JP7114457B2 - キメラ抗原受容体発現細胞の有効性および増殖を改善するための方法 - Google Patents
キメラ抗原受容体発現細胞の有効性および増殖を改善するための方法 Download PDFInfo
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- JP7114457B2 JP7114457B2 JP2018505581A JP2018505581A JP7114457B2 JP 7114457 B2 JP7114457 B2 JP 7114457B2 JP 2018505581 A JP2018505581 A JP 2018505581A JP 2018505581 A JP2018505581 A JP 2018505581A JP 7114457 B2 JP7114457 B2 JP 7114457B2
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- C12N5/06—Animal cells or tissues; Human cells or tissues
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- A61K38/46—Hydrolases (3)
- A61K38/50—Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
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- A61K2239/59—Reproductive system, e.g. uterus, ovaries, cervix or testes
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- C07K2317/622—Single chain antibody (scFv)
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- C07K2319/00—Fusion polypeptide
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021155858A JP7597688B2 (ja) | 2015-04-17 | 2021-09-24 | キメラ抗原受容体発現細胞の有効性および増殖を改善するための方法 |
| JP2024206929A JP2025061644A (ja) | 2015-04-17 | 2024-11-28 | キメラ抗原受容体発現細胞の有効性および増殖を改善するための方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562149249P | 2015-04-17 | 2015-04-17 | |
| US62/149,249 | 2015-04-17 | ||
| PCT/US2016/027751 WO2016168595A1 (en) | 2015-04-17 | 2016-04-15 | Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021155858A Division JP7597688B2 (ja) | 2015-04-17 | 2021-09-24 | キメラ抗原受容体発現細胞の有効性および増殖を改善するための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018516592A JP2018516592A (ja) | 2018-06-28 |
| JP2018516592A5 JP2018516592A5 (enExample) | 2019-05-30 |
| JP7114457B2 true JP7114457B2 (ja) | 2022-08-08 |
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Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018505581A Active JP7114457B2 (ja) | 2015-04-17 | 2016-04-15 | キメラ抗原受容体発現細胞の有効性および増殖を改善するための方法 |
| JP2021155858A Active JP7597688B2 (ja) | 2015-04-17 | 2021-09-24 | キメラ抗原受容体発現細胞の有効性および増殖を改善するための方法 |
| JP2024206929A Pending JP2025061644A (ja) | 2015-04-17 | 2024-11-28 | キメラ抗原受容体発現細胞の有効性および増殖を改善するための方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021155858A Active JP7597688B2 (ja) | 2015-04-17 | 2021-09-24 | キメラ抗原受容体発現細胞の有効性および増殖を改善するための方法 |
| JP2024206929A Pending JP2025061644A (ja) | 2015-04-17 | 2024-11-28 | キメラ抗原受容体発現細胞の有効性および増殖を改善するための方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11896614B2 (enExample) |
| EP (2) | EP4234685A3 (enExample) |
| JP (3) | JP7114457B2 (enExample) |
| CN (2) | CN118726268A (enExample) |
| AU (3) | AU2016249005B2 (enExample) |
| CA (1) | CA2982996A1 (enExample) |
| ES (1) | ES2948133T3 (enExample) |
| SG (1) | SG11201708516YA (enExample) |
| WO (1) | WO2016168595A1 (enExample) |
Families Citing this family (98)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY35340A (es) | 2013-02-20 | 2014-09-30 | Novartis Ag | Marcaje efectivo de leucemia humana usando células diseñadas con un receptor quimérico de antígeno anti-cd123 |
| EP2958943B1 (en) | 2013-02-20 | 2019-09-11 | The Trustees Of The University Of Pennsylvania | Treatment of cancer using humanized anti-egfrviii chimeric antigen receptor |
