JPH0667929B2 - ピペラジニルフエニルトリアゾロン誘導体、その製法ならびに利用 - Google Patents

ピペラジニルフエニルトリアゾロン誘導体、その製法ならびに利用

Info

Publication number
JPH0667929B2
JPH0667929B2 JP63069915A JP6991588A JPH0667929B2 JP H0667929 B2 JPH0667929 B2 JP H0667929B2 JP 63069915 A JP63069915 A JP 63069915A JP 6991588 A JP6991588 A JP 6991588A JP H0667929 B2 JPH0667929 B2 JP H0667929B2
Authority
JP
Japan
Prior art keywords
formula
compound
phenyl
triazol
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP63069915A
Other languages
English (en)
Japanese (ja)
Other versions
JPS63277674A (ja
Inventor
ジヤン・ヘーレス
レオ・ジヤコブス・ジヨゼフ・バツクス
ルイス・ジヨゼフ・エリザベス・バン・デル・ベケン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of JPS63277674A publication Critical patent/JPS63277674A/ja
Publication of JPH0667929B2 publication Critical patent/JPH0667929B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Auxiliary Devices For And Details Of Packaging Control (AREA)
JP63069915A 1987-03-25 1988-03-25 ピペラジニルフエニルトリアゾロン誘導体、その製法ならびに利用 Expired - Fee Related JPH0667929B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3020787A 1987-03-25 1987-03-25
US30207 1987-03-25

Publications (2)

Publication Number Publication Date
JPS63277674A JPS63277674A (ja) 1988-11-15
JPH0667929B2 true JPH0667929B2 (ja) 1994-08-31

Family

ID=21853062

Family Applications (1)

Application Number Title Priority Date Filing Date
JP63069915A Expired - Fee Related JPH0667929B2 (ja) 1987-03-25 1988-03-25 ピペラジニルフエニルトリアゾロン誘導体、その製法ならびに利用

Country Status (25)

Country Link
EP (1) EP0283992B1 (en, 2012)
JP (1) JPH0667929B2 (en, 2012)
KR (1) KR960012370B1 (en, 2012)
CN (1) CN1038588C (en, 2012)
AT (1) ATE80626T1 (en, 2012)
AU (1) AU600107B2 (en, 2012)
CA (1) CA1313875C (en, 2012)
CY (1) CY1837A (en, 2012)
DE (1) DE3874576T2 (en, 2012)
DK (1) DK168336B1 (en, 2012)
ES (1) ES2044991T3 (en, 2012)
FI (1) FI89798C (en, 2012)
GR (1) GR3006420T3 (en, 2012)
HK (1) HK50395A (en, 2012)
HU (1) HU204819B (en, 2012)
IE (1) IE61802B1 (en, 2012)
IL (1) IL85823A (en, 2012)
MA (1) MA21227A1 (en, 2012)
NO (1) NO168476C (en, 2012)
NZ (1) NZ223799A (en, 2012)
PH (1) PH25023A (en, 2012)
PT (1) PT87073B (en, 2012)
SU (1) SU1635900A3 (en, 2012)
TN (1) TNSN88025A1 (en, 2012)
ZA (1) ZA882118B (en, 2012)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1331757C (en) * 1988-02-29 1994-08-30 Janssen Pharmaceutica Naamloze Vennootschap 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols
US5075309A (en) * 1989-06-09 1991-12-24 Janssen Pharmaceutica N.V. Antifungal 4-[4-[4-[4-[[2-(2,4-difluorophenyl)-2-(1H-azolylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]triazolones and imidazolones
NZ233502A (en) * 1989-06-09 1991-11-26 Janssen Pharmaceutica Nv 4-(1,2,4-triazole- or imidazole-phenyl-substituted) -1-(1,3-dioxolan-4-ylmethoxyphenyl) piperazine derivatives; preparatory processes: fungicidal and antiviral compositions
WO1993007847A1 (en) * 1991-10-15 1993-04-29 Kenneth Vincent Mason Anti-seborrhoeic formulation
IL103558A0 (en) * 1991-10-30 1993-03-15 Schering Corp Tri-substituted tetrahydrofuran antifungals
TW218017B (en, 2012) * 1992-04-28 1993-12-21 Takeda Pharm Industry Co Ltd
PH30929A (en) * 1992-09-03 1997-12-23 Janssen Pharmaceutica Nv Beads having a core coated with an antifungal and a polymer.
CN1078210C (zh) * 1994-01-24 2002-01-23 詹森药业有限公司 水溶性吡咯系杀真菌剂
AU697744C (en) * 1994-10-27 2002-08-22 Elanco Animal Health Ireland Limited Apolipoprotein-B synthesis inhibitors
US5625064A (en) * 1995-04-19 1997-04-29 Schering Corporation Process for the preparation of triazolones
TW457240B (en) * 1995-04-20 2001-10-01 Janssen Pharmaceutica Nv Novel triazolones as apolipoprotein-B synthesis inhibitors
US20050025791A1 (en) 2002-06-21 2005-02-03 Julius Remenar Pharmaceutical compositions with improved dissolution
US7790905B2 (en) 2002-02-15 2010-09-07 Mcneil-Ppc, Inc. Pharmaceutical propylene glycol solvate compositions
US7446107B2 (en) 2002-02-15 2008-11-04 Transform Pharmaceuticals, Inc. Crystalline forms of conazoles and methods of making and using the same
US7927613B2 (en) 2002-02-15 2011-04-19 University Of South Florida Pharmaceutical co-crystal compositions
AU2003213719A1 (en) 2002-03-01 2003-09-16 Regents Of The University Of Michigan Multiple-component solid phases containing at least one active pharmaceutical ingredient
AU2003243354A1 (en) * 2002-05-31 2003-12-19 Transform Pharmaceuticals, Inc. Novel conazole crystalline forms and related processes, pharmaceutical compositions and methods
US8183290B2 (en) 2002-12-30 2012-05-22 Mcneil-Ppc, Inc. Pharmaceutically acceptable propylene glycol solvate of naproxen
EP1742941A1 (en) * 2004-04-22 2007-01-17 Transform Pharmaceuticals, Inc. Novel saperconazole crystalline forms and related processes, pharmaceutical compositions and methods
MX342850B (es) * 2010-05-19 2016-10-14 Sandoz Ag Proceso para la preparacion de triazolonas quirales.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4218458A (en) * 1978-06-23 1980-08-19 Janssen Pharmaceutica, N.V. Heterocyclic derivatives of (4-aryloxy-methyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
US4619931A (en) * 1983-02-28 1986-10-28 Janssen Pharmaceutica, N.V. [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles
CA1292472C (en) * 1985-12-03 1991-11-26 Alfonsus Guilielmus Knaeps Derivatives of ¬¬4-¬4-(4-phenyl-1-piperazinyl)- phenoxymethyl|-1,3-dioxolan-2-yl|methyl|-1h-imidazoles and 1h-1,2,4-triazoles

