JP6383789B2 - 配列タグによる大規模生体分子解析 - Google Patents
配列タグによる大規模生体分子解析 Download PDFInfo
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- JP6383789B2 JP6383789B2 JP2016524301A JP2016524301A JP6383789B2 JP 6383789 B2 JP6383789 B2 JP 6383789B2 JP 2016524301 A JP2016524301 A JP 2016524301A JP 2016524301 A JP2016524301 A JP 2016524301A JP 6383789 B2 JP6383789 B2 JP 6383789B2
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
- C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/30—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indices; for individual health risk assessment
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16Z—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS, NOT OTHERWISE PROVIDED FOR
- G16Z99/00—Subject matter not provided for in other main groups of this subclass
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
- Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Medical Informatics (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Data Mining & Analysis (AREA)
- Databases & Information Systems (AREA)
- Biomedical Technology (AREA)
- Primary Health Care (AREA)
- Bioinformatics & Computational Biology (AREA)
- Evolutionary Biology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Theoretical Computer Science (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361841878P | 2013-07-01 | 2013-07-01 | |
| US61/841,878 | 2013-07-01 | ||
| US201462001580P | 2014-05-21 | 2014-05-21 | |
| US62/001,580 | 2014-05-21 | ||
| PCT/US2014/044971 WO2015002908A1 (en) | 2013-07-01 | 2014-06-30 | Large-scale biomolecular analysis with sequence tags |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016523547A JP2016523547A (ja) | 2016-08-12 |
| JP2016523547A5 JP2016523547A5 (https=) | 2017-07-20 |
| JP6383789B2 true JP6383789B2 (ja) | 2018-08-29 |
Family
ID=52144148
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016524301A Active JP6383789B2 (ja) | 2013-07-01 | 2014-06-30 | 配列タグによる大規模生体分子解析 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US9708657B2 (https=) |
| EP (2) | EP3017066B1 (https=) |
| JP (1) | JP6383789B2 (https=) |
| CN (2) | CN105658812B (https=) |
| AU (2) | AU2014284501B2 (https=) |
| CA (1) | CA2916703C (https=) |
| ES (2) | ES2709212T3 (https=) |
| HK (1) | HK1223987A1 (https=) |
| WO (1) | WO2015002908A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023511200A (ja) * | 2020-01-22 | 2023-03-16 | ライフ テクノロジーズ コーポレーション | 自己免疫疾患および免疫不全疾患における免疫レパートリーバイオマーカー |
Families Citing this family (107)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9365901B2 (en) | 2008-11-07 | 2016-06-14 | Adaptive Biotechnologies Corp. | Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia |
| US9506119B2 (en) | 2008-11-07 | 2016-11-29 | Adaptive Biotechnologies Corp. | Method of sequence determination using sequence tags |
| US8628927B2 (en) | 2008-11-07 | 2014-01-14 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
| US9528160B2 (en) | 2008-11-07 | 2016-12-27 | Adaptive Biotechnolgies Corp. | Rare clonotypes and uses thereof |
| US8748103B2 (en) | 2008-11-07 | 2014-06-10 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
| CN104195227B (zh) | 2008-11-07 | 2017-04-12 | 适应生物技术公司 | 通过序列分析监测状况的方法 |
| EP2387627B1 (en) | 2009-01-15 | 2016-03-30 | Adaptive Biotechnologies Corporation | Adaptive immunity profiling and methods for generation of monoclonal antibodies |
| CN102459643B (zh) | 2009-06-25 | 2016-06-01 | 弗雷德哈钦森癌症研究中心 | 检测获得性免疫的方法 |
