JPH09504784A - 固型腫瘍、乳頭腫および疣贅の遺伝子治療 - Google Patents
固型腫瘍、乳頭腫および疣贅の遺伝子治療Info
- Publication number
- JPH09504784A JPH09504784A JP7507792A JP50779295A JPH09504784A JP H09504784 A JPH09504784 A JP H09504784A JP 7507792 A JP7507792 A JP 7507792A JP 50779295 A JP50779295 A JP 50779295A JP H09504784 A JPH09504784 A JP H09504784A
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Abstract
Description
Claims (1)
- 【特許請求の範囲】 1. 動物またはヒトにおける固型腫瘍、乳頭腫、または疣贅を措置するための 方法において: 該腫瘍、乳頭腫、または疣贅にアデノウィルス性ベクターを導入し、該ベ クターが機能的な表現のために、適切な距離で結合されている、5′mRNAリ ーダー配列、開始部位、酵素的にプロドラッグを毒性化合物に転換することがで きる蛋白質をコード表現する表現されるべき自殺遺伝子を含む核酸と、3′非翻 訳領域と、そしてポリアデニル化信号によって構成されているステップおよび該 プロドラッグを該動物またはヒトに投与するステップによって構成され、該プロ ドラッグがインビボで該毒性化合物に転換されることを特徴とする方法。 2. 該プロモータがラウスサルコーマウィルス−ロングターミナルリピート、 サイトメガロウィルス性プロモーター、マウス白血病−ロングターミナルリピー ト、類人猿ウィルス40初期および後期ブロモーター、およびヘルペス単一体ウィ ルス−チミジンキナーゼプロモーターで構成されるグループから選択されること を特徴とする請求項1の方法。 3. 上記遺伝子配列が、ヘルペス単一体ウィルスのチミジンキナーゼ、バリセ ラズスターウィルスのチミジンキナーゼ、およびバクテリア性サイトシンデアミ ナーゼで構成される蛋白質に関するコードを表現することを特徴を する請求項1の方法。 4. 該プロドラッグがガンシクロビル、アシクロビル、1−5−ヨードウラシ ル FIAU、5−フルオロサイトシン、6−メトキシプリンアラビノシド、お よびそれらの誘導物で構成されるグループから選択されることを特徴とする請求 項1の方法。 5. 固型腫瘍が、結腸、前立腺、乳房、肺、皮膚、骨、膵臓、子宮、睾丸、膀 胱、腎臓、脳、頭部、および頚部部癌によって構成されるグループから選択され ることを特徴とする請求項1の方法。 6. 乳頭腫が、鱗状細胞乳頭腫、コロイド叢乳頭腫および喉頭乳頭腫で構成さ れるグループから選択されることを特徴とする請求項1の方法。 7. 該疣贅が、生殖器疣贅、疣贅状表皮異形成および悪性疣贅で構成されるグ ループから選択されることを特徴とする請求項1の方法。 8. 該ガンシクロビルが約1mg/日/kg〜約20mg/日/kg体重の投与量で投与され ることを特徴とする請求項5の方法。 9. 該アシクロビルが、約1mg/日/kg〜約100mg/日/kg体重の投与量で投与され ることを特徴とする請求項5の方法。 10. 該FIAUが、約1mg/日/kg〜約50mg/日/kg体重の投与量で投与されてい ることを特徴とする請求項5の方法。 11. 表現されるべき上記自殺遺伝子配列がヘルペス単一体 ウィルスのチミジンキナーゼであり、プロドラッグがガンシクロビル、アシクロ ビル、FIAUまたはその誘導体であることを特徴とする請求項1の方法。 12. 表現されるべき上記自殺遺伝子配列がバクテリア性サイトシンデアミナー ゼである、上記プロドラッグが5−フルオロサイトシンまたはその誘導体である ことを特徴とする請求項1の方法。 13. 表現されるべき上記自殺遺伝子配列がバリセラゾスターウィルスチミジン キナーゼであり、プロドラッグが6−メトキシプリンアラビノシド、またはその 誘導体であることを特徴とする請求項1の方法。 14. 該腫瘍が肝臓癌であり、該プロモーターがアルブミンプロモーター、アル ファフェトプロテインブロモーター、α−アンチトリプシンプロモーター、およ びホスホエノルピルベートカルボキシナーゼプロモーターで構成されるグループ から選択されることを特徴とする請求項1の方法。 15. 該腫瘍が結腸癌であり、該プロモーターがカルボニックアンヒドラーゼI プロモーター、または悪性腫発生抗原プロモーターであることを特徴とする請求 項1の方法。 16. 該腫瘍が子宮癌であり、該プロモーターがエストロゲンプロモーター、ア ロマターゼサイトクロームP450プロモーター、コレステロール側鎖切断P450、 および17アルファ−ヒドロキシラーゼP450プロモーターで構成 されるグループから選択されることを特徴とする請求項1の方法。 17. 該腫瘍が前立腺癌であり、該プロモーターが前立腺特異抗原プロモーター 、gp91−ホックス遺伝子プロモーター、および前立腺固有カリクレインプロモー ターで構成されるグループから選択されることを特徴とする請求項1の方法。 18. 該腫瘍が乳癌であり、上記プロモーターがerb−B2プロモーター、erb−B3 プロモーター、β−カゼインプロモーター、WAB(ウェイ酸性蛋白質)プロ モーター、およびβ−ラクト−グロブリンプロモーターで構成されるグループか ら選択されることを特徴とする請求項1の方法。 19. 該腫瘍が肺癌であり、上記プロモーターが、界面活性剤プロモーター、悪 性腫瘍発生抗原プロモーター、およびウログロビンプロモーターによって構成さ れるグループから選択されることを特徴とする請求項1の方法。 20. 該腫瘍は皮膚癌であり、上記プロモーターがヒトケラチン1プロモーター 、ヒトケラチン6プロモーター、およびロイクリンプロモーターで構成されるグ ループから選択されることを特徴とする請求項1の方法。 21. 該腫瘍が脳癌であり、上記プロモーターがグリアル(glial)繊維酸性蛋白 質プロモーター、成熟した星状細胞特異蛋白質ミエリンプロモーター、およびチ ロシン ヒドロキシダーゼプロモーターで構成されるグループから選択されることを特徴 とする請求項1の方法。 22. 該腫瘍が膵臓癌であり、上記プロモーターがビリンプロモーター、グルカ ゴンプロモーター、島アミロイドポリペプチド(アミリン)プロモーター、およ びインシュリンプロモーターで構成されるグループから選択されることを特徴と する請求項1の方法。 23. 該腫瘍が甲状腺癌であり、上記プロモーターがチログロブリンプロモータ ーおよびカルシトニンプロモーターで構成されるグループから選択されることを 特徴とする請求項1の方法。 24. 該腫瘍が骨癌であり、上記プロモーターがアルファ1(I)コラーゲンプ ロモーター、オステオカルシンプロモーター、およびシアログリコプロテインプ ロモーターで構成されるグルーブから選択されることを特徴とする請求項1の方 法。 25. 該腫瘍が腎臓癌である、上記プロモーターがレニンプロモーター、肝臓/ 骨/腎臓アルカリ性ホスホターゼプロモーター、およびエリスロポイエチン(エ ポ)プロモーターで構成されるグループから選択されることを特徴とする請求項 1の方法。 26. 動物またはヒトの固型腫瘍、乳頭腫、および疣贅を措置する方法において 、DNA伝達システムによって個体に、自殺遺伝子と1つまたは複数の細胞毒性 遺伝子を投 与し、該DNA伝達システムがウィルス性ベクター、エピゾーム性ベタター、リ ポゾーム、陽イオン性脂質およびDNAまたはRNAなど細胞表面または抗原を 識別し、それに結合する分子構成、DNA結合分子構成、およびそれら細胞表面 から細胞質へのそれら複合体を輸送することができる溶解性分子構成で構成され る非ウィルス性伝達システムで構成されるグループから選択されることを特徴と するステップおよび該動物またはヒトに対してプロドラッグを投与するステップ とで構成され、該プロドラッグがインビボで該自殺遺伝子によって毒性化合物に 転化されることを特徴とする方法。 27. 自殺遺伝子配列がヘルペス単一体ウィルスのチミジンキナーゼ、バリセラ ゾスターのチミジンキナーゼ、およびバクテリア性シトシンデアミナーゼで構成 されるグループから選択されることを特徴とする請求項26の方法。 28. 該1つ、または複数のサイトカイン遺伝子配列がインターロイキン−1、 インターロイキン−2、インターロイキン−4、インターロイキン−6、インタ ーロイキン−7、インターロイキン−10、インターロイキン−12、インターフェ ロン−α、インターフェロン−β、インターフェロン−δ、腫瘍壊死因子−α、 腫瘍壊死因子−β、顆粒マクロファージコロニー刺激因子(GM−CSF)およ び顆粒細胞コロニー刺激因子(G−CSF)で構成されるグループから選択され ることを特徴とする請求項 26の方法。 29. 該プロドラッグがガンチクロビル、アシクロビル、1−5−ヨードウラシ ルFIAU、5−フルオロシトシン、6−メトキプリンアラビノシドおよびその 誘導体で構成されるグループから選択されることを特徴とする請求項26の方法。 30. 該腫瘍が結腸、前立腺、乳房、肺、皮膚、肝臓、骨、膵臓、子宮、睾丸、 膀胱、腎臓、頭部、または頚部癌で構成されるグループから選択されることを特 徴とする請求項26の方法。 31. 乳頭腫が鱗状細胞乳頭腫、脈絡膜叢乳頭腫、および喉頭乳頭腫で構成され るグループから選択されることを特徴とする請求項26の方法。 32. 該疣贅が生殖器疣贅、足裏疣贅、疣贅状表皮異形成および悪性疣贅で構成 されるグループから選択されることを特徴とする請求項26の方法。 33. 該ガンシクロビルが約1mg/日/kg〜約20mg/日/kg体重の範囲の投与量で投 与されることを特徴とする請求項29の方法。 34. 該アシクロビルが約1mg/日/kg〜約100mg/日/kg体重の範囲の投与量で投与 されることを特徴とする請求29の方法。 35. 該FIAUが約1mg/日/kg〜約50mg/日/kg体重の範囲の投与量で投与され ることを特徴とする請求項29の方法。 36. 上記表現されるべき自殺遺伝子配列がヘルペス単一体ウィルスのチミジン キナーゼであり、上記プロドラッグがガンシクロビル、アシクロビル、FIAU 、またはその誘導体であることを特徴とする請求項26の方法。 37. 上記表現されるべき自殺遺伝子がバクテリア性サイトシンデアミナーゼで あり、上記プロドラッグが5−フルオロシトシンまたはその誘導体であることを 特徴とする、請求項26の方法。 38. 上記表現されるべき自殺遺伝子配列がバリセラゾスターウィルスチミジン キナーゼであり、上記プロドラッグが6−メトキシプリンアラビノシドまたはそ の誘導体であることを特徴とする請求項26の方法。 39. 動物またはヒトの固型腫瘍、乳頭腫、または疣贅を措置する方法において 、第1のアデノウィルス性ベクターと、機能的表現のために適当な距離で順次結 合されたプロモーター、5′mRNAリーダー配列、開始部位、表現されるべき 自殺遺伝子で、プロドラッグを毒性化合物に転化させることができる蛋白質をコ ード表現する自殺遺伝子を含んでいる核酸カセット、3′非翻訳領域およびポリ アデニル化信号で構成される追加的アデノウィルス性ベクターを直接該腫瘍、乳 頭腫、または疣贅に導入するステップで、さらに該追加アデノウィルス性ベクタ ーが機能的な表現のために適切な距離で結合されたプロモーター、5′mRNA リーダー配列、開始部位、表現され るべきサイトカイン遺伝子を含んだ核酸、3′非翻訳領域、およびポリアデニル 化信号で構成されているステップとおよび該動物またはヒトにプロドラッグを投 与するステップとで構成され、該プロドラッグがインビボで該自殺遺伝子によっ て毒性物質に転化されることを特徴とする方法。 40. 該プロモーターがラウスサルコーマウィルス−ロングターミナルリピート 、サイトメガロウィルス性プロモーター、マウス白血病ウィルス−長末端反復、 霊長類ウイルス40初期および後期プロモーター、およびヘルペス単一体ウィルス −チミジンキナーゼプロモーターで構成されるグループから選択されることを特 徴とする、請求項39の方法。 41. 上記自殺遺伝子配列が、ヘルペス単一体ウィルスのチミジンキナーゼ、バ リセラゾスターウィルス、およびバクテリア性サイトシンデアミナーゼで構成さ れるグループから選択されることを特徴とする請求項39の方法。 42. 