JP7045191B2 - 駆虫性デプシペプチド化合物 - Google Patents

駆虫性デプシペプチド化合物 Download PDF

Info

Publication number
JP7045191B2
JP7045191B2 JP2017560499A JP2017560499A JP7045191B2 JP 7045191 B2 JP7045191 B2 JP 7045191B2 JP 2017560499 A JP2017560499 A JP 2017560499A JP 2017560499 A JP2017560499 A JP 2017560499A JP 7045191 B2 JP7045191 B2 JP 7045191B2
Authority
JP
Japan
Prior art keywords
alkyl
independently
formula
substituted
heteroaryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2017560499A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018516904A5 (enExample
JP2018516904A (ja
Inventor
ファロワ ロイク ル ヒール ド
チャールズ メン
グレゴリー パコフスキー
ヒョウン イク リー
アラン ロング
シプリアン オー オグブ
Original Assignee
ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド filed Critical ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド
Publication of JP2018516904A publication Critical patent/JP2018516904A/ja
Publication of JP2018516904A5 publication Critical patent/JP2018516904A5/ja
Priority to JP2022001528A priority Critical patent/JP2022058535A/ja
Application granted granted Critical
Publication of JP7045191B2 publication Critical patent/JP7045191B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
    • A01N37/46—N-acyl derivatives
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/84—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms six-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,4
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P17/00—Pest repellants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/15—Depsipeptides; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
JP2017560499A 2015-05-20 2016-05-20 駆虫性デプシペプチド化合物 Expired - Fee Related JP7045191B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022001528A JP2022058535A (ja) 2015-05-20 2022-01-07 駆虫性デプシペプチド化合物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562163997P 2015-05-20 2015-05-20
US62/163,997 2015-05-20
PCT/US2016/033522 WO2016187534A1 (en) 2015-05-20 2016-05-20 Anthelmintic depsipeptide compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022001528A Division JP2022058535A (ja) 2015-05-20 2022-01-07 駆虫性デプシペプチド化合物

Publications (3)

Publication Number Publication Date
JP2018516904A JP2018516904A (ja) 2018-06-28
JP2018516904A5 JP2018516904A5 (enExample) 2019-05-30
JP7045191B2 true JP7045191B2 (ja) 2022-03-31

Family

ID=56322274

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2017560499A Expired - Fee Related JP7045191B2 (ja) 2015-05-20 2016-05-20 駆虫性デプシペプチド化合物
JP2022001528A Pending JP2022058535A (ja) 2015-05-20 2022-01-07 駆虫性デプシペプチド化合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2022001528A Pending JP2022058535A (ja) 2015-05-20 2022-01-07 駆虫性デプシペプチド化合物

Country Status (32)

