JPH0588232B2 - - Google Patents

Info

Publication number
JPH0588232B2
JPH0588232B2 JP60052167A JP5216785A JPH0588232B2 JP H0588232 B2 JPH0588232 B2 JP H0588232B2 JP 60052167 A JP60052167 A JP 60052167A JP 5216785 A JP5216785 A JP 5216785A JP H0588232 B2 JPH0588232 B2 JP H0588232B2
Authority
JP
Japan
Prior art keywords
dimethoxy
benzo
thiophene
formula
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP60052167A
Other languages
English (en)
Japanese (ja)
Other versions
JPS60209577A (ja
Inventor
Retsudopasu Jeimuzu
Toomasu Roogan Robaato
Buranton Makufuazen Deiuitsudo
Gibuson Roi Robaato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo NV
Original Assignee
Akzo NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo NV filed Critical Akzo NV
Publication of JPS60209577A publication Critical patent/JPS60209577A/ja
Publication of JPH0588232B2 publication Critical patent/JPH0588232B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP60052167A 1984-03-16 1985-03-15 ベンゾチオフェン誘導体 Granted JPS60209577A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8406906 1984-03-16
GB848406906A GB8406906D0 (en) 1984-03-16 1984-03-16 Benzo-thiazole and benzothiophene derivatives

Publications (2)

Publication Number Publication Date
JPS60209577A JPS60209577A (ja) 1985-10-22
JPH0588232B2 true JPH0588232B2 (OSRAM) 1993-12-21

Family

ID=10558202

Family Applications (1)

Application Number Title Priority Date Filing Date
JP60052167A Granted JPS60209577A (ja) 1984-03-16 1985-03-15 ベンゾチオフェン誘導体

Country Status (14)