上記アデノウィルス性ベクターがインターロイキン−1、インターロイキ ン−2、インターロイキン−4、インターロイキン−6、インターロイキン−7 、インターロイキン−10、インターロイキン−12、インターフェロン−α、イン ターフェロン−β、インターフェロン−δ、腫瘍壊死因子−α、腫瘍壊死因子− β、顆粒細胞−マクロファージコロニー刺激因子(GM−CSF)および顆 粒細胞コロニー刺激因子(G−CSF)で構成されるグループから選択される蛋 白質をコード表現する1つ、または複数のサイトカイン遺伝子配列を含んでいる ことを特徴とする請求項39の方法。 43. 該プロドラッグがガンシクロビル、アシクロビル、1−5−ヨードウラシ ルFIAU、 5−フルオロシトシン、6−メトキシプリンアラビノシド、およ びそれらの誘導体で構成されるグループから選択されることを特徴とする請求項 39の方法。 44. 該腫瘍が結腸、前立腺、乳房、肺、皮膚、肝臓、骨、膵臓、子宮、睾丸、 膀胱、腎臓、頭部、または頚部癌で構成されるグループから選択されることを特 徴とする請求項39の方法。 45. 乳頭腫が鱗状細胞乳頭腫、脈絡膜叢乳頭腫、および喉頭乳頭腫で構成され るグループから選択されることを特徴とする請求項39の方法。 46. 該疣贅が生殖器疣贅、足裏疣贅、疣贅状表皮異形成および悪性疣贅で構成 されるグループから選択されることを特徴とする請求項39の方法。 47. 該ガンシクロビルが約1mg/日/kg〜約20mg/日/kg体重の範囲の投与量で投 与されることを特徴とする請求項43の方法。 48. 該アシクロビルが約1mg/日/kg〜約100mg/日/kg体重の範囲の投与量で投与 されることを特徴とする請求項43 の方法。 49. 該FTIUが約1mg/日/kg〜約50mg/日/kg体重の範囲の投与量で投与され ることを特徴とする請求項43の方法。 50. 上記表現されるべき自殺遺伝子配列がヘルペス単一体ウィルスのチミジン キナーゼであり、上記プロドラッグがガンシクロビル、アシクロビル、FIAU 、またはその誘導体であることを特徴とする請求項39の方法。 51. 上記表現されるべき自殺遺伝子がバクテリア性サイトシンデアミナーゼで あり、上記プロドラッグが5−フルオロシトシンまたはその誘導体であることを 特徴とする請求項39の方法。 52. 上記表現されるべき自殺遺伝子配列がバリセラゾスターウィルスチミジン キナーセであり、上記プロドラッグが6−メトキシプリンアラビノシドまたはそ の誘導体であることを特徴とする請求項39の方法。 53. 該腫瘍が肝臓癌であり、該プロモーターがアルブミンプロモーター、アル ファフェトプロテインプロモーター、α−アンチトリプシンプロモーターおよび ホスホエノルピルベートカルボキシナーゼプロモーターで構成されるグループか ら選択されることを特徴とする請求項39の方法。 54. 該腫瘍が結腸癌であり、該プロモーターがカルボニックアンヒドラーゼI プロモーター、または悪性腫発生抗原プロモーターであることを特徴とする請求 項39の方法。 55. 該腫瘍が子宮癌であり、該プロモーターがエストロゲンプロモーター、ア ロマターゼサイトクロームP450プロモーター、コレステロール側鎖切断P450、 および17アルファ−ヒドロキシラーゼP450プロモーターで構成されるグループ から選択されることを特徴とする請求項39の方法。 56. 該腫瘍が前立腺癌であり、該プロモーターが前立腺特異抗原プロモーター 、gp91−ホックス遺伝子プロモーター、および前立腺固有カリクレインプロモー ターで構成されるグループから選択されることを特徴とする請求項39の方法。 57. 該腫瘍が乳癌であり、上記プロモーターがerb−B2プロモーター、erb−B3 プロモーター、β−カゼインプロモーター、WAB(ウェイ酸性蛋白質)プロ モーター、およびβ−ラクトーグロブリンプロモーターで構成されるグループか ら選択されることを特徴とする請求項39の方法。 58. 該腫瘍が肺癌であり、上記プロモーターが、界面活性剤プロモーター、悪 性腫瘍発生抗原プロモーター、およびウログロビンプロモーターによって構成さ れるグループから選択されることを特徴とする請求項39の方法。 59. 該腫瘍は皮膚癌であり、上記プロモーターがヒトケラチン1プロモーター 、ヒトケラチン6プロモーター、およびロイクリンプロモーターで構成されるグ ループから 選択されることを特徴とする請求項39の方法。 60. 該腫瘍が脳癌であり、上記プロモーターがグリカル(glial)繊維酸性蛋白 質プロモーター、成熟した星状細胞特異蛋白質ミエリンプロモーター、およびチ ロシンヒドロキシダーゼプロモーターで構成されるグループから選択されること を特徴とする請求項39の方法。 61. 該腫瘍が膵臓癌であり、上記プロモーターがビリンプロモーター、グルカ ゴンプロモーター、島アミロイドポリペプチド(アミリン)プロモーター、およ びインシュリンプロモーターで構成されるグループから選択されることを特徴と する請求項39の方法。 62. 該腫瘍が甲状腺癌であり、上記プロモーターがチログロブリンプロモータ ーおよびカルシトニンプロモーターで構成されるグループから選択されることを 特徴とする請求項39の方法。 63. 該腫瘍が骨癌であり、上記プロモーターがアルファ1(I)コラーゲンプ ロモーター、オステオカルシンプロモーター、およびシアログリコプロテインプ ロモーターで構成されるグループから選択されることを特徴とする請求項39の方 法。 64. 該腫瘍が腎臓癌である、上記プロモーターがレニンプロモーター、肝臓/ 骨/腎臓アルカリ性ホスホターゼプロモーター、およびエリスロポイエチン(エ ポ)プロモーターで構成されるグループから選択されることを特徴 とする請求項39の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US08/112,745 US5631236A (en) | 1993-08-26 | 1993-08-26 | Gene therapy for solid tumors, using a DNA sequence encoding HSV-Tk or VZV-Tk |
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PCT/US1994/009784 WO1995005835A1 (en) | 1993-08-26 | 1994-08-25 | Gene therapy for solid tumors, papillomas and warts |
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JP (2) | JP4213201B2 (ja) |
AT (2) | ATE279525T1 (ja) |
AU (1) | AU677430B2 (ja) |
CA (1) | CA2169260C (ja) |
DE (2) | DE69434960T2 (ja) |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008519596A (ja) * | 2004-11-14 | 2008-06-12 | ヴァスキュラー バイオジェニックス リミテッド | 内皮細胞特異性を示すプロモーター及びそのプロモーターを使って血管形成を制御する方法 |
JP2011173903A (ja) * | 2002-10-08 | 2011-09-08 | Immunomedics Inc | 抗体療法 |
US8846401B2 (en) | 2000-11-17 | 2014-09-30 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same |
Families Citing this family (240)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6569679B1 (en) * | 1988-03-21 | 2003-05-27 | Chiron Corporation | Producer cell that generates adenoviral vectors encoding a cytokine and a conditionally lethal gene |
US6241982B1 (en) * | 1988-03-21 | 2001-06-05 | Chiron Corporation | Method for treating brain cancer with a conditionally lethal gene |
US6605712B1 (en) * | 1990-12-20 | 2003-08-12 | Arch Development Corporation | Gene transcription and ionizing radiation: methods and compositions |
US5631236A (en) | 1993-08-26 | 1997-05-20 | Baylor College Of Medicine | Gene therapy for solid tumors, using a DNA sequence encoding HSV-Tk or VZV-Tk |
JPH09503920A (ja) * | 1993-11-18 | 1997-04-22 | チロン ビアジーン,インコーポレイティド | 条件致死遺伝子を利用する組成物及び方法 |
FR2712602B1 (fr) * | 1993-11-18 | 1996-02-09 | Centre Nat Rech Scient | Virus recombinants, préparation et utilisation en thérapie génique. |
US5670347A (en) | 1994-05-11 | 1997-09-23 | Amba Biosciences Llc | Peptide-mediated gene transfer |
EP0707071B1 (en) | 1994-08-16 | 2003-07-30 | Crucell Holland B.V. | Recombinant vectors derived from adenovirus for use in gene therapy |
US5688773A (en) * | 1994-08-17 | 1997-11-18 | The General Hospital Corporation | Method of selectively destroying neoplastic cells |
US6638762B1 (en) * | 1994-11-28 | 2003-10-28 | Genetic Therapy, Inc. | Tissue-vectors specific replication and gene expression |
US5998205A (en) | 1994-11-28 | 1999-12-07 | Genetic Therapy, Inc. | Vectors for tissue-specific replication |
WO1996026743A1 (en) * | 1995-03-01 | 1996-09-06 | Human Gene Therapy Research Institute | Radiation enhanced gene therapy for treatment of tumors |
EP1304112B1 (en) * | 1995-03-28 | 2006-06-14 | Thomas Jefferson University | Implant comprising immunologically Isolated stromal cells and its use |
US6974571B2 (en) | 1995-03-28 | 2005-12-13 | Thomas Jefferson University | Isolated stromal cells and methods of using the same |
WO1996035455A1 (en) * | 1995-05-11 | 1996-11-14 | Genetic Therapy, Inc. | Gene therapy through transduction of oral epithelial cells |
