JP7041668B2 - Nlrp活性に関連する状態を処置するための化合物および組成物 - Google Patents

Nlrp活性に関連する状態を処置するための化合物および組成物 Download PDF

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JP7041668B2
JP7041668B2 JP2019505344A JP2019505344A JP7041668B2 JP 7041668 B2 JP7041668 B2 JP 7041668B2 JP 2019505344 A JP2019505344 A JP 2019505344A JP 2019505344 A JP2019505344 A JP 2019505344A JP 7041668 B2 JP7041668 B2 JP 7041668B2
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JP2019519598A (ja
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ドン‐ミン シェン
ゲイリー グリック
ショミール ゴーシュ
ウィリアム アール. ロウシュ
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ノバルティス アーゲー
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JP2019505344A 2016-04-18 2017-04-18 Nlrp活性に関連する状態を処置するための化合物および組成物 Expired - Fee Related JP7041668B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201662324071P 2016-04-18 2016-04-18
US201662324081P 2016-04-18 2016-04-18
US62/324,071 2016-04-18
US62/324,081 2016-04-18
US201662411358P 2016-10-21 2016-10-21
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Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6929792B2 (ja) 2015-02-16 2021-09-01 ザ ユニバーシティ オブ クィーンズランド スルホニル尿素及び関連化合物並びにその使用
EP3365724B1 (en) 2015-10-20 2021-05-05 Magic Leap, Inc. Selecting virtual objects in a three-dimensional space
CA3018758A1 (en) 2016-03-31 2017-10-05 Magic Leap, Inc. Interactions with 3d virtual objects using poses and multiple-dof controllers
UA126675C2 (uk) 2017-01-23 2023-01-11 Дженентек, Інк. Хімічні сполуки як інгібітори активності інтерлейкіну-1
US10768693B2 (en) 2017-04-19 2020-09-08 Magic Leap, Inc. Multimodal task execution and text editing for a wearable system
CN110914256A (zh) 2017-07-07 2020-03-24 英夫拉索姆有限公司 新颖磺酰胺羧酰胺化合物
US11370763B2 (en) 2017-07-24 2022-06-28 Novartis Ag Compounds and compositions for treating conditions associated with NLRP activity
JP7412328B2 (ja) * 2017-07-24 2024-01-12 ノバルティス アーゲー Nlrp活性に関連する状態を治療するための化合物及び組成物
MX2020001776A (es) * 2017-08-15 2020-03-24 Inflazome Ltd Sulfonilureas y sulfoniltioureas como inhibidores de nlrp3.
WO2019034693A1 (en) 2017-08-15 2019-02-21 Inflazome Limited SULFONYLURATES AND SULFONYLTHIOURES AS INHIBITORS OF NLRP3
TW201910317A (zh) 2017-08-15 2019-03-16 愛爾蘭商英弗雷佐姆有限公司 新穎化合物
WO2019043610A1 (en) 2017-08-31 2019-03-07 Cadila Healthcare Limited NEW SUBSTITUTED SULFONYLUREA DERIVATIVES
ES2927851T3 (es) 2017-10-17 2022-11-11 Novartis Ag Sulfonamidas y composiciones de las mismas para tratar afecciones asociadas con la actividad de NLRP
CN111315733A (zh) 2017-11-09 2020-06-19 英夫拉索姆有限公司 新颖磺酰胺甲酰胺化合物
WO2019092171A1 (en) 2017-11-09 2019-05-16 Inflazome Limited Novel sulfonamide carboxamide compounds
US11834433B2 (en) 2018-03-02 2023-12-05 Inflazome Limited Compounds
GB201803394D0 (en) 2018-03-02 2018-04-18 Inflazome Ltd Novel compounds
