JP7831937B2 - ゲノム組込みのための方法および組成物 - Google Patents

ゲノム組込みのための方法および組成物

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Publication number
JP7831937B2
JP7831937B2 JP2022514694A JP2022514694A JP7831937B2 JP 7831937 B2 JP7831937 B2 JP 7831937B2 JP 2022514694 A JP2022514694 A JP 2022514694A JP 2022514694 A JP2022514694 A JP 2022514694A JP 7831937 B2 JP7831937 B2 JP 7831937B2
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sequence
human
cells
mrna
orf2p
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JP2022546592A (ja
JP2022546592A5 (https=
Inventor
ゲッツ，ダニエル
ワーン，ユーシャオ
ビサリア，ナミタ
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クリエイト・メディシンズ，インコーポレーテッド
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    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
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    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
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    • C12N9/1276—RNA-directed DNA polymerase (2.7.7.49), i.e. reverse transcriptase or telomerase
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    • C07K2319/00—Fusion polypeptide
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    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C12N2015/8518—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic expressing industrially exogenous proteins, e.g. for pharmaceutical use, human insulin, blood factors, immunoglobulins, pseudoparticles
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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JP2022514694A 2019-09-03 2020-09-03 ゲノム組込みのための方法および組成物 Active JP7831937B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962895441P 2019-09-03 2019-09-03
US62/895,441 2019-09-03
US201962908800P 2019-10-01 2019-10-01
US62/908,800 2019-10-01
US202063039261P 2020-06-15 2020-06-15
US63/039,261 2020-06-15
PCT/US2020/049240 WO2021046243A2 (en) 2019-09-03 2020-09-03 Methods and compositions for genomic integration

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JP2022546592A JP2022546592A (ja) 2022-11-04
JP2022546592A5 JP2022546592A5 (https=) 2023-09-11
JP7831937B2 true JP7831937B2 (ja) 2026-03-17

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US (6) US11672874B2 (https=)
EP (1) EP4025686A4 (https=)
JP (1) JP7831937B2 (https=)
KR (1) KR20220097875A (https=)
CN (1) CN114981409A (https=)
AU (1) AU2020341479B2 (https=)
BR (1) BR112022003970A2 (https=)
CA (1) CA3149897A1 (https=)
GB (2) GB2605276B (https=)
IL (1) IL291048A (https=)
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CN114981409A (zh) 2019-09-03 2022-08-30 美洛德生物医药公司 用于基因组整合的方法和组合物
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