MX2020004855A - Metodos utiles en la sintesis de analogos de halicondrina b. - Google Patents
Metodos utiles en la sintesis de analogos de halicondrina b.Info
- Publication number
- MX2020004855A MX2020004855A MX2020004855A MX2020004855A MX2020004855A MX 2020004855 A MX2020004855 A MX 2020004855A MX 2020004855 A MX2020004855 A MX 2020004855A MX 2020004855 A MX2020004855 A MX 2020004855A MX 2020004855 A MX2020004855 A MX 2020004855A
- Authority
- MX
- Mexico
- Prior art keywords
- halichondrin
- analogs
- synthesis
- methods useful
- eribulin
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- FXNFULJVOQMBCW-VZBLNRDYSA-N halichondrin b Chemical class O([C@@H]1[C@@H](C)[C@@H]2O[C@@H]3C[C@@]4(O[C@H]5[C@@H](C)C[C@@]6(C[C@@H]([C@@H]7O[C@@H](C[C@@H]7O6)[C@@H](O)C[C@@H](O)CO)C)O[C@H]5C4)O[C@@H]3C[C@@H]2O[C@H]1C[C@@H]1C(=C)[C@H](C)C[C@@H](O1)CC[C@H]1C(=C)C[C@@H](O1)CC1)C(=O)C[C@H](O2)CC[C@H]3[C@H]2[C@H](O2)[C@@H]4O[C@@H]5C[C@@]21O[C@@H]5[C@@H]4O3 FXNFULJVOQMBCW-VZBLNRDYSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- UFNVPOGXISZXJD-JBQZKEIOSA-N eribulin Chemical compound C([C@H]1CC[C@@H]2O[C@@H]3[C@H]4O[C@@H]5C[C@](O[C@H]4[C@H]2O1)(O[C@@H]53)CC[C@@H]1O[C@H](C(C1)=C)CC1)C(=O)C[C@@H]2[C@@H](OC)[C@@H](C[C@H](O)CN)O[C@H]2C[C@@H]2C(=C)[C@H](C)C[C@H]1O2 UFNVPOGXISZXJD-JBQZKEIOSA-N 0.000 abstract 2
- -1 eribulin Chemical class 0.000 abstract 1
- 229960003649 eribulin Drugs 0.000 abstract 1
- 229960000439 eribulin mesylate Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
En general, la presente invención se refiere a métodos mejorados útiles en la síntesis de análogos de halicondrina B, tales como eribulina, y a sales farmacéuticamente aceptables de los mismos (por ejemplo, mesilato de eribulina).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361912714P | 2013-12-06 | 2013-12-06 | |
| PCT/US2014/068834 WO2015085193A1 (en) | 2013-12-06 | 2014-12-05 | Methods useful in the synthesis of halichondrin b analogs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2020004855A true MX2020004855A (es) | 2021-07-08 |
| MX384292B MX384292B (es) | 2025-03-14 |
Family
ID=53270478
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020004855A MX384292B (es) | 2013-12-06 | 2014-12-05 | Metodos utiles en la sintesis de analogos de halicondrina b. |
| MX2019011926A MX376869B (es) | 2013-12-06 | 2014-12-05 | Metodos utiles en la sintesis de analogos de halicondrina b. |
| MX2016006891A MX370611B (es) | 2013-12-06 | 2014-12-05 | Metodos utiles en la sintesis de analogos de halicondrina b. |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019011926A MX376869B (es) | 2013-12-06 | 2014-12-05 | Metodos utiles en la sintesis de analogos de halicondrina b. |
| MX2016006891A MX370611B (es) | 2013-12-06 | 2014-12-05 | Metodos utiles en la sintesis de analogos de halicondrina b. |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US9303039B2 (es) |
| EP (2) | EP3077399B1 (es) |
| JP (3) | JP6443812B2 (es) |
| CN (1) | CN105916861B (es) |
| BR (1) | BR112016012237B1 (es) |
| CA (1) | CA2931788C (es) |
| ES (1) | ES2723355T3 (es) |
| HU (1) | HUE043088T2 (es) |