Country Link
US (3) US10081656B2 (enExample)
EP (2) EP3298027B1 (enExample)
JP (2) JP7045191B2 (enExample)
KR (1) KR20180002886A (enExample)
CN (2) CN114891070A (enExample)
AR (1) AR104714A1 (enExample)
AU (2) AU2016264635B2 (enExample)
BR (1) BR112017024773A2 (enExample)
CA (1) CA2986478C (enExample)
CL (1) CL2017002936A1 (enExample)
CO (1) CO2017011738A2 (enExample)
CY (1) CY1124370T1 (enExample)
DK (1) DK3298027T3 (enExample)
ES (1) ES2916216T3 (enExample)
HR (1) HRP20211041T1 (enExample)
HU (1) HUE055535T2 (enExample)
IL (1) IL255735B (enExample)
LT (1) LT3298027T (enExample)
MX (2) MX379719B (enExample)
NZ (1) NZ737610A (enExample)
PH (1) PH12017502106A1 (enExample)
PL (1) PL3298027T3 (enExample)
PT (1) PT3298027T (enExample)
RS (1) RS62130B1 (enExample)
RU (1) RU2707298C2 (enExample)
SG (1) SG10202103403SA (enExample)
SI (1) SI3298027T1 (enExample)
SM (1) SMT202100417T1 (enExample)
TW (2) TWI749509B (enExample)
UY (1) UY36683A (enExample)
WO (1) WO2016187534A1 (enExample)
ZA (2) ZA201707806B (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114891070A (zh) 2015-05-20 2022-08-12 勃林格殷格翰动物保健美国公司 驱虫缩酚酸肽化合物
KR20220003663A (ko) 2015-12-28 2022-01-10 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 구충성 뎁시펩티드 화합물
WO2018039508A1 (en) 2016-08-25 2018-03-01 Merial, Inc. Method for reducing unwanted effects in parasiticidal treatments
MX2019005628A (es) 2016-11-16 2019-12-18 Boehringer Ingelheim Animal Health Usa Inc Compuestos depsipeptidos antihelminticos.
AU2018219273B2 (en) 2017-02-08 2023-08-17 Boehringer lngelheim Vetmedica GMBH In vivo model for parasitic worm infection and methods for evaluating antiparasitic compounds, including compounds active against canine heartworm
GB201713633D0 (en) * 2017-08-24 2017-10-11 Walshe Nigel Methods for production of emodepside from pf 1022a derivatives
AU2018363696B2 (en) * 2017-11-07 2023-09-14 Elanco Animal Health Gmbh Method for the synthesis of cyclic depsipeptides
BR112020010399A2 (pt) 2017-11-29 2020-11-24 Zoetis Services Llc depsipeptídeos endoparasitários
EP3749096A1 (en) 2018-02-08 2020-12-16 Boehringer Ingelheim Animal Health USA Inc. Parasiticidal compositions comprising eprinomectin and praziquantel, methods and uses thereof
CN112384511B (zh) * 2018-05-10 2024-01-30 硕腾服务有限责任公司 内寄生虫缩肽
EP3908330A1 (en) 2019-01-10 2021-11-17 Zoetis Services LLC Anthelmintic laboratory animal model for heartworm
BR112021018631A2 (pt) 2019-03-19 2021-11-23 Boehringer Ingelheim Animal Health Usa Inc Compostos anti-helmínticos de aza-benzotiofeno e aza-benzofurano
CN110343056B (zh) * 2019-07-19 2022-01-07 爱斯特（成都）生物制药股份有限公司 一种n-叔丁氧羰基-n-甲基-2-氨基-4,4-二甲基戊酸的制备方法
WO2021242581A1 (en) 2020-05-29 2021-12-02 Boehringer Ingelheim Animal Health USA Inc. Anthelmintic heterocyclic compounds
WO2022140728A1 (en) 2020-12-21 2022-06-30 Boehringer Ingelheim Animam Health Usa Inc. Parasiticidal collar comprising isoxazoline compounds
JP2025507585A (ja) 2022-02-17 2025-03-21 ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー 流体製品メーラーを提供する方法及びシステム
CN114920669A (zh) * 2022-06-28 2022-08-19 吉尔多肽生物制药(大连市)有限公司 一种n-甲基-n-苄氧羰基-l-天门冬氨酸（4-叔丁酯）二环己胺盐的合成方法
CN116606237A (zh) * 2023-05-23 2023-08-18 上海吉奉生物科技有限公司 一种色氨酸衍生物的合成方法
CN116640091A (zh) * 2023-05-25 2023-08-25 上海吉奉生物科技有限公司 一种Boc-3-（3-吡啶基）- L -丙氨酸的合成方法
CN116655534A (zh) * 2023-06-07 2023-08-29 上海吉奉生物科技有限公司 一种Boc-3-（3-吡唑）- L -丙氨酸的合成方法
EP4538282A1 (en) * 2023-10-13 2025-04-16 Vetoquinol SA Synthesis of emodepside

