TW202144332A - 法尼醇x(farnesoid x)受體促效劑之結晶形式 - Google Patents

法尼醇x(farnesoid x)受體促效劑之結晶形式 Download PDF

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TW202144332A
TW202144332A TW110109624A TW110109624A TW202144332A TW 202144332 A TW202144332 A TW 202144332A TW 110109624 A TW110109624 A TW 110109624A TW 110109624 A TW110109624 A TW 110109624A TW 202144332 A TW202144332 A TW 202144332A
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crystalline form
theta
disease
xrpd
crystalline
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TW110109624A
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Chinese (zh)
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尼可拉斯 D 史密斯
羅伯特 曼斯費德
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美商梅塔克林公司
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
TW110109624A 2020-03-18 2021-03-17 法尼醇x(farnesoid x)受體促效劑之結晶形式 TW202144332A (zh)

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US202062991213P 2020-03-18 2020-03-18
US62/991,213 2020-03-18

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TW202144332A true TW202144332A (zh) 2021-12-01

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US (1) US12545660B2 (enExample)
EP (1) EP4121010A4 (enExample)
JP (2) JP7664278B2 (enExample)
KR (1) KR20220155356A (enExample)
CN (1) CN115666521A (enExample)
AR (1) AR121596A1 (enExample)
AU (1) AU2021236648A1 (enExample)
BR (1) BR112022018596A2 (enExample)
CA (1) CA3171987A1 (enExample)
IL (1) IL296532A (enExample)
MX (2) MX2022011582A (enExample)
TW (1) TW202144332A (enExample)
WO (1) WO2021188692A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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WO2021188695A1 (en) * 2020-03-18 2021-09-23 Metacrine, Inc. Formulations of a farnesoid x receptor agonist
IL296532A (en) 2020-03-18 2022-11-01 Metacrine Inc Crystal forms of farnesoid x receptor agonist

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US12545660B2 (en) 2026-02-10
CN115666521A (zh) 2023-01-31
JP2025121901A (ja) 2025-08-20
CA3171987A1 (en) 2021-09-23
KR20220155356A (ko) 2022-11-22
EP4121010A1 (en) 2023-01-25
EP4121010A4 (en) 2024-04-10
WO2021188692A1 (en) 2021-09-23
US20230147756A1 (en) 2023-05-11
JP2023518399A (ja) 2023-05-01
AU2021236648A1 (en) 2022-10-13
BR112022018596A2 (pt) 2023-03-07
MX2025009319A (es) 2025-09-02
JP7664278B2 (ja) 2025-04-17
IL296532A (en) 2022-11-01
AR121596A1 (es) 2022-06-22
MX2022011582A (es) 2022-12-13

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