| IL (4) | IL245661A0 (es) |
| MX (3) | MX384292B (es) |
| RU (1) | RU2676486C1 (es) |
| SG (2) | SG10201805024YA (es) |
| WO (1) | WO2015085193A1 (es) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE046436T2 (hu) * | 2004-06-03 | 2020-02-28 | Eisai R&D Man Co Ltd | Köztitermékek halikondrin B elõállításához |
| US8093410B2 (en) | 2007-10-03 | 2012-01-10 | Eisai R&D Management Co., Ltd. | Intermediates and methods for the synthesis of halichondrin B analogs |
| CA2720632C (en) | 2008-04-04 | 2016-12-20 | Eisai R&D Management Co., Ltd. | Halichondrin b analogs |
| RU2579511C2 (ru) | 2010-01-26 | 2016-04-10 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Производные фуро[3,2-в]пирана, применимые в синтезе аналогов |
| EP3689881B1 (en) | 2013-11-04 | 2022-01-12 | Eisai R&D Management Co., Ltd. | Macrocyclization reactions and intermediates useful in the synthesis of analogs of halichondrin b |
| SG10201805024YA (en) * | 2013-12-06 | 2018-07-30 | Eisai R&D Man Co Ltd | Methods useful in the synthesis of halichondrin b analogs |
| EP3160970A4 (en) | 2014-06-30 | 2017-12-27 | President and Fellows of Harvard College | Synthesis of halichondrin analogs and uses thereof |
| US10344038B2 (en) | 2015-04-30 | 2019-07-09 | President And Fellows Of Harvard College | Chromium-mediated coupling and application to the synthesis of halichondrins |
| RU2020141025A (ru) | 2015-05-07 | 2020-12-28 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Реакции макроциклизации и промежуточные соединения и другие фрагменты, полезные в синтезе макролидов галихондринов |
| US10676481B2 (en) | 2016-02-12 | 2020-06-09 | Eisai R&D Management Co., Ltd. | Intermediates in the synthesis of eribulin and related methods of synthesis |
| PE20181953A1 (es) | 2016-03-02 | 2018-12-17 | Eisai Randd Man Co Ltd | Conjugados de anticuerpo y farmaco basados en eribulina y metodos para su uso |
| KR102404629B1 (ko) | 2016-06-30 | 2022-06-02 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 할리콘드린 마크롤리드 및 그의 유사체의 합성에 유용한 프린스 반응 및 중간체 |
| JP6978758B2 (ja) | 2016-11-11 | 2021-12-08 | プレジデント アンド フェローズ オブ ハーバード カレッジ | パラジウム媒介ケトール化 |
| US9938288B1 (en) | 2017-04-05 | 2018-04-10 | President And Fellows Of Harvard College | Macrocyclic compound and uses thereof |
| JP7168580B2 (ja) | 2017-04-05 | 2022-11-09 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 大環状化合物およびその使用 |
| WO2018217894A1 (en) * | 2017-05-24 | 2018-11-29 | Eisai R&D Management Co., Ltd. | Fluorine-labelled halichondrin derivatives and related methods of synthesis |
| BR112020000141A2 (pt) | 2017-07-06 | 2020-07-14 | President And Fellows Of Harvard College | síntese de halicondrinas |
| US11498892B2 (en) | 2017-07-06 | 2022-11-15 | President And Fellows Of Harvard College | Fe/Cu-mediated ketone synthesis |
| CN109694379B (zh) * | 2017-10-24 | 2020-09-11 | 江苏恒瑞医药股份有限公司 | 用于制备艾日布林的中间体及其制备方法 |
| WO2019099646A1 (en) | 2017-11-15 | 2019-05-23 | President And Fellows Of Harvard College | Macrocyclic compounds and uses thereof |
| WO2019097073A1 (en) | 2017-11-20 | 2019-05-23 | Basilea Pharmaceutica International AG | Pharmaceutical combinations for use in the treatment of neoplastic diseases |
