JP7714520B2 - 検体の状態を評価するためのデバイス、それを含むシステム、検体の状態を評価する方法及びそれに用いる乳酸デヒドロゲナーゼ - Google Patents

検体の状態を評価するためのデバイス、それを含むシステム、検体の状態を評価する方法及びそれに用いる乳酸デヒドロゲナーゼ

Info

Publication number
JP7714520B2
JP7714520B2 JP2022501977A JP2022501977A JP7714520B2 JP 7714520 B2 JP7714520 B2 JP 7714520B2 JP 2022501977 A JP2022501977 A JP 2022501977A JP 2022501977 A JP2022501977 A JP 2022501977A JP 7714520 B2 JP7714520 B2 JP 7714520B2
Authority
JP
Japan
Prior art keywords
lactic acid
pkldh
amino acid
seq
acid sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2022501977A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO2021167011A1 (https=
JPWO2021167011A5 (https=
Inventor
陽介 鉞
千晶 稲本
美月 中村
英一郎 菅
敦 一柳
遥香 平口
遼太 鈴木
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kikkoman Corp
Original Assignee
Kikkoman Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kikkoman Corp filed Critical Kikkoman Corp
Publication of JPWO2021167011A1 publication Critical patent/JPWO2021167011A1/ja
Publication of JPWO2021167011A5 publication Critical patent/JPWO2021167011A5/ja
Priority to JP2025119817A priority Critical patent/JP2025160264A/ja
Application granted granted Critical
Publication of JP7714520B2 publication Critical patent/JP7714520B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q3/00—Condition responsive control processes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01027—L-Lactate dehydrogenase (1.1.1.27)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2521/00—Reaction characterised by the enzymatic activity
    • C12Q2521/50—Other enzymatic activities
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/05—Oxidoreductases acting on the CH-OH group of donors (1.1) with a quinone or similar compound as acceptor (1.1.5)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/902—Oxidoreductases (1.)
    • G01N2333/904—Oxidoreductases (1.) acting on CHOH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2022501977A 2020-02-21 2021-02-18 検体の状態を評価するためのデバイス、それを含むシステム、検体の状態を評価する方法及びそれに用いる乳酸デヒドロゲナーゼ Active JP7714520B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025119817A JP2025160264A (ja) 2020-02-21 2025-07-16 検体の状態を評価するためのデバイス、それを含むシステム、検体の状態を評価する方法及びそれに用いる乳酸デヒドロゲナーゼ

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2020028722 2020-02-21
JP2020028722 2020-02-21
JP2020106467 2020-06-19
JP2020106467 2020-06-19
PCT/JP2021/006153 WO2021167011A1 (ja) 2020-02-21 2021-02-18 検体の状態を評価するためのデバイス、それを含むシステム、検体の状態を評価する方法及びそれに用いる乳酸デヒドロゲナーゼ

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025119817A Division JP2025160264A (ja) 2020-02-21 2025-07-16 検体の状態を評価するためのデバイス、それを含むシステム、検体の状態を評価する方法及びそれに用いる乳酸デヒドロゲナーゼ

Publications (3)

Publication Number Publication Date
JPWO2021167011A1 JPWO2021167011A1 (https=) 2021-08-26
JPWO2021167011A5 JPWO2021167011A5 (https=) 2024-01-26
JP7714520B2 true JP7714520B2 (ja) 2025-07-29

Family

ID=77392166

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2022501977A Active JP7714520B2 (ja) 2020-02-21 2021-02-18 検体の状態を評価するためのデバイス、それを含むシステム、検体の状態を評価する方法及びそれに用いる乳酸デヒドロゲナーゼ
JP2025119817A Pending JP2025160264A (ja) 2020-02-21 2025-07-16 検体の状態を評価するためのデバイス、それを含むシステム、検体の状態を評価する方法及びそれに用いる乳酸デヒドロゲナーゼ

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2025119817A Pending JP2025160264A (ja) 2020-02-21 2025-07-16 検体の状態を評価するためのデバイス、それを含むシステム、検体の状態を評価する方法及びそれに用いる乳酸デヒドロゲナーゼ

Country Status (5)

Country Link
US (1) US20230213499A1 (https=)
EP (1) EP4108678A4 (https=)
JP (2) JP7714520B2 (https=)
KR (1) KR20220143091A (https=)
WO (1) WO2021167011A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4223884A4 (en) * 2020-09-29 2024-12-11 Kikkoman Corporation METHOD FOR IMPROVING THE STABILITY OF A COMPOSITION CONTAINING FLAVIN-DEPENDENT LACTATE DEHYDROGENASE
WO2022258733A1 (en) 2021-06-09 2022-12-15 Directsens Gmbh Novel production method of flavocytochrome b2
US20240401002A1 (en) * 2021-08-03 2024-12-05 Kikkoman Corporation Novel flavin-dependent lactate dehydrogenase and method for improving stability of lactate dehydrogenase
TWI814233B (zh) * 2022-01-28 2023-09-01 住華科技股份有限公司 硼酸檢測試片及硼酸檢測方法