WO2019166619A1 (en) 2018-03-02 2019-09-06 Inflazome Limited Novel compounds
WO2019166632A1 (en) * 2018-03-02 2019-09-06 Inflazome Limited Novel compounds
US11884645B2 (en) 2018-03-02 2024-01-30 Inflazome Limited Sulfonyl acetamides as NLRP3 inhibitors
US20200399242A1 (en) * 2018-03-02 2020-12-24 Inflazome Limited Novel compounds
GB201803393D0 (en) 2018-03-02 2018-04-18 Inflazome Ltd Novel compounds
US12168653B2 (en) 2018-03-02 2024-12-17 Inflazome Limited Sulfonamide derivates as NLRP3 inhibitors
EP3759090A1 (en) 2018-03-02 2021-01-06 Inflazome Limited Novel compounds
GB201806578D0 (en) 2018-04-23 2018-06-06 Inflazome Ltd Novel compound
CR20200588A (es) 2018-05-04 2021-06-24 Inflazome Ltd Compuestos novedosos
JP2021529780A (ja) 2018-07-03 2021-11-04 ノバルティス アーゲー Nlrp3アンタゴニストを使用するtnf阻害剤に対して抵抗性の対象のための治療の方法又は治療を選択する方法
US20210395241A1 (en) 2018-07-03 2021-12-23 Novartis Ag Nlrp modulators
MX2021000660A (es) 2018-07-20 2021-03-25 Hoffmann La Roche Compuestos de sulfonilurea como inhibidores de la actividad de interleucina 1.
MA53172A (fr) 2018-07-20 2021-05-26 Hoffmann La Roche Composés de sulfonimidamide en tant qu'inhibiteurs de l'activité de l'interleukine 1
SG11202101480XA (en) 2018-08-15 2021-03-30 Inflazome Ltd Novel sulfonamideurea compounds
GB201902327D0 (en) 2019-02-20 2019-04-03 Inflazome Ltd Novel compounds
JP2022505562A (ja) * 2018-10-24 2022-01-14 ノバルティス アーゲー Nlrp活性に関連する状態を治療するための化合物及び組成物
CN113015730A (zh) * 2018-11-13 2021-06-22 诺华股份有限公司 用于治疗与nlrp活性相关的病症的化合物和组合物
CN113166081A (zh) * 2018-11-13 2021-07-23 诺华股份有限公司 用于治疗与nlrp活性相关的病症的化合物和组合物
EP3880658A1 (en) * 2018-11-16 2021-09-22 Novartis AG The compounds and compositions for treating conditions associated with nlrp activity
GB201819083D0 (en) 2018-11-23 2019-01-09 Inflazome Ltd Novel compounds
US20220227707A1 (en) * 2019-01-22 2022-07-21 Novartis Ag Compounds and compositions for treating conditions associated with nlrp activity
GB201905265D0 (en) 2019-04-12 2019-05-29 Inflazome Ltd Inflammasome inhibition
WO2020249669A1 (en) * 2019-06-12 2020-12-17 NodThera Limited Sulfonamide derivatives and uses thereof
CN114008030A (zh) 2019-06-21 2022-02-01 Ac免疫有限公司 用作nlrp3调节剂的稠合的1,2-噻唑和1,2-噻嗪
AU2020312800B2 (en) 2019-07-17 2026-04-23 Zomagen Biosciences Ltd N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)-4,5,6,7-tetrahydrobenzofuran -2-sulfonamide derivatives and related compounds as NLPR3 modulators for the treatment of multiple sclerosis (ms)
WO2021009567A1 (en) * 2019-07-17 2021-01-21 Zomagen Biosciences Ltd Nlrp3 modulators
JP2022545407A (ja) * 2019-08-16 2022-10-27 インフレイゾーム リミテッド Nlrp3阻害剤として有用な大環状スルホニルアミド誘導体
JP2022547882A (ja) 2019-09-06 2022-11-16 インフレイゾーム リミテッド Nlrp3阻害剤
BR112022014480A2 (pt) 2020-01-22 2022-09-13 Hoffmann La Roche Compostos, composições farmacêutica, método para tratar um distúrbio em um paciente, usos de um composto e de uma composição farmacêutica e kit
