ES2173182T3 - Derivado de 4,6-dl-butil-2,3-dihidrobenzotiofenos como antioxidantes de ldl. - Google Patents

Derivado de 4,6-dl-butil-2,3-dihidrobenzotiofenos como antioxidantes de ldl.

Info

Publication number
ES2173182T3
ES2173182T3 ES95914557T ES95914557T ES2173182T3 ES 2173182 T3 ES2173182 T3 ES 2173182T3 ES 95914557 T ES95914557 T ES 95914557T ES 95914557 T ES95914557 T ES 95914557T ES 2173182 T3 ES2173182 T3 ES 2173182T3
Authority
ES
Spain
Prior art keywords
optionally substituted
alkyl group
hydrogen atom
atom
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95914557T
Other languages
English (en)
Inventor
Yoshiaki Kato
Akira Ishikawa
Kunio Tamura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2173182T3 publication Critical patent/ES2173182T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C333/02—Monothiocarbamic acids; Derivatives thereof
    • C07C333/04—Monothiocarbamic acids; Derivatives thereof having nitrogen atoms of thiocarbamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/58—Radicals substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE PRESENTA UN COMPUESTO REPRESENTADO POR LA FORMULA (I): DONDE R{SUB,1} REPRESENTA UN ATOMO DE HIDROGENO, UN GRUPO ALQUILO INFERIOR, O UN GRUPO ACILO; R{SUB,2} Y R{SUB,3}, QUE PUEDEN SER IGUALES O DIFERENTES ENTRE SI, REPRESENTAN CADA UNO UN ATOMO DE HIDROGENO, UN GRUPO ALQUILO OPCIONALMENTE SUSTITUIDO, O UN GRUPO ALQUENILO OPCIONALMENTE SUSTITUIDO; R{SUB,4} REPRESENTA UN ATOMO DE HIDROGENO, UN GRUPO ALQUILO OPCIONALMENTE SUSTITUIDO, O UN GRUPO ALQUENILO OPCIONALMENTE SUSTITUIDO, O R{SUB,4} FORMA UN ENLACE DOBLE ENTRE EL ATOMO DE CARBONO AL QUE ESTA UNIDO R{SUB,3}, Y EL ATOMO DE CARBONO ADYACENTE, PARA FORMAR UN ESQUELETO DE BENZOTIOFENO; O R{SUB,3} Y R{SUB,4} CONJUNTAMENTE, FORMAN UN ESPIROCICLO DE 5 A 8 MIEMBROS, QUE PUEDE CONTENER UN HETEROATOMO, P.EJ. OXIGENO, AZUFRE O NITROGENO; Y N REPRESENTA UN ENTERO DE 0 A 2, O UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL MISMO. EL COMPUESTO DE FORMULA (I), PRESENTA UNA ACCION INHIBIDORA DE LA MODIFICACION OXIDATIVA DE LAS LDL, Y ES UTIL COMO AGENTE TERAPEUTICO DE LA ARTERIOSCLEROSIS.
ES95914557T 1994-04-11 1995-04-11 Derivado de 4,6-dl-butil-2,3-dihidrobenzotiofenos como antioxidantes de ldl. Expired - Lifetime ES2173182T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10736594 1994-04-11

Publications (1)

Publication Number Publication Date
ES2173182T3 true ES2173182T3 (es) 2002-10-16

Family

ID=14457243

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95914557T Expired - Lifetime ES2173182T3 (es) 1994-04-11 1995-04-11 Derivado de 4,6-dl-butil-2,3-dihidrobenzotiofenos como antioxidantes de ldl.

Country Status (8)

