JPH11246531A5 - - Google Patents
Info
- Publication number
- JPH11246531A5 JPH11246531A5 JP1998328502A JP32850298A JPH11246531A5 JP H11246531 A5 JPH11246531 A5 JP H11246531A5 JP 1998328502 A JP1998328502 A JP 1998328502A JP 32850298 A JP32850298 A JP 32850298A JP H11246531 A5 JPH11246531 A5 JP H11246531A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- optionally substituted
- group
- aryl
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19751251:8 | 1997-11-19 | ||
| DE19751251A DE19751251A1 (de) | 1997-11-19 | 1997-11-19 | Substituierte Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmezeutische Präparate |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPH11246531A JPH11246531A (ja) | 1999-09-14 |
| JPH11246531A5 true JPH11246531A5 (enExample) | 2006-02-02 |
| JP4567821B2 JP4567821B2 (ja) | 2010-10-20 |
Family
ID=7849203
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP32850298A Expired - Fee Related JP4567821B2 (ja) | 1997-11-19 | 1998-11-18 | 置換されたイミダゾリジン誘導体、その製法および使用ならびにそれを含有する医薬製剤 |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US6331552B1 (enExample) |
| EP (1) | EP0918059B1 (enExample) |
| JP (1) | JP4567821B2 (enExample) |
| KR (1) | KR100738820B1 (enExample) |
| CN (1) | CN1330638C (enExample) |
| AR (1) | AR016011A1 (enExample) |
| AT (1) | ATE243708T1 (enExample) |
| AU (1) | AU755893B2 (enExample) |
| BR (1) | BR9804695B1 (enExample) |
| CA (1) | CA2254420C (enExample) |
| CZ (1) | CZ297564B6 (enExample) |
| DE (2) | DE19751251A1 (enExample) |
| DK (1) | DK0918059T3 (enExample) |
| ES (1) | ES2202718T3 (enExample) |
| HR (1) | HRP980602B1 (enExample) |
| HU (1) | HU229481B1 (enExample) |
| ID (1) | ID21305A (enExample) |
| IL (1) | IL127132A (enExample) |
| MY (1) | MY118313A (enExample) |
| NO (1) | NO325303B1 (enExample) |
| NZ (1) | NZ332855A (enExample) |
| PL (1) | PL194692B1 (enExample) |
| PT (1) | PT918059E (enExample) |
| RU (1) | RU2239641C2 (enExample) |
| SI (1) | SI0918059T1 (enExample) |
| SK (1) | SK284851B6 (enExample) |
| TR (1) | TR199802344A2 (enExample) |
| TW (1) | TWI230155B (enExample) |
| ZA (1) | ZA9810543B (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19821483A1 (de) | 1998-05-14 | 1999-11-18 | Hoechst Marion Roussel De Gmbh | Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| US6972296B2 (en) | 1999-05-07 | 2005-12-06 | Encysive Pharmaceuticals Inc. | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors |
| US6723711B2 (en) | 1999-05-07 | 2004-04-20 | Texas Biotechnology Corporation | Propanoic acid derivatives that inhibit the binding of integrins to their receptors |
| DE19922462A1 (de) * | 1999-05-17 | 2000-11-23 | Aventis Pharma Gmbh | Spiro-imidazolidinderivate, ihre Herstellung ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| JP2003519697A (ja) | 1999-12-28 | 2003-06-24 | ファイザー・プロダクツ・インク | 炎症性疾患、自己免疫疾患および呼吸器疾患の処置に有用な非ペプチド系のvla−4依存性細胞結合阻害薬 |
| GB0010105D0 (en) * | 2000-04-26 | 2000-06-14 | Ml Lab Plc | Cell ablation |