Family Cites Families (168)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6426333B1 (en) 1996-09-19 2002-07-30 Merial Spot-on formulations for combating parasites
NL160809C (nl) 1970-05-15 1979-12-17 Duphar Int Res Werkwijze ter bereiding van benzoylureumverbindingen, alsmede werkwijze ter bereiding van insekticide prepara- ten op basis van benzoylureumverbindingen.
JPS4914624A (enExample) 1972-06-08 1974-02-08
US3950360A (en) 1972-06-08 1976-04-13 Sankyo Company Limited Antibiotic substances
US3818047A (en) 1972-08-07 1974-06-18 C Henrick Substituted pyrones
SE434277B (sv) 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
US4166452A (en) 1976-05-03 1979-09-04 Generales Constantine D J Jr Apparatus for testing human responses to stimuli
CH604517A5 (enExample) 1976-08-19 1978-09-15 Ciba Geigy Ag
US4256108A (en) 1977-04-07 1981-03-17 Alza Corporation Microporous-semipermeable laminated osmotic system
US4134973A (en) 1977-04-11 1979-01-16 Merck & Co., Inc. Carbohydrate derivatives of milbemycin and processes therefor
US4199569A (en) 1977-10-03 1980-04-22 Merck & Co., Inc. Selective hydrogenation products of C-076 compounds and derivatives thereof
US4144352A (en) 1977-12-19 1979-03-13 Merck & Co., Inc. Milbemycin compounds as anthelmintic agents
US4203976A (en) 1978-08-02 1980-05-20 Merck & Co., Inc. Sugar derivatives of C-076 compounds
US4265874A (en) 1980-04-25 1981-05-05 Alza Corporation Method of delivering drug with aid of effervescent activity generated in environment of use
JPS57139012A (en) 1981-02-23 1982-08-27 Sankyo Co Ltd Anthelmintic composition
US4427663A (en) 1982-03-16 1984-01-24 Merck & Co., Inc. 4"-Keto-and 4"-amino-4"-deoxy avermectin compounds and substituted amino derivatives thereof
DE3235931A1 (de) 1982-09-29 1984-03-29 Bayer Ag, 5090 Leverkusen Koeder zur bekaempfung von ungeziefer
JPS59199673A (ja) 1983-04-25 1984-11-12 Sumitomo Chem Co Ltd 含窒素複素環化合物、その製造法およびそれを有効成分とする有害生物防除剤
IL76708A (en) 1984-10-18 1990-01-18 Ciba Geigy Ag Substituted n-benzoyl-n'-(2,5-dichloro-4(1,1,2,3,3,3-hexafluoropropyloxy)-phenyl)ureas,their preparation and pesticidal compositions containing them
EP0192060B1 (de) 1985-02-04 1991-09-18 Nihon Bayer Agrochem K.K. Heterocyclische Verbindungen
EP0237482A1 (de) 1986-03-06 1987-09-16 Ciba-Geigy Ag C(29)-Carbonyloxi-milbemycin-Derivate zur Bekämpfung von tier- und pflanzenparasitären Schädlingen
DE3785936T2 (de) 1986-03-25 1993-08-26 Sankyo Co Makrolid-derivate, ihre herstellung und ihre verwendung.
EP0252879B1 (de) 1986-07-02 1992-05-06 Ciba-Geigy Ag Pestizide
US4855317A (en) 1987-03-06 1989-08-08 Ciba-Geigy Corporation Insecticides and parasiticides
US4871719A (en) 1987-03-24 1989-10-03 Ciba-Geigy Corporation Composition for controlling parasites in productive livestock
US4874749A (en) 1987-07-31 1989-10-17 Merck & Co., Inc. 4"-Deoxy-4-N-methylamino avermectin Bla/Blb
EP0319142B1 (en) 1987-11-03 1994-04-06 Beecham Group Plc Intermediates for the preparation of anthelmintic macrolide antibiotics
MA21697A1 (fr) 1988-12-19 1990-07-01 Dow Agrosciences Llc Composes de macrolides.
NO176766C (no) 1989-02-07 1995-05-24 Meiji Seika Kaisha Fremgangsmåte for fremstilling av en forbindelse med anthelmintaktivitet
NZ232422A (en) 1989-02-16 1992-11-25 Merck & Co Inc 13-ketal milbemycin derivatives and parasiticides
IE904606A1 (en) 1989-12-21 1991-07-03 Beecham Group Plc Novel products
NZ247278A (en) 1991-02-12 1995-03-28 Ancare Distributors Veterinary anthelmintic drench comprising a suspension of praziquantel in a liquid carrier
WO1992022555A1 (en) 1991-06-17 1992-12-23 Beecham Group Plc Paraherquamide derivatives, precursor thereof, processes for their preparation, microorganism used and their use as antiparasitic agents