Country Link
US (2) US4665206A (OSRAM)
EP (1) EP0158380B1 (OSRAM)
JP (1) JPS60209577A (OSRAM)
KR (1) KR870000920B1 (OSRAM)
AU (1) AU568428B2 (OSRAM)
CA (1) CA1254216A (OSRAM)
DE (1) DE3567459D1 (OSRAM)
DK (1) DK119285A (OSRAM)
ES (4) ES8707223A1 (OSRAM)
FI (1) FI80883C (OSRAM)
GB (1) GB8406906D0 (OSRAM)
HU (1) HU198030B (OSRAM)
IE (1) IE57977B1 (OSRAM)
ZA (1) ZA851807B (OSRAM)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE58555B1 (en) * 1984-12-10 1993-10-06 Warner Almbert Company Novel benzothiophenes and benzofurans having antiallergy activity
EP0253650A3 (en) * 1986-07-18 1989-09-13 Eli Lilly And Company Improvements relating to benzothiophene derivatives
US4873259A (en) * 1987-06-10 1989-10-10 Abbott Laboratories Indole, benzofuran, benzothiophene containing lipoxygenase inhibiting compounds
US4822809A (en) * 1987-11-13 1989-04-18 Abbott Laboratories Benzazole lipoxygenase inhibiting compounds
US4882354A (en) * 1987-12-16 1989-11-21 Norwich Eaton Pharmaceuticals, Inc. N-hydroxy-5-phenyl-2-furancarboximidamides useful as cardiotonic agents
EP0352832B1 (en) * 1988-07-05 1992-05-06 Akzo N.V. Compounds with bronchodilator activity
IE913683A1 (en) * 1990-10-26 1992-05-22 Akzo Nv USE OF A BENZO[b]THIOPHENE-2-CARBOXIMIDAMIDE DERIVATIVE
US5276052A (en) * 1990-10-26 1994-01-04 Akzo N.V. Use of a benzo[b]thiopene-2-carboximidamide derivative
DE4128871A1 (de) * 1991-08-30 1993-03-04 Boehringer Mannheim Gmbh Benzo(b)thiophenderivate, verfahren zu ihrer herstellung und arzneimittel
US5340833A (en) * 1992-05-01 1994-08-23 Eisai Co., Ltd. Urokinase inhibitors
US5436246A (en) * 1992-09-17 1995-07-25 Merrell Dow Pharmaceuticals Inc. Serotonin receptor agents
WO1995027710A1 (en) * 1994-04-11 1995-10-19 Chugai Seiyaku Kabushiki Kaisha 4,6-DI-t-BUTYL-2,3-DIHYDROBENZOTHIOPHENE DERIVATIVE
US5703116A (en) * 1995-04-18 1997-12-30 Geron Corporation Telomerase Inhibitors
US5863936A (en) * 1995-04-18 1999-01-26 Geron Corporation Telomerase inhibitors
US5760062A (en) * 1995-04-18 1998-06-02 Geron Corporation Telomerase inhibitors
US5656638A (en) * 1995-04-18 1997-08-12 Geron Corporation Telomerase inhibitors
US5770613A (en) * 1995-09-29 1998-06-23 Geron Corporation Telomerase inhibitors
US5767278A (en) * 1995-10-06 1998-06-16 Geron Corporation Telomerase inhibitors
CZ297324B6 (cs) * 1996-12-13 2006-11-15 Shionogi & Co., Ltd. Benzothiofenkarboxamidové deriváty a antagonisty PGD2, které je obsahují
US6362216B1 (en) 1998-10-27 2002-03-26 Array Biopharma Inc. Compounds which inhibit tryptase activity
SI1212089T1 (sl) 1999-08-21 2006-08-31 Altana Pharma Ag Sinergisticna kombinacija roflumilasta in salmeterola
WO2002094320A1 (en) 2001-05-23 2002-11-28 Tanabe Seiyaku Co., Ltd. Therapeutic compositions for repairing chondropathy
CA2447619A1 (en) 2001-05-23 2002-11-28 Tanabe Seiyaku Co., Ltd. A composition for accelerating bone fracture healing
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
JP2006522151A (ja) 2003-04-01 2006-09-28 アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ 不妊症におけるホスホジエステラーゼ阻害剤
US7935724B2 (en) 2003-10-09 2011-05-03 Merck Hdac Research, Llc Thiophene and benzothiophene hydroxamic acid derivatives
WO2006101454A1 (en) * 2005-03-21 2006-09-28 S*Bio Pte Ltd Benzothiophene derivatives: preparation and pharmaceutical applications
MY148644A (en) * 2005-07-18 2013-05-15 Orion Corp New pharmaceutical compounds
US20090221564A1 (en) * 2006-02-21 2009-09-03 Trigen Limited Heterocyclic Compounds and Their Use in the Treatment of Cardiovascular Disease
EP2079694B1 (en) 2006-12-28 2017-03-01 Rigel Pharmaceuticals, Inc. N-substituted-heterocycloalkyloxybenzamide compounds and methods of use
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
JP6251038B2 (ja) 2011-03-01 2017-12-20 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼｃアゴニストの調製方法
US9545446B2 (en) 2013-02-25 2017-01-17 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
US9486494B2 (en) 2013-03-15 2016-11-08 Synergy Pharmaceuticals, Inc. Compositions useful for the treatment of gastrointestinal disorders
CA2905438A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
JP6606491B2 (ja) 2013-06-05 2019-11-13 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼｃの超高純度アゴニスト、その作成および使用方法
AU2014305843B2 (en) 2013-08-09 2019-08-29 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport
US20200368223A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Methods for inhibiting phosphate transport
CN111296447B (zh) * 2020-03-24 2021-09-17 东营施普瑞石油工程技术有限公司 一种油田用杀菌剂及其制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB438211A (en) * 1934-06-01 1935-11-13 Ig Farbenindustrie Ag The manufacture of heterocyclic compounds
US2775593A (en) * 1948-10-01 1956-12-25 Schenley Ind Inc Thiosemicarbazones of aldehydes and ketones of the heterocyclic series
GB1231170A (OSRAM) * 1967-12-15 1971-05-12
BE759237A (fr) * 1969-11-21 1971-05-01 Montedison Spa Procede de preparation d'amides a partir de composes heterocycliques azotes
BE786520A (fr) * 1971-07-23 1973-01-22 Bayer Ag Nouveaux benzothiazoles substitues, leur preparation et leur application comme fongicides et bactericides
DE2258036A1 (de) * 1972-11-27 1974-05-30 Goedecke Ag Verfahren zur herstellung von benzo eckige klammer auf b eckige klammer zu thiophen-derivaten
FR2305982A1 (fr) * 1975-04-03 1976-10-29 Innothera Lab Sa Nouvelles benzothienyl amino (propyl et butyl) cetones, leur procede de preparation et leur application en therapeutique
CH636866A5 (de) * 1977-08-15 1983-06-30 Lilly Co Eli Thiadiazolylbenzamide und sie enthaltende insektizide mittel.
US4140785A (en) * 1978-05-08 1979-02-20 E. I. Du Pont De Nemours And Company N-(benzothienopyrazol)amide antirhinoviral agents
JPS5936670A (ja) * 1982-08-25 1984-02-28 Takeda Chem Ind Ltd ベンゾチアゾ−ル誘導体，その製造法およびそれを含有する摂食抑制剤

