JP6542222B2 - ベンゾキノリン化合物の製造方法 - Google Patents

ベンゾキノリン化合物の製造方法 Download PDF

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JP6542222B2
JP6542222B2 JP2016536571A JP2016536571A JP6542222B2 JP 6542222 B2 JP6542222 B2 JP 6542222B2 JP 2016536571 A JP2016536571 A JP 2016536571A JP 2016536571 A JP2016536571 A JP 2016536571A JP 6542222 B2 JP6542222 B2 JP 6542222B2
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certain embodiments
acid
compound
water
formula
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JP2017501141A (ja
JP2017501141A5 (enExample
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チェンジ・ジャン
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オースペックス ファーマシューティカルズ インコーポレイテッド
オースペックス ファーマシューティカルズ インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C223/00—Compounds containing amino and —CHO groups bound to the same carbon skeleton
    • C07C223/02—Compounds containing amino and —CHO groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • C07D455/06—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP2016536571A 2013-12-03 2014-11-24 ベンゾキノリン化合物の製造方法 Active JP6542222B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361911214P 2013-12-03 2013-12-03
US61/911,214 2013-12-03
PCT/US2014/067117 WO2015084622A1 (en) 2013-12-03 2014-11-24 Methods of manufacturing benzoquinoline compounds

Publications (3)

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JP2017501141A JP2017501141A (ja) 2017-01-12
JP2017501141A5 JP2017501141A5 (enExample) 2018-01-11
JP6542222B2 true JP6542222B2 (ja) 2019-07-10

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JP2016536571A Active JP6542222B2 (ja) 2013-12-03 2014-11-24 ベンゾキノリン化合物の製造方法

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US (8) US20150152099A1 (enExample)
EP (2) EP3424504A1 (enExample)
JP (1) JP6542222B2 (enExample)
KR (1) KR102391134B1 (enExample)
CN (1) CN105873589B (enExample)
AU (4) AU2014357518A1 (enExample)
BR (1) BR112016012747B1 (enExample)
CA (1) CA2930744A1 (enExample)
EA (2) EA201791466A1 (enExample)
HK (1) HK1224222A1 (enExample)
IL (1) IL245539B (enExample)
MX (1) MX369956B (enExample)
NZ (1) NZ720301A (enExample)
WO (1) WO2015084622A1 (enExample)

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EA201992168A1 (ru) 2017-03-15 2020-03-16 Ауспекс Фармасьютикалз, Инк. Аналоги деутетрабеназина, их получение и применение
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AU2020201091A1 (en) 2020-03-05
JP2017501141A (ja) 2017-01-12
BR112016012747A2 (enExample) 2017-08-08
KR102391134B1 (ko) 2022-04-28
AU2023203246A1 (en) 2023-06-15
IL245539B (en) 2021-06-30
CN105873589A (zh) 2016-08-17
EA032920B1 (ru) 2019-08-30
MX369956B (es) 2019-11-27
CA2930744A1 (en) 2015-06-11
EP3424504A1 (en) 2019-01-09
US20180230083A1 (en) 2018-08-16
AU2021209150A1 (en) 2021-08-19
KR20160087904A (ko) 2016-07-22
WO2015084622A1 (en) 2015-06-11
EP3076970A1 (en) 2016-10-12
IL245539A0 (en) 2016-06-30
EA201791466A1 (ru) 2017-11-30
AU2023203246B2 (en) 2025-02-27
US20150152099A1 (en) 2015-06-04
AU2014357518A1 (en) 2016-06-09
MX2016007056A (es) 2017-01-06
US20170197957A1 (en) 2017-07-13
US20200347008A1 (en) 2020-11-05
EP3076970A4 (en) 2017-07-26
NZ720301A (en) 2022-01-28
US20200331846A1 (en) 2020-10-22
BR112016012747B1 (pt) 2022-07-12
US20190092719A1 (en) 2019-03-28
US10513488B2 (en) 2019-12-24
US20170190654A1 (en) 2017-07-06
US12077487B2 (en) 2024-09-03
US20230060294A1 (en) 2023-03-02
CN105873589B (zh) 2019-11-01
EA201691162A1 (ru) 2016-11-30
AU2020201091B2 (en) 2021-04-29
HK1224222A1 (zh) 2017-08-18
HK1223020A1 (zh) 2017-07-21

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