| US8835358B2 (en) | 2009-12-15 | 2014-09-16 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse labels |
| KR20190002733A (ko) | 2010-12-30 | 2019-01-08 | 파운데이션 메디신 인코포레이티드 | 종양 샘플의 다유전자 분석의 최적화 |
| US10385475B2 (en) | 2011-09-12 | 2019-08-20 | Adaptive Biotechnologies Corp. | Random array sequencing of low-complexity libraries |
| EP2768982A4 (en) | 2011-10-21 | 2015-06-03 | Adaptive Biotechnologies Corp | QUANTIFICATION OF ADAPTIVE IMMUNOCELL GENOMES IN A COMPLEX MIX OF CELLS |
| US9824179B2 (en) | 2011-12-09 | 2017-11-21 | Adaptive Biotechnologies Corp. | Diagnosis of lymphoid malignancies and minimal residual disease detection |
| US9499865B2 (en) | 2011-12-13 | 2016-11-22 | Adaptive Biotechnologies Corp. | Detection and measurement of tissue-infiltrating lymphocytes |
| US10941396B2 (en) | 2012-02-27 | 2021-03-09 | Becton, Dickinson And Company | Compositions and kits for molecular counting |
| DK2823060T3 (en) | 2012-03-05 | 2018-05-28 | Adaptive Biotechnologies Corp | Determination of associated immune receptor chains from frequency-matched subunits |
| CA2872468C (en) | 2012-05-08 | 2020-10-27 | Adaptive Biotechnologies Corporation | Compositions and methods for measuring and calibrating amplification bias in multiplexed pcr reactions |
| JP6449160B2 (ja) | 2012-10-01 | 2019-01-09 | アダプティブ バイオテクノロジーズ コーポレイション | 適応免疫受容体多様性およびクローン性特性決定による免疫能力評価関連出願の相互参照 |
| US10150996B2 (en) | 2012-10-19 | 2018-12-11 | Adaptive Biotechnologies Corp. | Quantification of adaptive immune cell genomes in a complex mixture of cells |
| US9708657B2 (en) | 2013-07-01 | 2017-07-18 | Adaptive Biotechnologies Corp. | Method for generating clonotype profiles using sequence tags |
| ES2711168T3 (es) | 2013-08-28 | 2019-04-30 | Becton Dickinson Co | Análisis masivo en paralelo de células individuales |
| US9582877B2 (en) | 2013-10-07 | 2017-02-28 | Cellular Research, Inc. | Methods and systems for digitally counting features on arrays |
| ES2819277T3 (es) * | 2014-02-11 | 2021-04-15 | Hoffmann La Roche | Secuenciación dirigida y filtrado de UID |
| WO2015134787A2 (en) | 2014-03-05 | 2015-09-11 | Adaptive Biotechnologies Corporation | Methods using randomer-containing synthetic molecules |
| US11390921B2 (en) | 2014-04-01 | 2022-07-19 | Adaptive Biotechnologies Corporation | Determining WT-1 specific T cells and WT-1 specific T cell receptors (TCRs) |
| US10066265B2 (en) | 2014-04-01 | 2018-09-04 | Adaptive Biotechnologies Corp. | Determining antigen-specific t-cells |
| CA2966201A1 (en) | 2014-10-29 | 2016-05-06 | Adaptive Biotechnologies Corp. | Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples |
| US10246701B2 (en) | 2014-11-14 | 2019-04-02 | Adaptive Biotechnologies Corp. | Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture |
| WO2016086029A1 (en) | 2014-11-25 | 2016-06-02 | Adaptive Biotechnologies Corporation | Characterization of adaptive immune response to vaccination or infection using immune repertoire sequencing |
| EP3227464B1 (en) * | 2014-12-05 | 2022-04-20 | Foundation Medicine, Inc. | Multigene analysis of tumor samples |
| US10697010B2 (en) | 2015-02-19 | 2020-06-30 | Becton, Dickinson And Company | High-throughput single-cell analysis combining proteomic and genomic information |
| CA2976580A1 (en) | 2015-02-24 | 2016-09-01 | Adaptive Biotechnologies Corp. | Methods for diagnosing infectious disease and determining hla status using immune repertoire sequencing |