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009517045A (ja) 2005-11-23 2009-04-30 ネイチャーワークス・エル・エル・シー Ｌ−又はｄ−ラクタート：フェリチトクロームｃ酸化還元酵素遺伝子が機能しない乳酸産生酵母
WO2012068236A2 (en) 2010-11-16 2012-05-24 Dyadic International (Usa) Inc. Novel fungal oxidoreductases
JP2013066466A (ja) 2011-09-20 2013-04-18 F Hoffmann La Roche Ag 安定性が高められた変異型乳酸オキシダーゼ、ならびにそれに関連する生成物、方法および使用
JP2014501502A (ja) 2010-11-22 2014-01-23 キンバリー クラーク ワールドワイド インコーポレイテッド 良好な健康状態のバイオマーカを検出するための膣用インジケータ
WO2015017721A1 (en) 2013-07-31 2015-02-05 Novozymes A/S 3-hydroxypropionic acid production by recombinant yeasts expressing an insect aspartate 1-decarboxylase
WO2016138303A1 (en) 2015-02-27 2016-09-01 Novozymes A/S Mutant host cells for the production of 3-hydroxypropionic acid
WO2022071417A1 (ja) 2020-09-29 2022-04-07 キッコーマン株式会社 フラビン依存性乳酸デヒドロゲナーゼを含む組成物の安定性を向上する方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3211167A1 (de) * 1982-03-26 1983-09-29 Merck Patent Gmbh, 6100 Darmstadt Testsystem und verfahren zur bestimmung von substanzen in fluessigkeiten
EP0175577A3 (en) * 1984-09-21 1987-11-25 Jonathan L Kiel Microchemiluminescent assay system
JP3036711B2 (ja) * 1991-05-21 2000-04-24 旭化成工業株式会社 乳酸またはピルビン酸の高感度定量法および定量用組成物
JPH06153995A (ja) * 1992-11-26 1994-06-03 Sekisui Chem Co Ltd 細菌ホロルシフェラーゼを用いた測定法
IT1279043B1 (it) * 1995-05-24 1997-12-04 Co Ri Al Scpa Metodo per la determinazione di acido lattico in materiali organici di interesse alimentare e biosensore per l'esecuzione di tale metodo
DE19543493A1 (de) * 1995-11-22 1997-05-28 Boehringer Mannheim Gmbh Stabilisierte Coenzym-Lösungen und deren Verwendung zur Bestimmung von Dehydrogenasen bzw. deren Substrate im alkalischen Milieu
JP5593689B2 (ja) 2009-12-09 2014-09-24 東洋紡株式会社 乳酸オキシダーゼ組成物
US10619183B2 (en) 2013-08-09 2020-04-14 Kikkoman Corporation Modified amadoriase and method for producing the same, agent for improving surfactant resistance of amadoriase and composition for measuring HbA1c using the same
WO2016205378A1 (en) 2015-06-15 2016-12-22 Abbott Diabetes Care Inc. Stabilized lactate responsive enzymes, electrodes and sensors, and methods for making and using the same
JP6703893B2 (ja) 2015-12-01 2020-06-03 パナソニック インテレクチュアル プロパティ コーポレーション オブ アメリカＰａｎａｓｏｎｉｃ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｃｏｒｐｏｒａｔｉｏｎ ｏｆ Ａｍｅｒｉｃａ 体調推定装置、及び、体調推定システム
WO2017163521A1 (ja) 2016-03-23 2017-09-28 日本電気株式会社 情報処理装置、その制御方法ならびにその制御プログラム
CN109906270A (zh) * 2016-09-16 2019-06-18 嘉吉公司 经遗传修饰的乳酸消耗酵母以及使用此类经遗传修饰的酵母的发酵工艺
WO2019006413A1 (en) * 2017-06-30 2019-01-03 Abbott Diabetes Care METHOD AND APPARATUS FOR ANALYTE DETECTION USING ELECTROCHEMICAL BIOSENSOR
JP6941379B2 (ja) 2017-11-28 2021-09-29 株式会社ユピテル 電子機器およびプログラム

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009517045A (ja) 2005-11-23 2009-04-30 ネイチャーワークス・エル・エル・シー Ｌ−又はｄ−ラクタート：フェリチトクロームｃ酸化還元酵素遺伝子が機能しない乳酸産生酵母
WO2012068236A2 (en) 2010-11-16 2012-05-24 Dyadic International (Usa) Inc. Novel fungal oxidoreductases
JP2014501502A (ja) 2010-11-22 2014-01-23 キンバリー クラーク ワールドワイド インコーポレイテッド 良好な健康状態のバイオマーカを検出するための膣用インジケータ
JP2013066466A (ja) 2011-09-20 2013-04-18 F Hoffmann La Roche Ag 安定性が高められた変異型乳酸オキシダーゼ、ならびにそれに関連する生成物、方法および使用
WO2015017721A1 (en) 2013-07-31 2015-02-05 Novozymes A/S 3-hydroxypropionic acid production by recombinant yeasts expressing an insect aspartate 1-decarboxylase
WO2016138303A1 (en) 2015-02-27 2016-09-01 Novozymes A/S Mutant host cells for the production of 3-hydroxypropionic acid
WO2022071417A1 (ja) 2020-09-29 2022-04-07 キッコーマン株式会社 フラビン依存性乳酸デヒドロゲナーゼを含む組成物の安定性を向上する方法

