BR112016012237A2 - - Google Patents
Info
- Publication number
- BR112016012237A2 BR112016012237A2 BR112016012237A BR112016012237A BR112016012237A2 BR 112016012237 A2 BR112016012237 A2 BR 112016012237A2 BR 112016012237 A BR112016012237 A BR 112016012237A BR 112016012237 A BR112016012237 A BR 112016012237A BR 112016012237 A2 BR112016012237 A2 BR 112016012237A2
- Authority
- BR
- Brazil
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361912714P | 2013-12-06 | 2013-12-06 | |
| US61/912,714 | 2013-12-06 | ||
| PCT/US2014/068834 WO2015085193A1 (en) | 2013-12-06 | 2014-12-05 | Methods useful in the synthesis of halichondrin b analogs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112016012237A2 true BR112016012237A2 (enExample) | 2017-08-08 |
| BR112016012237B1 BR112016012237B1 (pt) | 2023-02-07 |
Family
ID=53270478
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112016012237-2A BR112016012237B1 (pt) | 2013-12-06 | 2014-12-05 | Métodos úteis na síntese de análogos de halicondrina b |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US9303039B2 (enExample) |
| EP (2) | EP3505520A1 (enExample) |
| JP (3) | JP6443812B2 (enExample) |
| CN (1) | CN105916861B (enExample) |
| BR (1) | BR112016012237B1 (enExample) |
| CA (1) | CA2931788C (enExample) |
| ES (1) | ES2723355T3 (enExample) |
| HU (1) | HUE043088T2 (enExample) |
| IL (4) | IL245661A0 (enExample) |
| MX (3) | MX370611B (enExample) |
| RU (1) | RU2676486C1 (enExample) |
| SG (2) | SG10201805024YA (enExample) |
| WO (1) | WO2015085193A1 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101899026B (zh) * | 2004-06-03 | 2016-08-03 | 卫材R&D管理有限公司 | 用于制备软海绵素b的类似物的中间体 |
| BRPI0817909B1 (pt) | 2007-10-03 | 2022-06-21 | Eisai R&D Management Co., Ltd | Métodos de obtenção e de preparação de uma composição diastereomericamente pura, compostos, e método para produzir os referidos compostos |
| JP6001857B2 (ja) | 2008-04-04 | 2016-10-05 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ハリコンドリンｂ類似体 |
| BR112012018232B8 (pt) | 2010-01-26 | 2023-01-10 | Eisai R&D Man Co Ltd | Compostos derivados de furo [3,2-b] pirano úteis na síntese de análogos de halicondrina b e métodos de sintetização de er-80402 e de eribulina |
| HUE049387T2 (hu) | 2013-11-04 | 2020-09-28 | Eisai R&D Man Co Ltd | A halichondrin B analógjainak szintézisében hasznos makrociklizációs reakciók és köztitermékek |
| SG10201805024YA (en) * | 2013-12-06 | 2018-07-30 | Eisai R&D Man Co Ltd | Methods useful in the synthesis of halichondrin b analogs |
| US10556910B2 (en) | 2014-06-30 | 2020-02-11 | President And Fellows Of Harvard College | Synthesis of halichondrin analogs and uses thereof |
| US10344038B2 (en) | 2015-04-30 | 2019-07-09 | President And Fellows Of Harvard College | Chromium-mediated coupling and application to the synthesis of halichondrins |
| MX380284B (es) | 2015-05-07 | 2025-03-12 | Eisai R&D Man Co Ltd | Reacciones de macrociclización e intermediarios y otros fragmentos útiles en la síntesis de macrólidos de halicondrina. |