US5202242A (en) 1991-11-08 1993-04-13 Dowelanco A83543 compounds and processes for production thereof
WO1993019053A1 (en) 1992-03-17 1993-09-30 Fujisawa Pharmaceutical Co., Ltd. Depsipeptide derivative, production thereof and use thereof
US5345377A (en) 1992-10-30 1994-09-06 Electric Power Research Institute, Inc. Harmonic controller for an active power line conditioner
US5591606A (en) 1992-11-06 1997-01-07 Dowelanco Process for the production of A83543 compounds with Saccharopolyspora spinosa
GB9300883D0 (en) 1993-01-18 1993-03-10 Pfizer Ltd Antiparasitic agents
AU695021B2 (en) 1993-02-19 1998-08-06 Meiji Seika Kaisha Ltd. PF1022 derivative cyclic depsipeptide
BR9406587A (pt) 1993-03-12 1996-01-02 Dowelanco Novos compostos a83543 e processo para a produção dos mesmos
DE4317457A1 (de) * 1993-05-26 1994-12-01 Bayer Ag Octacyclodepsipeptide mit endoparasitizider Wirkung
DE4317432A1 (de) * 1993-05-26 1994-12-01 Bayer Ag Octacyclodepsipeptide mit endoparasitizider Wirkung
US5646244A (en) 1993-09-06 1997-07-08 Fujisawa Pharmaceutical Co., Ltd. Cyclodepsipeptide compound
US5399582A (en) 1993-11-01 1995-03-21 Merck & Co., Inc. Antiparasitic agents
SE9303657D0 (sv) 1993-11-05 1993-11-05 Astra Ab Short-acting dihydropyridines
DE4400464A1 (de) 1994-01-11 1995-07-13 Bayer Ag Endoparasitizide Mittel
US5750548A (en) 1994-01-24 1998-05-12 Novartis Corp. 1- N-(halo-3-pyridylmethyl)!-N-methylamino-1-alklamino-2-nitroethylene derivatives for controlling fleas in domestic animals
DE4437198A1 (de) 1994-10-18 1996-04-25 Bayer Ag Verfahren zur Sulfonylierung, Sulfenylierung und Phosphorylierung von cyclischen Depsipeptiden
AUPM969994A0 (en) 1994-11-28 1994-12-22 Virbac S.A. Equine anthelmintic formulations
US5962499A (en) 1995-03-20 1999-10-05 Merck & Co., Inc. Nodulisporic acid derivatives
US6221894B1 (en) 1995-03-20 2001-04-24 Merck & Co., Inc. Nodulisporic acid derivatives
DE19520275A1 (de) 1995-06-02 1996-12-05 Bayer Ag Endoparasitizide Mittel
JP3910634B2 (ja) 1995-06-22 2007-04-25 明治製菓株式会社 Ｐｆ１０２２物質を産生する形質転換体、及び糸状菌綱に属する菌の形質転換方法
CN1162409C (zh) 1995-06-30 2004-08-18 藤泽药品工业株式会社 缩肽衍生物、其新型中间体以及中间体的制造方法
MY113806A (en) 1995-07-21 2002-05-31 Upjohn Co Antiparasitic marcfortines and paraherquamides
IL123776A (en) 1995-09-22 2002-09-12 Bayer Ag History of Cyclodepsipeptide 1022 PF
FR2739255B1 (fr) 1995-09-29 1998-09-04 Rhone Merieux Composition antiparasitaire pour le traitement et la protection des animaux de compagnie
DE19545639A1 (de) 1995-12-07 1997-06-12 Bayer Ag Verfahren zur Herstellung von substituierten Arylmilchsäure-haltigen Cyclodepsipeptiden mit 24 Ringatomen
FR2752525B1 (fr) 1996-08-20 2000-05-05 Rhone Merieux Procede de lutte contre les myiases des cheptels bovins et ovins et compositions pour la mise en oeuvre de ce procede
IE80657B1 (en) 1996-03-29 1998-11-04 Merial Sas Insecticidal combination to control mammal fleas in particular fleas on cats and dogs
US6010710A (en) 1996-03-29 2000-01-04 Merial Direct pour-on skin solution for antiparasitic use in cattle and sheep
US5885607A (en) 1996-03-29 1999-03-23 Rhone Merieux N-phenylpyrazole-based anti-flea and anti-tick external device for cats and dogs
US6001981A (en) 1996-06-13 1999-12-14 Dow Agrosciences Llc Synthetic modification of Spinosyn compounds
US6998131B2 (en) 1996-09-19 2006-02-14 Merial Limited Spot-on formulations for combating parasites
EP0953563B1 (en) 1996-10-07 2003-04-16 Fujisawa Pharmaceutical Co., Ltd. Process for producing depsipeptide derivatives and novel intermediates therefor
DE19713626A1 (de) 1997-04-02 1998-10-08 Bayer Ag Neue Thiodepsipeptide zur Bekämpfung von Endoparasiten und ein einfaches Verfahren zu ihrer Herstellung
CA2292698A1 (en) 1997-06-04 1998-12-10 Bayer Aktiengesellschaft Desoxycyclodepsipeptides and their use for combatting endoparasites
