JPH0251908B2 - - Google Patents

Info

Publication number
JPH0251908B2
JPH0251908B2 JP63135365A JP13536588A JPH0251908B2 JP H0251908 B2 JPH0251908 B2 JP H0251908B2 JP 63135365 A JP63135365 A JP 63135365A JP 13536588 A JP13536588 A JP 13536588A JP H0251908 B2 JPH0251908 B2 JP H0251908B2
Authority
JP
Japan
Prior art keywords
trifluoroethoxy
bis
mixture
reaction
product
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP63135365A
Other languages
English (en)
Japanese (ja)
Other versions
JPH01104044A (ja
Inventor
Emu Riaa Chaarusu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Riker Laboratories Inc
Original Assignee
Riker Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Riker Laboratories Inc filed Critical Riker Laboratories Inc
Publication of JPH01104044A publication Critical patent/JPH01104044A/ja
Publication of JPH0251908B2 publication Critical patent/JPH0251908B2/ja
Granted legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00Ethers; Compounds having groups, groups or groups
    • C07C43/02Ethers
    • C07C43/20Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/225Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46Friedel-Crafts reactions
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP63135365A 1979-03-19 1988-06-01 2,5−ビス(2,2,2,−トリフルオロエトキシ)−n−(2−ピペリジルメチル)ベンザミドの製造方法 Granted JPH01104044A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US2133179A 1979-03-19 1979-03-19
US2133279A 1979-03-19 1979-03-19
US21331 1979-03-19
US21332 1979-03-19

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP3467180A Division JPS55143967A (en) 1979-03-19 1980-03-18 Manufacture of 2*55bis*2*2*22trifluoroethoxy** nn*22piperidylmethyl*benzamide

Publications (2)

Publication Number Publication Date
JPH01104044A JPH01104044A (ja) 1989-04-21
JPH0251908B2 true JPH0251908B2 (pl) 1990-11-08

Family

ID=26694559

Family Applications (8)

Application Number Title Priority Date Filing Date
JP63135370A Granted JPH01125344A (ja) 1979-03-19 1988-06-01 2,5−ビス(2,2,2−トリフルオロエトキシ)安息香酸の製造方法
JP63135367A Granted JPH01125341A (ja) 1979-03-19 1988-06-01 2,5−ビス(2,2,2−トリフルオロエトキシ)アセトフェノン及びその製造方法
JP63135364A Granted JPH01104043A (ja) 1979-03-19 1988-06-01 2,5−ビス(2,2,2−トリフルオロエトキシ)−n−(2−ピペリジルメチル)ベンザミドの製造方法
JP63135366A Granted JPH01125339A (ja) 1979-03-19 1988-06-01 1,4−ビス(2,2,2−トリフルオロエトキシ)ベンゼンの製造方法
JP63135369A Granted JPH01125343A (ja) 1979-03-19 1988-06-01 2,5−ビス(2,2,2−トリフルオロエトキシ)−α,α,α−トリクロロアセトフェノン及びその製造方法
JP63135368A Granted JPH01125342A (ja) 1979-03-19 1988-06-01 2,5−ビス(2,2,2−トリフルオロエトキシ)−α,α−ジクロロアセトフェノン及びその製造方法
JP63135363A Granted JPH01104045A (ja) 1979-03-19 1988-06-01 2,5−ビス(2,2,2−トリフルオロエトキシ)−n−(2−ピペリジルメチル)ベンザミドの製造方法
JP63135365A Granted JPH01104044A (ja) 1979-03-19 1988-06-01 2,5−ビス(2,2,2,−トリフルオロエトキシ)−n−(2−ピペリジルメチル)ベンザミドの製造方法

Family Applications Before (7)

