PL2929031T4 - Kompozycje iRNA PCSK9 i sposoby ich zastosowania - Google Patents

Kompozycje iRNA PCSK9 i sposoby ich zastosowania

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Publication number
PL2929031T4
PL2929031T4 PL13811327T PL13811327T PL2929031T4 PL 2929031 T4 PL2929031 T4 PL 2929031T4 PL 13811327 T PL13811327 T PL 13811327T PL 13811327 T PL13811327 T PL 13811327T PL 2929031 T4 PL2929031 T4 PL 2929031T4
Authority
PL
Poland
Prior art keywords
methods
irna compositions
pcsk9
pcsk9 irna
compositions
Prior art date
Application number
PL13811327T
Other languages
English (en)
Polish (pl)
Other versions
PL2929031T3 (pl
Inventor
Anna Borodovsky
Rajeev G. KALLANTHOTTATHIL
Kevin Fitzgerald
Maria Frank-Kamenetsky
William Querbes
Martin Maier
Klaus CHARISSE
Satyanarayana Kuchimanchi
Muthiah Manoharan
Stuart Milstein
Original Assignee
Alnylam Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49841845&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2929031(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alnylam Pharmaceuticals, Inc. filed Critical Alnylam Pharmaceuticals, Inc.
Publication of PL2929031T3 publication Critical patent/PL2929031T3/pl
Publication of PL2929031T4 publication Critical patent/PL2929031T4/pl

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/31—Chemical structure of the backbone
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/343—Spatial arrangement of the modifications having patterns, e.g. ==--==--==--
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
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    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/353—Nature of the modification linked to the nucleic acid via an atom other than carbon
    • C12N2310/3533—Halogen
    • C—CHEMISTRY; METALLURGY
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/35—Special therapeutic applications based on a specific dosage / administration regimen

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  • Bioinformatics & Cheminformatics (AREA)
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  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
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  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
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  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
PL13811327T 2012-12-05 2013-12-05 Kompozycje iRNA PCSK9 i sposoby ich zastosowania PL2929031T4 (pl)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201261733518P 2012-12-05 2012-12-05
US201361793530P 2013-03-15 2013-03-15
US201361886916P 2013-10-04 2013-10-04
US201361892188P 2013-10-17 2013-10-17
PCT/US2013/073349 WO2014089313A1 (en) 2012-12-05 2013-12-05 PCSK9 iRNA COMPOSITIONS AND METHODS OF USE THEREOF
EP13811327.9A EP2929031B9 (en) 2012-12-05 2013-12-05 Pcsk9 irna compositions and methods of use thereof

Publications (2)

Publication Number Publication Date
PL2929031T3 PL2929031T3 (pl) 2018-04-30
PL2929031T4 true PL2929031T4 (pl) 2022-06-27

Family

ID=49841845

Family Applications (1)

Application Number Title Priority Date Filing Date
PL13811327T PL2929031T4 (pl) 2012-12-05 2013-12-05 Kompozycje iRNA PCSK9 i sposoby ich zastosowania

Country Status (30)

Country Link
US (2) US10125369B2 (enExample)
EP (3) EP2929031B9 (enExample)
JP (5) JP6574383B2 (enExample)
KR (2) KR102096014B1 (enExample)
CN (2) CN104854242B (enExample)
AR (1) AR093835A1 (enExample)
AU (4) AU2013355237C1 (enExample)
BR (1) BR112015013105B1 (enExample)
CA (1) CA2892160C (enExample)
CY (2) CY1120195T1 (enExample)
DK (1) DK2929031T5 (enExample)
ES (1) ES2657608T3 (enExample)
FR (1) FR21C1021I2 (enExample)
HK (1) HK1256621A1 (enExample)
HR (1) HRP20180126T2 (enExample)
HU (2) HUE035887T2 (enExample)
IL (2) IL238917B (enExample)
LT (2) LT2929031T (enExample)
LU (1) LUC00209I2 (enExample)
MX (2) MX367076B (enExample)
NL (1) NL301107I2 (enExample)
NO (1) NO2021024I1 (enExample)
NZ (1) NZ709013A (enExample)
PL (1) PL2929031T4 (enExample)
PT (1) PT2929031T (enExample)
RS (1) RS56783B9 (enExample)
SI (1) SI2929031T1 (enExample)
SM (1) SMT201800039T1 (enExample)
WO (1) WO2014089313A1 (enExample)
ZA (1) ZA201503829B (enExample)

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