JPH0134599B2 - - Google Patents

Info

Publication number
JPH0134599B2
JPH0134599B2 JP56213193A JP21319381A JPH0134599B2 JP H0134599 B2 JPH0134599 B2 JP H0134599B2 JP 56213193 A JP56213193 A JP 56213193A JP 21319381 A JP21319381 A JP 21319381A JP H0134599 B2 JPH0134599 B2 JP H0134599B2
Authority
JP
Japan
Prior art keywords
plasmid
trp
promoter
escherichia coli
atcc
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP56213193A
Other languages
English (en)
Japanese (ja)
Other versions
JPS58110600A (ja
Inventor
Seiga Ito
Tatsuya Nishi
Tamio Mizukami
Tadashi Matsumoto
Tetsuo Oka
Koreaki Taniguchi
Haruo Sugano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to JP56213193A priority Critical patent/JPS58110600A/ja
Priority to US06/452,290 priority patent/US4686191A/en
Priority to EP82111895A priority patent/EP0083069B1/en
Priority to DE8282111895T priority patent/DE3277307D1/de
Priority to CA000418366A priority patent/CA1211059A/en
Publication of JPS58110600A publication Critical patent/JPS58110600A/ja
Publication of JPH0134599B2 publication Critical patent/JPH0134599B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/14—Lymphokine; related peptides
    • Y10S930/142—Interferon

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
JP56213193A 1981-12-25 1981-12-25 ヒトβ型インタ−フエロン遺伝子を含む組みかえ体プラスミド Granted JPS58110600A (ja)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP56213193A JPS58110600A (ja) 1981-12-25 1981-12-25 ヒトβ型インタ−フエロン遺伝子を含む組みかえ体プラスミド
US06/452,290 US4686191A (en) 1981-12-25 1982-12-22 Recombinant plasmid containing human interferon-beta gene
EP82111895A EP0083069B1 (en) 1981-12-25 1982-12-22 Recombinant plasmid containing human interferon-beta gene
DE8282111895T DE3277307D1 (en) 1981-12-25 1982-12-22 Recombinant plasmid containing human interferon-beta gene
CA000418366A CA1211059A (en) 1981-12-25 1982-12-22 RECOMBINANT PLASMID CONTAINING HUMAN INTERFERON-.beta. GENE

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56213193A JPS58110600A (ja) 1981-12-25 1981-12-25 ヒトβ型インタ−フエロン遺伝子を含む組みかえ体プラスミド

Publications (2)

Publication Number Publication Date
JPS58110600A JPS58110600A (ja) 1983-07-01
JPH0134599B2 true JPH0134599B2 (enExample) 1989-07-20

Family

ID=16635072

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56213193A Granted JPS58110600A (ja) 1981-12-25 1981-12-25 ヒトβ型インタ−フエロン遺伝子を含む組みかえ体プラスミド

Country Status (5)

Country Link
US (1) US4686191A (enExample)
EP (1) EP0083069B1 (enExample)
JP (1) JPS58110600A (enExample)
CA (1) CA1211059A (enExample)
DE (1) DE3277307D1 (enExample)