US6190657B1 (en) | 1995-06-07 | 2001-02-20 | Yale University | Vectors for the diagnosis and treatment of solid tumors including melanoma |
US20020068049A1 (en) * | 1998-09-10 | 2002-06-06 | Henderson Daniel R. | Tissue specific adenoviral vectors |
US20040014709A1 (en) * | 1996-01-08 | 2004-01-22 | Canji, Inc. | Methods and compositions for interferon therapy |
US5789244A (en) * | 1996-01-08 | 1998-08-04 | Canji, Inc. | Compositions and methods for the treatment of cancer using recombinant viral vector delivery systems |
US7002027B1 (en) * | 1996-01-08 | 2006-02-21 | Canji, Inc. | Compositions and methods for therapeutic use |
US6392069B2 (en) | 1996-01-08 | 2002-05-21 | Canji, Inc. | Compositions for enhancing delivery of nucleic acids to cells |
US5998384A (en) * | 1996-01-26 | 1999-12-07 | Hisamitsu Pharmaceutical Co., Inc. | Endoscopic administration of an HSV-tk gene to treat digestive organ cancer |
DE19605279A1 (de) * | 1996-02-13 | 1997-08-14 | Hoechst Ag | Zielzellspezifische Vektoren für die Einschleusung von Genen in Zellen, Arzneimittel enthaltend derartige Vektoren und deren Verwendung |
US5948681A (en) * | 1996-08-14 | 1999-09-07 | Children's Hospital Of Philadelphia | Non-viral vehicles for use in gene transfer |
US6610839B1 (en) * | 1997-08-14 | 2003-08-26 | Geron Corporation | Promoter for telomerase reverse transcriptase |
US6777203B1 (en) | 1997-11-19 | 2004-08-17 | Geron Corporation | Telomerase promoter driving expression of therapeutic gene sequences |
JP2001502540A (ja) * | 1996-10-18 | 2001-02-27 | カンジ,インコーポレイテッド | インターフェロン―α核酸の送達および発現のための方法および組成物 |
EP0931156A2 (en) * | 1996-10-18 | 1999-07-28 | Valentis Inc. | Gene expression and delivery systems and uses |
US6544523B1 (en) | 1996-11-13 | 2003-04-08 | Chiron Corporation | Mutant forms of Fas ligand and uses thereof |
US5772993A (en) * | 1997-01-21 | 1998-06-30 | The University Of Virginia Patent Foundation | Osteocalcin promoter-based toxic gene therapy for the treatment of calcified tumors and tissues |
AU6954398A (en) | 1997-04-11 | 1998-11-11 | G.D. Searle & Co. | Antagonistic anti-avb3 integrin antibodies |
US6193968B1 (en) | 1997-04-11 | 2001-02-27 | The Burnham Institute | Methods for using anti-αvβ3 integrin antibody |
US6096718A (en) * | 1997-06-05 | 2000-08-01 | Gene Targeting Corp. | Tissue specific adenovirus vectors for breast cancer treatment |
US6207648B1 (en) | 1997-07-24 | 2001-03-27 | Trustees Of Boston University | Methods of using cytochrome P450 reductase for the enhancement of P450-based anti-cancer gene therapy |
US6696423B1 (en) | 1997-08-29 | 2004-02-24 | Biogen, Inc. | Methods and compositions for therapies using genes encoding secreted proteins such as interferon-beta |
US6080849A (en) | 1997-09-10 | 2000-06-27 | Vion Pharmaceuticals, Inc. | Genetically modified tumor-targeted bacteria with reduced virulence |
US7378244B2 (en) | 1997-10-01 | 2008-05-27 | Geron Corporation | Telomerase promoters sequences for screening telomerase modulators |
US7041654B2 (en) | 1997-10-03 | 2006-05-09 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Methods and compositions for inducing tumor-specific cytotoxicity |
US6087164A (en) * | 1997-10-03 | 2000-07-11 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Methods and compositions for inducing tumor-specific cytotoxicity |
AU1085099A (en) * | 1997-10-16 | 1999-05-03 | Children's Medical Center Corporation | Thymosin beta15 promoter and use thereof |
CA2308606A1 (en) | 1997-11-06 | 1999-05-20 | Chiron S.P.A. | Neisserial antigens |
AU1979599A (en) | 1998-01-14 | 1999-08-02 | Chiron S.P.A. | (neisseria meningitidis) antigens |
DE69936444T3 (de) * | 1998-02-03 | 2012-05-10 | Protiva Biotherapeutics Inc. | Systemische verabreichung von serum-stabilen plasmid-lipid partikeln zur krebstherapie |
US6410328B1 (en) | 1998-02-03 | 2002-06-25 | Protiva Biotherapeutics Inc. | Sensitizing cells to compounds using lipid-mediated gene and compound delivery |
DE69933856D1 (de) * | 1998-02-13 | 2006-12-14 | Koester Hubert | Verwendung von ribozymen zur bestimmung der funktion von genen |
FR2777570A1 (fr) * | 1998-04-17 | 1999-10-22 | Transgene Sa | Mutant ayant une activite phosphoribosyl transferase |
BR9910089A (pt) | 1998-05-01 | 2004-06-08 | Chiron Corp | Composições e antìgenos de neisseria meningitidis |
US5973119A (en) | 1998-06-05 | 1999-10-26 | Amgen Inc. | Cyclin E genes and proteins |
US20030017138A1 (en) * | 1998-07-08 | 2003-01-23 | Menzo Havenga | Chimeric adenoviruses |
US6344541B1 (en) | 1998-09-25 | 2002-02-05 | Amgen Inc. | DKR polypeptides |
US6552005B1 (en) * | 1998-09-29 | 2003-04-22 | Uab Research Foundation | Molecular chemotherapy enhancement of radiotherapy |
GB9824437D0 (en) * | 1998-11-06 | 1999-01-06 | Ylo Herttuala Seppo | Gene therapy |
US6929946B1 (en) * | 1998-11-20 | 2005-08-16 | Crucell Holland B.V. | Gene delivery vectors provided with a tissue tropism for smooth muscle cells, and/or endothelial cells |
EP1153136A2 (en) | 1998-12-09 | 2001-11-14 | The General Hospital Corporation | Enhanced packaging of herpes virus amplicons and generation of recombinant virus vectors |
US6869936B1 (en) * | 1999-03-04 | 2005-03-22 | Crucell Holland B.V. | Means and methods for fibroblast-like or macrophage-like cell transduction |
WO2000058479A1 (en) | 1999-03-26 | 2000-10-05 | Amgen Inc. | Beta secretase genes and polypeptides |
US6677155B1 (en) | 1999-04-22 | 2004-01-13 | The General Hospital Corporation | Triple hybrid amplicon vector systems to generate retroviral packaging lines |
