JP6443812B2 - ハリコンドリンｂ類縁体の合成に有用な方法 - Google Patents

ハリコンドリンｂ類縁体の合成に有用な方法 Download PDF

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Publication number
JP6443812B2
JP6443812B2 JP2016532033A JP2016532033A JP6443812B2 JP 6443812 B2 JP6443812 B2 JP 6443812B2 JP 2016532033 A JP2016532033 A JP 2016532033A JP 2016532033 A JP2016532033 A JP 2016532033A JP 6443812 B2 JP6443812 B2 JP 6443812B2
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eribulin
pharmaceutically acceptable
acceptable salt
alkyl
acetonitrile
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JP2016540752A (ja
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ルイス，ブライアン，エム
フ，ヨンボ
ツァン，ヒュイミン
千葉　博之
博之 千葉
雄毅 小松
雄毅 小松
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Eisai R&D Management Co Ltd
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Eisai R&D Management Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2016532033A 2013-12-06 2014-12-05 ハリコンドリンｂ類縁体の合成に有用な方法 Active JP6443812B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361912714P 2013-12-06 2013-12-06
US61/912,714 2013-12-06
PCT/US2014/068834 WO2015085193A1 (en) 2013-12-06 2014-12-05 Methods useful in the synthesis of halichondrin b analogs

Related Child Applications (1)

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JP2018194871A Division JP6634135B2 (ja) 2013-12-06 2018-10-16 ハリコンドリンｂ類縁体の合成に有用な方法

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JP2016540752A JP2016540752A (ja) 2016-12-28
JP6443812B2 true JP6443812B2 (ja) 2018-12-26

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JP2016532033A Active JP6443812B2 (ja) 2013-12-06 2014-12-05 ハリコンドリンｂ類縁体の合成に有用な方法
JP2018194871A Active JP6634135B2 (ja) 2013-12-06 2018-10-16 ハリコンドリンｂ類縁体の合成に有用な方法
JP2019225297A Active JP6905041B2 (ja) 2013-12-06 2019-12-13 ハリコンドリンｂ類縁体の合成に有用な方法

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JP2018194871A Active JP6634135B2 (ja) 2013-12-06 2018-10-16 ハリコンドリンｂ類縁体の合成に有用な方法
JP2019225297A Active JP6905041B2 (ja) 2013-12-06 2019-12-13 ハリコンドリンｂ類縁体の合成に有用な方法

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US (4) US9303039B2 (enExample)
EP (2) EP3505520A1 (enExample)
JP (3) JP6443812B2 (enExample)
CN (1) CN105916861B (enExample)
BR (1) BR112016012237B1 (enExample)
CA (1) CA2931788C (enExample)
ES (1) ES2723355T3 (enExample)
HU (1) HUE043088T2 (enExample)
IL (4) IL245661A0 (enExample)
MX (3) MX376869B (enExample)
RU (1) RU2676486C1 (enExample)
SG (2) SG10201805024YA (enExample)
WO (1) WO2015085193A1 (enExample)

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WO2019097073A1 (en) 2017-11-20 2019-05-23 Basilea Pharmaceutica International AG Pharmaceutical combinations for use in the treatment of neoplastic diseases
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CN112437775A (zh) * 2018-07-20 2021-03-02 雷迪博士实验室有限公司 用于制备艾日布林及其中间体的纯化方法
CN113166096A (zh) * 2018-10-09 2021-07-23 雷迪博士实验室有限公司 制备艾立布林的方法及其中间体
US20220089607A1 (en) * 2018-11-28 2022-03-24 Natco Pharma Limited Process for the preparation of high pure eribulin and its mesylate salt
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WO2022101931A1 (en) * 2020-11-10 2022-05-19 Natco Pharma Limited Process for the preparation of eribulin and its intermediates
CN113354659B (zh) * 2021-06-08 2022-04-08 江苏慧聚药业股份有限公司 甲磺酸艾日布林的合成
CN114380840B (zh) * 2022-01-27 2024-01-26 江苏慧聚药业股份有限公司 艾日布林的合成
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JP6443812B2 (ja) * 2013-12-06 2018-12-26 エーザイ・アール・アンド・ディー・マネジメント株式会社 ハリコンドリンｂ類縁体の合成に有用な方法
WO2016179607A1 (en) 2015-05-07 2016-11-10 Eisai R&D Management Co., Ltd. Macrocyclization reactions and intermediates and other fragments useful in the synthesis of halichondrin macrolides
MX377663B (es) 2016-02-12 2025-03-11 Eisai R&D Man Co Ltd Intermediarios en la sintesis de eribulina y metodos de sintesis relacionados.
MX390072B (es) 2016-06-30 2025-03-20 Eisai R&D Man Co Ltd Reaccion de prins e intermediarios utiles en la sintesis de macrolidos de halicondrina y analogos de los mismos.

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MX2020004855A (es) 2021-07-08
MX376869B (es) 2025-03-07
BR112016012237A2 (enExample) 2017-08-08
WO2015085193A1 (en) 2015-06-11
US10030032B2 (en) 2018-07-24
US9695188B2 (en) 2017-07-04
US20160176895A1 (en) 2016-06-23
SG10201805024YA (en) 2018-07-30
CN105916861A (zh) 2016-08-31
US20150158881A1 (en) 2015-06-11
IL281275A (en) 2021-04-29
IL245661A0 (en) 2016-06-30
EP3077399A1 (en) 2016-10-12
US20190010166A1 (en) 2019-01-10
EP3077399B1 (en) 2019-02-20
MX370611B (es) 2019-12-18
IL273736B (en) 2021-03-25
RU2676486C1 (ru) 2018-12-29
MX2016006891A (es) 2017-06-12
JP2016540752A (ja) 2016-12-28
IL265640A (en) 2019-05-30
JP2019031530A (ja) 2019-02-28
US10450324B2 (en) 2019-10-22
MX2019011926A (es) 2019-11-18
JP2020059739A (ja) 2020-04-16
JP6634135B2 (ja) 2020-01-22
IL273736A (en) 2020-05-31
US20170298078A1 (en) 2017-10-19
IL265640B (en) 2020-04-30
BR112016012237B1 (pt) 2023-02-07
MX384292B (es) 2025-03-14
US9303039B2 (en) 2016-04-05
CA2931788A1 (en) 2015-06-11
EP3077399A4 (en) 2017-05-10
ES2723355T3 (es) 2019-08-26
EP3505520A1 (en) 2019-07-03
SG11201604545XA (en) 2016-07-28
CA2931788C (en) 2022-05-24
JP6905041B2 (ja) 2021-07-21
IL281275B (en) 2021-12-01
HUE043088T2 (hu) 2019-08-28
CN105916861B (zh) 2018-12-14

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