| US10676481B2 (en) | 2016-02-12 | 2020-06-09 | Eisai R&D Management Co., Ltd. | Intermediates in the synthesis of eribulin and related methods of synthesis |
| JOP20170053B1 (ar) | 2016-03-02 | 2021-08-17 | Eisai Randd Man Co Ltd | مترافقات جسم مضاد وعقار أساسها إيريبولين وطرق استخدامها |
| SG11201811671XA (en) | 2016-06-30 | 2019-01-30 | Eisai R&D Man Co Ltd | Prins reaction and intermediates useful in the synthesis of halichondrin macrolides and analogs thereof |
| JP6978758B2 (ja) | 2016-11-11 | 2021-12-08 | プレジデント アンド フェローズ オブ ハーバード カレッジ | パラジウム媒介ケトール化 |
| JP7168580B2 (ja) | 2017-04-05 | 2022-11-09 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 大環状化合物およびその使用 |
| US9938288B1 (en) | 2017-04-05 | 2018-04-10 | President And Fellows Of Harvard College | Macrocyclic compound and uses thereof |
| WO2018217894A1 (en) * | 2017-05-24 | 2018-11-29 | Eisai R&D Management Co., Ltd. | Fluorine-labelled halichondrin derivatives and related methods of synthesis |
| US11498892B2 (en) | 2017-07-06 | 2022-11-15 | President And Fellows Of Harvard College | Fe/Cu-mediated ketone synthesis |
| IL295588B2 (en) | 2017-07-06 | 2024-03-01 | Harvard College | Synthesis of halichondrins |
| CN109694379B (zh) * | 2017-10-24 | 2020-09-11 | 江苏恒瑞医药股份有限公司 | 用于制备艾日布林的中间体及其制备方法 |
| ES2974243T3 (es) | 2017-11-15 | 2024-06-26 | Harvard College | Compuestos macrocíclicos y usos de los mismos |
| WO2019097073A1 (en) | 2017-11-20 | 2019-05-23 | Basilea Pharmaceutica International AG | Pharmaceutical combinations for use in the treatment of neoplastic diseases |
| KR20250057138A (ko) | 2018-01-03 | 2025-04-28 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 할리콘드린 마크롤리드 및 그의 유사체의 합성에 유용한 프린스 반응 및 화합물 |
| EP3823973A4 (en) * | 2018-07-20 | 2022-09-21 | Dr. Reddy's Laboratories Limited | PURIFICATION PROCESS FOR THE PREPARATION OF ERIBULIN AND ITS INTERMEDIATES |
| US20210340156A1 (en) * | 2018-10-09 | 2021-11-04 | Dr. Reddy's Laboratories Limited | Process for preparation of eribulin and intermediates thereof |
| US12522611B2 (en) * | 2018-11-28 | 2026-01-13 | Natco Pharma Limited | Process for the preparation of high pure Eribulin and its Mesylate salt |
| US11447499B2 (en) | 2019-06-14 | 2022-09-20 | Rk Pharma Inc. | Process for the preparation of eribulin mesylate intermediate |
| WO2022101931A1 (en) * | 2020-11-10 | 2022-05-19 | Natco Pharma Limited | Process for the preparation of eribulin and its intermediates |
| CN113354659B (zh) | 2021-06-08 | 2022-04-08 | 江苏慧聚药业股份有限公司 | 甲磺酸艾日布林的合成 |
| CN114380840B (zh) * | 2022-01-27 | 2024-01-26 | 江苏慧聚药业股份有限公司 | 艾日布林的合成 |
| WO2025106586A1 (en) * | 2023-11-13 | 2025-05-22 | Luxvitae Therapeutics Inc. | Macrocyclic ketone compounds and applications thereof |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU652180A1 (ru) | 1975-12-16 | 1979-03-15 | Краснодарский политехнический институт | 1(Фурил-2,)-2-(2-,, формилфурил-5,, ) этилен или его метильное производное как промежуточный продукт дл синтеза фуран-2,5-дикарбоновой кислоты и способ его получени |
| US5436238A (en) | 1992-03-12 | 1995-07-25 | President And Fellows Of Harvard College | Halichondrins and related compounds |