RU2245366C2 (ru) | 1999-04-30 | 2005-01-27 | Чирон С.Р.Л. | Антиген neisseria, кодирующая его нуклеиновая кислота, их использование |
GB9911683D0 (en) | 1999-05-19 | 1999-07-21 | Chiron Spa | Antigenic peptides |
WO2000073432A2 (en) * | 1999-06-01 | 2000-12-07 | Cornell Research Foundation, Inc. | Activation of dendritic cells to enhance immunity |
AU5458500A (en) * | 1999-06-02 | 2000-12-18 | Cell Genesys, Inc. | Regulation of systemic immune responses utilizing cytokines and antigens |
US6673602B1 (en) | 1999-06-11 | 2004-01-06 | The General Hospital Corporation | Herpes simplex virus amplicon vector targeting system and method of using same |
US7589069B1 (en) * | 1999-07-12 | 2009-09-15 | Saint Louis University | Replication-competent anti-cancer vectors |
GB9916529D0 (en) | 1999-07-14 | 1999-09-15 | Chiron Spa | Antigenic peptides |
US6544781B1 (en) | 1999-07-15 | 2003-04-08 | The General Hospital Corporation | Non-defective Epstein-Barr viral vector |
US6770632B1 (en) | 1999-07-16 | 2004-08-03 | The General Hospital Corporation | Folypolyglutamyl synthetase gene transfer to enhance antifolate |
US7459540B1 (en) | 1999-09-07 | 2008-12-02 | Amgen Inc. | Fibroblast growth factor-like polypeptides |
US6900043B1 (en) | 1999-09-21 | 2005-05-31 | Amgen Inc. | Phosphatases which activate map kinase pathways |
EP1414499A4 (en) * | 1999-10-04 | 2004-05-06 | Vion Pharmaceuticals Inc | NON-INVASIVE TUMOR IMAGING THROUGH TUMOR-TARGETED BACTERIA |
US6962696B1 (en) | 1999-10-04 | 2005-11-08 | Vion Pharmaceuticals Inc. | Compositions and methods for tumor-targeted delivery of effector molecules |
GB9924981D0 (en) | 1999-10-21 | 1999-12-22 | Univ Manchester | Gene therapy |
US6716824B1 (en) | 1999-10-22 | 2004-04-06 | F. Charles Brunicardi | Treatment of pancreatic adenocarcinoma by cytotoxic gene therapy |
EP2275552B1 (en) | 1999-10-29 | 2015-09-09 | GlaxoSmithKline Biologicals SA | Neisserial antigenic peptides |
PT2289545T (pt) | 2000-01-17 | 2016-09-06 | Glaxosmithkline Biologicals Sa | Vacina de omv suplementada contra meningococos |
US20050239061A1 (en) * | 2000-03-01 | 2005-10-27 | Marshall William S | Identification and use of effectors and allosteric molecules for the alteration of gene expression |
AU2001237256A1 (en) * | 2000-03-08 | 2001-09-17 | Neurosearch A/S | A method of sensitising endothelial cells to prodrugs |
US6897020B2 (en) | 2000-03-20 | 2005-05-24 | Newlink Genetics Inc. | Methods and compositions for elucidating relative protein expression levels in cells |
US7514239B2 (en) | 2000-03-28 | 2009-04-07 | Amgen Inc. | Nucleic acid molecules encoding beta-like glycoprotein hormone polypeptides and heterodimers thereof |
GB0008966D0 (en) | 2000-04-13 | 2000-05-31 | Imp College Innovations Ltd | Vectors for gene therapy |
US6331528B1 (en) * | 2000-04-25 | 2001-12-18 | Ajinomoto Co., Inc. | Method for treatment in gene therapy and use of guanine derivative therefor |
ES2317917T3 (es) | 2000-06-28 | 2009-05-01 | Amgen Inc. | Moleculas de receptor de linfopoyetina estromal timica y sus usos de las mismas. |
MXPA03003690A (es) | 2000-10-27 | 2004-05-05 | Chiron Spa | Acidos nucleicos y proteinas de los grupos a y b de estreptococos. |
US6576464B2 (en) * | 2000-11-27 | 2003-06-10 | Geron Corporation | Methods for providing differentiated stem cells |
US6713055B2 (en) | 2000-11-27 | 2004-03-30 | Geron Corporation | Glycosyltransferase vectors for treating cancer |
US6921665B2 (en) * | 2000-11-27 | 2005-07-26 | Roslin Institute (Edinburgh) | Selective antibody targeting of undifferentiated stem cells |
WO2003051402A1 (en) * | 2000-12-05 | 2003-06-26 | Uab Research Foundation | Adenoviral vector containing cyclooxygenase-2 promoter and uses thereof |
US6794376B2 (en) * | 2000-12-06 | 2004-09-21 | William Beaumont Hospital | Methods and compositions for enhancing diffusion of therapeutic agents through tissue |
US7214515B2 (en) * | 2001-01-05 | 2007-05-08 | The General Hospital Corporation | Viral delivery system for infectious transfer of large genomic DNA inserts |
GB0107661D0 (en) | 2001-03-27 | 2001-05-16 | Chiron Spa | Staphylococcus aureus |
GB0107658D0 (en) | 2001-03-27 | 2001-05-16 | Chiron Spa | Streptococcus pneumoniae |
AU2002258631B2 (en) * | 2001-03-27 | 2007-05-17 | New York University | Tumor therapy with alphavirus-based and high affinity laminin receptor-targeted vectors |
US8034791B2 (en) | 2001-04-06 | 2011-10-11 | The University Of Chicago | Activation of Egr-1 promoter by DNA damaging chemotherapeutics |
US20040242523A1 (en) * | 2003-03-06 | 2004-12-02 | Ana-Farber Cancer Institue And The Univiersity Of Chicago | Chemo-inducible cancer gene therapy |
JP2004532213A (ja) * | 2001-04-06 | 2004-10-21 | ザ ユニヴァーシティ オヴ シカゴ | Egr−1プロモーター活性の化学療法誘導 |
US8058248B2 (en) * | 2001-04-26 | 2011-11-15 | The United States Of America As Represented By The Secretary Of Agriculture | Foot and mouth disease virus vaccine comprising interferons |
US20030003074A1 (en) * | 2001-06-14 | 2003-01-02 | Macromed, Inc. | Formulations of lymphokines and method of use thereof for local or both local and systemic control of proliferative cell disorders |
US20060159657A1 (en) * | 2001-06-14 | 2006-07-20 | Macromed, Incorporated | Formulations of lymphokines and method of use thereof for local or both local and systemic control of proliferative cell disorders |
AU2002322493A1 (en) * | 2001-07-10 | 2003-01-29 | Ams Research Corporation | Surgical kit for treating prostate tissue |
US20140088177A1 (en) * | 2001-07-11 | 2014-03-27 | University Of Miami | Recombinant vsv for the treatment of tumor cells |
