JP7744350B2 - 置換ピラゾロ－ピリミジンおよびその使用 - Google Patents

置換ピラゾロ－ピリミジンおよびその使用

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Publication number
JP7744350B2
JP7744350B2 JP2022542901A JP2022542901A JP7744350B2 JP 7744350 B2 JP7744350 B2 JP 7744350B2 JP 2022542901 A JP2022542901 A JP 2022542901A JP 2022542901 A JP2022542901 A JP 2022542901A JP 7744350 B2 JP7744350 B2 JP 7744350B2
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Prior art keywords
pyrazolo
pyrazol
pyrimidin
morpholino
tolyl
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JP2022542901A
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Japanese (ja)
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JP2023510874A (ja
JP2023510874A5 (https=
Inventor
ディー． ロゼン，マーク
エー． ガレモ，ジュニア，ロバート
リャン，ウェイリン
コペック，ブライアン
ワイ． チョイ，アイレネ
ローズ，ジェーン
Original Assignee
バージ アナリティクス，インコーポレイテッド
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Publication of JP2023510874A5 publication Critical patent/JP2023510874A5/ja
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2022542901A 2020-01-13 2021-01-12 置換ピラゾロ－ピリミジンおよびその使用 Active JP7744350B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202062960412P 2020-01-13 2020-01-13
US62/960,412 2020-01-13
US202063074388P 2020-09-03 2020-09-03
US63/074,388 2020-09-03
PCT/US2021/013077 WO2021146192A1 (en) 2020-01-13 2021-01-12 Substituted pyrazolo-pyrimidines and uses thereof

Publications (3)

Publication Number Publication Date
JP2023510874A JP2023510874A (ja) 2023-03-15
JP2023510874A5 JP2023510874A5 (https=) 2024-01-18
JP7744350B2 true JP7744350B2 (ja) 2025-09-25

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022542901A Active JP7744350B2 (ja) 2020-01-13 2021-01-12 置換ピラゾロ－ピリミジンおよびその使用

Country Status (15)

Country Link
US (1) US12486274B2 (https=)
EP (1) EP4090426B1 (https=)
JP (1) JP7744350B2 (https=)
KR (1) KR20220140515A (https=)
CN (1) CN115209952B (https=)
AU (1) AU2021207804A1 (https=)
BR (1) BR112022013488A2 (https=)
CA (1) CA3167339A1 (https=)
CL (1) CL2022001887A1 (https=)
CO (1) CO2022011258A2 (https=)
IL (1) IL294504A (https=)
MX (1) MX2022008627A (https=)
PH (1) PH12022551623A1 (https=)
TW (1) TWI885039B (https=)
WO (1) WO2021146192A1 (https=)

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TWI885039B (zh) 2020-01-13 2025-06-01 美商邊際分析公司 經取代吡唑并嘧啶及其用途
US20240018151A1 (en) * 2020-10-19 2024-01-18 Tme Therapeutics Llc Novel inhibitors of pikfyve and methods using same
TW202313619A (zh) * 2021-06-01 2023-04-01 美商邊際分析公司 稠合雙環雜環化合物及其用途
US20250353852A1 (en) * 2021-12-08 2025-11-20 Kineta, Inc. Compounds and compositions that inhibit pikfyve
US20250388582A1 (en) * 2022-07-13 2025-12-25 Ildong Pharmaceutical Co., Ltd. Novel bicyclic heteroaryl compound and use thereof
WO2024168016A1 (en) * 2023-02-10 2024-08-15 Verge Analytics, Inc. Substituted pyrazolo-pyrimidines and uses thereof
CN120093763A (zh) * 2025-03-25 2025-06-06 上海天龙生物科技有限公司 治疗前列腺疾病和腺体类散结节的药物组合物及其应用

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