MA34055B1 - Chlorhydrate d'agomelatine hydrate et sa preparation - Google Patents
Chlorhydrate d'agomelatine hydrate et sa preparationInfo
- Publication number
- MA34055B1 MA34055B1 MA35192A MA35192A MA34055B1 MA 34055 B1 MA34055 B1 MA 34055B1 MA 35192 A MA35192 A MA 35192A MA 35192 A MA35192 A MA 35192A MA 34055 B1 MA34055 B1 MA 34055B1
- Authority
- MA
- Morocco
- Prior art keywords
- preparation
- agomelatin
- agomelatine
- hydrate hydrochloride
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
Abstract
L'invention porte sur un chlorhydrate d'agomélatine hydraté de formule (i), sur sa préparation, sur son utilisation et sur une composition pharmaceutique le contenant. Ledit chlorhydrate d'agomélatine hydraté obtenu par le présent procédé a une solubilité considérablement accrue par rapport à l'agomélatine et par conséquent est plus approprié pour la fabrication de formulations pharmaceutiques. à l'aide du présent procédé, une pureté élevée peut être obtenue par un procédé simple, dépourvu de toutes étapes compliquées. Dans la formule, x représente cl.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201010126254XA CN102190594A (zh) | 2010-03-17 | 2010-03-17 | 阿戈美拉汀氯化氢水合物及其制备方法 |
PCT/CN2011/071910 WO2011113362A1 (fr) | 2010-03-17 | 2011-03-17 | Chlorhydrate d'agomélatine hydraté et sa préparation |
Publications (1)
Publication Number | Publication Date |
---|---|
MA34055B1 true MA34055B1 (fr) | 2013-03-05 |
Family
ID=44599556
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA35192A MA34055B1 (fr) | 2010-03-17 | 2011-03-17 | Chlorhydrate d'agomelatine hydrate et sa preparation |
Country Status (36)
Country | Link |
---|---|
US (1) | US8729131B2 (fr) |
EP (1) | EP2547649B1 (fr) |
JP (1) | JP5634532B2 (fr) |
KR (1) | KR101406727B1 (fr) |
CN (2) | CN102190594A (fr) |
AP (1) | AP2012006492A0 (fr) |
AU (1) | AU2011229618B2 (fr) |
BR (1) | BR112012023317B1 (fr) |
CA (1) | CA2792417C (fr) |
CL (1) | CL2012002540A1 (fr) |
CR (1) | CR20120462A (fr) |
CU (1) | CU20120137A7 (fr) |
CY (1) | CY1116086T1 (fr) |
DK (1) | DK2547649T3 (fr) |
EA (1) | EA022067B1 (fr) |
EC (1) | ECSP12012155A (fr) |
ES (1) | ES2530772T3 (fr) |
GE (1) | GEP20156231B (fr) |
GT (1) | GT201200259A (fr) |
HK (1) | HK1177451A1 (fr) |
HR (1) | HRP20150071T1 (fr) |
IL (1) | IL221782A (fr) |
MA (1) | MA34055B1 (fr) |
ME (1) | ME02054B (fr) |
MX (1) | MX2012010541A (fr) |
NI (1) | NI201200140A (fr) |
NZ (1) | NZ602450A (fr) |
PE (1) | PE20130013A1 (fr) |
PL (1) | PL2547649T3 (fr) |
PT (1) | PT2547649E (fr) |
RS (1) | RS53815B1 (fr) |
SG (1) | SG183868A1 (fr) |
SI (1) | SI2547649T1 (fr) |
TN (1) | TN2012000435A1 (fr) |
UA (1) | UA105425C2 (fr) |
WO (1) | WO2011113362A1 (fr) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2551257A1 (fr) * | 2011-07-28 | 2013-01-30 | Laboratorios Del. Dr. Esteve, S.A. | Co-cristaux d'agomélatine avec formeurs de co-cristaux |
FR2978916B1 (fr) | 2011-08-10 | 2013-07-26 | Servier Lab | Composition pharmaceutique solide pour administration buccale d'agomelatine |
KR20150020191A (ko) * | 2012-05-14 | 2015-02-25 | 상하이 라이트핸드 팜테크 주식회사 | 아고멜라틴 산기 복합체와 그의 제조방법 및 용도 |
CN102702041B (zh) * | 2012-05-14 | 2013-08-14 | 上海右手医药科技开发有限公司 | 阿戈美拉汀苯磺酸类复合物及其制备方法 |
CN102718675B (zh) * | 2012-06-07 | 2015-03-25 | 上海右手医药科技开发有限公司 | 阿戈美拉汀甲磺酸复合物及其制备方法 |
CN102718676B (zh) * | 2012-06-26 | 2014-04-09 | 福建广生堂药业股份有限公司 | 阿戈美拉汀硫酸盐及其制备方法 |
WO2014096373A1 (fr) | 2012-12-21 | 2014-06-26 | Laboratorios Lesvi, S. L. | Procédé de préparation de n-(2-(7-méthoxy-1-naphtalényl)éthyl)acétamide et de formes solides de celui-ci |
FR3001894A1 (fr) | 2013-02-08 | 2014-08-15 | Servier Lab | Composition pharmaceutique solide pour administration buccale d'agomelatine |
WO2015013865A1 (fr) * | 2013-07-29 | 2015-02-05 | Les Laboratoires Servier | Complexes d'acides sulfoniques et d'agomélatine et leur préparation |
KR101470794B1 (ko) * | 2014-06-30 | 2014-12-08 | 순천향대학교 산학협력단 | 아고멜라틴 공결정의 제조 방법 및 이를 포함하는 조성물 |