AU2008201293B2 (en) * | 2001-07-11 | 2011-08-18 | University Of Miami | Recombinant VSV for the treatment of tumor cells |
JP2004537305A (ja) * | 2001-07-11 | 2004-12-16 | ユニバーシティー オブ マイアミ | 腫瘍細胞の処置のための組換えvsv |
US20030032597A1 (en) * | 2001-07-31 | 2003-02-13 | Sebestyen Magdolna G. | Targeting nucleic acids to a cellular nucleus |
AU2002365070A1 (en) * | 2001-08-03 | 2003-06-30 | Diversa Corporation | P450 enzymes, nucleic acids encoding them and methods of making and using them |
WO2003014140A1 (en) * | 2001-08-09 | 2003-02-20 | Board Of Trustees Of The University Of Arkansas | Compositions, methods and products comprising human papillomavirus for detecting and treating a cancer |
JP4354814B2 (ja) | 2001-09-29 | 2009-10-28 | ヨンセイ ユニバーシティ | 改善された疾患治療効果を有する組換えアデノウィルス及びそれを含む薬剤学的組成物 |
US20040086485A1 (en) * | 2001-10-04 | 2004-05-06 | Aguilar-Cordova Carlos Estuardo | Chemeric viral vectors for gene therapy |
US20030108524A1 (en) * | 2001-10-18 | 2003-06-12 | Melissa Diagana | Vectors for expressing multiple transgenes |
EP1436313B1 (en) | 2001-10-19 | 2010-09-22 | Vascular Biogenics Ltd. | Polynucleotide constructs, pharmaceutical compositions and methods for targeted downregulation of angiogenesis and anticancer therapy |
US20030086903A1 (en) * | 2001-11-02 | 2003-05-08 | Genvec, Inc. | Therapeutic regimen for treating cancer |
US20030143189A1 (en) * | 2001-11-14 | 2003-07-31 | Askill Ian N | Therapy for topical diseases |
ES2312649T3 (es) | 2001-12-12 | 2009-03-01 | Novartis Vaccines And Diagnostics S.R.L. | Inmunizacion frente a chlamydia trachomatis. |
EP1453536A4 (en) * | 2001-12-12 | 2009-08-26 | Mayne Pharma Int Pty Ltd | COMPOSITION FOR PRESERVING VIRUSES |
AU2003217693A1 (en) * | 2002-02-22 | 2003-09-09 | Board Of Trustees Of The University Of Illinois | Beta chain-associated regulator of apoptosis |
US7662924B2 (en) * | 2002-02-22 | 2010-02-16 | The Board Of Trustees Of The University Of Illinois | Beta chain-associated regulator of apoptosis |
US20040053836A1 (en) * | 2002-04-22 | 2004-03-18 | Philipp Mayer-Kuckuk | Method for modulating the production of a selected protein in vivo |
US7977049B2 (en) | 2002-08-09 | 2011-07-12 | President And Fellows Of Harvard College | Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms |
CA2421269A1 (en) | 2002-08-09 | 2004-02-09 | President And Fellows Of Harvard College | Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms |
US20040142864A1 (en) * | 2002-09-16 | 2004-07-22 | Plexxikon, Inc. | Crystal structure of PIM-1 kinase |
US20040052161A1 (en) * | 2002-09-17 | 2004-03-18 | Steven Liao | Mechanical clock having wireless manipulation and adjustment function |
US20050113324A1 (en) * | 2003-01-15 | 2005-05-26 | Bondarev Igor E. | Modulation of line-1 reverse transcriptase |
US20050048573A1 (en) * | 2003-02-03 | 2005-03-03 | Plexxikon, Inc. | PDE5A crystal structure and uses |
US20050170431A1 (en) * | 2003-02-28 | 2005-08-04 | Plexxikon, Inc. | PYK2 crystal structure and uses |
US20040191873A1 (en) * | 2003-03-27 | 2004-09-30 | Won-Bin Young | Method for high throughput elucidation of transcriptional profiles and genome annotation |
GB0308198D0 (en) | 2003-04-09 | 2003-05-14 | Chiron Srl | ADP-ribosylating bacterial toxin |
US20050079548A1 (en) * | 2003-07-07 | 2005-04-14 | Plexxikon, Inc. | Ligand development using PDE4B crystal structures |
US20050164300A1 (en) * | 2003-09-15 | 2005-07-28 | Plexxikon, Inc. | Molecular scaffolds for kinase ligand development |
ATE458500T1 (de) * | 2003-11-14 | 2010-03-15 | Genvec Inc | Pharmazeutische verbindung zur behandlung von lokal fortgeschrittenem primär inoperablen pankreaskarzinom (lapc). |
WO2005058368A1 (en) * | 2003-12-10 | 2005-06-30 | Canji, Inc. | Methods and compositions for treatment of interferon-resistant tumors |
US20070066641A1 (en) * | 2003-12-19 | 2007-03-22 | Prabha Ibrahim | Compounds and methods for development of RET modulators |
PL1696920T3 (pl) * | 2003-12-19 | 2015-03-31 | Plexxikon Inc | Związki i sposoby opracowywania modulatorów Ret |
GB0406215D0 (en) | 2004-03-19 | 2004-04-21 | Procure Therapeutics Ltd | Prostate stem cell |
PT1736541E (pt) | 2004-03-29 | 2013-01-31 | Galpharma Co Ltd | Nova proteína galectina 9 modificada e sua utilização |
US7585859B2 (en) * | 2004-05-06 | 2009-09-08 | Plexxikon, Inc. | PDE4B inhibitors and uses therefor |
ITMI20041032A1 (it) * | 2004-05-24 | 2004-08-24 | Neuroscienze S C A R L | Compositi farmaceutici |
ATE491799T1 (de) | 2004-05-26 | 2011-01-15 | Bayer Schering Pharma Ag | Chimäre adenoviren zur verwendung in der krebsbehandlung |
US7498342B2 (en) | 2004-06-17 | 2009-03-03 | Plexxikon, Inc. | Compounds modulating c-kit activity |
GB0413702D0 (en) | 2004-06-18 | 2004-07-21 | Molmed Spa | Thymidine kinase |
EP2298896A1 (en) | 2004-06-22 | 2011-03-23 | The Board of Trustees of the University of Illinois | Methods of inhibiting tumor cell proliferation with FOXM1 siRNA |
GB0416487D0 (en) * | 2004-07-23 | 2004-08-25 | Isis Innovation | Modified virus |
US8420611B2 (en) * | 2004-08-12 | 2013-04-16 | Cedars-Sinai Medical Center | Combined gene therapy for the treatment of macroscopic gliomas |
DE602005024148D1 (de) * | 2004-08-25 | 2010-11-25 | Univ Chicago | Verwendung der kombination aus temozolomid und tnf-alpha zur behandlung von glioblastoma |
EP1786813A2 (en) * | 2004-09-03 | 2007-05-23 | Plexxikon, Inc. | Bicyclic heteroaryl pde4b inhibitors |
DE102004054215A1 (de) * | 2004-11-10 | 2006-05-11 | Merck Patent Gmbh | Pyridopyrimidinonderivate |