| US5338865A (en) | 1992-03-12 | 1994-08-16 | President And Fellows Of Harvard College | Synthesis of halichondrin B and norhalichondrin B |
| GB9206244D0 (en) | 1992-03-23 | 1992-05-06 | Pharma Mar Sa | Cytotoxic compound from a marine sponge |
| TW255880B (enExample) | 1992-09-09 | 1995-09-01 | Hoechst Ag | |
| JP2001500498A (ja) | 1996-09-06 | 2001-01-16 | イーライ・リリー・アンド・カンパニー | 触媒選択的スルホニル化法 |
| IL139960A0 (en) | 1998-06-17 | 2002-02-10 | Eisai Co Ltd | Macrocylic analogs and methods of their use and preparation |
| US8097648B2 (en) | 1998-06-17 | 2012-01-17 | Eisai R&D Management Co., Ltd. | Methods and compositions for use in treating cancer |
| US6653341B1 (en) | 1998-06-17 | 2003-11-25 | Eisai Co., Ltd. | Methods and compositions for use in treating cancer |
| CN101899026B (zh) | 2004-06-03 | 2016-08-03 | 卫材R&D管理有限公司 | 用于制备软海绵素b的类似物的中间体 |
| CN109180615A (zh) * | 2004-06-03 | 2019-01-11 | 卫材R&D管理有限公司 | 用于制备软海绵素b的类似物的中间体 |
| US20060045846A1 (en) | 2004-08-30 | 2006-03-02 | Horstmann Thomas E | Reagents and methods for labeling terminal olefins |
| WO2006076100A2 (en) | 2004-12-09 | 2006-07-20 | Eisai Co. Ltd. | Tubulin isotype screening in cancer therapy using halichondrin b analogs |
| WO2008010776A1 (en) | 2006-07-21 | 2008-01-24 | Agency For Science, Technology And Research | Aigialomycin d and derivatives thereof and their use in treating cancer or malaria or a microbial infection |
| JPWO2009014105A1 (ja) | 2007-07-20 | 2010-10-07 | 株式会社山田養蜂場本社 | 新規カルボン酸およびそれを有効成分とする抗うつ用組成物 |
| BRPI0817909B1 (pt) | 2007-10-03 | 2022-06-21 | Eisai R&D Management Co., Ltd | Métodos de obtenção e de preparação de uma composição diastereomericamente pura, compostos, e método para produzir os referidos compostos |
| JP5134686B2 (ja) | 2007-11-16 | 2013-01-30 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ハリコンドリンｂアナログ合成のための新規な中間体及び前記中間体に用いるための新規な脱スルホニル化反応 |
| JP6001857B2 (ja) * | 2008-04-04 | 2016-10-05 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ハリコンドリンｂ類似体 |
| JP5371091B2 (ja) | 2009-01-23 | 2013-12-18 | 三菱レイヨン株式会社 | モノスルホン酸エステルの製造方法 |
| BR112012018232B8 (pt) | 2010-01-26 | 2023-01-10 | Eisai R&D Man Co Ltd | Compostos derivados de furo [3,2-b] pirano úteis na síntese de análogos de halicondrina b e métodos de sintetização de er-80402 e de eribulina |
| EP2354128A1 (en) | 2010-02-10 | 2011-08-10 | Sandoz Ag | Method for the preparation of rivaroxaban |
| WO2012147900A1 (en) | 2011-04-28 | 2012-11-01 | Eisai R&D Management Co., Ltd. | Microreactor process for halichondrin b analog synthesis |
| EP2785687B1 (en) | 2011-11-30 | 2019-02-20 | Sandoz AG | Process for preparation of (3r)-2,4-di-leaving group-3-methylbut-1-ene |
| CN104334562A (zh) | 2012-03-30 | 2015-02-04 | 阿方拉研究股份有限公司 | 用于制备软海绵素b的大环c1-酮类似物的合成方法及其中有用的中间体 |
| AU2014286880B2 (en) | 2013-07-03 | 2017-12-14 | Sandoz Ag | Synthetic process for preparation of macrocyclic C1-keto analogs of Halichondrin B and intermediates useful therein including intermediates containing -SO2-(p-TOLYL) groups |
| HUE049387T2 (hu) | 2013-11-04 | 2020-09-28 | Eisai R&D Man Co Ltd | A halichondrin B analógjainak szintézisében hasznos makrociklizációs reakciók és köztitermékek |