| DE10111877A1 (de) * | 2001-03-10 | 2002-09-12 | Aventis Pharma Gmbh | Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| DE10111876A1 (de) | 2001-03-10 | 2002-09-19 | Aventis Pharma Gmbh | Bis(trifluormethyl)hydantoine als Zwischenprodukte für pharmazeutische Wirkstoffe |
| US20030154499A1 (en) * | 2001-06-08 | 2003-08-14 | Monika Wasel-Nielen | Mouse unable to express functional alpha-4 integrin protein, and methods for assaying compounds or agents for alpha-4 integrin protein antagonist activity and a genetic marker for evaluating efficacy of modulators of signaling activity of a VLA-4 receptor |
| WO2003000662A2 (en) * | 2001-06-22 | 2003-01-03 | Aventis Pharmaceuticals Inc. | Chiral preparation of a diastereomeric compound |
| DE10134366A1 (de) * | 2001-07-14 | 2003-01-23 | Aventis Pharma Gmbh | Verfahren zur Herstellung der enantiomeren Formen von 2-substituierten 2-(2,5-Dioxoimidazolidin-l-yl)-essigsäure- Derivaten |
| DE10137595A1 (de) * | 2001-08-01 | 2003-02-13 | Aventis Pharma Gmbh | Neue Imidazolidinderivate, ihre Herstellung und ihre Verwendung |
| PT1474425E (pt) * | 2002-01-07 | 2006-09-29 | Eisai Co Ltd | Desazapurinas e sua utilizacao |
| JP4617449B2 (ja) * | 2002-07-11 | 2011-01-26 | ヴィキュロン ファーマシューティカルズ インコーポレイテッド | 抗菌活性を有するn−ヒドロキシアミド誘導体 |
| US7041693B2 (en) * | 2002-10-04 | 2006-05-09 | Bristol-Myers Squibb Company | Hydantoin derivatives as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE) |
| JP4591347B2 (ja) * | 2003-03-17 | 2010-12-01 | 宇部興産株式会社 | 3−アミノ−3−アリールプロピオン酸n−アルキルエステル及びその製造方法並びに光学活性3−アミノ−3−アリールプロピオン酸及びその対掌エステルの製造方法 |
| KR20060021870A (ko) | 2003-05-30 | 2006-03-08 | 랜박시 래보러터리스 리미티드 | 치환된 피롤 유도체와 hmg―co 억제제로서의 이의용도 |
| DE102004009822A1 (de) | 2004-02-28 | 2005-09-15 | Zf Lenksysteme Gmbh | Verfahren zum Betrieb eines Lenksystems mit Signalplausibilisierung |
| CA2627599A1 (en) | 2005-11-08 | 2007-05-18 | Ranbaxy Laboratories Limited | Process for (3r,5r)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-[(4-hydroxy methyl phenyl amino)carbonyl]-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid hemi calcium salt |
| EP2124996A4 (en) | 2007-02-20 | 2010-03-24 | Merrimack Pharmaceuticals Inc | METHOD FOR TREATING MULTIPLE SCLEROSIS BY ADMINISTERING AN ALPHA FETOPROTEIN COMBINED WITH AN INTEGRINANT AGONIST |
| MX2010011145A (es) | 2008-04-11 | 2011-04-11 | Merrimack Pharmaceuticals Inc | Enlazadores de la albumina de suero humana y conjugados de la misma. |
| WO2010022388A2 (en) * | 2008-08-22 | 2010-02-25 | Novomer, Inc. | Catalysts and methods for polymer synthesis |
| DE102009012314A1 (de) | 2009-03-09 | 2010-09-16 | Bayer Schering Pharma Aktiengesellschaft | Oxo-heterocyclisch substituierte Alkylcarbonsäuren und ihre Verwendung |
| SI3326645T1 (sl) | 2010-10-25 | 2020-09-30 | Biogen Ma Inc. | Metode za determinacijo razlik v alfa- 4 integrin aktivnosti s korelacijo razlik v SVCAM in/ali SMADCAM nivojih |
| EP3112353A1 (en) * | 2015-06-30 | 2017-01-04 | Studiengesellschaft Kohle MbH | Substituted imidazolium sulfuranes and their use |
| TW202528300A (zh) * | 2018-04-12 | 2025-07-16 | 美商莫菲克醫療股份有限公司 | 人類整合素α4β7拮抗劑 |
| AU2019387367A1 (en) | 2018-11-30 | 2021-06-10 | Nuvation Bio Inc. | Diarylhydantoin compounds and methods of use thereof |