KR100747646B1 (ko) | 2005-02-25 | 2007-08-08 | 연세대학교 산학협력단 | 데코린 유전자를 포함하는 유전자 전달 시스템 및 이를 포함하는 약제학적 항종양 조성물 |
CN101193643A (zh) | 2005-03-25 | 2008-06-04 | Alt解决方案公司 | 端粒酶阳性细胞中端粒长度的调节和癌症治疗 |
BRPI0610066A2 (pt) * | 2005-05-17 | 2010-05-25 | Plexxikon Inc | compostos que modulam atividade de c-kit e c-fms e usos para estes |
US8609623B2 (en) * | 2005-05-18 | 2013-12-17 | Alt Solutions Inc. | Pharmacological modulation of telomere length in cancer cells for prevention and treatment of cancer |
BRPI0611863B1 (pt) * | 2005-06-22 | 2021-11-23 | Plexxikon, Inc | Composto, bem como composição e kit compreendendo o mesmo, composto intermediário na preparação do mesmo, método para tratamento e uso do mesmo |
US7358489B2 (en) * | 2005-08-04 | 2008-04-15 | Airware, Inc. | Ultra low cost NDIR gas sensors |
US20110206692A1 (en) | 2006-06-09 | 2011-08-25 | Novartis Ag | Conformers of bacterial adhesins |
WO2008063888A2 (en) | 2006-11-22 | 2008-05-29 | Plexxikon, Inc. | Compounds modulating c-fms and/or c-kit activity and uses therefor |
AU2007336811A1 (en) | 2006-12-21 | 2008-07-03 | Plexxikon, Inc. | Compounds and methods for kinase modulation, and indications therefor |
PE20121126A1 (es) * | 2006-12-21 | 2012-08-24 | Plexxikon Inc | Compuestos pirrolo [2,3-b] piridinas como moduladores de quinasa |
WO2008079909A1 (en) * | 2006-12-21 | 2008-07-03 | Plexxikon, Inc. | Pyrrolo [2,3-b] pyridines as kinase modulators |
US9232959B2 (en) | 2007-01-02 | 2016-01-12 | Aquabeam, Llc | Multi fluid tissue resection methods and devices |
ES2959025T3 (es) | 2007-01-02 | 2024-02-19 | Aquabeam Llc | Dispositivos y procedimientos mínimamente invasivos para el tratamiento de enfermedades de la próstata |
WO2008095027A2 (en) * | 2007-01-30 | 2008-08-07 | Cedars-Sinai Medical Center | Adenoviral vector comprising herpes simplex virus type 1 thymidine kinase and a transgene for increasing the expression of the transgene |
US20090018098A1 (en) * | 2007-07-13 | 2009-01-15 | California Institute Of Technology | Targeting the absence: homozygous dna deletions as signposts for cancer therapy |
BRPI0814423B1 (pt) | 2007-07-17 | 2022-04-19 | Plexxikon, Inc | Compostos que modulam quinase e composição farmacêutica compreendendo os mesmos |
US8282918B2 (en) * | 2007-07-30 | 2012-10-09 | University Of Iowa Research Foundation | Polynucleotides encoding RPA4/RPA32 hybrid polypeptides |
DE102007056488A1 (de) * | 2007-11-22 | 2009-07-23 | Biontex Laboratories Gmbh | Steigerung von Transfektionseffizienzen nicht-viraler Genliefersysteme durch Blockierung des angeborenen Immunsystems |
WO2009088256A2 (ko) | 2008-01-09 | 2009-07-16 | Konkuk University Industrial Cooperation Corp | 배큘로바이러스-기반 백신 |
EP2259742B1 (en) * | 2008-03-06 | 2020-01-01 | AquaBeam LLC | Tissue ablation and cautery with optical energy carried in fluid stream |
US9181315B2 (en) | 2009-01-08 | 2015-11-10 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for induced brown fat differentiation |
ES2568509T3 (es) | 2009-01-15 | 2016-04-29 | Adaptive Biotechnologies Corporation | Perfilado de la inmunidad adaptativa y métodos para la generación de anticuerpos monoclonales |
US9073980B2 (en) | 2009-03-02 | 2015-07-07 | The Regents Of The University Of California | Tumor selective E1a and E1b mutants |
WO2016037137A1 (en) | 2014-09-05 | 2016-03-10 | Procept Biorobotics Corporation | Physician controlled tissue resection integrated with treatment mapping of target organ images |
US9848904B2 (en) | 2009-03-06 | 2017-12-26 | Procept Biorobotics Corporation | Tissue resection and treatment with shedding pulses |
WO2014127242A2 (en) | 2013-02-14 | 2014-08-21 | Procept Biorobotics Corporation | Aquablation aquabeam eye surgery methods and apparatus |
KR101764437B1 (ko) | 2009-03-20 | 2017-08-02 | 메소블라스트, 아이엔씨. | 재프로그램된 다분화능 세포의 생성 방법 |
AR078033A1 (es) | 2009-04-03 | 2011-10-12 | Plexxikon Inc | Una dispersion solida, que contiene al compuesto {3-[5-(4-(cloro-fenil)-1h-pirrolo[2,3-b]piridina-3-carbonil]-2,4-difluor-fenil}-amida del acido propano-1-sulfonico, composiciones y formulaciones que comprenden a dicha dispersion solida; metodos para fabricar dicha dispersion solida, formas 1 y 2 de |
EP2248903A1 (en) | 2009-04-29 | 2010-11-10 | Universitat Autònoma De Barcelona | Methods and reagents for efficient and targeted gene transfer to monocytes and macrophages |
US8329724B2 (en) | 2009-08-03 | 2012-12-11 | Hoffmann-La Roche Inc. | Process for the manufacture of pharmaceutically active compounds |
US9605844B2 (en) * | 2009-09-01 | 2017-03-28 | Cree, Inc. | Lighting device with heat dissipation elements |
GB0916997D0 (en) | 2009-09-28 | 2009-11-11 | Ark Therapeutics Ltd | Combination therapy |
ES2633317T3 (es) | 2009-11-06 | 2017-09-20 | Plexxikon, Inc. | Compuestos y métodos para la modulación de quinasas, e indicaciones para ello |
US20130040853A1 (en) | 2010-01-21 | 2013-02-14 | Dana-Farber Cancer Institute Inc. | Context Specific Genetic Screen Platform to Aid in Gene Discovery and Target Validation |
WO2016004071A1 (en) | 2014-06-30 | 2016-01-07 | Procept Biorobotics Corporation | Fluid jet tissue resection and cold coagulation (aquablation) methods and apparatus |
US9597379B1 (en) | 2010-02-09 | 2017-03-21 | David Gordon Bermudes | Protease inhibitor combination with therapeutic proteins including antibodies |
WO2011146938A1 (en) | 2010-05-21 | 2011-11-24 | NanoOncology, Inc. | Reagents and methods for treating cancer |