Families Citing this family (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58141796A (ja) * 1982-02-18 1983-08-23 Kyowa Hakko Kogyo Co Ltd ペプチドの製造法
AU575301B2 (en) * 1982-10-08 1988-07-28 Juridical Foundation, Japanese Foundation For Cancer Research Novel vector
JPH0740925B2 (ja) * 1983-03-14 1995-05-10 協和醗酵工業株式会社 新規ヒトインタ−フエロン−γポリペプチド
JPS59203495A (ja) * 1983-04-28 1984-11-17 Kyowa Hakko Kogyo Co Ltd 外来遺伝子の新規な発現方法
WO1985001066A1 (fr) * 1983-08-22 1985-03-14 Kyowa Hakko Kogyo Co., Ltd. Procede de production de peptides
JPS60188077A (ja) * 1984-03-09 1985-09-25 Teruhiko Beppu 仔牛プロキモシンｃＤΝＡの全配列を有する新規な発現プラスミド
DE3585176D1 (de) * 1984-06-22 1992-02-27 Hitachi Ltd Verfahren zum kontrollieren der zuechtung von rekombinanten.
FR2579224B1 (fr) * 1985-03-25 1987-05-22 Genetica Procede de preparation microbiologique de la serum-albumine humaine
DK156072C (da) * 1985-04-03 1989-11-06 Nordisk Gentofte Syntetisk dna-sekvens indeholdende et ribosombindingssted
DK174044B1 (da) 1986-12-23 2002-05-06 Kyowa Hakko Kogyo Kk Polypeptid afledt fra human granulocytkolonistimulerende faktor, og fremgangsmåde til fremstilling deraf, DNA kodende for nævnte polypeptid, rekombinant plasmid indeholdende nævnte DNA, og mikroorganismer indeholdende nævnte rekombinante plasmid.......
DE4128319A1 (de) * 1991-08-27 1993-03-04 Bioferon Biochem Substanz Neues rekombinantes human-ifn-beta, verfahren zu dessen herstellung und dieses enthaltende pharmazeutische zubereitungen
US5723125A (en) * 1995-12-28 1998-03-03 Tanox Biosystems, Inc. Hybrid with interferon-alpha and an immunoglobulin Fc linked through a non-immunogenic peptide
US6806076B1 (en) 1998-04-14 2004-10-19 Kyowa Hakko Kogyo Co., Ltd. Process for producing isoprenoid compounds by microorganisms and a method for screening compounds with antibiotic or weeding activity
WO1999063085A1 (fr) 1998-06-02 1999-12-09 Kyowa Hakko Kogyo Co., Ltd. ADN ASSOCIE A UNE GLOMERULONEPHRITE A DEPOTS MESANGIAUX D'IgA
US7144574B2 (en) 1999-08-27 2006-12-05 Maxygen Aps Interferon β variants and conjugates
US6531122B1 (en) 1999-08-27 2003-03-11 Maxygen Aps Interferon-β variants and conjugates
US7431921B2 (en) 1999-08-27 2008-10-07 Maxygen Aps Interferon beta-like molecules
AU2001274536A1 (en) 2000-06-15 2002-01-02 Kyowa Hakko Kogyo Co. Ltd. Insulin-like growth factor-binding protein
FR2810674A1 (fr) * 2000-06-22 2001-12-28 Pf Medicament Construction modifiee en amont du codon d'initiation pour la surexpression de proteines recombinantes
US20020169290A1 (en) * 2000-11-02 2002-11-14 Claus Bornaes New multimeric interferon beta polypeptides
US20040010130A1 (en) * 2001-02-22 2004-01-15 Motoya Katsuki Recombinant gene containing inverted repeat sequence and utilization thereof
CA2469846A1 (en) 2001-02-27 2002-09-26 Maxygen Aps New interferon beta-like molecules
US20040117868A1 (en) * 2002-01-29 2004-06-17 Jun Imamura Protein participating in restoration from cytoplasmic male sterility to fertility and gene encoding the same
CN1239515C (zh) 2001-04-25 2006-02-01 国家农艺研究院 参与由细胞质雄性不育恢复至可育的蛋白质及编码该蛋白质的基因
US6995236B2 (en) 2001-05-08 2006-02-07 Riken Sphingomyelin detecting probe
US7402418B2 (en) * 2001-09-20 2008-07-22 Plantech Research Institute Genes participating in the synthesis of fatty acid having trans-11-,cis-13-conjugated double bond and utilization thereof
JP2003144141A (ja) * 2001-11-14 2003-05-20 Gencom Co ＲＮＡｉ効果が増強したＥＳ細胞
CN100513576C (zh) 2002-05-08 2009-07-15 协和发酵生化株式会社 胞苷5’-二磷酸胆碱的制备方法
JP4171256B2 (ja) * 2002-07-18 2008-10-22 三菱化学株式会社 パピローマウイルスベクターを用いたＲＮＡｉ表現型を有する非ヒト哺乳動物の作製方法
EP1923464A1 (en) 2002-08-30 2008-05-21 Japan Science and Technology Agency Ligase of a hyperthermostable bacterium and chip using the same
JP2004180641A (ja) * 2002-12-06 2004-07-02 Gencom Co ＲＮＡｉ表現型を有する非ヒト哺乳動物の作製方法
CA2511553C (en) 2002-12-26 2013-07-30 Shin-Ichi Hashimoto Process for producing dipeptides
ATE486936T1 (de) * 2003-03-05 2010-11-15 Chemo Sero Therapeut Res Inst Verfahren zur herstellung eines heterologen proteins in e. coli
BRPI0507169A (pt) 2004-02-02 2007-06-26 Ambrx Inc polipeptìdeos do hormÈnio de crescimento humano modificados e seu usos
WO2006122971A2 (en) * 2005-05-19 2006-11-23 Bayer Schering Pharma Aktiengesellschaft Treatment of disease using an improved regulated expression system