| WO2016138496A1 (en) | 2015-02-27 | 2016-09-01 | Cellular Research, Inc. | Spatially addressable molecular barcoding |
| CN107208157B (zh) * | 2015-02-27 | 2022-04-05 | 贝克顿迪金森公司 | 用于条形编码核酸以用于测序的方法和组合物 |
| WO2016160844A2 (en) | 2015-03-30 | 2016-10-06 | Cellular Research, Inc. | Methods and compositions for combinatorial barcoding |
| AU2016242967B2 (en) | 2015-04-01 | 2021-07-01 | Adaptive Biotechnologies Corp. | Method of identifying human compatible T cell receptors specific for an antigenic target |
| EP3286332A4 (en) * | 2015-04-20 | 2018-12-12 | Cellecta, Inc. | Experimentally validated sets of gene specific primers for use in multiplex applications |
| US11655510B2 (en) | 2015-04-20 | 2023-05-23 | Cellecta, Inc. | Experimentally validated sets of gene specific primers for use in multiplex applications |
| CN107580632B (zh) | 2015-04-23 | 2021-12-28 | 贝克顿迪金森公司 | 用于全转录组扩增的方法和组合物 |
| WO2016196229A1 (en) | 2015-06-01 | 2016-12-08 | Cellular Research, Inc. | Methods for rna quantification |
| EP3332024B1 (en) * | 2015-08-06 | 2020-10-28 | F.Hoffmann-La Roche Ag | Target enrichment by single probe primer extension |
| CN108026524A (zh) | 2015-09-11 | 2018-05-11 | 赛卢拉研究公司 | 用于核酸文库标准化的方法和组合物 |
| SG11201803646YA (en) * | 2015-11-04 | 2018-05-30 | Atreca Inc | Combinatorial sets of nucleic acid barcodes for analysis of nucleic acids associated with single cells |
| ES2956757T3 (es) | 2016-05-02 | 2023-12-27 | Becton Dickinson Co | Codificación con códigos de barras moleculares precisa |
| US10301677B2 (en) | 2016-05-25 | 2019-05-28 | Cellular Research, Inc. | Normalization of nucleic acid libraries |
| EP3465502B1 (en) * | 2016-05-26 | 2024-04-10 | Becton, Dickinson and Company | Molecular label counting adjustment methods |
| US10640763B2 (en) | 2016-05-31 | 2020-05-05 | Cellular Research, Inc. | Molecular indexing of internal sequences |
| US10202641B2 (en) | 2016-05-31 | 2019-02-12 | Cellular Research, Inc. | Error correction in amplification of samples |
| US10428325B1 (en) | 2016-09-21 | 2019-10-01 | Adaptive Biotechnologies Corporation | Identification of antigen-specific B cell receptors |
| CA3034924C (en) | 2016-09-26 | 2025-11-18 | Becton, Dickinson And Company | MEASUREMENT OF PROTEIN EXPRESSION USING REAGENTS WITH BARCODED OLIGONUCLEOTIDE SEQUENCES |
| IL266197B2 (en) | 2016-10-24 | 2024-03-01 | Geneinfosec Inc | Hiding information contained within nucleic acids |
| CN109952612B (zh) | 2016-11-08 | 2023-12-01 | 贝克顿迪金森公司 | 用于表达谱分类的方法 |
| CN117056774B (zh) | 2016-11-08 | 2026-01-27 | 贝克顿迪金森公司 | 用于细胞标记分类的方法 |
| US10815525B2 (en) | 2016-12-22 | 2020-10-27 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10550429B2 (en) | 2016-12-22 | 2020-02-04 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| CN106755410B (zh) * | 2016-12-23 | 2019-12-06 | 孙涛 | 一种基于高通量测序同时检测t细胞和b细胞免疫组库的方法 |
| CN110573253B (zh) | 2017-01-13 | 2021-11-02 | 赛卢拉研究公司 | 流体通道的亲水涂层 |
| CN110382708A (zh) | 2017-02-01 | 2019-10-25 | 赛卢拉研究公司 | 使用阻断性寡核苷酸进行选择性扩增 |
| CN106835292B (zh) * | 2017-04-05 | 2019-04-09 | 北京泛生子基因科技有限公司 | 一步法快速构建扩增子文库的方法 |
| EP3625715A4 (en) | 2017-05-19 | 2021-03-17 | 10X Genomics, Inc. | DATA SET ANALYSIS SYSTEMS AND METHODS |
| JP7536450B2 (ja) | 2017-06-05 | 2024-08-20 | ベクトン・ディキンソン・アンド・カンパニー | 単一細胞用のサンプルインデックス付加 |
| US11450121B2 (en) * | 2017-06-27 | 2022-09-20 | The Regents Of The University Of California | Label-free digital brightfield analysis of nucleic acid amplification |