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
A0A4T0X365, July 31, 2019 uploaded, [retrieved Apr 16, 2021], Definition: Uncharacterized protein，Database Uniprot[online]
D W Reed，The Archaeoglobus fulgidus D-lactate dehydrogenase is a Zn(2+) flavoprotein，J Bacteriol，1999年12月，181(24)，7580-7587
RALF OSTENDORP，Extremely thermostable L(+)-lactate dehydrogenase from Thermotoga maritima: Cloning, characterization, and crystallization of the recombinant enzyme in its tetrameric and octameric state，Profein Science，1996年，Vol.5，Page.862-873
Robert Riley，Comparative genomics of biotechnologically important yeasts，PNAS，2016年08月30日，Vol.113 No.5，Page.9882-9887
UPI0007F33D28 | UniParc | UniProt，2016年09月23日，https://www.uniprot.org/uniparc/UPI0007F33D28/entry
UPI001135A80B | UniParc | UniProt，2019年07月31日，https://www.uniprot.org/uniparc/UPI001135A80B/entry
赤沼哲史，極限環境で働くタンパク質の特徴と利用 好熱菌のタンパク質はなぜ熱に強いか，生化学，2009年12月25日，Vol.81 No.12，Vol.81 No.12
鈴木遼太，フラビン依存性乳酸デヒドロゲナーゼの電子伝達機構の解析，日本農芸化学会大会講演要旨集，2023年03月05日，Vol.2023，Page.ROMBUNNO.2C05-03
鈴木遼太，乳酸センサ用フラビン依存性乳酸デヒドロゲナーゼの探索および特性評価，日本農芸化学会大会講演要旨集，2022年03月05日，Vol.2022，Page.ROMBUNNO.4C05-08

Also Published As

Publication number Publication date
JPWO2021167011A1 (https=) 2021-08-26
EP4108678A1 (en) 2022-12-28
EP4108678A4 (en) 2024-03-27
WO2021167011A1 (ja) 2021-08-26
KR20220143091A (ko) 2022-10-24
JP2025160264A (ja) 2025-10-22
US20230213499A1 (en) 2023-07-06

Similar Documents

Publication Publication Date Title
JP7714520B2 (ja) 検体の状態を評価するためのデバイス、それを含むシステム、検体の状態を評価する方法及びそれに用いる乳酸デヒドロゲナーゼ
Mandpe et al. Glucose oxidase-based biosensor for glucose detection from biological fluids
JP4359595B2 (ja) グルコースセンサおよびグルコース濃度測定装置
US9353395B2 (en) Glucose dehydrogenase/cytochrome fusion protein
EP2989201B1 (en) Novel glucose oxidase variants
EP2003199B1 (en) Glucose dehydrogenase
JP6311270B2 (ja) 耐熱性に優れたフラビンアデニンジヌクレオチド依存性グルコースデヒドロゲナーゼ
JP6133029B2 (ja) 安定性が高められた変異型乳酸オキシダーゼ、ならびにそれに関連する生成物、方法および使用
KR20110050752A (ko) 플라빈 결합형 글루코오스 디히드로게나아제
JPWO2014002973A1 (ja) 新規なグルコース脱水素酵素
WO2015099112A1 (ja) 熱安定性が向上したフラビン結合型グルコースデヒドロゲナーゼ
JP2014018096A (ja) フラビン結合型グルコースデヒドロゲナーゼを含む組成物の安定性を向上する方法
US9796963B2 (en) Glucose dehydrogenase
JP6635913B2 (ja) 比活性が向上したフラビン結合型グルコースデヒドロゲナーゼ
JP6934720B2 (ja) 基質特異性が向上したフラビン結合型グルコースデヒドロゲナーゼ
WO2022072677A1 (en) Engineered stable lactate oxidoreductases, compositions, devices, kits and uses thereof
Masakari et al. Comparison of the stability of Mucor-derived flavin adenine dinucleotide-dependent glucose dehydrogenase and glucose oxidase
TWI867923B (zh) 乳酸氧化酶變異體及其在乳酸檢測的用途
JP2012019756A (ja) フラビンアデニンジヌクレオチド依存性グルコースデヒドロゲナーゼを用いるグルコース測定方法
JP2018046816A (ja) 耐熱性に優れたフラビンアデニンジヌクレオチド依存性グルコースデヒドロゲナーゼ
Asif et al. Zinc Oxide Nanorods and Their Application to Intracellular Glucose Measurements: and Bengt Danielsson
JP2006081407A (ja) Ｐｑｑ依存性グルコースデヒドロゲナーゼの製造方法
WO2020116330A1 (ja) グルコースデヒドロゲナーゼ
AZIZ DEVELOPMENT OF A BIOSENSOR BASED ON AMINE OXIDASE FROM

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20240118

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20240118

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20241119

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20250117

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20250317

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20250617

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20250716

R150 Certificate of patent or registration of utility model

Ref document number: 7714520

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150