MX369956B - Metodos para preparar compuestos de benzoquinolina. - Google Patents
Metodos para preparar compuestos de benzoquinolina.Info
- Publication number
- MX369956B MX369956B MX2016007056A MX2016007056A MX369956B MX 369956 B MX369956 B MX 369956B MX 2016007056 A MX2016007056 A MX 2016007056A MX 2016007056 A MX2016007056 A MX 2016007056A MX 369956 B MX369956 B MX 369956B
- Authority
- MX
- Mexico
- Prior art keywords
- tetrabenazine
- methods
- deuterated
- manufacturing
- vmat2
- Prior art date
Links
- WZJYKHNJTSNBHV-UHFFFAOYSA-N benzo[h]quinoline Chemical class C1=CN=C2C3=CC=CC=C3C=CC2=C1 WZJYKHNJTSNBHV-UHFFFAOYSA-N 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 229960005333 tetrabenazine Drugs 0.000 abstract 5
- MKJIEFSOBYUXJB-HOCLYGCPSA-N (3S,11bS)-9,10-dimethoxy-3-isobutyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one Chemical compound C1CN2C[C@H](CC(C)C)C(=O)C[C@H]2C2=C1C=C(OC)C(OC)=C2 MKJIEFSOBYUXJB-HOCLYGCPSA-N 0.000 abstract 4
- 102000009659 Vesicular Monoamine Transport Proteins Human genes 0.000 abstract 4
- 108010020033 Vesicular Monoamine Transport Proteins Proteins 0.000 abstract 4
- 239000003112 inhibitor Substances 0.000 abstract 2
- 208000023105 Huntington disease Diseases 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/001—Acyclic or carbocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C223/00—Compounds containing amino and —CHO groups bound to the same carbon skeleton
- C07C223/02—Compounds containing amino and —CHO groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
- C07D455/06—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Catalysts (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361911214P | 2013-12-03 | 2013-12-03 | |
| PCT/US2014/067117 WO2015084622A1 (en) | 2013-12-03 | 2014-11-24 | Methods of manufacturing benzoquinoline compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2016007056A MX2016007056A (es) | 2017-01-06 |
| MX369956B true MX369956B (es) | 2019-11-27 |
Family
ID=53264424
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016007056A MX369956B (es) | 2013-12-03 | 2014-11-24 | Metodos para preparar compuestos de benzoquinolina. |
Country Status (14)
| Country | Link |
|---|---|
| US (8) | US20150152099A1 (enExample) |
| EP (2) | EP3076970A4 (enExample) |
| JP (1) | JP6542222B2 (enExample) |
| KR (1) | KR102391134B1 (enExample) |
| CN (1) | CN105873589B (enExample) |
| AU (4) | AU2014357518A1 (enExample) |
| BR (1) | BR112016012747B1 (enExample) |
| CA (1) | CA2930744A1 (enExample) |
| EA (2) | EA201791466A1 (enExample) |
| HK (1) | HK1224222A1 (enExample) |
| IL (1) | IL245539B (enExample) |
| MX (1) | MX369956B (enExample) |
| NZ (1) | NZ720301A (enExample) |
| WO (1) | WO2015084622A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6362601B2 (ja) | 2012-09-18 | 2018-07-25 | オースペックス・ファーマシューティカルズ・インコーポレイテッドＡｕｓｐｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 小胞モノアミン輸送体２の重水素化ベンゾキノリン阻害剤の製剤薬物動態 |
| US9550780B2 (en) | 2012-09-18 | 2017-01-24 | Auspex Pharmaceuticals, Inc. | Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2 |
| AU2014357518A1 (en) | 2013-12-03 | 2016-06-09 | Auspex Pharmaceuticals, Inc. | Methods of manufacturing benzoquinoline compounds |
| PL3265085T3 (pl) | 2015-03-06 | 2022-11-07 | Auspex Pharmaceuticals, Inc. | Sposoby leczenia zaburzeń związanych z nieprawidłowymi ruchami mimowolnymi |
| US10479787B2 (en) * | 2016-04-22 | 2019-11-19 | Lupin Limited | Process for preparation of tetrabenazine and deutetrabenazine |