US6207647B1 (en) 1997-07-18 2001-03-27 Smithkline Beecham Corporation RatA
DE19811559A1 (de) 1998-03-17 1999-09-23 Bayer Ag Cyclooctadepsipeptide
DE19828043A1 (de) 1998-06-24 1999-12-30 Bayer Ag Ektoparasitizide Mittel
US6174540B1 (en) 1998-09-14 2001-01-16 Merck & Co., Inc. Long acting injectable formulations containing hydrogenated caster oil
DE19921887A1 (de) 1999-05-12 2000-11-16 Bayer Ag Endoparasitizide Mittel
DE19926620A1 (de) * 1999-06-11 2000-12-14 Bayer Ag Neue Cycloiminodepsipeptide, Verfahren zu ihrer Herstellung und ihre Verwendung zur Bekämpfung von Endoparasiten
DE19962145A1 (de) 1999-12-22 2001-06-28 Bayer Ag Schädlingsbekämpfungsmittel/Depsipeptide
DE19962147A1 (de) 1999-12-22 2001-06-28 Bayer Ag Schädlingsbekämpfungsmittel / PF 1022-221
US6787342B2 (en) 2000-02-16 2004-09-07 Merial Limited Paste formulations
DE10008128A1 (de) 2000-02-22 2001-08-23 Bayer Ag Endoparasitizide Mittel
PE20011289A1 (es) 2000-04-07 2001-12-21 Upjohn Co Composiciones antihelminticas que comprenden lactonas macrociclicas y espirodioxepinoindoles
DE10031044A1 (de) 2000-06-26 2002-01-03 Bayer Ag Endoparasitizide Mittel zur freiwilligen oralen Aufnahme durch Tiere
US6399786B1 (en) 2000-07-14 2002-06-04 Merck & Co., Inc. Nonacyclic nodulisporic acid derivatives
DE10104362A1 (de) 2001-02-01 2002-08-08 Bayer Ag Kristallmodifikation eines cyclischen Depsipeptids mit besserer Wirksamkeit
UY26592A1 (es) 2001-02-20 2001-09-28 Bayer Ag Agentes endoparasiticidas
US6893652B2 (en) 2001-08-27 2005-05-17 Wyeth Endoparasiticidal gel composition
US7001889B2 (en) 2002-06-21 2006-02-21 Merial Limited Anthelmintic oral homogeneous veterinary pastes
US20040151759A1 (en) 2002-08-16 2004-08-05 Douglas Cleverly Non-animal product containing veterinary formulations
TW200409760A (en) 2002-09-11 2004-06-16 Novartis Ag Organic compounds
US20040236191A1 (en) 2003-05-19 2004-11-25 Poliska Steven A. System and method for identifying and labeling livestock products, and managing data associated with those products
TWI366442B (en) 2003-07-30 2012-06-21 Novartis Ag Palatable ductile chewable veterinary composition
DE10358525A1 (de) 2003-12-13 2005-07-07 Bayer Healthcare Ag Endoparasitizide Mittel zur topischen Applikation
ES2351972T3 (es) 2004-02-27 2011-02-14 Ic Services Procedimiento y set para la identificación de animales.
CN1930136B (zh) 2004-03-05 2012-02-08 日产化学工业株式会社 异*唑啉取代苯甲酰胺化合物及有害生物防除剂
DE102004055316A1 (de) 2004-11-16 2006-05-18 Bayer Healthcare Ag Verhinderung vertikaler Endoparasiten-Infektionen
US20060202835A1 (en) 2005-02-25 2006-09-14 Osborne Industries, Inc. Dual frequency identification device
ES2443690T3 (es) 2005-09-02 2014-02-20 Nissan Chemical Industries, Ltd. Compuesto de benzamida sustituido con isoxazolina y agente controlador de organismos dañinos
US7955632B2 (en) 2005-12-07 2011-06-07 Bayer B.V. Process for manufacturing chewable dosage forms for drug delivery and products thereof
EP1965645A2 (en) 2005-12-14 2008-09-10 E.I. Du Pont De Nemours And Company Isoxazolines for controlling invertebrate pests
TW200803740A (en) 2005-12-16 2008-01-16 Du Pont 5-aryl isoxazolines for controlling invertebrate pests
TWI412322B (zh) 2005-12-30 2013-10-21 Du Pont 控制無脊椎害蟲之異唑啉
BRPI0707091B8 (pt) 2006-03-10 2018-02-14 Nissan Chemical Ind Ltd composto de isoxalina e benzaldoxima substituído ou um sal do mesmo; pesticida, agroquímico, endo- ou ecto-parasiticidapara mamíferos ou pássaros, inseticida e acaricida contendo como um ou mais ingredientes ativos selecionados a partir do composto de isoxalina substituído e o sal do mesmo
AU2007240954A1 (en) 2006-04-20 2007-11-01 E. I. Du Pont De Nemours And Company Pyrazolines for controlling invertebrate pests
WO2007125984A1 (ja) 2006-04-28 2007-11-08 Nihon Nohyaku Co., Ltd. イソキサゾリン誘導体及び有害生物防除剤並びにその使用方法
