KR20220143091A - 검체의 상태를 평가하기 위한 디바이스, 그것을 포함하는 시스템, 검체의 상태를 평가하는 방법 및 그에 사용되는 유산 데히드로게나아제 - Google Patents

검체의 상태를 평가하기 위한 디바이스, 그것을 포함하는 시스템, 검체의 상태를 평가하는 방법 및 그에 사용되는 유산 데히드로게나아제 Download PDF

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KR20220143091A
KR20220143091A KR1020227032145A KR20227032145A KR20220143091A KR 20220143091 A KR20220143091 A KR 20220143091A KR 1020227032145 A KR1020227032145 A KR 1020227032145A KR 20227032145 A KR20227032145 A KR 20227032145A KR 20220143091 A KR20220143091 A KR 20220143091A
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요스케 마사카리
치아키 이나모토
미키 나카무라
에이치로 간
아츠시 이치야나기
하루카 히라구치
료타 스즈키
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기꼬만 가부시키가이샤
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    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
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    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/902—Oxidoreductases (1.)
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KR1020227032145A 2020-02-21 2021-02-18 검체의 상태를 평가하기 위한 디바이스, 그것을 포함하는 시스템, 검체의 상태를 평가하는 방법 및 그에 사용되는 유산 데히드로게나아제 Pending KR20220143091A (ko)

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JPJP-P-2020-028722 2020-02-21
JP2020028722 2020-02-21
JP2020106467 2020-06-19
JPJP-P-2020-106467 2020-06-19
PCT/JP2021/006153 WO2021167011A1 (ja) 2020-02-21 2021-02-18 検体の状態を評価するためのデバイス、それを含むシステム、検体の状態を評価する方法及びそれに用いる乳酸デヒドロゲナーゼ

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US (1) US20230213499A1 (https=)
EP (1) EP4108678A4 (https=)
JP (2) JP7714520B2 (https=)
KR (1) KR20220143091A (https=)
WO (1) WO2021167011A1 (https=)

Families Citing this family (4)

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EP4223884A4 (en) * 2020-09-29 2024-12-11 Kikkoman Corporation METHOD FOR IMPROVING THE STABILITY OF A COMPOSITION CONTAINING FLAVIN-DEPENDENT LACTATE DEHYDROGENASE
WO2022258733A1 (en) 2021-06-09 2022-12-15 Directsens Gmbh Novel production method of flavocytochrome b2
US20240401002A1 (en) * 2021-08-03 2024-12-05 Kikkoman Corporation Novel flavin-dependent lactate dehydrogenase and method for improving stability of lactate dehydrogenase
TWI814233B (zh) * 2022-01-28 2023-09-01 住華科技股份有限公司 硼酸檢測試片及硼酸檢測方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5593689B2 (ja) 2009-12-09 2014-09-24 東洋紡株式会社 乳酸オキシダーゼ組成物
JP2017100039A (ja) 2015-12-01 2017-06-08 パナソニック インテレクチュアル プロパティ コーポレーション オブ アメリカＰａｎａｓｏｎｉｃ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｃｏｒｐｏｒａｔｉｏｎ ｏｆ Ａｍｅｒｉｃａ 体調推定装置、体調推定システム及びプロセッサ
WO2017163521A1 (ja) 2016-03-23 2017-09-28 日本電気株式会社 情報処理装置、その制御方法ならびにその制御プログラム
JP2018519507A (ja) 2015-06-15 2018-07-19 アボット ダイアベティス ケア インコーポレイテッドＡｂｂｏｔｔ Ｄｉａｂｅｔｅｓ Ｃａｒｅ Ｉｎｃ． 安定した乳酸応答性の酵素、電極およびセンサ並びにそれらの製造方法および使用方法
JP2019150649A (ja) 2017-11-28 2019-09-12 株式会社ユピテル 電子機器およびプログラム