US11618751B1 (en) 2022-03-25 2023-04-04 Ventus Therapeutics U.S., Inc. Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 derivatives
CA3175729A1 (en) 2020-03-16 2021-09-23 Zomagen Biosciences Ltd Nlrp3 modulators
CN121177307A (zh) * 2020-03-19 2025-12-23 南洋理工大学 包含nlrp1炎性体激活抑制剂的化合物或组合物用于治疗人气道炎症的用途
CN115279739B (zh) * 2020-03-27 2025-07-22 尼科治疗有限公司 取代哒嗪化合物
CN111419842A (zh) * 2020-04-24 2020-07-17 南方医科大学南方医院 炎症小体抑制剂cy-09用于制备治疗非酒精性脂肪性肝炎的药物的用途
CN115768749B (zh) * 2020-06-11 2024-04-19 辰欣药业股份有限公司 二甲基亚磺酰亚胺衍生物
US12624010B2 (en) 2020-06-19 2026-05-12 Ac Immune Sa Dihydrooxazole and thiourea derivatives modulating the NLRP3 inflammasome pathway
WO2022022646A1 (zh) * 2020-07-29 2022-02-03 南京明德新药研发有限公司 含硒五元杂芳环化合物
WO2022023907A1 (en) 2020-07-31 2022-02-03 Novartis Ag Methods of selecting and treating patients at elevated risk of major adverse cardiac events
US11319319B1 (en) 2021-04-07 2022-05-03 Ventus Therapeutics U.S., Inc. Compounds for inhibiting NLRP3 and uses thereof
US11932630B2 (en) 2021-04-16 2024-03-19 Novartis Ag Heteroaryl aminopropanol derivatives
WO2022230912A1 (ja) 2021-04-28 2022-11-03 アステラス製薬株式会社 置換トリアジン化合物
CA3226995A1 (en) 2021-07-21 2023-01-26 Nico Therapeutics, Inc. Annulated pyridazine compound
JP2025502732A (ja) 2021-12-22 2025-01-28 エーシー・イミューン・エス・アー ジヒドロオキサゾール誘導体化合物
CN114213358A (zh) * 2021-12-22 2022-03-22 上海泰坦科技股份有限公司 一种2-溴-5-甲醛基噻唑的合成方法
JP2025524640A (ja) 2022-07-14 2025-07-30 エーシー・イミューン・エス・アー Nlrp3インフラマソーム経路の調節剤としてのピロロトリアジン及びイミダゾトリアジン誘導体
WO2024023266A1 (en) 2022-07-28 2024-02-01 Ac Immune Sa Novel compounds
CN120152974A (zh) 2022-10-26 2025-06-13 天维生物制药有限公司 缩环哒嗪衍生物
US12331048B2 (en) 2022-10-31 2025-06-17 Ventus Therapeutics U.S., Inc. Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 inhibitors
PE20252770A1 (es) * 2023-03-17 2025-12-22 Ventus Therapeutics U S Inc Derivados de amida para inhibir nlrp3 y usos de estos
AU2024280075A1 (en) 2023-06-02 2025-12-11 Merck Sharp & Dohme Llc 5,6-Unsaturated Bicyclic Heterocycles Useful as Inhibitors of Nod-Like Receptor Protein 3
WO2025133307A1 (en) 2023-12-22 2025-06-26 Ac Immune Sa Heterocyclic modulators of the nlrp3 inflammasome pathway
TW202545527A (zh) 2024-01-16 2025-12-01 英商諾得瑟拉公司 Nlrp3及glp-1a組合療法
CN122555708A (zh) 2024-01-17 2026-08-11 Ac免疫有限公司 用作nlrp3炎症小体通路抑制剂的咪唑并[1,2-d][1,2,4]三嗪衍生物
CN122555707A (zh) 2024-01-17 2026-08-11 Ac免疫有限公司 用作nlrp3炎症小体通路抑制剂的咪唑并[1,2-d][1,2,4]三嗪衍生物
WO2025163069A1 (en) 2024-01-31 2025-08-07 Ac Immune Sa Novel compounds
WO2026057747A1 (en) 2024-09-11 2026-03-19 Ac Immune Sa Therapeutic use of nlrp3 inflammasome pathway inhibitor compounds
WO2026132518A1 (en) 2024-12-20 2026-06-25 Ac Immune Sa Heterocyclic compounds modulating the nlrp3 inflammasome pathway

