycaprolactone based amphiphilic block copolymers: molecular design, self-assembly and biomedical applications
EP1320359B1 (en) Thermogelling biodegradable aqueous polymer solution
Ravi Kumar et al. Polymeric controlled drug-delivery systems: perspective issues and opportunities
ES2262182T3 (es) Metodos y composiciones para reducir o eliminar la formacion de adherencias postoperatorias.
CN103827177B (zh) 用于生物活性化合物的受控释放的生物可降解的、半结晶的、相分离的、热塑性多嵌段共聚物
EP1014998B1 (en) Polymeric compositions
EP0927214B1 (en) Polymerizable biodegradable polymers including carbonate or dioxanone linkages
US20040077780A1 (en) Thermogelling oligopeptide polymers
US20120164100A1 (en) Temperature sensitive hydrogel and block copolymers
AU2001294828A1 (en) Thermogelling biodegradable aqueous polymer solution
JP2014502286A (ja) ペンダント型親水性物質を有する生分解性組成物および関連デバイス
US20150099808A1 (en) Amphiphilic copolymers and compositions containing such polymers
Fomina et al. Biocompatible hydrogels based on biodegradable polyesters and their copolymers
JP4303196B2 (ja) ゼラチン誘導体および該誘導体からなる高分子ミセル
Snežana et al. Polymeric matrix systems for drug delivery
Grigoras Pullulan-based hydrogels
CA2396229C (en) Compliant polymeric materials formed from macromers

Legal Events

Date Code Title Description
A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20050405

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20050630

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A712

Effective date: 20050708

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20050815

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20051005

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20060919

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20070110

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20070110

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20070208

A912 Re-examination (zenchi) completed and case transferred to appeal board

Free format text: JAPANESE INTERMEDIATE CODE: A912

Effective date: 20070329

A761 Written withdrawal of application

Free format text: JAPANESE INTERMEDIATE CODE: A761

Effective date: 20080910