JP6594856B2 - 医療用の安定な遷延性ｇｌｐ−１／グルカゴン受容体コアゴニスト - Google Patents
医療用の安定な遷延性ｇｌｐ−１／グルカゴン受容体コアゴニスト Download PDFInfo
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- JP6594856B2 JP6594856B2 JP2016508190A JP2016508190A JP6594856B2 JP 6594856 B2 JP6594856 B2 JP 6594856B2 JP 2016508190 A JP2016508190 A JP 2016508190A JP 2016508190 A JP2016508190 A JP 2016508190A JP 6594856 B2 JP6594856 B2 JP 6594856B2
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Classifications
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
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| US61/814,969 | 2013-04-23 | ||
| EP13196656.6 | 2013-12-11 | ||
| EP13196656 | 2013-12-11 | ||
| PCT/EP2014/058084 WO2014170496A1 (en) | 2013-04-18 | 2014-04-22 | Stable, protracted glp-1/glucagon receptor co-agonists for medical use |
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Cited By (1)
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| JP2019167361A (ja) * | 2013-04-18 | 2019-10-03 | ノヴォ ノルディスク アー／エス | 医療用の安定な遷延性ｇｌｐ−１／グルカゴン受容体コアゴニスト |
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| UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
| CA2895875A1 (en) | 2012-12-21 | 2014-06-26 | Sanofi | Exendin-4 derivatives |
| PL2986313T3 (pl) | 2013-04-18 | 2019-12-31 | Novo Nordisk A/S | Stabilni, dłużej działający współagoniści receptora glp-1/glukagonu do zastosowań medycznych |
| EP3080154B1 (en) | 2013-12-13 | 2018-02-07 | Sanofi | Dual glp-1/gip receptor agonists |
| WO2015086730A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Non-acylated exendin-4 peptide analogues |
| WO2015086733A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Dual glp-1/glucagon receptor agonists |
| EP3080150B1 (en) | 2013-12-13 | 2018-08-01 | Sanofi | Exendin-4 peptide analogues as dual glp-1/gip receptor agonists |
| TW201625668A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 作為胜肽性雙重ｇｌｐ－１／昇糖素受體激動劑之艾塞那肽－４衍生物 |
| TW201625670A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自ｅｘｅｎｄｉｎ－４之雙重ｇｌｐ－１／升糖素受體促效劑 |
| TW201625669A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑 |
| CA2949701C (en) * | 2014-05-28 | 2023-12-12 | Mederis Diabetes, Llc | Improved peptide pharmaceuticals for insulin resistance |
| US10570184B2 (en) | 2014-06-04 | 2020-02-25 | Novo Nordisk A/S | GLP-1/glucagon receptor co-agonists for medical use |
| US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
| KR102418477B1 (ko) * | 2014-12-30 | 2022-07-08 | 한미약품 주식회사 | 글루카곤 유도체 |
| CN107636009B (zh) * | 2014-12-30 | 2021-04-16 | 韩美药品株式会社 | 具有改善的稳定性的胰高血糖素衍生物 |
| AR105319A1 (es) | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
| WO2016198628A1 (en) | 2015-06-12 | 2016-12-15 | Sanofi | Non-acylated exendin-4 derivatives as dual glp-1/glucagon receptor agonists |
| WO2016198624A1 (en) | 2015-06-12 | 2016-12-15 | Sanofi | Exendin-4 derivatives as trigonal glp-1/glucagon/gip receptor agonists |
| TWI713541B (zh) | 2015-06-30 | 2020-12-21 | 南韓商韓美藥品股份有限公司 | 升糖素衍生物及包含該衍生物之長效接合物之組成物 |
| AR105284A1 (es) | 2015-07-10 | 2017-09-20 | Sanofi Sa | Derivados de exendina-4 como agonistas peptídicos duales específicos de los receptores de glp-1 / glucagón |
| TWI622596B (zh) | 2015-10-26 | 2018-05-01 | 美國禮來大藥廠 | 升糖素受體促效劑 |
| HUE059737T2 (hu) | 2015-12-31 | 2022-12-28 | Hanmi Pharm Ind Co Ltd | Glükagon, GLP-1 és GIP receptor aktiváló tripla aktivátor |
| MX2018008681A (es) * | 2016-01-13 | 2018-09-17 | Novo Nordisk As | Analogos del dominio a similar al factor de crecimiento epidermico (egf(a)) con sustituyentes de acidos grasos. |