| US11542269B2 (en) | 2018-01-03 | 2023-01-03 | Eisai R&D Management Co., Ltd. | Prins reaction and compounds useful in the synthesis of halichondrin macrolides and analogs thereof |
| WO2020016847A2 (en) * | 2018-07-20 | 2020-01-23 | Dr. Reddy’S Laboratories Limited | Purification process for preparation of eribulin and intermediates thereof |
| US20210340156A1 (en) * | 2018-10-09 | 2021-11-04 | Dr. Reddy's Laboratories Limited | Process for preparation of eribulin and intermediates thereof |
| WO2020110146A1 (en) * | 2018-11-28 | 2020-06-04 | Natco Pharma Limited | Process for the preparation of high pure eribulin and its mesylate salt |
| US11447499B2 (en) | 2019-06-14 | 2022-09-20 | Rk Pharma Inc. | Process for the preparation of eribulin mesylate intermediate |
| WO2022101931A1 (en) * | 2020-11-10 | 2022-05-19 | Natco Pharma Limited | Process for the preparation of eribulin and its intermediates |
| CN113354659B (zh) * | 2021-06-08 | 2022-04-08 | 江苏慧聚药业股份有限公司 | 甲磺酸艾日布林的合成 |
| CN114380840B (zh) * | 2022-01-27 | 2024-01-26 | 江苏慧聚药业股份有限公司 | 艾日布林的合成 |
| WO2025106586A1 (en) * | 2023-11-13 | 2025-05-22 | Luxvitae Therapeutics Inc. | Macrocyclic ketone compounds and applications thereof |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU652180A1 (ru) | 1975-12-16 | 1979-03-15 | Краснодарский политехнический институт | 1(Фурил-2,)-2-(2-,, формилфурил-5,, ) этилен или его метильное производное как промежуточный продукт дл синтеза фуран-2,5-дикарбоновой кислоты и способ его получени |
| US5338865A (en) | 1992-03-12 | 1994-08-16 | President And Fellows Of Harvard College | Synthesis of halichondrin B and norhalichondrin B |
| US5436238A (en) | 1992-03-12 | 1995-07-25 | President And Fellows Of Harvard College | Halichondrins and related compounds |
| GB9206244D0 (en) | 1992-03-23 | 1992-05-06 | Pharma Mar Sa | Cytotoxic compound from a marine sponge |
| TW255880B (es) | 1992-09-09 | 1995-09-01 | Hoechst Ag | |
| US6194586B1 (en) * | 1996-09-06 | 2001-02-27 | Eli Lilly And Company | Selective sulphonation of the primary alcohol of a diol containing both primary and secondary alcohols |
| US6653341B1 (en) | 1998-06-17 | 2003-11-25 | Eisai Co., Ltd. | Methods and compositions for use in treating cancer |
| US8097648B2 (en) | 1998-06-17 | 2012-01-17 | Eisai R&D Management Co., Ltd. | Methods and compositions for use in treating cancer |
| DK1087960T3 (da) | 1998-06-17 | 2011-06-14 | Eisai R&D Man Co Ltd | Makrocykliske analoger og fremgangsmåder til deres anvendelse og fremstilling |
| CA2822994C (en) * | 2004-06-03 | 2016-09-27 | Eisai R&D Management Co., Ltd. | Intermediates for the preparation of analogs of halichondrin b |
| HUE046436T2 (hu) * | 2004-06-03 | 2020-02-28 | Eisai R&D Man Co Ltd | Köztitermékek halikondrin B elõállításához |
| US20060045846A1 (en) | 2004-08-30 | 2006-03-02 | Horstmann Thomas E | Reagents and methods for labeling terminal olefins |
| JP2008522623A (ja) | 2004-12-09 | 2008-07-03 | エーザイ株式会社 | ハリコンドリンｂアナログを使用した癌治療でのチューブリンアイソタイプのスクリーニング |
