JP6400470B2 - 多重特異性Ｆａｂ融合タンパク質および使用法 - Google Patents

多重特異性Ｆａｂ融合タンパク質および使用法 Download PDF

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JP6400470B2
JP6400470B2 JP2014511496A JP2014511496A JP6400470B2 JP 6400470 B2 JP6400470 B2 JP 6400470B2 JP 2014511496 A JP2014511496 A JP 2014511496A JP 2014511496 A JP2014511496 A JP 2014511496A JP 6400470 B2 JP6400470 B2 JP 6400470B2
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fusion protein
binding
fab
antigen
binding domain
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JP2014519322A (ja
JP2014519322A5 (https=
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ホンシン ゾウ，
ホンシン ゾウ，
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Generon Shanghai Corp Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2014511496A 2011-05-16 2012-05-16 多重特異性Ｆａｂ融合タンパク質および使用法 Active JP6400470B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161486690P 2011-05-16 2011-05-16
US61/486,690 2011-05-16
PCT/US2012/038177 WO2012158818A2 (en) 2011-05-16 2012-05-16 Multi-specific fab fusion proteins and methods of use

Related Child Applications (1)

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JP2018098731A Division JP7037435B2 (ja) 2011-05-16 2018-05-23 多重特異性Ｆａｂ融合タンパク質および使用法

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JP2014519322A JP2014519322A (ja) 2014-08-14
JP2014519322A5 JP2014519322A5 (https=) 2015-07-02
JP6400470B2 true JP6400470B2 (ja) 2018-10-03

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JP2018098731A Active JP7037435B2 (ja) 2011-05-16 2018-05-23 多重特異性Ｆａｂ融合タンパク質および使用法
JP2021000128A Active JP7229566B2 (ja) 2011-05-16 2021-01-04 多重特異性Ｆａｂ融合タンパク質および使用法
JP2022034409A Withdrawn JP2022071161A (ja) 2011-05-16 2022-03-07 多重特異性Ｆａｂ融合タンパク質および使用法
JP2024042150A Pending JP2024073594A (ja) 2011-05-16 2024-03-18 多重特異性Ｆａｂ融合タンパク質および使用法

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JP2021000128A Active JP7229566B2 (ja) 2011-05-16 2021-01-04 多重特異性Ｆａｂ融合タンパク質および使用法
JP2022034409A Withdrawn JP2022071161A (ja) 2011-05-16 2022-03-07 多重特異性Ｆａｂ融合タンパク質および使用法
JP2024042150A Pending JP2024073594A (ja) 2011-05-16 2024-03-18 多重特異性Ｆａｂ融合タンパク質および使用法

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US (3) US8846042B2 (https=)
EP (1) EP2710042A2 (https=)
JP (5) JP6400470B2 (https=)
CN (3) CN103842383B (https=)
WO (1) WO2012158818A2 (https=)

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WO2025160458A1 (en) * 2024-01-25 2025-07-31 Marengo Therapeutics, Inc. Multifunctional molecules binding to tcr and uses thereof
US12460000B2 (en) 2018-09-07 2025-11-04 Itabmed (Hk) Limited Anti-CD19 and anti-CD3 bispecific antigen binding proteins and uses thereof
US12577305B2 (en) 2018-12-24 2026-03-17 Itabmed (Hk) Limited Multispecific antigen binding proteins capable of binding CD19 and CD3, and use thereof

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