WO2008005489A2 (en) 2006-07-05 2008-01-10 Aventis Agriculture 1-aryl-5-alkyl pyrazole derivative compounds, processes of making and methods of using thereof
JP2008044880A (ja) 2006-08-15 2008-02-28 Bayer Cropscience Ag 殺虫性イソオキサゾリン類
GB0623357D0 (en) * 2006-11-22 2007-01-03 Karus Therapeutics Ltd Chemical compounds
JP5206993B2 (ja) 2007-03-07 2013-06-12 日産化学工業株式会社 イソキサゾリン置換ベンズアミド化合物及び有害生物防除剤
JP5380278B2 (ja) 2007-03-16 2014-01-08 クミアイ化学工業株式会社 除草剤組成物
JP5256753B2 (ja) 2007-03-29 2013-08-07 住友化学株式会社 イソオキサゾリン化合物とその有害生物防除用途
KR20090130064A (ko) 2007-04-10 2009-12-17 바이엘 크롭사이언스 아게 살충성 아릴 이속사졸린 유도체
HUE029127T2 (en) 2007-05-15 2017-02-28 Merial Inc Arylazol-2-yl-cyanoethylamino compounds, a process for their preparation and use
US8623875B2 (en) 2007-06-13 2014-01-07 E.I. Du Pont De Nemours And Company Isoxazoline insecticides
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
US8952175B2 (en) 2007-06-27 2015-02-10 Nissan Chemical Industries, Ltd. Method for production of 3-hydroxypropan-1-one compound, method for production of 2-propen-1-one compound and method for production of isoxazoline compound
PT2170321E (pt) 2007-06-29 2013-08-01 Zoetis Llc Combinação anti-helmíntica
JP5316808B2 (ja) 2007-06-29 2013-10-16 日産化学工業株式会社 置換イソキサゾリン又はエノンオキシム化合物および有害生物防除剤
TWI556741B (zh) 2007-08-17 2016-11-11 英特威特國際股份有限公司 異唑啉組成物及其作為抗寄生蟲藥上的應用
WO2009035004A1 (ja) 2007-09-10 2009-03-19 Nissan Chemical Industries, Ltd. 置換イソキサゾリン化合物および有害生物防除剤
MX2010003557A (es) 2007-10-03 2010-04-12 Du Pont Compuestos de isoxazolina de naftaleno para el control de plagas de invertebrados.
DE102008022520A1 (de) 2008-05-07 2009-11-12 Bayer Animal Health Gmbh Feste Arzneimittelformulierung mit verzögerter Freisetzung
DE102008030764A1 (de) 2008-06-28 2009-12-31 Bayer Animal Health Gmbh Kombination von Amidin-Derivaten mit cyclischen Depsipeptiden
DE102008031284A1 (de) 2008-07-02 2010-01-07 Bayer Schering Pharma Aktiengesellschaft Neue Bekämpfungsmöglichkeit der Giardiose
DE102008031283A1 (de) 2008-07-02 2010-01-07 Bayer Schering Pharma Aktiengesellschaft Neue Bekämpfungsmöglichkeit von durch Trichomonadida hervorgerufenen Krankheiten
EP2306837B2 (en) 2008-07-09 2023-10-25 Basf Se Pesticidal active mixtures comprising isoxazoline compounds i
CA2973871C (en) 2008-07-09 2019-09-10 Nissan Chemical Industries, Ltd. Production method of isoxazoline-substituted benzoic acid amide compound
US8597688B2 (en) 2008-07-09 2013-12-03 Basf Se Pesticidal mixtures comprising isoxazoline compounds II
CA2732217A1 (en) 2008-09-04 2010-03-11 Peter Renold Insecticidal compounds
US9820977B2 (en) 2008-10-03 2017-11-21 Bayer Healthcare Llc Systemic treatment of blood-sucking and blood-consuming parasites by oral administration of a parasiticidal agent
NZ592382A (en) 2008-10-21 2013-03-28 Merial Ltd Thioamide compounds, method of making and method of using thereof
US20110262969A1 (en) 2008-12-16 2011-10-27 Achim Harder Method for producing optically active, cyclic depsipeptides comprising lactic acid and phenyl lactic and having 24 ring atoms, using fungus strains of rosellinia type, and further species of xylariaceae
US8377942B2 (en) 2008-12-18 2013-02-19 Novartis Ag Isoxazolines derivatives and their use as pesticide
RU2518462C2 (ru) 2008-12-19 2014-06-10 Новартис Аг Органические соединения
US8633134B2 (en) 2008-12-23 2014-01-21 Basf Se Substituted amidine compounds for combating animal pests
KR101002530B1 (ko) 2009-02-18 2010-12-17 삼성에스디아이 주식회사 알에프아이디 통신 장치
WO2010108733A1 (en) 2009-03-26 2010-09-30 Syngenta Participations Ag Insecticidal compounds
EP2414353A1 (en) 2009-04-01 2012-02-08 Basf Se Isoxazoline compounds for combating invertebrate pests
TWI487486B (zh) 2009-12-01 2015-06-11 Syngenta Participations Ag 以異唑啉衍生物為主之殺蟲化合物
JP5779787B2 (ja) 2009-12-11 2015-09-16 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ 真菌株から由来の新規な２４員のシクロオクタデプシペプチドおよびその駆虫剤または内部寄生虫駆除剤としての使用