Also Published As

Publication number Publication date
HK50395A (en) 1995-04-13
DK163288A (da) 1988-09-26
EP0283992B1 (en) 1992-09-16
HUT50333A (en) 1990-01-29
ZA882118B (en) 1989-11-29
FI89798C (fi) 1993-11-25
NO168476C (no) 1992-02-26
SU1635900A3 (ru) 1991-03-15
FI89798B (fi) 1993-08-13
HU204819B (en) 1992-02-28
NZ223799A (en) 1989-12-21
JPS63277674A (ja) 1988-11-15
CA1313875C (en) 1993-02-23
CY1837A (en) 1995-12-01
CN1038588C (zh) 1998-06-03
MA21227A1 (fr) 1988-10-01
EP0283992A3 (en) 1989-06-14
GR3006420T3 (en, 2012) 1993-06-21
IE61802B1 (en) 1994-11-30
ATE80626T1 (de) 1992-10-15
KR960012370B1 (ko) 1996-09-20
KR880011147A (ko) 1988-10-26
IE880893L (en) 1988-09-25
FI881404A0 (fi) 1988-03-24
ES2044991T3 (es) 1994-01-16
FI881404A7 (fi) 1988-09-26
NO881306L (no) 1988-09-26
PT87073A (pt) 1988-04-01
PT87073B (pt) 1992-07-31
DK163288D0 (da) 1988-03-24
IL85823A (en) 1993-05-13
IL85823A0 (en) 1988-09-30
CN88101660A (zh) 1988-11-09
EP0283992A2 (en) 1988-09-28
AU600107B2 (en) 1990-08-02
NO168476B (no) 1991-11-18
AU1358588A (en) 1988-09-29
DE3874576T2 (de) 1993-02-18
TNSN88025A1 (fr) 1990-07-10
NO881306D0 (no) 1988-03-24
PH25023A (en) 1991-01-28
DK168336B1 (da) 1994-03-14
DE3874576D1 (de) 1992-10-22

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Legal Events

Date Code Title Description
LAPS Cancellation because of no payment of annual fees