WO2012064743A2 (en) | 2010-11-08 | 2012-05-18 | The Johns Hopkins University | Methods for improving heart function |
WO2012095548A2 (es) | 2011-01-13 | 2012-07-19 | Centro De Investigación Biomédica En Red De Enfermedades Neurodegenerativas (Ciberned) | Compuestos para el tratamiento de enfermedades neurodegenerativas |
MA34948B1 (fr) | 2011-02-07 | 2014-03-01 | Plexxikon Inc | Composes et procedes de modulation de kinase, et leurs indications |
TWI558702B (zh) | 2011-02-21 | 2016-11-21 | 普雷辛肯公司 | 醫藥活性物質的固態形式 |
RU2631487C2 (ru) | 2011-05-17 | 2017-09-22 | Плексксикон Инк. | Модуляция киназ и показания к её применению |
KR101293620B1 (ko) | 2011-08-19 | 2013-08-13 | 국립암센터 | 트랜스-스플라이싱 라이보자임 및 암치료 유전자를 포함하는 재조합 아데노바이러스 및 이의 용도 |
US10093705B2 (en) | 2011-09-13 | 2018-10-09 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for brown fat induction and activity using FNDC5 |
WO2013055911A1 (en) | 2011-10-14 | 2013-04-18 | Dana-Farber Cancer Institute, Inc. | Znf365/zfp365 biomarker predictive of anti-cancer response |
US9404090B2 (en) | 2011-11-24 | 2016-08-02 | Viromed Co., Ltd. | Adenovirus producing novel cell line and the use thereof |
EP2819599B1 (en) | 2012-02-29 | 2018-05-23 | Procept Biorobotics Corporation | Automated image-guided tissue resection and treatment |
US9150570B2 (en) | 2012-05-31 | 2015-10-06 | Plexxikon Inc. | Synthesis of heterocyclic compounds |
US9259343B2 (en) | 2012-07-06 | 2016-02-16 | Newman Technologies LLC | Device for mitigating plantar fasciitis |
CN109965976B (zh) | 2013-09-06 | 2022-05-31 | 普罗赛普特生物机器人公司 | 利用致脱脉冲的用于消融组织的装置 |
AU2014338864C1 (en) | 2013-10-25 | 2020-07-16 | Akamis Bio Limited | Oncolytic adenoviruses armed with heterologous genes |
EP4331590A3 (en) | 2013-10-29 | 2024-04-17 | President and Fellows of Harvard College | Nuclear factor erythroid 2-like 2 (nrf2) for use in treatment of age-related macular degeneration |
EP3134546A4 (en) | 2014-04-24 | 2017-12-06 | Dana-Farber Cancer Institute, Inc. | Tumor suppressor and oncogene biomarkers predictive of anti-immune checkpoint inhibitor response |
EP3204516B1 (en) | 2014-10-06 | 2023-04-26 | Dana-Farber Cancer Institute, Inc. | Angiopoietin-2 biomarkers predictive of anti-immune checkpoint response |
EP3204119B1 (en) | 2014-10-09 | 2021-06-09 | Dana-Farber Cancer Institute, Inc. | Multiple-variable il-2 dose regimen for treating immune disorders |
US20170151281A1 (en) | 2015-02-19 | 2017-06-01 | Batu Biologics, Inc. | Chimeric antigen receptor dendritic cell (car-dc) for treatment of cancer |
CN104740681A (zh) * | 2015-03-02 | 2015-07-01 | 吉林大学 | 一种聚乳酸-羟基乙酸/腺病毒复合纳米纤维支架材料、制备方法及其应用 |
WO2016144673A1 (en) | 2015-03-06 | 2016-09-15 | Dana-Farber Cancer Institute, Inc. | Pd-l2 biomarkers predictive of pd-1 pathway inhibitor responses in esophagogastric cancers |
WO2016164641A1 (en) | 2015-04-08 | 2016-10-13 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
IL284375B (en) | 2015-04-30 | 2022-07-01 | Psioxus Therapeutics Ltd | A replication-competent group b oncolytic adenovirus |
WO2017019804A2 (en) | 2015-07-28 | 2017-02-02 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
WO2017066561A2 (en) | 2015-10-16 | 2017-04-20 | President And Fellows Of Harvard College | Regulatory t cell pd-1 modulation for regulating t cell effector immune responses |
AU2016343978A1 (en) | 2015-10-29 | 2018-05-17 | Dana-Farber Cancer Institute, Inc. | Methods for identification, assessment, prevention, and treatment of metabolic disorders using PM20D1 and N-lipidated amino acids |
SG11201804711RA (en) | 2015-12-07 | 2018-07-30 | Plexxikon Inc | Compounds and methods for kinase modulation, and indications therefor |
BR112018012180A2 (pt) | 2015-12-17 | 2018-12-04 | Psioxus Therapeutics Ltd | vírus de codificação de um anticorpo ou fragmento de complexo anti-tcr |
US20210309965A1 (en) | 2016-03-21 | 2021-10-07 | Dana-Farber Cancer Institute, Inc. | T-cell exhaustion state-specific gene expression regulators and uses thereof |
US10183058B2 (en) | 2016-06-17 | 2019-01-22 | Nymox Corporation | Method of preventing or reducing the progression of prostate cancer |
US10172910B2 (en) | 2016-07-28 | 2019-01-08 | Nymox Corporation | Method of preventing or reducing the incidence of acute urinary retention |
GB201713765D0 (en) | 2017-08-28 | 2017-10-11 | Psioxus Therapeutics Ltd | Modified adenovirus |
US10532081B2 (en) | 2016-09-07 | 2020-01-14 | Nymox Corporation | Method of ameliorating or preventing the worsening or the progression of symptoms of BPH |
EP3515559A4 (en) | 2016-09-20 | 2020-07-15 | Dana-Farber Cancer Institute, Inc. | COMPOSITIONS AND METHODS FOR THE IDENTIFICATION, ASSESSMENT, PREVENTION AND TREATMENT OF AML USING USP10 BIOMARKERS AND MODULATORS |
TW201815766A (zh) | 2016-09-22 | 2018-05-01 | 美商普雷辛肯公司 | 用於ido及tdo調節之化合物及方法以及其適應症 |
US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
EP3558991A2 (en) | 2016-12-23 | 2019-10-30 | Plexxikon Inc. | Compounds and methods for cdk8 modulation and indications therefor |
WO2018226685A2 (en) | 2017-06-06 | 2018-12-13 | Dana-Farber Cancer Institute, Inc. | Methods for sensitizing cancer cells to t cell-mediated killing by modulating molecular pathways |
US10428067B2 (en) | 2017-06-07 | 2019-10-01 | Plexxikon Inc. | Compounds and methods for kinase modulation |
WO2019108777A1 (en) | 2017-11-29 | 2019-06-06 | Research Development Foundation | Elimination of proliferating cells from stem cell-derived grafts |
WO2019117632A1 (ko) | 2017-12-13 | 2019-06-20 | 한양대학교 산학협력단 | 재조합 아데노바이러스 및 이를 포함하는 줄기세포 |
