JPH11130798A5 - - Google Patents

Info

Publication number
JPH11130798A5
JPH11130798A5 JP1998230368A JP23036898A JPH11130798A5 JP H11130798 A5 JPH11130798 A5 JP H11130798A5 JP 1998230368 A JP1998230368 A JP 1998230368A JP 23036898 A JP23036898 A JP 23036898A JP H11130798 A5 JPH11130798 A5 JP H11130798A5
Authority
JP
Japan
Prior art keywords
amino acid
insulin
cysteine
arg
arginine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1998230368A
Other languages
English (en)
Japanese (ja)
Other versions
JPH11130798A (ja
JP4291900B2 (ja
Filing date
Publication date
Priority claimed from DE19735711A external-priority patent/DE19735711C2/de
Application filed filed Critical
Publication of JPH11130798A publication Critical patent/JPH11130798A/ja
Publication of JPH11130798A5 publication Critical patent/JPH11130798A5/ja
Application granted granted Critical
Publication of JP4291900B2 publication Critical patent/JP4291900B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP23036898A 1997-08-18 1998-08-17 正しく結合したシスチン橋を有するインスリン前駆体を取得するための改良された方法 Expired - Lifetime JP4291900B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19735711A DE19735711C2 (de) 1997-08-18 1997-08-18 Verfahren zur Herstellung eines Vorläufers von Insulin oder Insulinderivaten mit korrekt verbundenen Cystinbrücken
DE19735711:3 1997-08-18

Publications (3)

Publication Number Publication Date
JPH11130798A JPH11130798A (ja) 1999-05-18
JPH11130798A5 true JPH11130798A5 (enExample) 2005-11-04
JP4291900B2 JP4291900B2 (ja) 2009-07-08

Family

ID=7839275

Family Applications (1)

Application Number Title Priority Date Filing Date
JP23036898A Expired - Lifetime JP4291900B2 (ja) 1997-08-18 1998-08-17 正しく結合したシスチン橋を有するインスリン前駆体を取得するための改良された方法

Country Status (20)

