CA3167339A1 - Substituted pyrazolo-pyrimidines and uses thereof - Google Patents

Substituted pyrazolo-pyrimidines and uses thereof

Info

Publication number
CA3167339A1
CA3167339A1 CA3167339A CA3167339A CA3167339A1 CA 3167339 A1 CA3167339 A1 CA 3167339A1 CA 3167339 A CA3167339 A CA 3167339A CA 3167339 A CA3167339 A CA 3167339A CA 3167339 A1 CA3167339 A1 CA 3167339A1
Authority
CA
Canada
Prior art keywords
pyrazolo
pyrazol
pyrimidin
compound
morpholino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3167339A
Other languages
English (en)
French (fr)
Inventor
Mark D. Rosen
Jr. Robert A. Galemmo
Weiling Liang
Jane RHODES
Brian KOPEC
Irene Y. Choi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Verge Analytics Inc
Original Assignee
Verge Analytics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Verge Analytics Inc filed Critical Verge Analytics Inc
Publication of CA3167339A1 publication Critical patent/CA3167339A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA3167339A 2020-01-13 2021-01-12 Substituted pyrazolo-pyrimidines and uses thereof Pending CA3167339A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202062960412P 2020-01-13 2020-01-13
US62/960,412 2020-01-13
US202063074388P 2020-09-03 2020-09-03
US63/074,388 2020-09-03
PCT/US2021/013077 WO2021146192A1 (en) 2020-01-13 2021-01-12 Substituted pyrazolo-pyrimidines and uses thereof

Publications (1)

Publication Number Publication Date
CA3167339A1 true CA3167339A1 (en) 2021-07-22

Family

ID=74626126

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3167339A Pending CA3167339A1 (en) 2020-01-13 2021-01-12 Substituted pyrazolo-pyrimidines and uses thereof

Country Status (15)

Country Link
US (1) US12486274B2 (https=)
EP (1) EP4090426B1 (https=)
JP (1) JP7744350B2 (https=)
KR (1) KR20220140515A (https=)
CN (1) CN115209952B (https=)
AU (1) AU2021207804A1 (https=)
BR (1) BR112022013488A2 (https=)
CA (1) CA3167339A1 (https=)
CL (1) CL2022001887A1 (https=)
CO (1) CO2022011258A2 (https=)
IL (1) IL294504A (https=)
MX (1) MX2022008627A (https=)
PH (1) PH12022551623A1 (https=)
TW (1) TWI885039B (https=)
WO (1) WO2021146192A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20220140515A (ko) 2020-01-13 2022-10-18 버지 애널리틱스, 인크. 치환된 피라졸로-피리미딘 및 그의 용도
US20240018151A1 (en) * 2020-10-19 2024-01-18 Tme Therapeutics Llc Novel inhibitors of pikfyve and methods using same
AR126013A1 (es) * 2021-06-01 2023-08-30 Verge Analytics Inc Compuestos heterocíclicos bicíclicos fusionados y usos de los mismos
US20250353852A1 (en) * 2021-12-08 2025-11-20 Kineta, Inc. Compounds and compositions that inhibit pikfyve
WO2024014885A1 (ko) * 2022-07-13 2024-01-18 일동제약(주) 신규 바이사이클릭 헤테로아릴 화합물 및 이의 용도
US20260053813A1 (en) * 2023-02-10 2026-02-26 Verge Analytics, Inc. Substituted Pyrazolo-Pyrimidines and Uses Thereof
CN120093763A (zh) * 2025-03-25 2025-06-06 上海天龙生物科技有限公司 治疗前列腺疾病和腺体类散结节的药物组合物及其应用

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