| CN114901316B (zh) * | 2019-08-05 | 2024-02-13 | 宝利普拉斯生物转染公司 | 包含接枝到阳离子聚合物上的三唑化合物的用于将核酸分子转染到细胞中的组合物及其应用 |
| IL319053A (en) | 2019-10-16 | 2025-04-01 | Morphic Therapeutic Inc | Inhibition of human integrin a4B7 |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE235866C (enExample) | ||||
| DE3044236A1 (de) | 1980-11-25 | 1982-06-16 | Hoechst Ag, 6000 Frankfurt | Aminosaeurederivate und verfahren zu ihrer herstellung |
| DE2937779A1 (de) | 1979-09-19 | 1981-04-09 | Hoechst Ag, 6000 Frankfurt | Aminosaeurederivate und verfahren zu ihrer herstellung |
| FR2487829A2 (fr) | 1979-12-07 | 1982-02-05 | Science Union & Cie | Nouveaux imino acides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme |
| FR2503155A2 (fr) | 1980-10-02 | 1982-10-08 | Science Union & Cie | Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme |
| US4350704A (en) | 1980-10-06 | 1982-09-21 | Warner-Lambert Company | Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids |
| EP0046953B1 (de) | 1980-08-30 | 1989-12-06 | Hoechst Aktiengesellschaft | Aminosäurederivate, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und deren Verwendung |
| US4344949A (en) | 1980-10-03 | 1982-08-17 | Warner-Lambert Company | Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids |
| LU88621I2 (fr) | 1980-10-23 | 1995-09-01 | Schering Corp | Sandopril |
| US4374847A (en) | 1980-10-27 | 1983-02-22 | Ciba-Geigy Corporation | 1-Carboxyalkanoylindoline-2-carboxylic acids |
| DE3226768A1 (de) | 1981-11-05 | 1983-05-26 | Hoechst Ag, 6230 Frankfurt | Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung |
| IE55867B1 (en) | 1981-12-29 | 1991-02-14 | Hoechst Ag | New derivatives of bicyclic aminoacids,processes for their preparation,agents containing these compounds and their use,and new bicyclic aminoacids as intermediates and processes for their preparation |
| DE3210496A1 (de) | 1982-03-23 | 1983-10-06 | Hoechst Ag | Neue derivate bicyclischer aminsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue bicyclische aminosaeuren als zwischenstufen und verfahren zu deren herstellung |
| DE3211397A1 (de) | 1982-03-27 | 1983-11-10 | Hoechst Ag, 6230 Frankfurt | Spiro (4.(3+n))-2-aza-3-carbonsaeure-derivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung |
| DE3211676A1 (de) | 1982-03-30 | 1983-10-06 | Hoechst Ag | Neue derivate von cycloalka (c) pyrrol-carbonsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue cycloalka (c) pyrrol-carbonsaeuren als zwischenstufen und verfahren zu deren herstellung |
| DE3227055A1 (de) | 1982-07-20 | 1984-01-26 | Hoechst Ag, 6230 Frankfurt | Neue derivate der 2-aza-bicyclo(2.2.2)octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie 2-aza-bicyclo(2.2.2)octan-3-carbonsaeure als zwischenstufe und verfahren zu deren herstellung |
| DE3242151A1 (de) | 1982-11-13 | 1984-05-17 | Hoechst Ag, 6230 Frankfurt | Neue derivate tricyclischer aminosaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung, sowie neue bicyclische aminosaeuren als zwischenstufen und verfahren zu deren herstellung |