| WO2008010776A1 (en) | 2006-07-21 | 2008-01-24 | Agency For Science, Technology And Research | Aigialomycin d and derivatives thereof and their use in treating cancer or malaria or a microbial infection |
| WO2009014105A1 (ja) | 2007-07-20 | 2009-01-29 | Yamada Apiculture Center, Inc. | 新規カルボン酸およびそれを有効成分とする抗うつ用組成物 |
| US8093410B2 (en) | 2007-10-03 | 2012-01-10 | Eisai R&D Management Co., Ltd. | Intermediates and methods for the synthesis of halichondrin B analogs |
| WO2009064029A1 (en) | 2007-11-16 | 2009-05-22 | Eisai R & D Management Co., Ltd. | Novel intermediate for halichondrin b analog synthesis and novel desulfonylation reaction used for the intermediate |
| CA2720632C (en) | 2008-04-04 | 2016-12-20 | Eisai R&D Management Co., Ltd. | Halichondrin b analogs |
| JP5371091B2 (ja) | 2009-01-23 | 2013-12-18 | 三菱レイヨン株式会社 | モノスルホン酸エステルの製造方法 |
| RU2579511C2 (ru) | 2010-01-26 | 2016-04-10 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Производные фуро[3,2-в]пирана, применимые в синтезе аналогов |
| EP2354128A1 (en) | 2010-02-10 | 2011-08-10 | Sandoz Ag | Method for the preparation of rivaroxaban |
| WO2012147900A1 (en) | 2011-04-28 | 2012-11-01 | Eisai R&D Management Co., Ltd. | Microreactor process for halichondrin b analog synthesis |
| AU2012344697A1 (en) | 2011-11-30 | 2014-07-10 | Alphora Research Inc. | Process for preparation of (3R)-2,4-di-leaving group-3-methylbut-1-ene |
| US9278979B2 (en) | 2012-03-30 | 2016-03-08 | Alphora Research Inc. | Synthetic process for preparation of macrocyclic C1-keto analogs of halichondrin B and intermediates useful therein |
| US9850254B2 (en) | 2013-07-03 | 2017-12-26 | Sandoz Ag | Synthetic process for preparation of macrocyclic C1-keto analogs of Halichondrin B and intermediates useful therein including intermediates containing-SO2-(p-tolyl) groups |
| EP3689881B1 (en) | 2013-11-04 | 2022-01-12 | Eisai R&D Management Co., Ltd. | Macrocyclization reactions and intermediates useful in the synthesis of analogs of halichondrin b |
| SG10201805024YA (en) * | 2013-12-06 | 2018-07-30 | Eisai R&D Man Co Ltd | Methods useful in the synthesis of halichondrin b analogs |
| RU2020141025A (ru) | 2015-05-07 | 2020-12-28 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Реакции макроциклизации и промежуточные соединения и другие фрагменты, полезные в синтезе макролидов галихондринов |
| US10676481B2 (en) | 2016-02-12 | 2020-06-09 | Eisai R&D Management Co., Ltd. | Intermediates in the synthesis of eribulin and related methods of synthesis |
| KR102404629B1 (ko) | 2016-06-30 | 2022-06-02 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 할리콘드린 마크롤리드 및 그의 유사체의 합성에 유용한 프린스 반응 및 중간체 |
-
2014
- 2014-12-05 SG SG10201805024YA patent/SG10201805024YA/en unknown
- 2014-12-05 HU HUE14866945A patent/HUE043088T2/hu unknown
- 2014-12-05 EP EP14866945.0A patent/EP3077399B1/en active Active
- 2014-12-05 WO PCT/US2014/068834 patent/WO2015085193A1/en not_active Ceased
- 2014-12-05 US US14/562,086 patent/US9303039B2/en active Active
- 2014-12-05 ES ES14866945T patent/ES2723355T3/es active Active
- 2014-12-05 MX MX2020004855A patent/MX384292B/es unknown