US20080076729A1 (en) * 2005-05-19 2008-03-27 Schering Aktiengesellachaft Interferon-beta gene therapy using an improved, regulated expression system
US20070179113A1 (en) * 2005-05-19 2007-08-02 Schering Aktiengesellachaft GM-CSF gene therapy for Crohn's disease using an improved regulated expression system
DOP2006000117A (es) * 2005-05-19 2007-11-30 Schering Ag Terapia génica de interferon-beta usando un sistema mejorado de expresión regulada
US20090270314A1 (en) 2005-09-29 2009-10-29 Tohoku University Polypeptide having anti-angiogenic activity
CN101351551A (zh) 2005-11-29 2009-01-21 协和发酵工业株式会社 新型蛋白质和编码该蛋白质的dna
CA2632419A1 (en) 2005-12-06 2007-06-14 Kyowa Hakko Kogyo Co., Ltd. Genetically recombinant anti-perp antibody
EP1978094B1 (en) 2005-12-27 2012-03-14 Kyowa Hakko Bio Co., Ltd. Method for production of l-glutamine
CN101511870B (zh) 2006-06-06 2014-04-09 协和发酵麒麟株式会社 能够与肝素结合性表皮生长因子样生长因子结合的单克隆抗体
JP5256039B2 (ja) 2006-09-25 2013-08-07 協和発酵バイオ株式会社 ジペプチドの製造法
EP2123751A4 (en) 2007-01-25 2010-06-02 Kyowa Hakko Kirin Co Ltd NEW PEPTIDE
WO2008114733A1 (ja) 2007-03-16 2008-09-25 Kyowa Hakko Kirin Co., Ltd. 抗Claudin-4抗体
WO2008123308A1 (ja) 2007-03-29 2008-10-16 National University Corporation Okayama University バソヒビン含有治療剤
CN101715484B (zh) 2007-04-06 2014-02-19 协和发酵生化株式会社 二肽的制造方法
EP2489741B1 (en) 2007-04-06 2016-06-08 Kyowa Hakko Bio Co., Ltd. Method for production of glutathione or gamma-glutamylcysteine
US8114630B2 (en) 2007-05-02 2012-02-14 Ambrx, Inc. Modified interferon beta polypeptides and their uses
EP2221380A1 (en) 2007-09-27 2010-08-25 Shionogi & Co., Ltd. Method for producing hydroxylated adamantane using cytochrome p450
AU2008332296A1 (en) 2007-12-05 2009-06-11 Kyowa Hakko Kirin Co., Ltd. Monoclonal antibody capable of binding to heparin-binding epidermal growth factor-like growth factor
JP5425775B2 (ja) 2008-06-30 2014-02-26 協和発酵キリン株式会社 抗ｃｄ２７抗体
CN102099468B (zh) 2008-07-17 2014-01-15 协和发酵麒麟株式会社 抗-系统asc氨基酸转运蛋白2(asct2)抗体
CN102232111B (zh) 2008-10-09 2014-12-03 协和梅迪克斯株式会社 果糖基肽氧化酶
WO2010074266A1 (ja) 2008-12-26 2010-07-01 協和発酵キリン株式会社 抗cd4抗体
US8623619B2 (en) 2009-02-09 2014-01-07 Kyowa Hakko Bio Co., Ltd. Process for producing L-amino acid
NZ595825A (en) 2009-04-20 2012-10-26 Kyowa Hakko Kirin Co Ltd Antibody containing igg2 having amino acid mutation introduced therein
HUE040213T2 (hu) 2010-06-11 2019-02-28 Kyowa Hakko Kirin Co Ltd Anti-TIM antitest
JP5058332B2 (ja) 2010-07-14 2012-10-24 住友ゴム工業株式会社 イソプレンオリゴマー、ポリイソプレン、及びこれらの製造方法、ゴム組成物、並びに空気入りタイヤ
KR20140033152A (ko) 2011-06-20 2014-03-17 교와 핫꼬 기린 가부시키가이샤 항erbB3 항체
WO2014007198A1 (ja) 2012-07-02 2014-01-09 協和発酵キリン株式会社 抗ｂｍｐ９抗体を有効成分とする、腎性貧血、がん性貧血などの貧血に対する治療剤
WO2014087863A1 (ja) 2012-12-07 2014-06-12 協和発酵キリン株式会社 抗ｆｏｌｒ１抗体
JP6328115B2 (ja) 2013-07-09 2018-05-23 協和メデックス株式会社 糖化ヘキサペプチドオキシダーゼとその利用
US10844407B2 (en) 2016-03-04 2020-11-24 Niigata University Variant type tetraprenyl-β-curcumene cyclase and method for producing ambrein
WO2018021301A1 (ja) 2016-07-26 2018-02-01 静岡県 抗ｂ７－ｈ４抗体
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US11155845B2 (en) 2017-04-13 2021-10-26 Kyowa Hakko Bio Co., Ltd. Method for producing theanine
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US11414655B2 (en) 2017-09-01 2022-08-16 Niigata University Efficient method for producing ambrein
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US11485779B2 (en) 2017-12-12 2022-11-01 Kyowa Kirin Co., Ltd. Anti-BMP10 monoclonal antibody or fragment thereof
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CA3104997A1 (en) 2018-06-26 2020-01-02 Kyowa Kirin Co., Ltd. Antibody binding to chondroitin sulfate proteoglycan 5
US11613728B2 (en) 2018-08-10 2023-03-28 Kyowa Hakko Bio Co., Ltd. Microorganism producing eicosapentaenoic acid and method for producing eicosapentaenoic acid
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JP6968468B2 (ja) 2019-01-31 2021-11-17 Ｓｐｉｂｅｒ株式会社 組換えタンパク質の製造方法
US12466891B2 (en) 2019-05-15 2025-11-11 Kyowa Kirin Co., Ltd. Bispecific antibody binding to CD40 and GPC3
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Also Published As

Publication number Publication date
JPS58110600A (ja) 1983-07-01
US4686191A (en) 1987-08-11
CA1211059A (en) 1986-09-09
EP0083069A3 (en) 1984-03-28
EP0083069B1 (en) 1987-09-16
EP0083069A2 (en) 1983-07-06
DE3277307D1 (en) 1987-10-22

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