JP7664278B2 - ファルネソイドｘ受容体アゴニストの結晶質形態 - Google Patents

ファルネソイドｘ受容体アゴニストの結晶質形態 Download PDF

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JP7664278B2
JP7664278B2 JP2022555915A JP2022555915A JP7664278B2 JP 7664278 B2 JP7664278 B2 JP 7664278B2 JP 2022555915 A JP2022555915 A JP 2022555915A JP 2022555915 A JP2022555915 A JP 2022555915A JP 7664278 B2 JP7664278 B2 JP 7664278B2
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compound
crystalline
methoxy
methylphenyl
methyl
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JP2023518399A5 (enExample
JP2023518399A (ja
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ディー． スミス，ニコラス
マンスフィールド，ロバート
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オルガノボ，インク．
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2022555915A 2020-03-18 2021-03-17 ファルネソイドｘ受容体アゴニストの結晶質形態 Active JP7664278B2 (ja)

Priority Applications (1)

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JP2025062686A JP2025121901A (ja) 2020-03-18 2025-04-04 ファルネソイドｘ受容体アゴニストの結晶質形態

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US202062991213P 2020-03-18 2020-03-18
US62/991,213 2020-03-18
PCT/US2021/022790 WO2021188692A1 (en) 2020-03-18 2021-03-17 Crystalline forms of a farnesoid x receptor agonist

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JP2023518399A JP2023518399A (ja) 2023-05-01
JP2023518399A5 JP2023518399A5 (enExample) 2024-03-21
JP7664278B2 true JP7664278B2 (ja) 2025-04-17

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US (1) US12545660B2 (enExample)
EP (1) EP4121010A4 (enExample)
JP (2) JP7664278B2 (enExample)
KR (1) KR20220155356A (enExample)
CN (1) CN115666521A (enExample)
AR (1) AR121596A1 (enExample)
AU (1) AU2021236648A1 (enExample)
BR (1) BR112022018596A2 (enExample)
CA (1) CA3171987A1 (enExample)
IL (1) IL296532A (enExample)
MX (2) MX2022011582A (enExample)
TW (1) TW202144332A (enExample)
WO (1) WO2021188692A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023518398A (ja) * 2020-03-18 2023-05-01 メタクリン，インク． ファルネソイドｘ受容体アゴニストの製剤

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113056271B (zh) 2018-09-18 2024-10-29 奥加诺沃公司 法尼醇x受体激动剂及其用途
IL296532A (en) 2020-03-18 2022-11-01 Metacrine Inc Crystal forms of farnesoid x receptor agonist

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WO2018170166A1 (en) 2017-03-15 2018-09-20 Metacrine, Inc. Farnesoid x receptor agonists and uses thereof
WO2020061116A1 (en) 2018-09-18 2020-03-26 Metacrine, Inc. Farnesoid x receptor agonists and uses thereof
JP2022500393A (ja) 2018-09-18 2022-01-04 メタクリン，インク． ファルネソイドｘ受容体アゴニストおよびその使用
JP2022500392A (ja) 2018-09-18 2022-01-04 メタクリン，インク． ファルネソイドｘ受容体アゴニストおよびその使用
JP2022500391A (ja) 2018-09-18 2022-01-04 メタクリン，インク． ファルネソイドｘ受容体アゴニストおよびその使用
JP2023518398A (ja) 2020-03-18 2023-05-01 メタクリン，インク． ファルネソイドｘ受容体アゴニストの製剤
JP2023518397A (ja) 2020-03-18 2023-05-01 メタクリン，インク． 疾患の治療のためのファルネソイドｘ受容体アゴニスト

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JP2023518398A (ja) 2020-03-18 2023-05-01 メタクリン，インク． ファルネソイドｘ受容体アゴニストの製剤
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Cited By (2)

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Publication number Priority date Publication date Assignee Title
JP2023518398A (ja) * 2020-03-18 2023-05-01 メタクリン，インク． ファルネソイドｘ受容体アゴニストの製剤
JP7721555B2 (ja) 2020-03-18 2025-08-12 イーライ リリー アンド カンパニー ファルネソイドｘ受容体アゴニストの製剤

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US12545660B2 (en) 2026-02-10
CN115666521A (zh) 2023-01-31
TW202144332A (zh) 2021-12-01
JP2025121901A (ja) 2025-08-20
CA3171987A1 (en) 2021-09-23
KR20220155356A (ko) 2022-11-22
EP4121010A1 (en) 2023-01-25
EP4121010A4 (en) 2024-04-10
WO2021188692A1 (en) 2021-09-23
US20230147756A1 (en) 2023-05-11
JP2023518399A (ja) 2023-05-01
AU2021236648A1 (en) 2022-10-13
BR112022018596A2 (pt) 2023-03-07
MX2025009319A (es) 2025-09-02
IL296532A (en) 2022-11-01
AR121596A1 (es) 2022-06-22
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