Application Number Title Priority Date Filing Date
JP63135370A Granted JPH01125344A (ja) 1979-03-19 1988-06-01 2,5−ビス(2,2,2−トリフルオロエトキシ)安息香酸の製造方法
JP63135367A Granted JPH01125341A (ja) 1979-03-19 1988-06-01 2,5−ビス(2,2,2−トリフルオロエトキシ)アセトフェノン及びその製造方法
JP63135364A Granted JPH01104043A (ja) 1979-03-19 1988-06-01 2,5−ビス(2,2,2−トリフルオロエトキシ)−n−(2−ピペリジルメチル)ベンザミドの製造方法
JP63135366A Granted JPH01125339A (ja) 1979-03-19 1988-06-01 1,4−ビス(2,2,2−トリフルオロエトキシ)ベンゼンの製造方法
JP63135369A Granted JPH01125343A (ja) 1979-03-19 1988-06-01 2,5−ビス(2,2,2−トリフルオロエトキシ)−α,α,α−トリクロロアセトフェノン及びその製造方法
JP63135368A Granted JPH01125342A (ja) 1979-03-19 1988-06-01 2,5−ビス(2,2,2−トリフルオロエトキシ)−α,α−ジクロロアセトフェノン及びその製造方法
JP63135363A Granted JPH01104045A (ja) 1979-03-19 1988-06-01 2,5−ビス(2,2,2−トリフルオロエトキシ)−n−(2−ピペリジルメチル)ベンザミドの製造方法

Country Status (14)

