AU2016264635B2 - Anthelmintic depsipeptide compounds - Google Patents
Anthelmintic depsipeptide compounds Download PDFInfo
- Publication number
- AU2016264635B2 AU2016264635B2 AU2016264635A AU2016264635A AU2016264635B2 AU 2016264635 B2 AU2016264635 B2 AU 2016264635B2 AU 2016264635 A AU2016264635 A AU 2016264635A AU 2016264635 A AU2016264635 A AU 2016264635A AU 2016264635 B2 AU2016264635 B2 AU 2016264635B2
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- AU
- Australia
- Prior art keywords
- independently
- zpr
- alkyl
- cme
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- VXTBOLJHIXCLSX-AWEZNQCLSA-N O[C@@H](Cc1ccc(C2=CCCCC2)c(F)c1)C(O)=O Chemical compound O[C@@H](Cc1ccc(C2=CCCCC2)c(F)c1)C(O)=O VXTBOLJHIXCLSX-AWEZNQCLSA-N 0.000 description 1
- PFVGTFOAFWSXLG-NRFANRHFSA-N O[C@@H](Cc1ccc(C2=CCCCC2)c(F)c1)C(OCc1ccccc1)=O Chemical compound O[C@@H](Cc1ccc(C2=CCCCC2)c(F)c1)C(OCc1ccccc1)=O PFVGTFOAFWSXLG-NRFANRHFSA-N 0.000 description 1
- UGWFIQYWLKBNLH-ZDUSSCGKSA-N O[C@@H](Cc1ccc(C2=CCOCC2)c(F)c1)C(O)=O Chemical compound O[C@@H](Cc1ccc(C2=CCOCC2)c(F)c1)C(O)=O UGWFIQYWLKBNLH-ZDUSSCGKSA-N 0.000 description 1
- YVPYVGILADXNJV-MRVPVSSYSA-N O[C@H](Cc(cc1)ccc1Br)C(O)=O Chemical compound O[C@H](Cc(cc1)ccc1Br)C(O)=O YVPYVGILADXNJV-MRVPVSSYSA-N 0.000 description 1
- CLBYTIBKUHIJSF-BPGUCPLFSA-N O[C@H](Cc(cc1)ccc1C(C=C1)=CCC1F)C(OCc1ccccc1)=O Chemical compound O[C@H](Cc(cc1)ccc1C(C=C1)=CCC1F)C(OCc1ccccc1)=O CLBYTIBKUHIJSF-BPGUCPLFSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
- A01N37/46—N-acyl derivatives
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/84—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms six-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,4
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P17/00—Pest repellants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/15—Depsipeptides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Environmental Sciences (AREA)
- Wood Science & Technology (AREA)
- Plant Pathology (AREA)
- Zoology (AREA)
- Pest Control & Pesticides (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2020213297A AU2020213297A1 (en) | 2015-05-20 | 2020-08-04 | Anthelmintic depsipeptide compounds |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562163997P | 2015-05-20 | 2015-05-20 | |
| US62/163,997 | 2015-05-20 | ||
| PCT/US2016/033522 WO2016187534A1 (en) | 2015-05-20 | 2016-05-20 | Anthelmintic depsipeptide compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2020213297A Division AU2020213297A1 (en) | 2015-05-20 | 2020-08-04 | Anthelmintic depsipeptide compounds |
Publications (2)
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| AU2016264635A1 AU2016264635A1 (en) | 2017-12-14 |
| AU2016264635B2 true AU2016264635B2 (en) | 2020-05-28 |
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| AU2016264635A Ceased AU2016264635B2 (en) | 2015-05-20 | 2016-05-20 | Anthelmintic depsipeptide compounds |