| US9745368B2 (en) | 2013-03-15 | 2017-08-29 | The Trustees Of The University Of Pennsylvania | Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy |
| TWI654206B (zh) | 2013-03-16 | 2019-03-21 | 諾華公司 | 使用人類化抗-cd19嵌合抗原受體治療癌症 |
| HRP20240398T1 (hr) | 2013-10-18 | 2024-06-07 | Novartis Ag | Označeni inhibitori prostata specifičnog membranskog antigena (psma), njihova upotreba kao sredstava za snimanje i farmaceutska sredstva za liječenje raka prostate |
| AU2014366047B2 (en) | 2013-12-19 | 2021-03-25 | Novartis Ag | Human mesothelin chimeric antigen receptors and uses thereof |
| US10287354B2 (en) | 2013-12-20 | 2019-05-14 | Novartis Ag | Regulatable chimeric antigen receptor |
| EP4303229A3 (en) | 2014-01-21 | 2024-04-17 | Novartis AG | Enhanced antigen presenting ability of car t cells by co-introduction of costimulatory molecules |
| EP4406610A3 (en) | 2014-04-07 | 2024-10-30 | Novartis AG | Treatment of cancer using anti-cd19 chimeric antigen receptor |
| MX390943B (es) | 2014-07-21 | 2025-03-21 | Novartis Ag | Receptores de antígeno quimérico cd33 y usos de los mismos. |
| US10568947B2 (en) | 2014-07-21 | 2020-02-25 | Novartis Ag | Treatment of cancer using a CLL-1 chimeric antigen receptor |
| WO2016014553A1 (en) | 2014-07-21 | 2016-01-28 | Novartis Ag | Sortase synthesized chimeric antigen receptors |
| MY181834A (en) | 2014-07-21 | 2021-01-08 | Novartis Ag | Treatment of cancer using humanized anti-bcma chimeric antigen receptor |
| MY189028A (en) | 2014-08-19 | 2022-01-20 | Novartis Ag | Anti-cd123 chimeric antigen receptor (car) for use in cancer treatment |
| JP6839074B2 (ja) | 2014-09-17 | 2021-03-03 | ノバルティス アーゲー | 養子免疫療法のためのキメラ受容体での細胞毒性細胞のターゲティング |
| CN114107424A (zh) | 2014-10-08 | 2022-03-01 | 诺华股份有限公司 | 预测针对嵌合抗原受体疗法的治疗应答性的生物标志及其用途 |
| KR20250075716A (ko) | 2014-12-29 | 2025-05-28 | 노파르티스 아게 | 키메라 항원 수용체-발현 세포를 제조하는 방법 |
| WO2016115482A1 (en) | 2015-01-16 | 2016-07-21 | Novartis Pharma Ag | Phosphoglycerate kinase 1 (pgk) promoters and methods of use for expressing chimeric antigen receptor |
| WO2016126608A1 (en) | 2015-02-02 | 2016-08-11 | Novartis Ag | Car-expressing cells against multiple tumor antigens and uses thereof |
| HUE059218T2 (hu) | 2015-04-08 | 2022-11-28 | Novartis Ag | CD20-terápiák, CD22-terápiák és kombinációs terápiák CD19 kiméra antigénreceptort (CAR-t) expresszáló sejttel |
| SG11201708516YA (en) | 2015-04-17 | 2017-11-29 | David Maxwell Barrett | Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells |
| EP3286211A1 (en) | 2015-04-23 | 2018-02-28 | Novartis AG | Treatment of cancer using chimeric antigen receptor and protein kinase a blocker |
| SG10201912978PA (en) | 2015-07-21 | 2020-02-27 | Novartis Ag | Methods for improving the efficacy and expansion of immune cells |
| EP3331913A1 (en) | 2015-08-07 | 2018-06-13 | Novartis AG | Treatment of cancer using chimeric cd3 receptor proteins |
| EP3344996A2 (en) | 2015-09-03 | 2018-07-11 | The Trustees Of The University Of Pennsylvania | Biomarkers predictive of cytokine release syndrome |
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| US20240398913A1 (en) | 2024-12-05 |
| WO2016168595A1 (en) | 2016-10-20 |
| SG11201708516YA (en) | 2017-11-29 |
| WO2016168595A8 (en) | 2018-02-01 |
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