JP6417421B2 - 荷電連結体及び共役体のためのその使用 - Google Patents

荷電連結体及び共役体のためのその使用 Download PDF

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JP6417421B2
JP6417421B2 JP2016554198A JP2016554198A JP6417421B2 JP 6417421 B2 JP6417421 B2 JP 6417421B2 JP 2016554198 A JP2016554198 A JP 2016554198A JP 2016554198 A JP2016554198 A JP 2016554198A JP 6417421 B2 JP6417421 B2 JP 6417421B2
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antibody
conjugate
cell
acid
drug
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JP2017506649A5 (OSRAM
JP2017506649A (ja
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ヨンシン ジャオ，ロバート
ヨンシン ジャオ，ロバート
リ，シン
ファン，ユアンユアン
ヤン，チンリャン
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Hangzhou Dac Biotech Co Ltd
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    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
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    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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JP2016554198A 2014-02-28 2014-02-28 荷電連結体及び共役体のためのその使用 Active JP6417421B2 (ja)

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PCT/CN2014/072769 WO2015127685A1 (en) 2014-02-28 2014-02-28 Charged linkers and their uses for conjugation

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JP2017506649A JP2017506649A (ja) 2017-03-09
JP2017506649A5 JP2017506649A5 (OSRAM) 2018-04-26
JP6417421B2 true JP6417421B2 (ja) 2018-11-07

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JP (1) JP6417421B2 (OSRAM)
CN (2) CN114262344A (OSRAM)
AU (1) AU2014384434B2 (OSRAM)
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DK (1) DK3122757T3 (OSRAM)
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US11873281B2 (en) 2012-07-12 2024-01-16 Hangzhou Dac Biotech Co., Ltd. Conjugates of cell binding molecules with cytotoxic agents
JP6117921B2 (ja) 2012-07-12 2017-04-19 ハンヂョウ ディーエイシー バイオテック カンパニー リミテッド 細胞毒性剤と細胞結合受容体との共役体
PT3122757T (pt) 2014-02-28 2023-11-03 Hangzhou Dac Biotech Co Ltd Ligantes carregados e as suas utilizações em conjugação
US11299528B2 (en) 2014-03-11 2022-04-12 D&D Pharmatech Inc. Long acting TRAIL receptor agonists for treatment of autoimmune diseases
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