Country Link
US (1) US5789436A (es)
EP (1) EP0791589B1 (es)
CN (1) CN1073563C (es)
AT (1) ATE214059T1 (es)
AU (1) AU683552B2 (es)
DE (1) DE69525763T2 (es)
ES (1) ES2173182T3 (es)
WO (1) WO1995027710A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW565558B (en) * 1995-11-09 2003-12-11 Chugai Pharmaceutical Co Ltd Intimal thickening inhibitory agent
DE19548708A1 (de) * 1995-12-23 1997-06-26 Merck Patent Gmbh Cyclische Sulfone
AU2791897A (en) * 1996-06-26 1998-01-14 Chugai Seiyaku Kabushiki Kaisha Remedies for renal diseases and organ-preserving agents
KR20010012189A (ko) * 1997-05-08 2001-02-15 나가야마 오사무 동맥경화증의 예방ㆍ치료제
TW472051B (en) 1997-05-23 2002-01-11 Chugai Pharmaceutical Co Ltd 2,3-dihydrobenzofuran derivatives
ES2174538T3 (es) * 1997-11-28 2002-11-01 Knoll Ag Procedimiento para la obtencion de substancias exentas de disolventes, no cristalinas, biologicamente activas.
AU3053199A (en) 1998-04-01 1999-10-25 Ono Pharmaceutical Co. Ltd. Fused thiophene derivatives and drugs containing the same as the active ingredient
DE10038709A1 (de) * 2000-08-09 2002-02-28 Aventis Pharma Gmbh Substituierte und unsubstituierte Benzooxathiazole sowie daraus abgeleitete Verbindungen
EP1362854B1 (en) * 2001-02-22 2007-10-31 Teijin Pharma Limited Benzo[b[thiophene derivatives and process for producing the same
US20050159476A1 (en) * 2002-03-29 2005-07-21 Chugai Seiyaku Kabushiki Kaisha Pharmaceutical composition for preventing or treating respiratory disease
CN102391521B (zh) * 2011-06-30 2013-08-21 北京林业大学 一种改性碱木质素及其制备方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3530146A (en) * 1968-07-01 1970-09-22 American Cyanamid Co Substituted benzothiophendione compounds
JPS505356A (es) * 1973-05-30 1975-01-21
GB1456323A (en) * 1974-06-06 1976-11-24 Labaz Benzothiophenes process for preparing them and pharmaceutical compositions containing the same
US4001426A (en) * 1974-10-17 1977-01-04 Smithkline Corporation Substituted benzofurans and benzothiophenes
US4224330A (en) * 1979-09-13 1980-09-23 Zoecon Corporation Esters and thiolesters of benzothienyl acids
JPS5646879A (en) * 1979-09-25 1981-04-28 Takeda Chem Ind Ltd Spiro compound, its preparation, and preventive and remedy for circulatory system disorder
US4436748A (en) * 1980-10-20 1984-03-13 Hoechst-Roussel Pharmaceuticals Inc. Benzo[b]thiophenes
US4418068A (en) * 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
US4521320A (en) * 1983-10-21 1985-06-04 Ciba Geigy Corporation Thiocarbamate stabilizers
EP0150966B1 (en) * 1984-01-26 1989-07-12 FISONS plc Benzopyran derivatives, compositions containing them and processes for their preparation
GB8402047D0 (en) * 1984-01-26 1984-02-29 Fisons Plc Nitrogen heterocycles
GB8406906D0 (en) * 1984-03-16 1984-04-18 Akzo Nv Benzo-thiazole and benzothiophene derivatives
GB8417559D0 (en) * 1984-07-10 1984-08-15 Pfizer Ltd Anti-diarrhoeal agents
US5112852A (en) * 1986-12-23 1992-05-12 Merrell Dow Pharmaceuticals Inc. Allenyl amines
ATE79876T1 (de) * 1988-03-16 1992-09-15 Ciba Geigy Ag Thioverbindungen.
US4963580A (en) * 1988-10-18 1990-10-16 Merck & Co., Inc. Substituted 5-hydroxy-2,3-dihydrobenzothiophenes as inhibitors of leukotriene biosynthesis
GB2224028A (en) * 1988-10-18 1990-04-25 Merck & Co Inc Substituted 5-hydroxy-2,3-dihydrobenzothiophenes as inhibitors of leukotriene biosynthesis
JPH02121975A (ja) * 1988-10-28 1990-05-09 Eisai Co Ltd ２，３−ジヒドロベンゾフラン誘導体
DE4115184A1 (de) * 1991-05-09 1992-11-12 Bayer Ag Benzothiophen-2-carboxamid-s,s-dioxide
FR2681324B1 (fr) * 1991-09-18 1993-10-29 Adir Cie Nouveaux derives de la trimetazidine, leur procede de preparation et les compositions pharmaceutiques les contenant.
DE4204969A1 (de) * 1992-02-19 1993-08-26 Basf Ag Verfahren zur herstellung von benzo(b)thiophenen
EP0639573A1 (de) * 1993-08-03 1995-02-22 Hoechst Aktiengesellschaft Benzokondensierte 5-Ringheterocyclen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, ihre Verwendung als Diagnostikum, sowie sie enthaltendes Medikament

Also Published As

Publication number Publication date
DE69525763D1 (de) 2002-04-11
CN1073563C (zh) 2001-10-24
EP0791589A1 (en) 1997-08-27
EP0791589A4 (es) 1997-08-27
WO1995027710A1 (fr) 1995-10-19
ATE214059T1 (de) 2002-03-15
AU2148595A (en) 1995-10-30
EP0791589B1 (en) 2002-03-06
DE69525763T2 (de) 2002-10-02
CN1148386A (zh) 1997-04-23
AU683552B2 (en) 1997-11-13
US5789436A (en) 1998-08-04

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