JP7081923B2 - アポｅ模倣ペプチド及び血漿コレステロールを取り除くためのより高い効果 - Google Patents

アポｅ模倣ペプチド及び血漿コレステロールを取り除くためのより高い効果 Download PDF

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JP7081923B2
JP7081923B2 JP2017505143A JP2017505143A JP7081923B2 JP 7081923 B2 JP7081923 B2 JP 7081923B2 JP 2017505143 A JP2017505143 A JP 2017505143A JP 2017505143 A JP2017505143 A JP 2017505143A JP 7081923 B2 JP7081923 B2 JP 7081923B2
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peptide
apoe
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acid
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JP2017528437A (ja
JP2017528437A5 (enExample
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ガタダハリ エム アナンタラマイアー
デニス ゴールドバーグ
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ユーエイビー リサーチ ファンデーション
リピメティックス ディヴェロップメント リミテッド ライアビリティ カンパニー
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides

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  • General Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Marine Sciences & Fisheries (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2017505143A 2014-07-31 2015-07-20 アポｅ模倣ペプチド及び血漿コレステロールを取り除くためのより高い効果 Active JP7081923B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462031585P 2014-07-31 2014-07-31
US62/031,585 2014-07-31
PCT/US2015/041162 WO2016018665A1 (en) 2014-07-31 2015-07-20 Apoe mimetic peptides and higher potency to clear plasma cholesterol

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JP2020137431A Division JP7095037B2 (ja) 2014-07-31 2020-08-17 アポｅ模倣ペプチド及び血漿コレステロールを取り除くためのより高い効果

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JP2017528437A JP2017528437A (ja) 2017-09-28
JP2017528437A5 JP2017528437A5 (enExample) 2018-08-23
JP7081923B2 true JP7081923B2 (ja) 2022-06-07

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JP2020137431A Active JP7095037B2 (ja) 2014-07-31 2020-08-17 アポｅ模倣ペプチド及び血漿コレステロールを取り除くためのより高い効果

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US (2) US10653747B2 (enExample)
EP (1) EP3189069B1 (enExample)
JP (2) JP7081923B2 (enExample)
CN (1) CN107074923B (enExample)
AU (1) AU2015298263B2 (enExample)
BR (1) BR112017001860A2 (enExample)
CA (1) CA2954475C (enExample)
IL (1) IL250302B (enExample)
MX (1) MX383117B (enExample)
WO (1) WO2016018665A1 (enExample)

Families Citing this family (13)

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MX2015012818A (es) * 2013-03-14 2016-05-12 Uab Research Foundation Mimeticos de apolipoproteina y usos de los mismos.
BR112017001860A2 (pt) 2014-07-31 2018-02-27 Uab Research Foundation peptídeo sintético, composição farmacêutica, métodos, regime de dosagem, e, anticorpo monoclonal
IL258604B2 (en) 2015-10-14 2024-09-01 Massachusetts Eye & Ear Infirmary High-dose statins for age-related macular degeneration
WO2017120568A1 (en) * 2016-01-08 2017-07-13 Lipimetix Development, Inc. Apoe mimetic peptide compositions
JP2020514407A (ja) * 2017-01-24 2020-05-21 マクリーゲン, インク.Macregen, Inc. アポリポプロテイン模倣物を用いる加齢黄斑変性と他の眼疾患の治療
WO2018190896A1 (en) 2017-04-13 2018-10-18 Lipimetix Development, Inc. Apoe mimetic peptide compositions
WO2019199976A1 (en) 2018-04-11 2019-10-17 Lipimetix Development, Inc. Apoe mimetic peptide compositions
EP3919504A1 (en) 2018-11-08 2021-12-08 Saitama University Liposome-binding peptide, construct for producing liposome-binding peptide, and liposome
CN111617232B (zh) * 2020-06-04 2023-04-18 安域生物科技(杭州)有限公司 一类ApoE受体蛋白短肽阻断剂在阿尔茨海默病的应用
CN114940711B (zh) * 2021-10-25 2023-05-12 中山大学 载脂蛋白a-i模拟肽及其应用
EP4519300A1 (en) * 2022-05-05 2025-03-12 The United States of America, as represented by The Secretary, Department of Health and Human Services Short apolipoprotein e mimetic peptides and methods of use
WO2024238337A1 (en) * 2023-05-17 2024-11-21 The Medical College Of Wisconsin Dual-domain peptide for depleting hmgb1 from the circulation via liver hspg system
WO2025147594A1 (en) * 2024-01-04 2025-07-10 University Of Florida Research Foundation, Incorporated Peptides and method of use in preparing nanodiscs

Citations (1)

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Publication number Priority date Publication date Assignee Title
JP2010537638A (ja) 2007-08-28 2010-12-09 ユーエービー リサーチ ファウンデーション 合成アポリポ蛋白質ｅ模倣ポリペプチドおよび使用方法

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