MX2022011582A - Formas cristalinas de un agonista del receptor farnesoide x. - Google Patents
Formas cristalinas de un agonista del receptor farnesoide x.Info
- Publication number
- MX2022011582A MX2022011582A MX2022011582A MX2022011582A MX2022011582A MX 2022011582 A MX2022011582 A MX 2022011582A MX 2022011582 A MX2022011582 A MX 2022011582A MX 2022011582 A MX2022011582 A MX 2022011582A MX 2022011582 A MX2022011582 A MX 2022011582A
- Authority
- MX
- Mexico
- Prior art keywords
- farnesoid
- receptor agonist
- crystalline forms
- hydroxyazetidine
- metho
- Prior art date
Links
- 229940121360 farnesoid X receptor (fxr) agonists Drugs 0.000 title abstract 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
En el presente documento se describe el agonista del receptor farnesoide X, 3-hidroxiazetidinatrans-1-carboxilato de 4-((4-(1-(terc-butil)-1H-pirazol-4-il)piridin-2-il)((4-(4-metoxi- 3- metilfenil)biciclo[2.2.2]octan-1-il)metil)carbamoil)ciclohexilo , incluidas formas cristalinas y sales, solvatos y formulaciones farmacéuticamente aceptables de este.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202062991213P | 2020-03-18 | 2020-03-18 | |
PCT/US2021/022790 WO2021188692A1 (en) | 2020-03-18 | 2021-03-17 | Crystalline forms of a farnesoid x receptor agonist |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022011582A true MX2022011582A (es) | 2022-12-13 |
Family
ID=77771306
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022011582A MX2022011582A (es) | 2020-03-18 | 2021-03-17 | Formas cristalinas de un agonista del receptor farnesoide x. |
Country Status (13)
Country | Link |
---|---|
US (1) | US20230147756A1 (es) |
EP (1) | EP4121010A4 (es) |
JP (1) | JP2023518399A (es) |
KR (1) | KR20220155356A (es) |
CN (1) | CN115666521A (es) |
AR (1) | AR121596A1 (es) |
AU (1) | AU2021236648A1 (es) |
BR (1) | BR112022018596A2 (es) |
CA (1) | CA3171987A1 (es) |
IL (1) | IL296532A (es) |
MX (1) | MX2022011582A (es) |
TW (1) | TW202144332A (es) |
WO (1) | WO2021188692A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112021004919A2 (pt) | 2018-09-18 | 2021-06-01 | Metacrine, Inc. | agonistas de receptor farnesoide x e usos dos mesmos |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050143449A1 (en) * | 2002-11-15 | 2005-06-30 | The Salk Institute For Biological Studies | Non-steroidal farnesoid X receptor modulators and methods for the use thereof |
JP7174709B2 (ja) * | 2017-03-15 | 2022-11-17 | メタクリン,インク. | ファルネソイドx受容体アゴニストおよびその使用 |
JP7258763B2 (ja) * | 2017-03-15 | 2023-04-17 | メタクリン,インク. | ファルネソイドx受容体アゴニストおよびその使用 |
BR112021004919A2 (pt) * | 2018-09-18 | 2021-06-01 | Metacrine, Inc. | agonistas de receptor farnesoide x e usos dos mesmos |
EP3852736A4 (en) * | 2018-09-18 | 2022-05-18 | Metacrine, Inc. | FARNESOID-X RECEPTOR AGONISTS AND USES THEREOF |
-
2021
- 2021-03-17 CA CA3171987A patent/CA3171987A1/en active Pending
- 2021-03-17 CN CN202180036362.4A patent/CN115666521A/zh active Pending
- 2021-03-17 BR BR112022018596A patent/BR112022018596A2/pt not_active Application Discontinuation
- 2021-03-17 EP EP21770893.2A patent/EP4121010A4/en active Pending
- 2021-03-17 MX MX2022011582A patent/MX2022011582A/es unknown
- 2021-03-17 AR ARP210100667A patent/AR121596A1/es unknown
- 2021-03-17 JP JP2022555915A patent/JP2023518399A/ja active Pending
- 2021-03-17 IL IL296532A patent/IL296532A/en unknown
- 2021-03-17 KR KR1020227036019A patent/KR20220155356A/ko unknown
- 2021-03-17 TW TW110109624A patent/TW202144332A/zh unknown
- 2021-03-17 WO PCT/US2021/022790 patent/WO2021188692A1/en unknown
- 2021-03-17 US US17/906,582 patent/US20230147756A1/en active Pending
- 2021-03-17 AU AU2021236648A patent/AU2021236648A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20230147756A1 (en) | 2023-05-11 |
BR112022018596A2 (pt) | 2023-03-07 |
KR20220155356A (ko) | 2022-11-22 |
EP4121010A1 (en) | 2023-01-25 |
AU2021236648A1 (en) | 2022-10-13 |
AR121596A1 (es) | 2022-06-22 |
JP2023518399A (ja) | 2023-05-01 |
IL296532A (en) | 2022-11-01 |
CN115666521A (zh) | 2023-01-31 |
TW202144332A (zh) | 2021-12-01 |
WO2021188692A1 (en) | 2021-09-23 |
CA3171987A1 (en) | 2021-09-23 |
EP4121010A4 (en) | 2024-04-10 |
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