MX2016006891A - Metodos utiles en la sintesis de analogos de halicondrina b. - Google Patents

Metodos utiles en la sintesis de analogos de halicondrina b.

Info

Publication number
MX2016006891A
MX2016006891A MX2016006891A MX2016006891A MX2016006891A MX 2016006891 A MX2016006891 A MX 2016006891A MX 2016006891 A MX2016006891 A MX 2016006891A MX 2016006891 A MX2016006891 A MX 2016006891A MX 2016006891 A MX2016006891 A MX 2016006891A
Authority
MX
Mexico
Prior art keywords
halichondrin
analogs
synthesis
methods useful
eribulin
Prior art date
Application number
MX2016006891A
Other languages
English (en)
Other versions
MX370611B (es
Inventor
M Lewis Bryan
Hu Yongbo
Zhang Huiming
Chiba Hiroyuki
Komatsu Yuki
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of MX2016006891A publication Critical patent/MX2016006891A/es
Publication of MX370611B publication Critical patent/MX370611B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

La presente invención proporciona un método novedoso para producir un compuesto representado por la fórmula (III), el cual comprende tratar un compuesto representado por la fórmula (I) con un compuesto de cromo trivalente y por lo menos un tipo de metal seleccionado a partir del grupo que consiste en manganeso y zinc, y la presente invención proporciona además al compuesto novedoso representado por la fórmula (I).
MX2016006891A 2013-12-06 2014-12-05 Metodos utiles en la sintesis de analogos de halicondrina b. MX370611B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361912714P 2013-12-06 2013-12-06
PCT/US2014/068834 WO2015085193A1 (en) 2013-12-06 2014-12-05 Methods useful in the synthesis of halichondrin b analogs

Publications (2)

Publication Number Publication Date
MX2016006891A true MX2016006891A (es) 2017-06-12
MX370611B MX370611B (es) 2019-12-18

Family

ID=53270478

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2020004855A MX2020004855A (es) 2013-12-06 2014-12-05 Metodos utiles en la sintesis de analogos de halicondrina b.
MX2016006891A MX370611B (es) 2013-12-06 2014-12-05 Metodos utiles en la sintesis de analogos de halicondrina b.
MX2019011926A MX2019011926A (es) 2013-12-06 2016-05-26 Metodos utiles en la sintesis de analogos de halicondrina b.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2020004855A MX2020004855A (es) 2013-12-06 2014-12-05 Metodos utiles en la sintesis de analogos de halicondrina b.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2019011926A MX2019011926A (es) 2013-12-06 2016-05-26 Metodos utiles en la sintesis de analogos de halicondrina b.

Country Status (13)

Country Link
US (4) US9303039B2 (es)
EP (2) EP3077399B1 (es)
JP (3) JP6443812B2 (es)
CN (1) CN105916861B (es)
BR (1) BR112016012237B1 (es)
CA (1) CA2931788C (es)
ES (1) ES2723355T3 (es)
HU (1) HUE043088T2 (es)
IL (4) IL245661A0 (es)
MX (3) MX2020004855A (es)
RU (1) RU2676486C1 (es)
SG (2) SG11201604545XA (es)
WO (1) WO2015085193A1 (es)

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CN109694379B (zh) * 2017-10-24 2020-09-11 江苏恒瑞医药股份有限公司 用于制备艾日布林的中间体及其制备方法
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JP2021532102A (ja) * 2018-07-20 2021-11-25 ドクター レディズ ラボラトリーズ リミテッド エリブリンおよびその中間体の調製のための精製プロセス
US20210340156A1 (en) * 2018-10-09 2021-11-04 Dr. Reddy's Laboratories Limited Process for preparation of eribulin and intermediates thereof
WO2020110146A1 (en) * 2018-11-28 2020-06-04 Natco Pharma Limited Process for the preparation of high pure eribulin and its mesylate salt
US11447499B2 (en) 2019-06-14 2022-09-20 Rk Pharma Inc. Process for the preparation of eribulin mesylate intermediate
WO2022101931A1 (en) * 2020-11-10 2022-05-19 Natco Pharma Limited Process for the preparation of eribulin and its intermediates
CN113354659B (zh) * 2021-06-08 2022-04-08 江苏慧聚药业股份有限公司 甲磺酸艾日布林的合成
CN114380840B (zh) * 2022-01-27 2024-01-26 江苏慧聚药业股份有限公司 艾日布林的合成

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HUE049387T2 (hu) 2013-11-04 2020-09-28 Eisai R&D Man Co Ltd A halichondrin B analógjainak szintézisében hasznos makrociklizációs reakciók és köztitermékek
US9303039B2 (en) * 2013-12-06 2016-04-05 Eisai R&D Management Co., Ltd. Methods useful in the synthesis of halichondrin B analogs
CN107849057B (zh) 2015-05-07 2020-11-10 卫材R&D管理有限公司 用于合成软海绵素大环内酯的大环化反应及中间体和其他片段
EP3413887B1 (en) 2016-02-12 2021-04-07 Eisai R&D Management Co., Ltd. Intermediates in the synthesis of eribulin and related methods of synthesis
US11136335B2 (en) 2016-06-30 2021-10-05 Eisai R&D Management Co., Ltd. Prins reaction and intermediates useful in the synthesis of halichondrin macrolides and analogs thereof

Also Published As

Publication number Publication date
CA2931788C (en) 2022-05-24
EP3077399B1 (en) 2019-02-20
SG10201805024YA (en) 2018-07-30
RU2676486C1 (ru) 2018-12-29
BR112016012237A2 (es) 2017-08-08
JP2019031530A (ja) 2019-02-28
WO2015085193A1 (en) 2015-06-11
JP6905041B2 (ja) 2021-07-21
EP3077399A4 (en) 2017-05-10
IL245661A0 (en) 2016-06-30
US20160176895A1 (en) 2016-06-23
JP6443812B2 (ja) 2018-12-26
CN105916861B (zh) 2018-12-14
CN105916861A (zh) 2016-08-31
EP3505520A1 (en) 2019-07-03
EP3077399A1 (en) 2016-10-12
IL281275A (en) 2021-04-29
ES2723355T3 (es) 2019-08-26
IL265640B (en) 2020-04-30
MX370611B (es) 2019-12-18
US20170298078A1 (en) 2017-10-19
IL281275B (en) 2021-12-01
IL273736A (en) 2020-05-31
IL265640A (en) 2019-05-30
MX2019011926A (es) 2019-11-18
US9695188B2 (en) 2017-07-04
JP6634135B2 (ja) 2020-01-22
JP2016540752A (ja) 2016-12-28
US20150158881A1 (en) 2015-06-11
US20190010166A1 (en) 2019-01-10
IL273736B (en) 2021-03-25
US10450324B2 (en) 2019-10-22
US10030032B2 (en) 2018-07-24
BR112016012237B1 (pt) 2023-02-07
MX2020004855A (es) 2021-07-08
HUE043088T2 (hu) 2019-08-28
SG11201604545XA (en) 2016-07-28
CA2931788A1 (en) 2015-06-11
US9303039B2 (en) 2016-04-05
JP2020059739A (ja) 2020-04-16

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