| SG10201805024YA (en) * | 2013-12-06 | 2018-07-30 | Eisai R&D Man Co Ltd | Methods useful in the synthesis of halichondrin b analogs |
| MX380284B (es) | 2015-05-07 | 2025-03-12 | Eisai R&D Man Co Ltd | Reacciones de macrociclización e intermediarios y otros fragmentos útiles en la síntesis de macrólidos de halicondrina. |
| US10676481B2 (en) | 2016-02-12 | 2020-06-09 | Eisai R&D Management Co., Ltd. | Intermediates in the synthesis of eribulin and related methods of synthesis |
| SG11201811671XA (en) | 2016-06-30 | 2019-01-30 | Eisai R&D Man Co Ltd | Prins reaction and intermediates useful in the synthesis of halichondrin macrolides and analogs thereof |
-
2014
- 2014-12-05 SG SG10201805024YA patent/SG10201805024YA/en unknown
- 2014-12-05 EP EP18209462.3A patent/EP3505520A1/en active Pending
- 2014-12-05 US US14/562,086 patent/US9303039B2/en active Active
- 2014-12-05 HU HUE14866945A patent/HUE043088T2/hu unknown
- 2014-12-05 MX MX2016006891A patent/MX370611B/es active IP Right Grant
- 2014-12-05 CN CN201480066353.XA patent/CN105916861B/zh active Active
- 2014-12-05 JP JP2016532033A patent/JP6443812B2/ja active Active
- 2014-12-05 BR BR112016012237-2A patent/BR112016012237B1/pt active IP Right Grant
- 2014-12-05 WO PCT/US2014/068834 patent/WO2015085193A1/en not_active Ceased
- 2014-12-05 MX MX2019011926A patent/MX376869B/es active IP Right Grant
- 2014-12-05 EP EP14866945.0A patent/EP3077399B1/en active Active
- 2014-12-05 MX MX2020004855A patent/MX384292B/es unknown
- 2014-12-05 SG SG11201604545XA patent/SG11201604545XA/en unknown
- 2014-12-05 RU RU2016124265A patent/RU2676486C1/ru active
- 2014-12-05 ES ES14866945T patent/ES2723355T3/es active Active
- 2014-12-05 CA CA2931788A patent/CA2931788C/en active Active
-
2016
- 2016-03-03 US US15/059,965 patent/US9695188B2/en active Active
- 2016-05-16 IL IL245661A patent/IL245661A0/en active IP Right Grant
-
2017
- 2017-06-30 US US15/638,493 patent/US10030032B2/en active Active
-
2018
- 2018-07-10 US US16/031,629 patent/US10450324B2/en active Active
- 2018-10-16 JP JP2018194871A patent/JP6634135B2/ja active Active
-
2019
- 2019-03-26 IL IL265640A patent/IL265640B/en active IP Right Grant
- 2019-12-13 JP JP2019225297A patent/JP6905041B2/ja active Active
-
2020
- 2020-04-01 IL IL273736A patent/IL273736B/en active IP Right Grant
-
2021
- 2021-03-04 IL IL281275A patent/IL281275B/en unknown
Also Published As
Similar Documents
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
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| B15K | Others concerning applications: alteration of classification |
Free format text: A CLASSIFICACAO ANTERIOR ERA: C07D 491/22 Ipc: C07D 491/22 (2006.01), A61P 35/00 (2006.01) |
|
| B07G | Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette] |
Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO EM FUNCAO DA REVOGACAO DO ART. 229-C DA LEI NO 9.279, DE 1996, POR FORCA DA LEI NO 14.195, DE 2021 |
|
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 05/12/2014, OBSERVADAS AS CONDICOES LEGAIS |