| FR3050112B1 (fr) | 2016-04-15 | 2020-09-04 | Soc Civ Immobiliere Gecinq | Utilisation de l'acide fenofibrique dans le traitement des maladies hepatiques |
| PE20190355A1 (es) | 2016-06-29 | 2019-03-07 | Hanmi Pharm Ind Co Ltd | Derivado de glucagon, conjugado del mismo, composicion que comprende el mismo y uso terapeutico del mismo |
| US11130794B2 (en) | 2017-07-19 | 2021-09-28 | Novo Nordisk A/S | Bifunctional compounds |
| GB201720187D0 (en) * | 2017-12-04 | 2018-01-17 | Imperial Innovations Ltd | Novel Compounds |
| IL311775A (en) | 2018-01-03 | 2024-05-01 | Mederis Diabetes Llc | Improved peptide drugs for the treatment of NASH and other disorders |
| CA3097939A1 (en) | 2018-05-04 | 2019-11-07 | Novo Nordisk A/S | Gip derivatives and uses thereof |
| US20200268835A1 (en) | 2019-02-27 | 2020-08-27 | Novo Nordisk A/S | Compounds For Use in NASH |
| AU2021224246A1 (en) * | 2020-02-21 | 2022-09-15 | Spitfire Pharma Llc | GLP-1R and GCGR agonists, formulations, and methods of use |
| CN117202924A (zh) | 2020-12-07 | 2023-12-08 | 斯皮特弗尔制药有限责任公司 | 使用glp-1r和gcgr平衡激动剂降低血糖和/或体重的治疗方案和方法 |
| JP7604666B2 (ja) | 2021-01-20 | 2024-12-23 | バイキング・セラピューティクス・インコーポレイテッド | 代謝及び肝臓障害の処置のための組成物及び方法 |
| WO2023044290A1 (en) | 2021-09-15 | 2023-03-23 | Viking Therapeutics, Inc. | Compositions and methods for the treatment of metabolic and liver disorders |
| TW202346323A (zh) * | 2022-02-07 | 2023-12-01 | 英商梅迪繆思有限公司 | 具有改善的生物穩定性的ｇｌｐ—１及升糖素雙重激動肽 |
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-
2014
- 2014-04-22 PL PL14719715T patent/PL2986313T3/pl unknown
- 2014-04-22 RU RU2015146600A patent/RU2683039C2/ru active
- 2014-04-22 SI SI201431291T patent/SI2986313T1/sl unknown
- 2014-04-22 JP JP2016508190A patent/JP6594856B2/ja active Active
- 2014-04-22 BR BR112015025464A patent/BR112015025464A2/pt not_active IP Right Cessation
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- 2014-04-22 CN CN201480034914.8A patent/CN105307672B/zh active Active
- 2014-04-22 EP EP14719715.6A patent/EP2986313B1/en active Active
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- 2014-04-22 AU AU2014255608A patent/AU2014255608B2/en not_active Ceased
- 2014-04-22 CA CA2909581A patent/CA2909581A1/en not_active Withdrawn
- 2014-04-22 WO PCT/EP2014/058084 patent/WO2014170496A1/en not_active Ceased
- 2014-04-22 KR KR1020157032329A patent/KR20160021758A/ko not_active Withdrawn
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019167361A (ja) * | 2013-04-18 | 2019-10-03 | ノヴォ ノルディスク アー／エス | 医療用の安定な遷延性ｇｌｐ−１／グルカゴン受容体コアゴニスト |
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| CA2909581A1 (en) | 2014-10-23 |
| JP2016526012A (ja) | 2016-09-01 |
| MX2015014408A (es) | 2017-07-28 |
| US9751927B2 (en) | 2017-09-05 |
| US20180044394A1 (en) | 2018-02-15 |
| MY174727A (en) | 2020-05-11 |
| BR112015025464A2 (pt) | 2017-10-10 |
| ZA201507010B (en) | 2017-08-30 |
| US20160355562A1 (en) | 2016-12-08 |
| RU2015146600A3 (cg-RX-API-DMAC7.html) | 2018-03-29 |
| CN105307672B (zh) | 2021-01-05 |
| CN105307672A (zh) | 2016-02-03 |
| PL2986313T3 (pl) | 2019-12-31 |
| US20150374794A1 (en) | 2015-12-31 |
| EP2986313A1 (en) | 2016-02-24 |
| MX362275B (es) | 2019-01-10 |
| WO2014170496A1 (en) | 2014-10-23 |
| SI2986313T1 (sl) | 2019-09-30 |
| AU2014255608B2 (en) | 2018-01-25 |
| RU2015146600A (ru) | 2017-05-24 |
| RS59124B1 (sr) | 2019-09-30 |
| EP2986313B1 (en) | 2019-06-12 |
| KR20160021758A (ko) | 2016-02-26 |
| RU2683039C2 (ru) | 2019-03-26 |
| US9474790B2 (en) | 2016-10-25 |
| AU2014255608A1 (en) | 2015-10-08 |
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