JPH0587071B2 - - Google Patents

Info

Publication number
JPH0587071B2
JPH0587071B2 JP62228679A JP22867987A JPH0587071B2 JP H0587071 B2 JPH0587071 B2 JP H0587071B2 JP 62228679 A JP62228679 A JP 62228679A JP 22867987 A JP22867987 A JP 22867987A JP H0587071 B2 JPH0587071 B2 JP H0587071B2
Authority
JP
Japan
Prior art keywords
alkyl
formula
substituted
cycloalkyl
parts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP62228679A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6485975A (en
Inventor
Heruman Marugareeta Arufuonsu
Jan Etogaruto Furaine Edei
Sharuru San Jeraaru
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of JPS6485975A publication Critical patent/JPS6485975A/ja
Publication of JPH0587071B2 publication Critical patent/JPH0587071B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP62228679A 1986-09-15 1987-09-14 Novel (1h-imidazole-1-ylmethyl) substituted benzimidazole derivative Granted JPS6485975A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US90790386A 1986-09-15 1986-09-15

Publications (2)

Publication Number Publication Date
JPS6485975A JPS6485975A (en) 1989-03-30
JPH0587071B2 true JPH0587071B2 (OSRAM) 1993-12-15

Family

ID=25424835

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62228679A Granted JPS6485975A (en) 1986-09-15 1987-09-14 Novel (1h-imidazole-1-ylmethyl) substituted benzimidazole derivative

Country Status (23)