ES2569486T3 (es) 2009-12-17 2016-05-11 Merial, Inc. Compuestos de dihidroazol antiparasitarios y composiciones que comprenden los mismos
US8999889B2 (en) 2010-02-01 2015-04-07 Basf Se Substituted ketonic isoxazoline compounds and derivatives for combating animal pests
EP2538789A1 (en) 2010-02-25 2013-01-02 Syngenta Participations AG Pesticidal mixtures containing isoxazoline derivatives and a fungicide
CA2791067A1 (en) 2010-02-25 2011-09-01 Syngenta Participations Ag Pesticidal mixtures containing isoxazoline derivatives and insecticide or nematoicidal biological agent
EA201201179A1 (ru) 2010-02-25 2013-04-30 Зингента Партисипейшнс Аг Способ получения изоксазолиновых производных
CA2794428A1 (en) 2010-04-08 2011-10-13 Pfizer Inc. Substituted 3,5-diphenyl-isoxazoline derivatives as insecticides and acaricides
US20130203591A1 (en) 2010-06-09 2013-08-08 Syngenta Crop Protection Llc Pesticidal mixtures including isoxazoline derivatives
US20130210623A1 (en) 2010-06-09 2013-08-15 Syngenta Crop Protection Llc Pesticidal mixtures including isoxazoline derivatives
UY33403A (es) 2010-06-17 2011-12-30 Novartis Ag Compuestos orgánicos con novedosas isoxazolinas, sus n-óxidos, s-óxidos y sales
KR101508862B1 (ko) 2010-08-05 2015-04-07 조에티스 엘엘씨 구충제로서 이속사졸린 유도체
WO2012028556A1 (en) 2010-08-31 2012-03-08 Bayer Animal Health Gmbh Macrocyclic lactones and their use and their combinations with other active substances
AU2011306489B2 (en) 2010-09-24 2015-11-05 Zoetis Services Llc Isoxazoline oximes as antiparasitic agents
WO2012065031A2 (en) 2010-11-11 2012-05-18 Mlp Technology Inc. Animal data management
WO2012086462A1 (ja) 2010-12-20 2012-06-28 日本曹達株式会社 イソオキサゾリン化合物および有害生物防除剤
KR101992589B1 (ko) 2010-12-27 2019-06-24 인터벳 인터내셔널 비.브이. 글리코푸롤을 포함하는 국소 적용 이속사졸린 제제
HUE058291T2 (hu) 2010-12-27 2022-07-28 Intervet Int Bv Topikális lokalizált izoxazolin formuláció
BR112013020520A2 (pt) 2011-02-10 2016-07-12 Novartis Ag derivados de isoxazolina, composição para o controle de parasitas os compreendendo e uso dos mesmos
US9848290B2 (en) 2011-03-10 2017-12-19 Aruba Networks, Inc. Location based computerized system and method thereof
HRP20160601T1 (hr) 2011-03-10 2016-07-01 Zoetis Services Llc Spirociklički derivati izoksazolina kao antiparazitska sredstva
EP2683713B1 (en) 2011-03-10 2015-04-22 Novartis Tiergesundheit AG Isoxazole derivatives
AR086168A1 (es) * 2011-04-20 2013-11-27 Novartis Ag Procesos para la elaboracion de depsipeptidos macrociclicos e intermediarios
AR088668A1 (es) 2011-11-21 2014-06-25 Lilly Co Eli Moleculas pequeñas que contienen boro
MY175307A (en) 2011-12-21 2020-06-18 Bayer Ip Gmbh Preparations comprising amorphous emodepside
HUE043949T2 (hu) 2012-02-06 2019-09-30 Boehringer Ingelheim Animal Health Usa Inc Szisztémásan ható hatóanyagokat tartalmazó, parazitaellenes, szájon át adagolt állatgyógyászati készítmények, eljárások és alkalmazásuk
HUE042661T2 (hu) 2012-06-13 2019-07-29 Meiji Seika Pharma Co Ltd Új ciklusos depszipeptid származék és ezt tartalmazó kártevõirtó szer
CN104603139B (zh) 2012-09-07 2016-12-07 硕腾服务有限责任公司 作为抗寄生虫剂的螺环衍生物
US9404206B2 (en) 2013-02-28 2016-08-02 Nike, Inc. Feeder for knitting machine having pushing member
US20140306005A1 (en) 2013-04-14 2014-10-16 Forever Yours, Inc. Method for Data Transport and Recovery of Dependent Creatures
US9447084B2 (en) 2013-11-01 2016-09-20 Merial, Inc. Antiparisitic and pesticidal isoxazoline compounds
CN114891070A (zh) 2015-05-20 2022-08-12 勃林格殷格翰动物保健美国公司 驱虫缩酚酸肽化合物
KR20220003663A (ko) * 2015-12-28 2022-01-10 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 구충성 뎁시펩티드 화합물
MX2019005628A (es) 2016-11-16 2019-12-18 Boehringer Ingelheim Animal Health Usa Inc Compuestos depsipeptidos antihelminticos.