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000511200A (ja) 1997-01-29 2000-08-29 ファイザー・インク スルホニルウレア誘導体、およびインターロイキン−1の活性を制御する上でのスルホニルウレア誘導体の使用
JP2001097946A (ja) 1999-09-30 2001-04-10 Mitsubishi Chemicals Corp アシルスルホンアミド誘導体

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5962490A (en) * 1987-09-25 1999-10-05 Texas Biotechnology Corporation Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
DE3826230A1 (de) 1988-08-02 1990-02-08 Hoechst Ag Heterocyclische n-acylsufonamide, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung als herbizide oder wachstumsregulatoren
JPH0454168A (ja) 1990-06-25 1992-02-21 Kumiai Chem Ind Co Ltd N―スルホニルアミド誘導体及び除草剤
JP2701247B2 (ja) 1993-02-09 1998-01-21 日本製紙株式会社 新規なnーアシルーアリールスルホン酸アミド及びそれを使用した感熱記録シート
GB9828442D0 (en) 1998-12-24 1999-02-17 Karobio Ab Novel thyroid receptor ligands and method II
TW200745066A (en) * 2005-09-16 2007-12-16 Torrent Pharmaceuticals Ltd Novel PTP1B inhibitors
GB0725214D0 (en) * 2007-12-24 2008-02-06 Karobio Ab Pharmaceutical compounds
CN103159649B (zh) 2011-12-19 2016-03-09 天津市国际生物医药联合研究院 磺酰胺类化合物的制备及其应用
CN103172547B (zh) 2011-12-20 2016-10-12 天津市国际生物医药联合研究院 磺酰胺衍生物的制备及其应用
CN103159674A (zh) 2013-04-03 2013-06-19 苏州安诺生物医药技术有限公司 2-苯烷酰胺类化合物及其制备方法、药物组合物和用途

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000511200A (ja) 1997-01-29 2000-08-29 ファイザー・インク スルホニルウレア誘導体、およびインターロイキン−1の活性を制御する上でのスルホニルウレア誘導体の使用
JP2001097946A (ja) 1999-09-30 2001-04-10 Mitsubishi Chemicals Corp アシルスルホンアミド誘導体

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
AKAGI, T.,Pesticide Science,1996年,Vol. 47,pp. 309-318
CLOUDSDALE, I. S. et al.,ACS Symposium Series,1995年,Vol. 584,pp. 37-45
COLL, R. C. et al.,Nature Medicine (New York, NY, United States),2015年,Vol. 21,pp. 248-255
JHAN, Y.-H. et al.,Tetrahedron Letters,2013年,Vol. 54,pp. 1155-1159
LUO, Y. et al.,BIOORGANIC & MEDICINAL CHEMISTRY,2011年,Vol. 19,pp. 6069-6076
MIURA, T. et al.,Chemistry Letters ,2009年,Vol. 38,pp. 328-329
REDDY, C. R. et al.,Tetrahedron Letters,2007年,Vol. 48,pp. 7528-7532
ROZENTSVEIG, I. B. et al.,Molecular Diversity,2010年,Vol. 14,pp. 533-541
SMITH, E. W. et al.,JOURNAL OF MEDICINAL CHEMISTRY,2016年,Vol. 59,pp. 4342-4351

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