| WO2019060804A1 (en) * | 2017-09-25 | 2019-03-28 | Cellular Research, Inc. | IMMUNE BAR CODE RECEIVER ERROR CORRECTION |
| DE102017124667A1 (de) | 2017-10-23 | 2019-04-25 | Schaeffler Technologies AG & Co. KG | Messsystem zur Überwachung einer Spindel |
| US11254980B1 (en) | 2017-11-29 | 2022-02-22 | Adaptive Biotechnologies Corporation | Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements |
| CN111492068B (zh) | 2017-12-19 | 2025-03-21 | 贝克顿迪金森公司 | 与寡核苷酸相关联的颗粒 |
| WO2019157529A1 (en) | 2018-02-12 | 2019-08-15 | 10X Genomics, Inc. | Methods characterizing multiple analytes from individual cells or cell populations |
| EP3788170B1 (en) | 2018-05-03 | 2025-01-01 | Becton, Dickinson and Company | Molecular barcoding on opposite transcript ends |
| CA3097976A1 (en) | 2018-05-03 | 2019-11-07 | Becton, Dickinson And Company | High throughput multiomics sample analysis |
| WO2019217758A1 (en) | 2018-05-10 | 2019-11-14 | 10X Genomics, Inc. | Methods and systems for molecular library generation |
| SG11202011696TA (en) | 2018-06-11 | 2020-12-30 | Foundation Medicine Inc | Compositions and methods for evaluating genomic alterations |
| ES2992135T3 (es) | 2018-10-01 | 2024-12-09 | Becton Dickinson Co | Determinar secuencias de transcripción 5 |
| JP7618548B2 (ja) | 2018-11-08 | 2025-01-21 | ベクトン・ディキンソン・アンド・カンパニー | ランダムプライミングを使用した単一細胞の全トランスクリプトーム解析 |
| US11492660B2 (en) | 2018-12-13 | 2022-11-08 | Becton, Dickinson And Company | Selective extension in single cell whole transcriptome analysis |
| JP7571012B2 (ja) | 2018-12-17 | 2024-10-22 | イルミナ インコーポレイテッド | 配列決定用ライブラリーを調製するための方法および手段 |
| US20220112557A1 (en) | 2019-01-10 | 2022-04-14 | Iovance Biotherapeutics, Inc. | System and methods for monitoring adoptive cell therapy clonality and persistence |
| US11371076B2 (en) | 2019-01-16 | 2022-06-28 | Becton, Dickinson And Company | Polymerase chain reaction normalization through primer titration |
| EP4242322B1 (en) | 2019-01-23 | 2024-08-21 | Becton, Dickinson and Company | Oligonucleotides associated with antibodies |
| CN113454234B (zh) | 2019-02-14 | 2025-03-18 | 贝克顿迪金森公司 | 杂合体靶向和全转录物组扩增 |
| AU2020239904B2 (en) * | 2019-03-19 | 2025-10-02 | Stichting Euroclonality | Means and methods for accurately assessing clonal immunoglobulin (IG)/T cell receptor (TR) gene rearrangements. |
| US20220064731A1 (en) * | 2019-04-03 | 2022-03-03 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Primers for multiplex pcr |
| WO2020214642A1 (en) | 2019-04-19 | 2020-10-22 | Becton, Dickinson And Company | Methods of associating phenotypical data and single cell sequencing data |
| CN120099137A (zh) | 2019-07-22 | 2025-06-06 | 贝克顿迪金森公司 | 单细胞染色质免疫沉淀测序测定 |
| JP7522189B2 (ja) | 2019-11-08 | 2024-07-24 | ベクトン・ディキンソン・アンド・カンパニー | 免疫レパートリーシーケンシングのための完全長v(d)j情報を得るためのランダムプライミングの使用 |
| EP4090764A1 (en) | 2020-01-13 | 2022-11-23 | Becton, Dickinson and Company | Cell capture using du-containing oligonucleotides |
| US11649497B2 (en) | 2020-01-13 | 2023-05-16 | Becton, Dickinson And Company | Methods and compositions for quantitation of proteins and RNA |
| WO2021155057A1 (en) | 2020-01-29 | 2021-08-05 | Becton, Dickinson And Company | Barcoded wells for spatial mapping of single cells through sequencing |
| US12449419B1 (en) | 2020-02-12 | 2025-10-21 | 10X Genomics, Inc. | Methods for detecting binding of peptide-MHC monomers to T cells |
| CN115428088A (zh) | 2020-02-13 | 2022-12-02 | 10X基因组学有限公司 | 用于基因表达和dna染色质可及性的联合交互式可视化的系统和方法 |
