CO2022011258A2 - Pirazolo-pirimidinas sustituidas y usos de las mismas - Google Patents
Pirazolo-pirimidinas sustituidas y usos de las mismasInfo
- Publication number
- CO2022011258A2 CO2022011258A2 CONC2022/0011258A CO2022011258A CO2022011258A2 CO 2022011258 A2 CO2022011258 A2 CO 2022011258A2 CO 2022011258 A CO2022011258 A CO 2022011258A CO 2022011258 A2 CO2022011258 A2 CO 2022011258A2
- Authority
- CO
- Colombia
- Prior art keywords
- pyrimidines
- compounds
- substituted pyrazolo
- treatment
- pikfyve
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
RESUMEN La presente divulgación proporciona compuestos que son inhibidores de las cinasas PIKfyve útiles para el tratamiento de las enfermedades neurológicas tratables por medio de la inhibición de PIKfyve. También se proporcionan composiciones farmacéuticas que contienen dichos compuestos y métodos de tratamiento con dichos compuestos.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202062960412P | 2020-01-13 | 2020-01-13 | |
| US202063074388P | 2020-09-03 | 2020-09-03 | |
| PCT/US2021/013077 WO2021146192A1 (en) | 2020-01-13 | 2021-01-12 | Substituted pyrazolo-pyrimidines and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO2022011258A2 true CO2022011258A2 (es) | 2022-09-30 |
Family
ID=74626126
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CONC2022/0011258A CO2022011258A2 (es) | 2020-01-13 | 2022-08-10 | Pirazolo-pirimidinas sustituidas y usos de las mismas |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20230133203A1 (es) |
| EP (1) | EP4090426A1 (es) |
| JP (1) | JP2023510874A (es) |
| KR (1) | KR20220140515A (es) |
| CN (1) | CN115209952A (es) |
| AU (1) | AU2021207804A1 (es) |
| BR (1) | BR112022013488A2 (es) |
| CA (1) | CA3167339A1 (es) |
| CL (1) | CL2022001887A1 (es) |
| CO (1) | CO2022011258A2 (es) |
| IL (1) | IL294504A (es) |
| MX (1) | MX2022008627A (es) |
| TW (1) | TW202140483A (es) |
| WO (1) | WO2021146192A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022256300A1 (en) * | 2021-06-01 | 2022-12-08 | Verge Analytics, Inc. | Fused bicyclic heterocyclic compounds and uses thereof |
| WO2024014885A1 (ko) * | 2022-07-13 | 2024-01-18 | 일동제약(주) | 신규 바이사이클릭 헤테로아릴 화합물 및 이의 용도 |
| WO2024168016A1 (en) * | 2023-02-10 | 2024-08-15 | Verge Analytics, Inc. | Substituted pyrazolo-pyrimidines and uses thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0751926B1 (en) | 1994-03-25 | 2007-09-12 | Isotechnika,Inc. | Enhancement of the efficacy of drugs by deuteration |
| US6334997B1 (en) | 1994-03-25 | 2002-01-01 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| WO2016210372A2 (en) | 2015-06-25 | 2016-12-29 | University Of Southern California | Methods to treat neurological diseases |
| CA3056909A1 (en) * | 2017-03-24 | 2018-09-27 | Nanosyn, Inc. | Fused triazolo-pyrimidine compounds having useful pharmaceutical application |
| EP3676264A1 (en) * | 2017-08-28 | 2020-07-08 | Acurastem Inc. | Pikfyve kinase inhibitors |
| US12030896B2 (en) * | 2018-07-05 | 2024-07-09 | Mayo Foundation For Medical Education And Research | PIKfyve inhibitors |
-
2021
- 2021-01-12 JP JP2022542901A patent/JP2023510874A/ja active Pending
- 2021-01-12 IL IL294504A patent/IL294504A/en unknown
- 2021-01-12 WO PCT/US2021/013077 patent/WO2021146192A1/en active Application Filing
- 2021-01-12 TW TW110101124A patent/TW202140483A/zh unknown
- 2021-01-12 KR KR1020227027606A patent/KR20220140515A/ko unknown
- 2021-01-12 US US17/792,304 patent/US20230133203A1/en active Pending
- 2021-01-12 CA CA3167339A patent/CA3167339A1/en active Pending
- 2021-01-12 CN CN202180018763.7A patent/CN115209952A/zh active Pending
- 2021-01-12 BR BR112022013488A patent/BR112022013488A2/pt unknown
- 2021-01-12 MX MX2022008627A patent/MX2022008627A/es unknown
- 2021-01-12 AU AU2021207804A patent/AU2021207804A1/en active Pending
- 2021-01-12 EP EP21705700.9A patent/EP4090426A1/en active Pending
-
2022
- 2022-07-12 CL CL2022001887A patent/CL2022001887A1/es unknown
- 2022-08-10 CO CONC2022/0011258A patent/CO2022011258A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN115209952A (zh) | 2022-10-18 |
| EP4090426A1 (en) | 2022-11-23 |
| CL2022001887A1 (es) | 2023-04-10 |
| WO2021146192A1 (en) | 2021-07-22 |
| US20230133203A1 (en) | 2023-05-04 |
| KR20220140515A (ko) | 2022-10-18 |
| CA3167339A1 (en) | 2021-07-22 |
| JP2023510874A (ja) | 2023-03-15 |
| AU2021207804A1 (en) | 2022-09-01 |
| TW202140483A (zh) | 2021-11-01 |
| IL294504A (en) | 2022-09-01 |
| MX2022008627A (es) | 2022-11-08 |
| BR112022013488A2 (pt) | 2022-09-13 |
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