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3211167A1 (de) * 1982-03-26 1983-09-29 Merck Patent Gmbh, 6100 Darmstadt Testsystem und verfahren zur bestimmung von substanzen in fluessigkeiten
EP0175577A3 (en) * 1984-09-21 1987-11-25 Jonathan L Kiel Microchemiluminescent assay system
JP3036711B2 (ja) * 1991-05-21 2000-04-24 旭化成工業株式会社 乳酸またはピルビン酸の高感度定量法および定量用組成物
JPH06153995A (ja) * 1992-11-26 1994-06-03 Sekisui Chem Co Ltd 細菌ホロルシフェラーゼを用いた測定法
IT1279043B1 (it) * 1995-05-24 1997-12-04 Co Ri Al Scpa Metodo per la determinazione di acido lattico in materiali organici di interesse alimentare e biosensore per l'esecuzione di tale metodo
DE19543493A1 (de) * 1995-11-22 1997-05-28 Boehringer Mannheim Gmbh Stabilisierte Coenzym-Lösungen und deren Verwendung zur Bestimmung von Dehydrogenasen bzw. deren Substrate im alkalischen Milieu
WO2007117282A2 (en) * 2005-11-23 2007-10-18 Natureworks Llc Lactic acid-producing yeast cells having nonfunctional l-or d-lactate: ferricytochrome c oxidoreductase gene
WO2012068236A2 (en) * 2010-11-16 2012-05-24 Dyadic International (Usa) Inc. Novel fungal oxidoreductases
US9034593B2 (en) * 2010-11-22 2015-05-19 Kimberly-Clark Worldwide, Inc. Vaginal indicator to detect biomarkers of good health
EP2573171B1 (en) * 2011-09-20 2015-04-15 Roche Diagnostics GmbH Mutant lactate oxidase with increased stability and product, methods and uses involving the same
US9845484B2 (en) * 2013-07-31 2017-12-19 Novozymes A/S 3-hydroxypropionic acid production by recombinant yeasts expressing an insect aspartate 1-decarboxylase
US10619183B2 (en) 2013-08-09 2020-04-14 Kikkoman Corporation Modified amadoriase and method for producing the same, agent for improving surfactant resistance of amadoriase and composition for measuring HbA1c using the same
CN107406821B (zh) * 2015-02-27 2021-10-15 诺维信公司 用于生产3-羟基丙酸的突变宿主细胞
CN109906270A (zh) * 2016-09-16 2019-06-18 嘉吉公司 经遗传修饰的乳酸消耗酵母以及使用此类经遗传修饰的酵母的发酵工艺
WO2019006413A1 (en) * 2017-06-30 2019-01-03 Abbott Diabetes Care METHOD AND APPARATUS FOR ANALYTE DETECTION USING ELECTROCHEMICAL BIOSENSOR
EP4223884A4 (en) * 2020-09-29 2024-12-11 Kikkoman Corporation METHOD FOR IMPROVING THE STABILITY OF A COMPOSITION CONTAINING FLAVIN-DEPENDENT LACTATE DEHYDROGENASE

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5593689B2 (ja) 2009-12-09 2014-09-24 東洋紡株式会社 乳酸オキシダーゼ組成物
JP2018519507A (ja) 2015-06-15 2018-07-19 アボット ダイアベティス ケア インコーポレイテッドＡｂｂｏｔｔ Ｄｉａｂｅｔｅｓ Ｃａｒｅ Ｉｎｃ． 安定した乳酸応答性の酵素、電極およびセンサ並びにそれらの製造方法および使用方法
JP2017100039A (ja) 2015-12-01 2017-06-08 パナソニック インテレクチュアル プロパティ コーポレーション オブ アメリカＰａｎａｓｏｎｉｃ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｃｏｒｐｏｒａｔｉｏｎ ｏｆ Ａｍｅｒｉｃａ 体調推定装置、体調推定システム及びプロセッサ
WO2017163521A1 (ja) 2016-03-23 2017-09-28 日本電気株式会社 情報処理装置、その制御方法ならびにその制御プログラム
JP2019150649A (ja) 2017-11-28 2019-09-12 株式会社ユピテル 電子機器およびプログラム

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Japanese version of sepsis treatment guidelines, 2016, PNAS September 15, 2015, 112(37), 11642-11647
Methods Enzymol., 53, 238-56, 1978
sports performance study, 3, 31-48, 2011

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WO2021167011A1 (ja) 2021-08-26
JP2025160264A (ja) 2025-10-22
US20230213499A1 (en) 2023-07-06

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