Country Link
EP (1) EP0260744B1 (OSRAM)
JP (1) JPS6485975A (OSRAM)
KR (1) KR960014353B1 (OSRAM)
CN (1) CN1020903C (OSRAM)
AU (1) AU595064B2 (OSRAM)
BG (1) BG61321B2 (OSRAM)
CA (1) CA1323366C (OSRAM)
CY (1) CY1803A (OSRAM)
DE (1) DE3783107T2 (OSRAM)
DK (1) DK174728B1 (OSRAM)
ES (1) ES2053524T3 (OSRAM)
FI (1) FI87781C (OSRAM)
GR (1) GR3006841T3 (OSRAM)
HK (1) HK123694A (OSRAM)
HU (1) HU198039B (OSRAM)
IE (1) IE60514B1 (OSRAM)
IL (1) IL83892A (OSRAM)
NO (1) NO167202C (OSRAM)
NZ (1) NZ221729A (OSRAM)
PH (1) PH25022A (OSRAM)
PT (1) PT85692B (OSRAM)
SU (1) SU1662350A3 (OSRAM)
ZA (1) ZA876881B (OSRAM)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
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US4826862A (en) * 1988-02-12 1989-05-02 Janssen Pharmaceutica, N.V. Anthelminthic [(5(6) (1H-azole-1-ylmethyl)benzimidazole]carbamates
GB8827820D0 (en) * 1988-11-29 1988-12-29 Janssen Pharmaceutica Nv (1h-azol-1-ylmethyl)substituted quinoline derivatives
CA2002859C (en) * 1988-11-29 1998-12-29 Jean P. F. Van Wauwe Method of treating epithelial disorders
CA2002864C (en) * 1988-11-29 1999-11-16 Eddy J. E. Freyne (1h-azol-1-ylmethyl) substituted quinoline, quinazoline or quinoxaline derivatives
FR2643903A1 (fr) * 1989-03-03 1990-09-07 Union Pharma Scient Appl Nouveaux derives de benzimidazole, leurs procedes de preparation, intermediaires de synthese, compositions pharmaceutiques les contenant, utiles notamment pour le traitement des maladies cardiovasculaires, et des ulceres duodenaux
PT95899A (pt) * 1989-11-17 1991-09-13 Glaxo Group Ltd Processo para a preparacao de derivados indole
US5021448A (en) * 1990-02-22 1991-06-04 Ciba-Geigy Corporation Method of reducing serum uric acid and/or increasing renal uric acid clearance with thromboxane synthetase inhibitor inhibitor and/or thromboxane receptor antagonist
FR2663028B1 (fr) * 1990-06-08 1994-10-14 Roussel Uclaf Nouveaux derives de benzimidazole, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
US5216003A (en) * 1992-01-02 1993-06-01 G. D. Searle & Co. Diacid-containing benzimidazole compounds for treatment of neurotoxic injury
WO1995004723A1 (en) * 1993-08-04 1995-02-16 Yamanouchi Pharmaceutical Co., Ltd. Imidazolylalkylamine derivative and pharmaceutical composition thereof
FI961418L (fi) * 1993-09-30 1996-03-29 Yamanouchi Pharma Co Ltd Atsolijohdannainen ja sen farmaseuttinen seos
AU689206B2 (en) * 1994-02-18 1998-03-26 Janssen Pharmaceutica N.V. Enantiomerically pure (+)-liarozole
TW418203B (en) * 1994-02-18 2001-01-11 Janssen Pharmaceutica Nv Enantiomerically pure (-)-liarozole
GB9418443D0 (en) * 1994-09-13 1994-11-02 Pfizer Ltd Therapeutic agents
US6696459B1 (en) 1994-12-22 2004-02-24 Ligand Pharmaceuticals Inc. Steroid receptor modulator compounds and methods
US5696127A (en) * 1994-12-22 1997-12-09 Ligand Pharmaceuticals Incorporated Steroid receptor modulator compounds and methods
EP1043325B1 (en) * 1994-12-22 2004-06-16 Ligand Pharmaceuticals Incorporated Steroid receptor modulator compounds and methods
TW316902B (OSRAM) * 1994-12-28 1997-10-01 Janssen Pharmaceutica Nv
NZ302392A (en) * 1995-03-01 1998-08-26 Yamanouchi Pharma Co Ltd Tricyclic substituted imidazole derivatives and medicaments thereof
US6288100B1 (en) * 1995-06-06 2001-09-11 American Home Products Corporation Benzimidazole derivatives
DE19535500A1 (de) * 1995-09-25 1997-03-27 Bayer Ag Verfahren zur Herstellung von 3-Chlor-3'-nitro-4'-methoxybenzophenon
TR199801249T2 (xx) * 1995-12-28 1998-10-21 Fujisawa Pharmaceutical Co,Ltd. Benzimidazol t�revleri.
CZ297769B6 (cs) 1996-06-27 2007-03-28 Janssen Pharmaceutica N. V. N-[4-(heteroarylmetyl)fenyl]-heteroarylaminy, zpusob jejich prípravy a jejich pouzití jako léciva
FR2751649B1 (fr) * 1996-07-26 1998-08-28 Adir Nouveaux derives de benzimidazole, de benzoxazole et de benzothiazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
IT1286866B1 (it) * 1996-10-28 1998-07-17 Menarini Farma Ind Composti furano-eterociclici,loro preparazione ed uso come inibitori di aromatasi
IL130077A0 (en) * 1996-11-25 2000-02-29 Procter & Gamble Guanidinyl heterocycle compounds useful as alpha-2 adrenoceptor agonists
CA2281598A1 (en) 1997-02-21 1998-08-27 Tetsuya Aono Fused ring compounds, process for producing the same and use thereof
TW453999B (en) 1997-06-27 2001-09-11 Fujisawa Pharmaceutical Co Benzimidazole derivatives
DE69824885T2 (de) 1997-12-11 2005-07-21 Janssen Pharmaceutica N.V. Anilide als vitamin-a-säure-mimetika
DE19831985A1 (de) 1998-07-16 2000-01-20 Bayer Ag Substituierte Benzimidazole, ihre Herstellung und ihre Verwendung als Mittel gegen parasitäre Protozoen
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
WO2000075117A1 (en) * 1999-06-04 2000-12-14 Elan Pharma International Ltd. Compositions and methods for inhibiting cell death
CA2401502C (en) 2000-03-16 2010-09-21 F. Hoffmann-La Roche Ag Carboxylic acid derivatives as ip antagonists
CA2429133C (en) 2000-11-17 2009-08-18 Takeda Chemical Industries, Ltd. Novel imidazole derivatives, production method thereof and use thereof
US6960586B2 (en) 2000-11-20 2005-11-01 Takeda Pharmaceutical Company Limited Imidazole derivatives, process for their preparation and their use
ATE440096T1 (de) 2000-12-08 2009-09-15 Takeda Pharmaceutical Substituierte thiazolderivate mit 3- pyridylgruppen, verfahren zu deren herstellung und deren verwendung
US7405235B2 (en) 2001-05-04 2008-07-29 Paratek Pharmaceuticals, Inc. Transcription factor modulating compounds and methods of use thereof
US6492517B1 (en) * 2001-07-19 2002-12-10 Air Products And Chemicals, Inc. Method for preparing halomethyl heterocyclic compounds
US7253154B2 (en) * 2001-11-16 2007-08-07 Nippon Chemiphar Co., Ltd. Substituted thiazolopyrimidines as xanthine oxidase inhibitors
EP1558341A4 (en) * 2002-11-01 2010-09-08 Paratek Pharm Innc TRANSCRIPTION FACTOR MODULATING CONNECTIONS AND THEIR USE
US20060148893A1 (en) * 2003-06-10 2006-07-06 Blanc Jean-Baptiste E Chemical compounds
FR2860235A1 (fr) * 2003-09-29 2005-04-01 Yang Ji Chemical Company Ltd Utilisation d'un compose de formule (i) inhibiteur de l'aromatase a des fins therapeutiques et composes de formule (i) en tant que tels
JP2008504233A (ja) 2004-04-23 2008-02-14 パラテック ファーマシューティカルズ インコーポレイテッド 転写因子調節化合物およびその使用法
EP1812406B1 (en) * 2004-09-30 2018-09-12 Janssen Pharmaceutica N.V. Novel benzimidazole derivatives useful as selective androgen receptor modulators (sarms)
WO2006039243A1 (en) 2004-09-30 2006-04-13 Janssen Pharmaceutica N.V. Novel benzimidazole derivatives useful as selective androgen receptor modulators (sarms)
AU2007208139B2 (en) * 2006-01-24 2012-09-27 Janssen Pharmaceutica N.V. 2-substituted benzimidazoles as selective androgen receptor modulators (sarms)
EP2295432A1 (en) 2006-02-10 2011-03-16 TransTech Pharma Inc. Process for the preparation of aminobenzimidazole derivatives
KR101307497B1 (ko) * 2006-04-19 2013-09-11 주식회사 동진쎄미켐 디이미다졸계 화합물 및 이를 이용한 유기발광소자
CN100496308C (zh) * 2006-06-02 2009-06-10 上海烟草（集团）公司 造纸法再造烟叶半逆流多级萃取工艺
EP1992228A1 (en) * 2007-05-14 2008-11-19 Bayer CropScience AG Insecticidal substituted thiourea derivatives
BRPI0811783A2 (pt) * 2007-05-23 2014-11-11 Allergan Inc Compostos de ((heteroarila bicíclica)imidazolil)metil-heteroarila como agonistas dos receptores adrenérgicos.
DE102009038950A1 (de) 2009-08-26 2011-03-03 Bayer Animal Health Gmbh Neue antiparasitäre Kombination von Wirkstoffen
EP2630136A1 (en) * 2010-10-21 2013-08-28 Universität des Saarlandes Selective cyp11b1 inhibitors for the treatment of cortisol dependent diseases
CA2850508A1 (en) * 2011-09-30 2013-04-04 Endo Pharmaceuticals Inc. Imidazole derivatives as cyp17 inhibitors for the treatment of cancer
US9199975B2 (en) 2011-09-30 2015-12-01 Asana Biosciences, Llc Biaryl imidazole derivatives for regulating CYP17
KR101884447B1 (ko) * 2015-07-06 2018-08-01 삼성에스디아이 주식회사 모노머, 유기막 조성물, 유기막, 및 패턴형성방법
US20240417486A1 (en) * 2021-10-04 2024-12-19 Bolt Biotherapeutics, Inc. Asymmetric bis-benzimidazole sting agonist immunoconjugates and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR75101B (OSRAM) * 1980-10-23 1984-07-13 Pfizer
GB8307865D0 (en) * 1983-03-22 1983-04-27 Fujisawa Pharmaceutical Co Benzimidazole derivatives
EP0178413A1 (en) * 1984-08-17 1986-04-23 Beecham Group Plc Benzimidazoles

