JP6574383B2 - ＰＣＳＫ９ｉＲＮＡ組成物及びその使用方法 - Google Patents

ＰＣＳＫ９ｉＲＮＡ組成物及びその使用方法 Download PDF

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JP6574383B2
JP6574383B2 JP2015545846A JP2015545846A JP6574383B2 JP 6574383 B2 JP6574383 B2 JP 6574383B2 JP 2015545846 A JP2015545846 A JP 2015545846A JP 2015545846 A JP2015545846 A JP 2015545846A JP 6574383 B2 JP6574383 B2 JP 6574383B2
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rnai agent
pharmaceutical composition
pcsk9
nucleotides
nucleotide
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JP2016506240A5 (enExample
JP2016506240A (ja
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アナ・ボロドフスキー
ラジーブ・ジー・カラントッタティル
ケビン・フィッツジェラルド
マリア・フランク−カメネツキー
ウィリアム・クアーベス
マルティン・マイアー
クラウス・カリセ
サティアナラヤーナ・クチマンチ
ムティア・マノハラン
スチュアート・ミルスタイン
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Alnylam Pharmaceuticals Inc
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
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    • C12N2310/3533—Halogen
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    • C12N2320/30—Special therapeutic applications
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  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
JP2015545846A 2012-12-05 2013-12-05 ＰＣＳＫ９ｉＲＮＡ組成物及びその使用方法 Active JP6574383B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201261733518P 2012-12-05 2012-12-05
US61/733,518 2012-12-05
US201361793530P 2013-03-15 2013-03-15
US61/793,530 2013-03-15
US201361886916P 2013-10-04 2013-10-04
US61/886,916 2013-10-04
US201361892188P 2013-10-17 2013-10-17
US61/892,188 2013-10-17
PCT/US2013/073349 WO2014089313A1 (en) 2012-12-05 2013-12-05 PCSK9 iRNA COMPOSITIONS AND METHODS OF USE THEREOF

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JP2016506240A JP2016506240A (ja) 2016-03-03
JP2016506240A5 JP2016506240A5 (enExample) 2017-01-19
JP6574383B2 true JP6574383B2 (ja) 2019-09-11

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JP2019016678A Active JP7239335B2 (ja) 2012-12-05 2019-02-01 ＰＣＳＫ９ ｉＲＮＡ組成物及びその使用方法
JP2021025455A Withdrawn JP2021097680A (ja) 2012-12-05 2021-02-19 ＰＣＳＫ９ ｉＲＮＡ組成物及びその使用方法
JP2023068284A Active JP7670747B2 (ja) 2012-12-05 2023-04-19 ＰＣＳＫ９ ｉＲＮＡ組成物及びその使用方法
JP2025067855A Pending JP2025128073A (ja) 2012-12-05 2025-04-17 ＰＣＳＫ９ ｉＲＮＡ組成物及びその使用方法

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JP2021025455A Withdrawn JP2021097680A (ja) 2012-12-05 2021-02-19 ＰＣＳＫ９ ｉＲＮＡ組成物及びその使用方法
JP2023068284A Active JP7670747B2 (ja) 2012-12-05 2023-04-19 ＰＣＳＫ９ ｉＲＮＡ組成物及びその使用方法
JP2025067855A Pending JP2025128073A (ja) 2012-12-05 2025-04-17 ＰＣＳＫ９ ｉＲＮＡ組成物及びその使用方法

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US (2) US10125369B2 (enExample)
EP (3) EP2929031B9 (enExample)
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KR (2) KR102096014B1 (enExample)
CN (2) CN104854242B (enExample)
AR (1) AR093835A1 (enExample)
AU (4) AU2013355237C1 (enExample)
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HR (1) HRP20180126T2 (enExample)
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NL (1) NL301107I2 (enExample)
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NZ (1) NZ709013A (enExample)
PL (1) PL2929031T4 (enExample)
PT (1) PT2929031T (enExample)
RS (1) RS56783B9 (enExample)
SI (1) SI2929031T1 (enExample)
SM (1) SMT201800039T1 (enExample)
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Cited By (1)

* Cited by examiner, † Cited by third party
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JP2019103501A (ja) * 2012-12-05 2019-06-27 アルナイラム ファーマシューティカルズ， インコーポレイテッドＡｌｎｙｌａｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． ＰＣＳＫ９ ｉＲＮＡ組成物及びその使用方法

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CN110446785B (zh) 2017-01-23 2024-04-26 瑞泽恩制药公司 Hsd17b13变体及其应用
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EP3609532A1 (en) 2017-04-13 2020-02-19 Cadila Healthcare Limited Novel peptide based pcsk9 vaccine
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JP2021097680A (ja) * 2012-12-05 2021-07-01 アルナイラム ファーマシューティカルズ， インコーポレイテッドＡｌｎｙｌａｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． ＰＣＳＫ９ ｉＲＮＡ組成物及びその使用方法
JP7239335B2 (ja) 2012-12-05 2023-03-14 アルナイラム ファーマシューティカルズ， インコーポレイテッド ＰＣＳＫ９ ｉＲＮＡ組成物及びその使用方法

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