Country Link
JP (8) JPH01125344A (pl)
CA (1) CA1137486A (pl)
CH (1) CH643829A5 (pl)
DE (1) DE3010195A1 (pl)
DK (3) DK167062B1 (pl)
ES (1) ES8104227A1 (pl)
FR (7) FR2454438A1 (pl)
GB (2) GB2045760B (pl)
IE (1) IE49558B1 (pl)
IL (1) IL59623A (pl)
IT (1) IT1195262B (pl)
NL (1) NL191486C (pl)
PT (1) PT70967A (pl)
SE (5) SE447992B (pl)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2519980A1 (fr) * 1982-01-21 1983-07-22 Rhone Poulenc Spec Chim Procede de sulfonylation d'halogeno ou trihalogenomethylbenzenes
FR2519979A1 (fr) * 1982-01-21 1983-07-22 Rhone Poulenc Spec Chim Procede de preparation de trifluoromethoxy ou trifluoromethylthiophenylsulfones
FR2519974A1 (fr) * 1982-01-21 1983-07-22 Rhone Poulenc Spec Chim Procede d'acylation d'halogeno ou trihalogenomethylbenzenes
FR2519975A1 (fr) * 1982-01-21 1983-07-22 Rhone Poulenc Spec Chim Procede de preparation de trifluoromethoxy ou trifluoromethylthiophenylcetones
FR2525588A1 (fr) * 1982-04-22 1983-10-28 Rhone Poulenc Spec Chim Procede de preparation de phenylcetones a partir d'halogeno ou trihalogenomethylbenzenes et de composes aliphatiques ou aromatiques trihalogenomethyles
EP0175188A1 (de) * 1984-09-11 1986-03-26 Nihon Tokushu Noyaku Seizo K.K. Carbamoylimidazol-Derivate
US4675448A (en) * 1985-02-13 1987-06-23 Ethyl Corporation Chlorination process
FR2579591B1 (fr) * 1985-03-29 1988-10-14 Rhone Poulenc Spec Chim Procede de preparation de derives pentafluoroethoxy et pentafluoroethylthiobenzeniques
FR2579594B1 (fr) * 1985-03-29 1987-06-05 Rhone Poulenc Spec Chim Procede de preparation de trifluoroethoxy ou trifluoroethylthiobenzenes
DE3786037T2 (de) * 1986-04-25 1993-11-25 Abbott Lab Tracer zur Benutzung in immunologischen Fluoreszenz-Polarisationsverfahren zum Nachweis von Flecainid.
NZ219913A (en) * 1986-04-25 1990-08-28 Riker Laboratories Inc Various flecainide derivatives and antibodies raised thereto
DE3644798A1 (de) * 1986-12-31 1988-07-14 Hoechst Ag Neue nitrohaloalkoxybenzole, verfahren zu ihrer herstellung und ihre verwendung
FR2640262B1 (fr) * 1988-12-14 1991-05-31 Rhone Poulenc Chimie Procede de preparation de cetones aryliques trifluoroethoxylees
US6316627B1 (en) * 1997-04-21 2001-11-13 Fine Tech Ltd. Process for the preparation of flecainide
IL120715A (en) * 1997-04-21 2000-07-16 Finetech Ltd Process for the preparation of (2,2,2,-trifluoroethoxy)benzoic acids
IL121288A (en) 1997-07-11 2000-10-31 Finetech Ltd Process and a novel intermediate for the preparation of flecainide
US7196197B2 (en) 2003-09-17 2007-03-27 Apotex Pharmachem Inc. Process for the preparation of Flecainide, its pharmaceutically acceptable salts and important intermediates thereof
JP4894226B2 (ja) * 2005-10-31 2012-03-14 Dic株式会社 ハイドロキノン骨格を有する含フッ素液晶化合物の製造方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3539642A (en) * 1967-07-19 1970-11-10 Geigy Chem Corp 2-phenyl-2-(1-naphthyl)acetamides
US3772304A (en) * 1969-10-30 1973-11-13 Hoffmann La Roche 4-hydroxy-isoquinolines and processes for their preparation
US3719687A (en) * 1970-07-22 1973-03-06 Riker Laboratories Inc N-(2-dialkylaminoalkylene)amides of 1,1-dihydroperfluoroalkoxy-substituted aryl acids and salts thereof
US3655728A (en) 1970-07-22 1972-04-11 Riker Laboratories Inc N-(2 - dialkylaminoalkylene)-esters of fluoroalkoxy-substituted aryl carboxylic acid and salts thereof
US3967949A (en) * 1973-06-18 1976-07-06 Eli Lilly And Company Fluoroalkoxyphenyl-substituted nitrogen heterocycles as plant stunting agents
US4169108A (en) * 1973-08-16 1979-09-25 Sterling Drug Inc. 5(OR 6)-[(Substituted-amino)alkyl]-2,3-naphthalenediols
US4005209A (en) * 1974-04-01 1977-01-25 Riker Laboratories, Inc. Antiarrhythmic method utilizing fluoroalkoxy-N-piperidyl and pyridyl benzamides
US3900481A (en) * 1974-04-01 1975-08-19 Riker Laboratories Inc Derivatives of pyrrolidine and piperidine
US4013670A (en) * 1974-04-01 1977-03-22 Riker Laboratories, Inc. Derivatives of pyrrolidine and piperidine
IL49803A (en) * 1975-06-28 1979-11-30 Fisons Ltd Preparation of pyrogallol
DE2616478C2 (de) * 1976-04-14 1986-05-22 Brickl, Rolf, Dr., 7951 Warthausen Fluoracylresorcine enthaltende Arzneimittel, Biocide und Kosmetika
JPS6023656B2 (ja) * 1976-09-02 1985-06-08 川研フアインケミカル株式会社 アルコキシ芳香族化合物の製造方法
US4071524A (en) * 1976-11-08 1978-01-31 Riker Laboratories, Inc. Derivatives of urea
US4097481A (en) * 1976-11-08 1978-06-27 Riker Laboratories, Inc. Tertiary amide derivatives of pyrrolidine and piperidine