| EP3568394A1 (en) | 2017-01-10 | 2019-11-20 | Sandoz AG | Crystalline valbenazine free base |
| CA3054238A1 (en) | 2017-02-27 | 2018-08-30 | Sandoz Ag | Crystalline forms of valbenazine salts |
| TWI772382B (zh) | 2017-03-15 | 2022-08-01 | 美商奧斯拜客斯製藥有限公司 | 氘代丁苯那嗪(deutetrabenazine)之類似物、其製備方法及用途 |
| WO2019130252A2 (en) * | 2017-12-29 | 2019-07-04 | Mylan Laboratories Ltd | Methods and intermediates for preparing deutetrabenazine |
| WO2019150387A1 (en) * | 2018-02-01 | 2019-08-08 | Alaparthi Lakshmi Prasad | A novel process for preparation of deutetrabenazine |
| WO2020079165A1 (en) | 2018-10-18 | 2020-04-23 | Oncopeptides Ab | Compounds containing deuterium |
| WO2020086765A1 (en) * | 2018-10-24 | 2020-04-30 | Neurocrine Biosciences, Inc. | Processes for preparing a vmat2 inhibitor |
| CN111960999B (zh) * | 2020-07-20 | 2021-11-02 | 暨明医药科技（苏州）有限公司 | 一种丁苯那嗪中间体的合成方法 |
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| AU2014357518A1 (en) | 2013-12-03 | 2016-06-09 | Auspex Pharmaceuticals, Inc. | Methods of manufacturing benzoquinoline compounds |
| KR20160111999A (ko) | 2014-01-27 | 2016-09-27 | 오스펙스 파마슈티칼스, 인코포레이티드 | 소포성 모노아민 수송체 2의 벤조퀴놀린 억제제 |
-
2014
- 2014-11-24 AU AU2014357518A patent/AU2014357518A1/en not_active Abandoned
- 2014-11-24 HK HK16112664.2A patent/HK1224222A1/zh unknown
- 2014-11-24 MX MX2016007056A patent/MX369956B/es active IP Right Grant
- 2014-11-24 BR BR112016012747-1A patent/BR112016012747B1/pt active IP Right Grant
- 2014-11-24 US US14/551,909 patent/US20150152099A1/en not_active Abandoned
- 2014-11-24 EA EA201791466A patent/EA201791466A1/ru unknown
- 2014-11-24 CA CA2930744A patent/CA2930744A1/en not_active Abandoned
- 2014-11-24 KR KR1020167017402A patent/KR102391134B1/ko active Active
- 2014-11-24 NZ NZ720301A patent/NZ720301A/en unknown
- 2014-11-24 CN CN201480066154.9A patent/CN105873589B/zh active Active
- 2014-11-24 WO PCT/US2014/067117 patent/WO2015084622A1/en not_active Ceased
- 2014-11-24 EA EA201691162A patent/EA032920B1/ru not_active IP Right Cessation
- 2014-11-24 JP JP2016536571A patent/JP6542222B2/ja active Active
- 2014-11-24 EP EP14867514.3A patent/EP3076970A4/en not_active Withdrawn
- 2014-11-24 EP EP18179389.4A patent/EP3424504A1/en not_active Withdrawn
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2016
- 2016-05-08 IL IL245539A patent/IL245539B/en active IP Right Grant
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2017
- 2017-03-21 US US15/464,938 patent/US20170190654A1/en not_active Abandoned
- 2017-03-29 US US15/472,779 patent/US10513488B2/en active Active
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2018
- 2018-04-12 US US15/952,031 patent/US20180230083A1/en not_active Abandoned
- 2018-11-30 US US16/205,525 patent/US20190092719A1/en not_active Abandoned
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2019
- 2019-11-12 US US16/680,674 patent/US20200331846A1/en not_active Abandoned
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2020
- 2020-02-14 AU AU2020201091A patent/AU2020201091B2/en active Active
- 2020-04-15 US US16/849,603 patent/US20200347008A1/en not_active Abandoned
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2021
- 2021-07-26 AU AU2021209150A patent/AU2021209150A1/en not_active Abandoned
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2022
- 2022-08-02 US US17/879,600 patent/US12077487B2/en active Active
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2023
- 2023-05-23 AU AU2023203246A patent/AU2023203246B2/en active Active
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