| DE3246503A1 (de) | 1982-12-16 | 1984-06-20 | Hoechst Ag, 6230 Frankfurt | Derivate der cis, endo-2-azabicyclo-(5.3.0)-decan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung |
| DE3643012A1 (de) | 1986-12-17 | 1988-06-30 | Hoechst Ag | 2,3-disubstituierte isoxazolidine, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung |
| DE3818850A1 (de) | 1988-06-03 | 1989-12-07 | Hoechst Ag | Oligopeptide mit zyklischen prolin-analogen aminosaeuren |
| DE4009506A1 (de) * | 1990-03-24 | 1991-09-26 | Hoechst Ag | Hydantoinderivate |
| DE4126277A1 (de) * | 1991-08-08 | 1993-02-11 | Cassella Ag | Hydantoinderivate |
| RU2032672C1 (ru) * | 1991-08-20 | 1995-04-10 | Институт физико-органической химии и углехимии им.Л.М.Литвиненко АН Украины | 1,3-бис-(2,3-диакрилоилоксипропил) -5,5-диметил-2,4-имидазолидиндион в качестве модификатора фотополимеризующихся акрилатных композиций |
| CA2127462C (en) * | 1992-01-13 | 1999-03-23 | Roy R. Lobb | Treatment for asthma |
| CA2129637C (en) * | 1992-02-12 | 1999-05-04 | Roy R. Lobb | Treatment for inflammatory bowel disease |
| DE4207254A1 (de) * | 1992-03-07 | 1993-09-09 | Cassella Ag | 4-oxo-2-thioxoimidazolidin-derivate |
| DE4213634A1 (de) * | 1992-04-24 | 1993-10-28 | Cassella Ag | 2,4-Dioxo-imidazolidin-Derivate |
| DE4224414A1 (de) * | 1992-07-24 | 1994-01-27 | Cassella Ag | Phenylimidazolidin-derivate, ihre Herstellung und ihre Verwendung |
| DE4228717A1 (de) * | 1992-08-28 | 1994-03-03 | Cassella Ag | Imidazolidin-Derivate |
| WO1994015958A2 (en) | 1993-01-08 | 1994-07-21 | Tanabe Seiyaku Co., Ltd. | Peptide inhibitors of cell adhesion |
| NZ261259A (en) | 1993-01-12 | 1996-12-20 | Biogen Inc | Humanised recombinant anti-vla4 antibody and diagnostic compositions and medicaments |
| EP0682529B2 (en) | 1993-02-09 | 2005-12-28 | Biogen Idec MA, Inc. | Antibody for the treatment of insulin dependent diabetes |
| DE4308034A1 (de) | 1993-03-13 | 1994-09-15 | Cassella Ag | Neue Heterocyclen, ihre Herstellung und ihre Verwendung |
| DE4427979A1 (de) * | 1993-11-15 | 1996-02-15 | Cassella Ag | Substituierte 5-Ring-Heterocyclen, ihre Herstellung und ihre Verwendung |
| AU693143B2 (en) | 1993-12-06 | 1998-06-25 | Cytel Corporation | CS-1 peptidomimetics, compositions and methods of using the same |
| CN1211123C (zh) | 1994-01-25 | 2005-07-20 | 雅典娜神经科学公司 | 抗白细胞粘附分子vla-4的人源化抗体 |
| JPH10502349A (ja) * | 1994-06-29 | 1998-03-03 | テキサス・バイオテクノロジー・コーポレイシヨン | インテグリンα▲下4▼β▲下1▼のVCAM−1またはフィブロネクチンへの結合を阻害する方法 |
| US5811391A (en) | 1994-08-25 | 1998-09-22 | Cytel Corporation | Cyclic CS-1 peptidomimetics, compositions and methods of using same |
| GB9524630D0 (en) | 1994-12-24 | 1996-01-31 | Zeneca Ltd | Chemical compounds |
| US6306840B1 (en) | 1995-01-23 | 2001-10-23 | Biogen, Inc. | Cell adhesion inhibitors |
| DE19515177A1 (de) | 1995-04-28 | 1996-10-31 | Cassella Ag | Hydantoinderivate als Zwischenprodukte für pharmazeutische Wirkstoffe |
| US6248713B1 (en) | 1995-07-11 | 2001-06-19 | Biogen, Inc. | Cell adhesion inhibitors |