Also Published As

Publication number Publication date
GR3006841T3 (OSRAM) 1993-06-30
CN87106423A (zh) 1988-04-20
KR960014353B1 (ko) 1996-10-15
CN1020903C (zh) 1993-05-26
DE3783107D1 (de) 1993-01-28
PH25022A (en) 1991-01-28
PT85692B (pt) 1990-06-29
FI873977A0 (fi) 1987-09-14
IL83892A0 (en) 1988-02-29
EP0260744A2 (en) 1988-03-23
IE872487L (en) 1988-03-15
FI873977A7 (fi) 1988-03-16
DE3783107T2 (de) 1993-04-22
SU1662350A3 (ru) 1991-07-07
ES2053524T3 (es) 1994-08-01
NO167202C (no) 1991-10-16
DK479487D0 (da) 1987-09-14
HK123694A (en) 1994-11-18
PT85692A (en) 1987-10-01
DK174728B1 (da) 2003-10-06
NO873840D0 (no) 1987-09-14
KR880003935A (ko) 1988-06-01
CY1803A (en) 1987-09-09
JPS6485975A (en) 1989-03-30
AU7838587A (en) 1988-04-14
NZ221729A (en) 1989-07-27
BG61321B2 (bg) 1997-05-30
IL83892A (en) 1991-11-21
EP0260744A3 (en) 1989-01-18
FI87781C (fi) 1993-02-25
DK479487A (da) 1988-03-16
NO873840L (no) 1988-03-16
CA1323366C (en) 1993-10-19
AU595064B2 (en) 1990-03-22
IE60514B1 (en) 1994-07-27
ZA876881B (en) 1989-04-26
FI87781B (fi) 1992-11-13
EP0260744B1 (en) 1992-12-16
HU198039B (en) 1989-07-28
HUT45051A (en) 1988-05-30
NO167202B (no) 1991-07-08

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