EP3613745B1 (fr) | 2015-07-02 | 2021-09-01 | Acerta Pharma B.V. | Formes et formulations solides de (s)-4-(8-amino-3-(1-(but-2-ynoyl)pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-n-(pyridin-2-yl)benzamide |
US10367757B2 (en) * | 2016-08-27 | 2019-07-30 | Nicira, Inc. | Extension of network control system into public cloud |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2658818B1 (fr) * | 1990-02-27 | 1993-12-31 | Adir Cie | Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
DE01991193T1 (de) * | 2000-10-30 | 2004-07-08 | Teva Pharmaceutical Industries Ltd. | Neue kristall- und solvatformen von ondansetronhydrochlorid und verfahren zu deren herstellung |
FR2890562B1 (fr) * | 2005-09-09 | 2012-10-12 | Servier Lab | Utilisation de l'agomelatine pour l'obtention de medicaments destines au traitement des troubles du sommeil chez le patient deprime |
FR2899472B1 (fr) * | 2006-04-07 | 2008-09-12 | Servier Lab | Utilisation de l'agomelatine pour l'obtention de medicaments destines au traitement du trouble anxiete generalisee |
FR2934859B1 (fr) | 2008-08-05 | 2010-08-13 | Servier Lab | Nouveau procede de synthese de l'agomelatine |
CN101481321B (zh) * | 2009-02-27 | 2012-04-18 | 上海医药工业研究院 | 阿戈美拉汀卤化氢复合物及其制备方法 |
WO2012046253A2 (fr) * | 2010-10-08 | 2012-04-12 | Msn Laboratories Limited | Procédé de préparation de n-[2- (7-méthoxy-l-naphthyl) éthyl] acétamide et ses nouvelles formes cristallines |
-
2010
- 2010-03-17 CN CN201010126254XA patent/CN102190594A/zh active Pending
-
2011
- 2011-03-17 SG SG2012065009A patent/SG183868A1/en unknown
- 2011-03-17 ME MEP-2015-23A patent/ME02054B/me unknown
- 2011-03-17 RS RS20150041A patent/RS53815B1/en unknown
- 2011-03-17 MA MA35192A patent/MA34055B1/fr unknown
- 2011-03-17 BR BR112012023317-3A patent/BR112012023317B1/pt not_active IP Right Cessation
- 2011-03-17 SI SI201130403T patent/SI2547649T1/sl unknown
- 2011-03-17 AP AP2012006492A patent/AP2012006492A0/xx unknown
- 2011-03-17 DK DK11755679.5T patent/DK2547649T3/en active
- 2011-03-17 AU AU2011229618A patent/AU2011229618B2/en not_active Ceased
- 2011-03-17 PE PE2012001448A patent/PE20130013A1/es active IP Right Grant
- 2011-03-17 JP JP2012557392A patent/JP5634532B2/ja active Active
- 2011-03-17 US US13/635,063 patent/US8729131B2/en active Active
- 2011-03-17 EP EP11755679.5A patent/EP2547649B1/fr active Active
- 2011-03-17 WO PCT/CN2011/071910 patent/WO2011113362A1/fr active Application Filing
- 2011-03-17 KR KR1020127026895A patent/KR101406727B1/ko active IP Right Grant
- 2011-03-17 GE GEAP201112869A patent/GEP20156231B/en unknown
- 2011-03-17 CA CA2792417A patent/CA2792417C/fr active Active
- 2011-03-17 MX MX2012010541A patent/MX2012010541A/es active IP Right Grant
- 2011-03-17 UA UAA201211720A patent/UA105425C2/ru unknown
- 2011-03-17 EA EA201201294A patent/EA022067B1/ru unknown
- 2011-03-17 PT PT117556795T patent/PT2547649E/pt unknown
- 2011-03-17 NZ NZ602450A patent/NZ602450A/en not_active IP Right Cessation
- 2011-03-17 CN CN201180024357.8A patent/CN102958911B/zh not_active Expired - Fee Related
- 2011-03-17 PL PL11755679T patent/PL2547649T3/pl unknown
- 2011-03-17 ES ES11755679T patent/ES2530772T3/es active Active
-
2012
- 2012-08-31 TN TNP2012000435A patent/TN2012000435A1/en unknown
- 2012-09-04 IL IL221782A patent/IL221782A/en not_active IP Right Cessation
- 2012-09-11 CR CR20120462A patent/CR20120462A/es unknown
- 2012-09-12 NI NI201200140A patent/NI201200140A/es unknown
- 2012-09-13 CL CL2012002540A patent/CL2012002540A1/es unknown
- 2012-09-14 EC ECSP12012155 patent/ECSP12012155A/es unknown
- 2012-09-17 GT GT201200259A patent/GT201200259A/es unknown
- 2012-09-17 CU CU2012000137A patent/CU20120137A7/es unknown
-
2013
- 2013-04-16 HK HK13104588.5A patent/HK1177451A1/zh not_active IP Right Cessation
-
2015
- 2015-01-20 HR HRP20150071AT patent/HRP20150071T1/hr unknown
- 2015-01-22 CY CY20151100071T patent/CY1116086T1/el unknown
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