Also Published As

Publication number Publication date
FR2468569A1 (fr) 1981-05-08
FR2468570B1 (pl) 1983-03-11
FR2468576B1 (pl) 1983-01-21
JPH0372212B2 (pl) 1991-11-18
DK112180A (da) 1980-09-20
SE8901532L (sv) 1989-04-27
JPH01104043A (ja) 1989-04-21
PT70967A (en) 1980-04-01
NL191486C (nl) 1995-08-04
SE463260B (sv) 1990-10-29
ES489629A0 (es) 1981-04-01
FR2468570A1 (fr) 1981-05-08
SE8901533L (sv) 1989-04-27
ES8104227A1 (es) 1981-04-01
DK164857C (da) 1993-01-18
FR2468591A1 (fr) 1981-05-08
DE3010195C2 (pl) 1990-10-25
SE463419B (sv) 1990-11-19
SE8002003L (sv) 1980-09-20
FR2468571A1 (fr) 1981-05-08
FR2468590B1 (pl) 1983-09-23
JPH022870B2 (pl) 1990-01-19
GB2097000A (en) 1982-10-27
SE8401554D0 (sv) 1984-03-21
IL59623A (en) 1983-07-31
SE8901533D0 (sv) 1989-04-27
GB2097000B (en) 1983-11-30
GB2045760B (en) 1983-05-11
JPH0339498B2 (pl) 1991-06-14
JPH01104044A (ja) 1989-04-21
JPH01125339A (ja) 1989-05-17
FR2468591B1 (pl) 1983-07-22
DK122290D0 (da) 1990-05-17
SE8401554L (sv) 1984-03-21
CA1137486A (en) 1982-12-14
DE3010195A1 (de) 1980-10-02
JPH01104045A (ja) 1989-04-21
SE8401555L (sv) 1984-03-21
NL8001551A (nl) 1980-09-23
SE447993B (sv) 1987-01-12
IT1195262B (it) 1988-10-12
JPH01125341A (ja) 1989-05-17
SE463418B (sv) 1990-11-19
IE800549L (en) 1980-09-19
JPH01125343A (ja) 1989-05-17
FR2468576A1 (fr) 1981-05-08
JPH01125344A (ja) 1989-05-17
IL59623A0 (en) 1980-06-30
FR2468571B1 (pl) 1983-03-11
JPH01125342A (ja) 1989-05-17
DK167062B1 (da) 1993-08-23
IT8020746A0 (it) 1980-03-18
IE49558B1 (en) 1985-10-30
DK79891A (da) 1991-04-30
DK122290A (da) 1990-05-17
SE8401555D0 (sv) 1984-03-21
FR2468569B1 (pl) 1983-03-11
FR2468590A1 (fr) 1981-05-08
JPH0149695B2 (pl) 1989-10-25
JPH022869B2 (pl) 1990-01-19
SE8901532D0 (sv) 1989-04-27
NL191486B (nl) 1995-04-03
DK164857B (da) 1992-08-31
JPH0251907B2 (pl) 1990-11-08
JPH0251906B2 (pl) 1990-11-08
SE447992B (sv) 1987-01-12
DK79891D0 (da) 1991-04-30
CH643829A5 (de) 1984-06-29
FR2454438A1 (fr) 1980-11-14
GB2045760A (en) 1980-11-05
FR2454438B1 (pl) 1982-07-23

Similar Documents

Publication Publication Date Title
JPH0251908B2 (pl)
KR20090055638A (ko) 2,5-비스-(2,2,2-트리플루오로에톡시)-n-(2-피페리딜메틸)벤즈아미드 및 그 염들의 제조방법
JPS6357429B2 (pl)
NO20025652L (no) Fremgangsmåte for fremstilling av trifluoretoksysubstituerte benzosyrer
US4650873A (en) Process for the preparation of a derivative of piperidine
US4617396A (en) Process for the preparation of derivatives of piperidine
US4642384A (en) Process for the preparation of derivatives of pyrrolidine and piperidine
JP4489532B2 (ja) 3−ホルミル−5−トリフルオロメチルベンゾニトリル誘導体とその製造方法
IE49559B1 (en) Process for the preparation of 1,4-bis(2,2,2-trifluoroethoxy)benzene
JP4956760B2 (ja) 3−ブロモ安息香酸またはそのアルキルエステルの製造方法
JPH02255633A (ja) ビス(トリフルオロメチルフェニル)メタノールの製造法
JPS6210065A (ja) 4−アシルアミノピリジン類の製造法
JPS6230190B2 (pl)
JPS58185567A (ja) ピラゾ−ル誘導体の製造法