Also Published As

Publication number Publication date
ES8704925A1 (es) 1987-04-16
GB8406906D0 (en) 1984-04-18
KR850006391A (ko) 1985-10-05
JPS60209577A (ja) 1985-10-22
ES8707223A1 (es) 1987-07-16
IE57977B1 (en) 1993-06-02
HU198030B (en) 1989-07-28
FI80883B (fi) 1990-04-30
ES8704924A1 (es) 1987-04-16
DE3567459D1 (en) 1989-02-16
ES8704926A1 (es) 1987-04-16
FI80883C (fi) 1990-08-10
ES551281A0 (es) 1987-04-16
IE850592L (en) 1985-09-16
DK119285A (da) 1985-09-17
ES551280A0 (es) 1987-04-16
FI851038L (fi) 1985-09-17
US4665206A (en) 1987-05-12
EP0158380B1 (en) 1989-01-11
ZA851807B (en) 1985-10-30
US4929636A (en) 1990-05-29
FI851038A0 (fi) 1985-03-15
ES541336A0 (es) 1987-07-16
EP0158380A1 (en) 1985-10-16
HUT37410A (en) 1985-12-28
AU3985285A (en) 1985-09-19
CA1254216A (en) 1989-05-16
AU568428B2 (en) 1987-12-24
ES551282A0 (es) 1987-04-16
KR870000920B1 (ko) 1987-05-07
DK119285D0 (da) 1985-03-15

Similar Documents

Publication Publication Date Title
JPH0588232B2 (OSRAM)
US4675332A (en) Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents
KR900003496B1 (ko) 티에닐 축합 피라졸 유도체의 제조방법
JP3435411B2 (ja) 心不整脈の治療のためのベンゾイルベンゾフラン誘導体
US4703053A (en) Benzothiophenes and benzofurans and antiallergic use thereof
US4163794A (en) 2,3-Dihydro-6,7-disubstituted-5-furoyl benzofuran-2-carboxylic acids
JPS582936B2 (ja) ５↓−アロイルピロ−ル酢酸およびその塩類の製法
IE912595A1 (en) Derivatives of benzofuran, benzothiophene, indole and¹indolizine, process for their preparation as well as the¹compositions containing them
FI80691B (fi) Foerfarande foer framstaellning av bensotiofener och bensofuraner med antiallergisk aktivitet.
PL219848B1 (pl) Pochodne benzofuranu lub benzotiofenu, sposób wytwarzania pochodnych benzofuranu lub benzotiofenu, lek, środek farmaceutyczny lub weterynaryjny i zastosowanie pochodnych benzofuranu lub benzotiofenu
AU2006271631B2 (en) New pharmaceutical compounds
US4181727A (en) 2,3-Dihydro-6,7-disubstituted-5-acyl benzofuran-2-carboxylic acids
US4401669A (en) 2,3-Dihydro-substituted-5-benzoyl benzofuran-2-carboxylic acids and their use in treating hypertension
AU617489B2 (en) Pyridazinone derivatives
JPH10237073A (ja) 新規な置換グアニジン誘導体およびその製法
AU2001248340B2 (en) Method for producing benzo annelated heterocycles
IT8347666A1 (it) "Derivati del benzotiofene, loro preparazione e loro impiego come medicamenti".
US6093710A (en) Benzothiophene derivatives, their preparation and use as urokinase inhibitors
IE902836A1 (en) Substituted dibenzofurans and methods of using same
FI69461B (fi) Analogifoerfarande foer framstaellning av nya saosom laekemedelsaktivaemnen anvaendbara bensotiofen-2-on-3-karboxamider
HU217822B (hu) Eljárás 3-benzoil-2-(4-hidroxi-fenil)-benzo[béta]tiofén-származékok előállítására
US6034252A (en) Substituted thienocycloalkylpyrazoles: dopamine receptor subtype specific ligands
JPH0699427B2 (ja) 新規なベンゾチオフェン
KR20080011652A (ko) 디벤즈옥세핀 유도체의 제조 방법