Country Link
US (3) US5986048A (enExample)
EP (2) EP0980874B1 (enExample)
JP (1) JP4291900B2 (enExample)
KR (2) KR100537842B1 (enExample)
CN (3) CN101186940B (enExample)
AR (1) AR016821A1 (enExample)
AT (2) ATE217636T1 (enExample)
AU (1) AU744824B2 (enExample)
BR (2) BR9803755A (enExample)
CA (1) CA2245151C (enExample)
CZ (1) CZ295679B6 (enExample)
DE (3) DE19735711C2 (enExample)
DK (2) DK0980874T3 (enExample)
ES (2) ES2176870T3 (enExample)
HU (2) HU228161B1 (enExample)
ID (1) ID20717A (enExample)
PL (1) PL191901B1 (enExample)
PT (2) PT980874E (enExample)
RU (2) RU2205836C2 (enExample)
TR (1) TR199801587A3 (enExample)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19735711C2 (de) 1997-08-18 2001-04-26 Aventis Pharma Gmbh Verfahren zur Herstellung eines Vorläufers von Insulin oder Insulinderivaten mit korrekt verbundenen Cystinbrücken
DE19930676B4 (de) 1999-07-02 2006-01-19 Sanofi-Aventis Deutschland Gmbh Verfahren zur Stabilisierung von Insulin, Insulinderivaten und/oder deren Vorläufer in komplexen Mischungen bei deren Lagerung in wäßrigen Lösungsmitteln
JP2003530316A (ja) 1999-12-22 2003-10-14 ノボ ノルディスク アクティーゼルスカブ スクランブルした一本鎖ポリペプチドの抽出的再生法
AU2001280436A1 (en) * 2000-07-12 2002-01-21 Eli Lilly And Company Process to increase protein stability
DE10235168A1 (de) * 2002-08-01 2004-02-12 Aventis Pharma Deutschland Gmbh Verfahren zur Reinigung von Preproinsulin
DE102004015965A1 (de) * 2004-04-01 2005-10-20 Aventis Pharma Gmbh Verfahren zur Gewinnung von Insulinen durch verbesserte Luftbegasung der Faltung
JP5036727B2 (ja) 2005-12-22 2012-09-26 ジェネンテック， インコーポレイテッド ヘパリン結合タンパク質の組み換え体産生
CN101506222B (zh) * 2006-07-14 2013-10-02 健泰科生物技术公司 重组蛋白的重折叠
CA2692585A1 (en) * 2007-07-03 2010-01-04 Amgen Inc. Measurement of protein using inclusion body dry weight
RU2451750C2 (ru) * 2007-09-24 2012-05-27 Общество С Ограниченной Ответственностью "Герофарм" Способ получения рекомбинантного с-пептида проинсулина человека
BRPI0907371A2 (pt) 2008-01-09 2015-11-24 Sanofi Aventis Deutschland derivados de insulina com um perfil de tempo-ação muito retardado
US9296806B2 (en) * 2008-04-30 2016-03-29 Wockhardt Limited Processes for refolding of insulin
RS59913B1 (sr) 2008-10-17 2020-03-31 Sanofi Aventis Deutschland Kombinacija insulina i glp-1-agonista
CA2780043C (en) 2009-11-13 2019-01-29 Sanofi-Aventis Deutschland Gmbh Pharmaceutical composition comprising a glp-1 agonist and methionine
ES2534191T3 (es) 2009-11-13 2015-04-20 Sanofi-Aventis Deutschland Gmbh Composición farmacéutica que comprende un agonista de GLP-1, una insulina y metionina
SG187904A1 (en) 2010-08-30 2013-04-30 Sanofi Aventis Deutschland Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
AR087744A1 (es) 2011-09-01 2014-04-16 Sanofi Aventis Deutschland Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa
US12157766B2 (en) * 2012-08-05 2024-12-03 Absci Corporation Cytoplasmic expression system
US10421795B2 (en) 2012-12-17 2019-09-24 Merck Sharp & Dohme Corp. Process for purifying insulin and analogues thereof
WO2014133324A1 (ko) * 2013-02-26 2014-09-04 한미약품 주식회사 신규한 인슐린 아날로그 및 이의 용도
CN103694339B (zh) * 2013-12-04 2017-10-13 珠海联邦制药股份有限公司 一种甘精胰岛素前体的复性方法
US10407483B2 (en) 2014-03-14 2019-09-10 Merck Sharp & Dohme Corp. Purifying insulin using cation exchange and reverse phase chromatography in the presence of an organic modifier and elevated temperature
SI3229828T1 (sl) 2014-12-12 2023-06-30 Sanofi-Aventis Deutschland Gmbh Formulacija s fiksnim razmerjem inzulin glargin/liksisenatid
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
CN104911203A (zh) * 2015-06-30 2015-09-16 成都易胜科生物科技有限公司 一种重组人胰岛素的工业制备方法
EP3344651B1 (en) 2015-09-02 2022-03-02 Merck Sharp & Dohme Corp. A process for obtaining insulin with correctly formed disulfide bonds
US10689430B2 (en) 2016-05-25 2020-06-23 Merck Sharp & Dohme Corp. Insulin receptor partial agonists
WO2018018613A1 (zh) 2016-07-29 2018-02-01 广东东阳光药业有限公司 一种提高抗体纯度的细胞培养基和培养方法
CN113773400B (zh) * 2020-06-09 2023-08-18 宁波鲲鹏生物科技有限公司 一种门冬胰岛素衍生物及其应用
CN113773391B (zh) * 2020-06-09 2023-10-20 宁波鲲鹏生物科技有限公司 一种门冬胰岛素的制备方法
CN113773396A (zh) * 2020-06-10 2021-12-10 宁波鲲鹏生物科技有限公司 一种地特胰岛素衍生物及其应用
JP7749397B2 (ja) * 2021-09-30 2025-10-06 キヤノン株式会社 超音波ファントム及び超音波ファントムの製造方法

Family Cites Families (9)

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Publication number Priority date Publication date Assignee Title
NZ199391A (en) * 1981-01-02 1985-12-13 Genentech Inc Chimeric polypeptides comprising a proinsulin sequence,and preparation by recombinant dna technique;production of human insulin
DE3501641A1 (de) * 1985-01-19 1986-07-24 Hoechst Ag, 6230 Frankfurt Verfahren zur gewinnung von insulin-vorlaeufern aus reaktionsgemischen, die bei der faltung von insulin-vorlaeufern aus den entsprechenden s-sulfonaten anfallen
GR1005153B (el) * 1989-08-29 2006-03-13 The General Hospital Corporation Πρωτεινες συντηξεως, παρασκευη τους και χρηση τους.
RU2045535C1 (ru) * 1991-06-18 1995-10-10 Институт биоорганической химии им.М.М.Шемякина и Ю.А.Овчинникова РАН Способ получения проинсулина человека
ES2097426T3 (es) * 1992-12-02 1997-04-01 Hoechst Ag Procedimiento para la obtencion de proinsulina con puentes de cistina correctamente unidos.
DE4405179A1 (de) * 1994-02-18 1995-08-24 Hoechst Ag Verfahren zur Gewinnung von Insulin mit korrekt verbundenen Cystinbrücken
RU2081122C1 (ru) * 1994-06-16 1997-06-10 Институт биоорганической химии им.М.М.Шемякина и Ю.А.Овчинникова РАН Способ выделения и очистки инсулина или его биотехнологических предшественников
PT871474E (pt) * 1994-12-29 2007-02-28 Ferring Int Ct Sa Produção de insulina humana
DE19735711C2 (de) 1997-08-18 2001-04-26 Aventis Pharma Gmbh Verfahren zur Herstellung eines Vorläufers von Insulin oder Insulinderivaten mit korrekt verbundenen Cystinbrücken

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