- 2014-12-05 CA CA2931788A patent/CA2931788C/en active Active
- 2014-12-05 RU RU2016124265A patent/RU2676486C1/ru active
- 2014-12-05 JP JP2016532033A patent/JP6443812B2/ja active Active
- 2014-12-05 EP EP18209462.3A patent/EP3505520A1/en active Pending
- 2014-12-05 MX MX2019011926A patent/MX376869B/es active IP Right Grant
- 2014-12-05 SG SG11201604545XA patent/SG11201604545XA/en unknown
- 2014-12-05 BR BR112016012237-2A patent/BR112016012237B1/pt active IP Right Grant
- 2014-12-05 MX MX2016006891A patent/MX370611B/es active IP Right Grant
- 2014-12-05 CN CN201480066353.XA patent/CN105916861B/zh active Active
-
2016
- 2016-03-03 US US15/059,965 patent/US9695188B2/en active Active
- 2016-05-16 IL IL245661A patent/IL245661A0/en active IP Right Grant
-
2017
- 2017-06-30 US US15/638,493 patent/US10030032B2/en active Active
-
2018
- 2018-07-10 US US16/031,629 patent/US10450324B2/en active Active
- 2018-10-16 JP JP2018194871A patent/JP6634135B2/ja active Active
-
2019
- 2019-03-26 IL IL265640A patent/IL265640B/en active IP Right Grant
- 2019-12-13 JP JP2019225297A patent/JP6905041B2/ja active Active
-
2020
- 2020-04-01 IL IL273736A patent/IL273736B/en active IP Right Grant
-
2021
- 2021-03-04 IL IL281275A patent/IL281275B/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2019011926A (es) | Metodos utiles en la sintesis de analogos de halicondrina b. | |
| CY1123953T1 (el) | Καθυστερημενης απελευθερωσης συνθεσεις λινακλοτιδης | |
| CR20150370A (es) | Compuestos antivirales | |
| GT201700146A (es) | Compuestos de triazolopirimidina y usos de los mismos | |
| CR20140464A (es) | Compuestos de heterociclilo | |
| UY34602A (es) | ?Derivados de bencimidazolil- e imidazopiridinil-metilamina? | |
| CY1118379T1 (el) | Αναστολεις ιου ηπατιτιδας c | |
| UY35469A (es) | Moduladores de p2x7 | |
| MX2014014166A (es) | Metodos para mejorar la seguridad del transporte de la barrera hematoencefalica. | |
| BR112016014180A2 (pt) | reguladores de nrf2 | |
| JOP20140114B1 (ar) | مركبات حلقية غير متجانسة واستخداماتها | |
| UY35675A (es) | Derivados sustituidos de quinazolin-4-ona | |
| UY34472A (es) | Derivados modificados de 4-fenil-piridina | |
| EA201401054A1 (ru) | N-циклиламиды в качестве нематоцидов | |
| UY34697A (es) | Métodos para preparar análogos de nucleótidos | |
| CR20160291A (es) | Análogos de cortistatina y síntesis y usos de los mismos | |
| SV2016005294A (es) | 2-amino-6-metil-4,4a,5,6-tetrahidropirano(3,4-d)(1,3)tiazin-8a(8h)-il-1,3-tiazol-4-ilamidas | |
| DOP2013000307A (es) | Antagonistas de trpv4 | |
| CR20150440A (es) | Nuevos derivados de piridina | |
| MX2015012833A (es) | Composiciones antibioticas de ceftolozano. | |
| MX2015009479A (es) | Compuestos y metodos para tratar infecciones bacterianas. | |
| CR20150511A (es) | Nuevos derivados de purina | |
| DOP2017000058A (es) | Derivados de tetrahidroquinolina como inhibidores del bromodominio | |
| CY1119871T1 (el) | Στερεη μορφη αλατος της aλφa-6-mpeg6-o- υδροξυκωδονης ως αγωνιστες οπιοειδων και χρησεις αυτων | |
| MX2015014470A (es) | Analogos de combretastatina. |