| EP0796855B1 (de) * | 1996-03-20 | 2002-02-06 | Hoechst Aktiengesellschaft | Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten |
| SG124234A1 (en) | 1996-07-25 | 2006-08-30 | Biogen Idec Inc | Cell adhesion inhibitors |
| DE19647381A1 (de) * | 1996-11-15 | 1998-05-20 | Hoechst Ag | Neue Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten |
| DE19647380A1 (de) * | 1996-11-15 | 1998-05-20 | Hoechst Ag | 5-Ring-Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten |
| DE19647382A1 (de) * | 1996-11-15 | 1998-05-20 | Hoechst Ag | Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten |
| DE19648053C1 (de) | 1996-11-20 | 1998-03-12 | Siemens Ag | Elektromagnetisches Schaltgerät |
| WO1998042656A1 (en) | 1997-03-21 | 1998-10-01 | Cytel Corporation | Novel compounds |
-
1997
- 1997-11-19 DE DE19751251A patent/DE19751251A1/de not_active Withdrawn
-
1998
- 1998-11-13 AT AT98121670T patent/ATE243708T1/de active
- 1998-11-13 DK DK98121670T patent/DK0918059T3/da active
- 1998-11-13 PT PT98121670T patent/PT918059E/pt unknown
- 1998-11-13 SI SI9830509T patent/SI0918059T1/xx unknown
- 1998-11-13 ES ES98121670T patent/ES2202718T3/es not_active Expired - Lifetime
- 1998-11-13 DE DE59808804T patent/DE59808804D1/de not_active Expired - Lifetime
- 1998-11-13 EP EP98121670A patent/EP0918059B1/de not_active Expired - Lifetime
- 1998-11-16 ID IDP981494A patent/ID21305A/id unknown
- 1998-11-17 TR TR1998/02344A patent/TR199802344A2/xx unknown
- 1998-11-17 SK SK1580-98A patent/SK284851B6/sk not_active IP Right Cessation
- 1998-11-17 CA CA002254420A patent/CA2254420C/en not_active Expired - Fee Related
- 1998-11-17 HU HU9802653A patent/HU229481B1/hu not_active IP Right Cessation
- 1998-11-17 AR ARP980105821A patent/AR016011A1/es active IP Right Grant
- 1998-11-17 CZ CZ0372698A patent/CZ297564B6/cs not_active IP Right Cessation
- 1998-11-17 NZ NZ332855A patent/NZ332855A/en not_active IP Right Cessation
- 1998-11-18 IL IL12713298A patent/IL127132A/xx not_active IP Right Cessation
- 1998-11-18 HR HR980602A patent/HRP980602B1/xx not_active IP Right Cessation
- 1998-11-18 NO NO19985368A patent/NO325303B1/no not_active IP Right Cessation
- 1998-11-18 ZA ZA9810543A patent/ZA9810543B/xx unknown
- 1998-11-18 KR KR1019980049376A patent/KR100738820B1/ko not_active Expired - Fee Related
- 1998-11-18 RU RU98120859/04A patent/RU2239641C2/ru not_active IP Right Cessation
- 1998-11-18 MY MYPI98005253A patent/MY118313A/en unknown
- 1998-11-18 JP JP32850298A patent/JP4567821B2/ja not_active Expired - Fee Related
- 1998-11-18 BR BRPI9804695-0A patent/BR9804695B1/pt not_active IP Right Cessation
- 1998-11-18 AU AU92421/98A patent/AU755893B2/en not_active Ceased
- 1998-11-19 PL PL329790A patent/PL194692B1/pl unknown
- 1998-11-19 CN CNB981225195A patent/CN1330638C/zh not_active Expired - Fee Related
- 1998-12-04 TW TW087118969A patent/TWI230155B/zh not_active IP Right Cessation
-
2000
- 2000-03-01 US US09/516,587 patent/US6331552B1/en not_active Expired - Lifetime
-
2001
- 2001-09-14 US US09/952,028 patent/US6521654B2/en not_active Expired - Lifetime
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