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
International Journal of Antimicrobial Agents，2003年，Vol.22，p.318-331
Trends in Parasitology，2012年，Vol.28, No.9，p.385-394

Also Published As

Publication number Publication date
CO2017011738A2 (es) 2018-02-09
NZ737610A (en) 2023-07-28
HUE055535T2 (hu) 2021-12-28
IL255735A (en) 2018-01-31
EP3298027A1 (en) 2018-03-28
CY1124370T1 (el) 2022-07-22
ES2916216T3 (es) 2022-06-29
LT3298027T (lt) 2021-08-10
SMT202100417T1 (it) 2021-09-14
CA2986478A1 (en) 2016-11-24
CN107835818B (zh) 2022-04-29
AU2016264635B2 (en) 2020-05-28
IL255735B (en) 2021-03-25
RU2707298C2 (ru) 2019-11-26
RU2017144495A3 (enExample) 2019-06-20
ZA201907637B (en) 2023-02-22
PT3298027T (pt) 2022-01-26
AR104714A1 (es) 2017-08-09
EP3922639A1 (en) 2021-12-15
US12286455B2 (en) 2025-04-29
MX2017014744A (es) 2018-05-28
US20170022253A1 (en) 2017-01-26
US10081656B2 (en) 2018-09-25
TWI749509B (zh) 2021-12-11
US10793604B2 (en) 2020-10-06
MX2021001566A (es) 2022-09-12
TWI693237B (zh) 2020-05-11
US20200354408A1 (en) 2020-11-12
PL3298027T3 (pl) 2021-11-08
RS62130B1 (sr) 2021-08-31
MX395486B (es) 2025-03-25
CN114891070A (zh) 2022-08-12
CL2017002936A1 (es) 2018-03-16
HK1245285A1 (en) 2018-08-24
BR112017024773A2 (pt) 2018-11-06
KR20180002886A (ko) 2018-01-08
AU2016264635A1 (en) 2017-12-14
CN107835818A (zh) 2018-03-23
SG10202103403SA (en) 2021-05-28
ZA201707806B (en) 2021-06-30
RU2017144495A (ru) 2019-06-20
HRP20211041T1 (hr) 2021-10-01
UY36683A (es) 2016-12-30
CA2986478C (en) 2023-08-08
AU2020213297A1 (en) 2020-08-27
DK3298027T3 (da) 2021-08-09
PH12017502106A1 (en) 2018-05-28
TW201706287A (zh) 2017-02-16
SI3298027T1 (sl) 2021-08-31
WO2016187534A1 (en) 2016-11-24
US20180362589A1 (en) 2018-12-20
TW202108604A (zh) 2021-03-01
JP2018516904A (ja) 2018-06-28
MX379719B (es) 2025-03-11
EP3298027B1 (en) 2021-04-28
JP2022058535A (ja) 2022-04-12

Similar Documents

Publication Publication Date Title
JP7045191B2 (ja) 駆虫性デプシペプチド化合物
JP6943859B2 (ja) 駆虫性デプシペプチド化合物
US12312356B2 (en) Anthelmintic heterocyclic compounds
US12559503B2 (en) Anthelmintic aza-benzothiophene and aza-benzofuran compounds
WO2020014068A1 (en) Anthelminthic heterocyclic compounds
JP2020504710A (ja) 駆虫性デプシペプチド化合物
RU2798093C2 (ru) Противогельминтные гетероциклические соединения
BR112021000257B1 (pt) Compostos heterocíclicos anti-helmínticos

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20190419

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20190419

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A712

Effective date: 20200107

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20200511

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200811

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20210114

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210412

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20210913

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220107

C60 Trial request (containing other claim documents, opposition documents)

Free format text: JAPANESE INTERMEDIATE CODE: C60

Effective date: 20220107

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20220118

C21 Notice of transfer of a case for reconsideration by examiners before appeal proceedings

Free format text: JAPANESE INTERMEDIATE CODE: C21

Effective date: 20220119

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20220314

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20220318

R150 Certificate of patent or registration of utility model

Ref document number: 7045191

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

LAPS Cancellation because of no payment of annual fees