EP3810189A1 (en) | 2018-06-19 | 2021-04-28 | Armo Biosciences, Inc. | Compositions and methods of use of il-10 agents in conjunction with chimeric antigen receptor cell therapy |
EP3876977A1 (en) | 2018-11-06 | 2021-09-15 | The Regents Of The University Of California | Chimeric antigen receptors for phagocytosis |
ES2957688T3 (es) | 2018-11-07 | 2024-01-24 | Consejo Superior Investigacion | Construcción génica suicida doble e inducible y su uso en terapia génica |
US20220289854A1 (en) | 2019-04-30 | 2022-09-15 | Dana-Farber Cancer Institute, Inc. | Methods for treating cancer using combinations of anti-cx3cr1 and immune checkpoint blockade agents |
US11026973B2 (en) | 2019-04-30 | 2021-06-08 | Myeloid Therapeutics, Inc. | Engineered phagocytic receptor compositions and methods of use thereof |
GB2605276A (en) | 2019-09-03 | 2022-09-28 | Myeloid Therapeutics Inc | Methods and compositions for genomic integration |
US10980836B1 (en) | 2019-12-11 | 2021-04-20 | Myeloid Therapeutics, Inc. | Therapeutic cell compositions and methods of manufacturing and use thereof |
IL294388A (en) | 2020-01-14 | 2022-08-01 | Synthekine Inc | il2 orthologs and methods of use |
MX2023001490A (es) | 2020-08-05 | 2023-04-27 | Synthekine Inc | Moleculas de union a il27r\03b1 y metodos de uso. |
CN116322754A (zh) | 2020-08-05 | 2023-06-23 | 辛德凯因股份有限公司 | Il10ra结合分子及使用方法 |
US20230272094A1 (en) | 2020-08-05 | 2023-08-31 | Synthekine, Inc. | Il2rb/il2rg synthetic cytokines |
EP4192489A2 (en) | 2020-08-05 | 2023-06-14 | Synthekine, Inc. | Il2rb binding molecules and methods of use |
EP4208718A1 (en) | 2020-09-02 | 2023-07-12 | Johansson Swartling, Fredrik | Predicting cancer relapse and treatment of cancer diseases |
EP4229222A2 (en) | 2020-10-19 | 2023-08-23 | Dana-Farber Cancer Institute, Inc. | Germline biomarkers of clinical response and benefit to immune checkpoint inhibitor therapy |
GB2617474A (en) | 2020-11-04 | 2023-10-11 | Myeloid Therapeutics Inc | Engineered chimeric fusion protein compositions and methods of use thereof |
WO2022104104A2 (en) | 2020-11-13 | 2022-05-19 | Dana-Farber Cancer Institute, Inc. | Personalized fusion cell vaccines |
WO2022261183A2 (en) | 2021-06-08 | 2022-12-15 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for treating and/or identifying an agent for treating intestinal cancers |
WO2023097119A2 (en) | 2021-11-29 | 2023-06-01 | Dana-Farber Cancer Institute, Inc. | Methods and compositions to modulate riok2 |
WO2023158732A1 (en) | 2022-02-16 | 2023-08-24 | Dana-Farber Cancer Institute, Inc. | Methods for decreasing pathologic alpha-synuclein using agents that modulate fndc5 or biologically active fragments thereof |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993002556A1 (en) * | 1991-07-26 | 1993-02-18 | University Of Rochester | Cancer therapy utilizing malignant cells |
US5529774A (en) * | 1991-08-13 | 1996-06-25 | The Regents Of The University Of California | In vivo transfer of the HSV-TK gene implanted retroviral producer cells |
ES2144426T3 (es) * | 1991-10-25 | 2000-06-16 | Sidney Kimmel Cancer Ct | Terapia genica linfoquimica del cancer en combinacion con antigenos tumorales. |
WO1993010218A1 (en) | 1991-11-14 | 1993-05-27 | The United States Government As Represented By The Secretary Of The Department Of Health And Human Services | Vectors including foreign genes and negative selective markers |
CA2131620A1 (en) * | 1992-03-20 | 1993-09-30 | Louis C. Smith | A dna transporter system and method of use |
AU675948B2 (en) * | 1992-05-01 | 1997-02-27 | United States Of America, As Represented By The Secretary, Department Of Health And Human Services, The | Bystander effect tumoricidal therapy |
FR2705686B1 (fr) * | 1993-05-28 | 1995-08-18 | Transgene Sa | Nouveaux adénovirus défectifs et lignées de complémentation correspondantes. |
US5631236A (en) * | 1993-08-26 | 1997-05-20 | Baylor College Of Medicine | Gene therapy for solid tumors, using a DNA sequence encoding HSV-Tk or VZV-Tk |
CA2173495A1 (en) * | 1993-10-06 | 1995-04-13 | Kenneth W. Culver | Treatment of tumors by genetic transformation of tumor cells with genes encoding negative selective markers and cytokines |
-
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
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US8846401B2 (en) | 2000-11-17 | 2014-09-30 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same |
US8859745B2 (en) | 2000-11-17 | 2014-10-14 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same |
JP2011173903A (ja) * | 2002-10-08 | 2011-09-08 | Immunomedics Inc | 抗体療法 |
JP2008519596A (ja) * | 2004-11-14 | 2008-06-12 | ヴァスキュラー バイオジェニックス リミテッド | 内皮細胞特異性を示すプロモーター及びそのプロモーターを使って血管形成を制御する方法 |
JP2012010710A (ja) * | 2004-11-14 | 2012-01-19 | Vascular Biogenics Ltd | 内皮細胞特異性を示すプロモーター及びそのプロモーターを使って血管形成を制御する方法 |
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ATE360697T1 (de) | 2007-05-15 |
DE69434960T2 (de) | 2008-01-17 |
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CA2169260A1 (en) | 1995-03-02 |
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US5631236A (en) | 1997-05-20 |
WO1995005835A1 (en) | 1995-03-02 |
AU7677694A (en) | 1995-03-21 |
DE69434069D1 (de) | 2004-11-18 |
EP0719147A1 (en) | 1996-07-03 |
ATE279525T1 (de) | 2004-10-15 |
AU677430B2 (en) | 1997-04-24 |
EP1469075A1 (en) | 2004-10-20 |
DE69434960D1 (de) | 2007-06-06 |
DE69434069T2 (de) | 2006-02-23 |
JP2008106072A (ja) | 2008-05-08 |
EP1469075B1 (en) | 2007-04-25 |
CA2169260C (en) | 2010-08-17 |
EP0719147A4 (en) | 1998-09-16 |
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