CN1330638C - 取代的咪唑烷衍生物,其制备、用途以及含有它们的药物制剂 - Google Patents

取代的咪唑烷衍生物,其制备、用途以及含有它们的药物制剂 Download PDF

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CN1330638C
CN1330638C CNB981225195A CN98122519A CN1330638C CN 1330638 C CN1330638 C CN 1330638C CN B981225195 A CNB981225195 A CN B981225195A CN 98122519 A CN98122519 A CN 98122519A CN 1330638 C CN1330638 C CN 1330638C
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alkyl
group
aryl
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CN1225360A (zh
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V·威纳
H·U·斯蒂尔兹
W·施米特
D·塞夫杰
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Sanofi Aventis Deutschland GmbH
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Aventis Pharma Deutschland GmbH
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    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
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    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/74—Two oxygen atoms, e.g. hydantoin with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to other ring members
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Neurosurgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
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  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
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CNB981225195A 1997-11-19 1998-11-19 取代的咪唑烷衍生物,其制备、用途以及含有它们的药物制剂 Expired - Fee Related CN1330638C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19751251A DE19751251A1 (de) 1997-11-19 1997-11-19 Substituierte Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmezeutische Präparate
DE19751251.8 1997-11-19

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CN1225360A CN1225360A (zh) 1999-08-11
CN1330638C true CN1330638C (zh) 2007-08-08

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US (2) US6331552B1 (enExample)
EP (1) EP0918059B1 (enExample)
JP (1) JP4567821B2 (enExample)
KR (1) KR100738820B1 (enExample)
CN (1) CN1330638C (enExample)
AR (1) AR016011A1 (enExample)
AT (1) ATE243708T1 (enExample)
AU (1) AU755893B2 (enExample)
BR (1) BR9804695B1 (enExample)
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CZ (1) CZ297564B6 (enExample)
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ES (1) ES2202718T3 (enExample)
HR (1) HRP980602B1 (enExample)
HU (1) HU229481B1 (enExample)
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NZ (1) NZ332855A (enExample)
PL (1) PL194692B1 (enExample)
PT (1) PT918059E (enExample)
RU (1) RU2239641C2 (enExample)
SI (1) SI0918059T1 (enExample)
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TR (1) TR199802344A2 (enExample)
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MX2010011145A (es) 2008-04-11 2011-04-11 Merrimack Pharmaceuticals Inc Enlazadores de la albumina de suero humana y conjugados de la misma.
WO2010022388A2 (en) * 2008-08-22 2010-02-25 Novomer, Inc. Catalysts and methods for polymer synthesis
DE102009012314A1 (de) 2009-03-09 2010-09-16 Bayer Schering Pharma Aktiengesellschaft Oxo-heterocyclisch substituierte Alkylcarbonsäuren und ihre Verwendung
SI3326645T1 (sl) 2010-10-25 2020-09-30 Biogen Ma Inc. Metode za determinacijo razlik v alfa- 4 integrin aktivnosti s korelacijo razlik v SVCAM in/ali SMADCAM nivojih
EP3112353A1 (en) * 2015-06-30 2017-01-04 Studiengesellschaft Kohle MbH Substituted imidazolium sulfuranes and their use
TW202528300A (zh) * 2018-04-12 2025-07-16 美商莫菲克醫療股份有限公司 人類整合素α4β7拮抗劑
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