| AU2020213297A Abandoned AU2020213297A1 (en) | 2015-05-20 | 2020-08-04 | Anthelmintic depsipeptide compounds |
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| Application Number | Title | Priority Date | Filing Date |
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| AU2020213297A Abandoned AU2020213297A1 (en) | 2015-05-20 | 2020-08-04 | Anthelmintic depsipeptide compounds |
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| MX379719B (es) | 2015-05-20 | 2025-03-11 | Boehringer Ingelheim Animal Health Usa Inc | Compuestos depsipeptidicos como anthelmínticos. |
| KR20220003663A (ko) | 2015-12-28 | 2022-01-10 | 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 | 구충성 뎁시펩티드 화합물 |
| WO2018039508A1 (en) | 2016-08-25 | 2018-03-01 | Merial, Inc. | Method for reducing unwanted effects in parasiticidal treatments |
| BR112019009977A2 (pt) | 2016-11-16 | 2019-08-27 | Boehringer Ingelheim Animal Health Usa Inc | compostos depsipeptídicos anti-helmínticos |
| CA3052054A1 (en) | 2017-02-08 | 2018-08-16 | Boehringer Ingelheim Animal Health USA Inc. | In vivo model for parasitic worm infection and methods for evaluating antiparasitic compounds, including compounds active against canine heartworm |
| GB201713633D0 (en) * | 2017-08-24 | 2017-10-11 | Walshe Nigel | Methods for production of emodepside from pf 1022a derivatives |
| CN111757880A (zh) * | 2017-11-07 | 2020-10-09 | 拜耳动物保健有限责任公司 | 用于合成环状缩肽的方法 |
| SG11202003832WA (en) * | 2017-11-29 | 2020-06-29 | Zoetis Services Llc | Endoparasitic depsipeptides |
| US11583545B2 (en) | 2018-02-08 | 2023-02-21 | Boehringer Ingelheim Animal Health USA Inc. | Parasiticidal compositions comprising eprinomectin and praziquantel, methods and uses thereof |
| WO2019217449A1 (en) * | 2018-05-10 | 2019-11-14 | Zoetis Services Llc | Endoparasitic depsipeptides |
| BR112021013488A2 (pt) | 2019-01-10 | 2021-09-14 | Zoetis Services Llc | Modelo animal de laboratório antelmíntico para dirofilariose |
| CN119285648A (zh) | 2019-03-19 | 2025-01-10 | 勃林格殷格翰动物保健有限公司 | 驱虫的氮杂-苯并噻吩和氮杂-苯并呋喃化合物 |
| CN110343056B (zh) * | 2019-07-19 | 2022-01-07 | 爱斯特（成都）生物制药股份有限公司 | 一种n-叔丁氧羰基-n-甲基-2-氨基-4,4-二甲基戊酸的制备方法 |
| CR20220665A (es) | 2020-05-29 | 2023-07-19 | Boehringer Ingelheim Pharma | Compuestos heterocíclicos como anthelmínticos |
| AU2021410052B2 (en) | 2020-12-21 | 2025-01-09 | Boehringer Ingelheim Vetmedica Gmbh | Parasiticidal collar comprising isoxazoline compounds |
| JP2025507585A (ja) | 2022-02-17 | 2025-03-21 | ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー | 流体製品メーラーを提供する方法及びシステム |
| CN114920669A (zh) * | 2022-06-28 | 2022-08-19 | 吉尔多肽生物制药(大连市)有限公司 | 一种n-甲基-n-苄氧羰基-l-天门冬氨酸（4-叔丁酯）二环己胺盐的合成方法 |
| CN116606237A (zh) * | 2023-05-23 | 2023-08-18 | 上海吉奉生物科技有限公司 | 一种色氨酸衍生物的合成方法 |
| CN116640091A (zh) * | 2023-05-25 | 2023-08-25 | 上海吉奉生物科技有限公司 | 一种Boc-3-（3-吡啶基）- L -丙氨酸的合成方法 |
| CN116655534A (zh) * | 2023-06-07 | 2023-08-29 | 上海吉奉生物科技有限公司 | 一种Boc-3-（3-吡唑）- L -丙氨酸的合成方法 |
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