| EP4111168A1 (en) | 2020-02-25 | 2023-01-04 | Becton Dickinson and Company | Bi-specific probes to enable the use of single-cell samples as single color compensation control |
| CN111370074B (zh) * | 2020-02-27 | 2023-07-07 | 北京晶泰科技有限公司 | 一种分子序列的生成方法、装置和计算设备 |
| WO2021173502A1 (en) * | 2020-02-28 | 2021-09-02 | 10X Genomics, Inc. | Systems and methods for identifying adaptive immune cell clonotypes |
| CN111304309A (zh) * | 2020-03-06 | 2020-06-19 | 上海韦翰斯生物医药科技有限公司 | 一种测序平台标签序列污染的检测方法 |
| EP4150118A1 (en) | 2020-05-14 | 2023-03-22 | Becton Dickinson and Company | Primers for immune repertoire profiling |
| US12157913B2 (en) | 2020-06-02 | 2024-12-03 | Becton, Dickinson And Company | Oligonucleotides and beads for 5 prime gene expression assay |
| KR20230021697A (ko) * | 2020-06-09 | 2023-02-14 | 심센 다이아그노스틱스 에이비 | 림프구 클론성 결정 |
| US11932901B2 (en) | 2020-07-13 | 2024-03-19 | Becton, Dickinson And Company | Target enrichment using nucleic acid probes for scRNAseq |
| WO2022026909A1 (en) | 2020-07-31 | 2022-02-03 | Becton, Dickinson And Company | Single cell assay for transposase-accessible chromatin |
| WO2022084295A1 (en) * | 2020-10-19 | 2022-04-28 | Imba - Institut Für Molekulare Biotechnologie Gmbh | Method for parallel nucleic acid analysis |
| EP3985129A1 (en) * | 2020-10-19 | 2022-04-20 | IMBA-Institut für Molekulare Biotechnologie GmbH | Method for parallel nucleic acid analysis |
| US11739443B2 (en) | 2020-11-20 | 2023-08-29 | Becton, Dickinson And Company | Profiling of highly expressed and lowly expressed proteins |
| EP4263859A1 (en) | 2020-12-15 | 2023-10-25 | Becton, Dickinson and Company | Single cell secretome analysis |
| JP2024512608A (ja) | 2021-03-24 | 2024-03-19 | ジェネンテック, インコーポレイテッド | Tリンパ球における効率的なtcr遺伝子編集 |
| CN115966258A (zh) * | 2021-10-12 | 2023-04-14 | 苏州科锐迈德生物医药科技有限公司 | 基于莱文斯坦距离筛选ires的方法及其筛选的多核苷酸 |
| CN114282691A (zh) * | 2021-10-27 | 2022-04-05 | 腾讯科技(深圳)有限公司 | 一种联邦学习方法、装置、设备、存储介质及计算机程序 |
| WO2023216030A1 (zh) * | 2022-05-07 | 2023-11-16 | 深圳华大智造科技股份有限公司 | 一种占位引物和去除方法 |
| CN117746982B (zh) * | 2023-12-15 | 2025-10-10 | 上海唯可生物科技有限公司 | 基于外源dna插入突变导致的优势克隆的检测方法 |
Family Cites Families (375)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3270960A (en) | 1964-09-11 | 1966-09-06 | Sperry Rand Corp | Fluid sensor |
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| DE3211263A1 (de) | 1981-03-31 | 1983-01-27 | Otsuka Pharmaceutical Co. Ltd., Tokyo | Human-interferon verwandte peptide, antigene und antikoerper, sowie verfahren zu deren herstellung |
| DE3238353A1 (de) | 1982-10-15 | 1984-04-19 | Max Planck Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen | Verfahren zur simultanen quantitativen bestimmung der blutzellen und reagenz hierfuer |
| US5189147A (en) | 1984-06-13 | 1993-02-23 | Massachusetts Institute Of Technology | Meterodimeric T lymphocyte receptor antibody |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4965188A (en) | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| DE3541033A1 (de) | 1985-11-19 | 1987-05-21 | Boehringer Mannheim Gmbh | Verfahren zur quantifizierung von zellpopulationen bzw. subpopulationen sowie hierfuer geeignetes reagenz |
| US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
| US5149625A (en) | 1987-08-11 | 1992-09-22 | President And Fellows Of Harvard College | Multiplex analysis of DNA |
| US4942124A (en) | 1987-08-11 | 1990-07-17 | President And Fellows Of Harvard College | Multiplex sequencing |
| US5667967A (en) | 1990-05-01 | 1997-09-16 | The Board Of Trustees Of The Leland Stanford Junior University | T-cell receptor varible transcripts as disease related markers |
| US5506126A (en) | 1988-02-25 | 1996-04-09 | The General Hospital Corporation | Rapid immunoselection cloning method |
| US5168038A (en) | 1988-06-17 | 1992-12-01 | The Board Of Trustees Of The Leland Stanford Junior University | In situ transcription in cells and tissues |
| WO1990004648A1 (en) | 1988-10-20 | 1990-05-03 | Alexander Alan Morley | Method for diagnosis of monoclonality in leukaemia and lymphoma |
| US5075217A (en) | 1989-04-21 | 1991-12-24 | Marshfield Clinic | Length polymorphisms in (dC-dA)n ·(dG-dT)n sequences |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5231012A (en) | 1989-06-28 | 1993-07-27 | Schering Corporation | Nucleic acids encoding cytokine synthesis inhibitory factor (interleukin-10) |
| CA2020958C (en) | 1989-07-11 | 2005-01-11 | Daniel L. Kacian | Nucleic acid sequence amplification methods |
| US5298396A (en) | 1989-11-15 | 1994-03-29 | National Jewish Center For Immunology And Respiratory Medicine | Method for identifying T cells disease involved in autoimmune disease |
| US5336598A (en) | 1989-11-15 | 1994-08-09 | National Jewish Center For Immunology And Respiratory Medicine | Method for diagnosing a superantigen caused pathologial condition via assay of T-cells |
| US5126022A (en) | 1990-02-28 | 1992-06-30 | Soane Tecnologies, Inc. | Method and device for moving molecules by the application of a plurality of electrical fields |
| US6054034A (en) | 1990-02-28 | 2000-04-25 | Aclara Biosciences, Inc. | Acrylic microchannels and their use in electrophoretic applications |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US6916605B1 (en) | 1990-07-10 | 2005-07-12 | Medical Research Council | Methods for producing members of specific binding pairs |
| EP0542810A1 (en) | 1990-08-02 | 1993-05-26 | B.R. Centre Limited | Methods for the production of proteins with a desired function |
| US5210015A (en) | 1990-08-06 | 1993-05-11 | Hoffman-La Roche Inc. | Homogeneous assay system using the nuclease activity of a nucleic acid polymerase |
| IE76732B1 (en) | 1990-08-07 | 1997-11-05 | Becton Dickinson Co | One step test for absolute counts |
| US5699798A (en) | 1990-08-10 | 1997-12-23 | University Of Washington | Method for optically imaging solid tumor tissue |
| US5635354A (en) | 1991-01-09 | 1997-06-03 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Method for describing the repertoires of antibodies (Ab) and of T-cell receptors (TcR) of an individual's immune system |
| US5364759B2 (en) | 1991-01-31 | 1999-07-20 | Baylor College Medicine | Dna typing with short tandem repeat polymorphisms and identification of polymorphic short tandem repeats |
| AU660306B2 (en) | 1991-02-12 | 1995-06-22 | Roussel-Uclaf | Nucleotidic sequences coding for variable regions of beta chains of human T lymphocyte receptors, corresponding peptidic segments and diagnostic and therapeutic applications |
| JP3080178B2 (ja) | 1991-02-18 | 2000-08-21 | 東洋紡績株式会社 | 核酸配列の増幅方法およびそのための試薬キット |
| US6091000A (en) | 1991-03-15 | 2000-07-18 | Duke University | SCID mouse engrafted with human synovium tissue |
| JP3266311B2 (ja) | 1991-05-02 | 2002-03-18 | 生化学工業株式会社 | 新規ポリペプチドおよびこれを用いる抗hiv剤 |
| US20040018489A1 (en) | 1991-09-09 | 2004-01-29 | Ma Wupo | Detection of RNA |
| US5674679A (en) | 1991-09-27 | 1997-10-07 | Amersham Life Science, Inc. | DNA cycle sequencing |
| US5981179A (en) | 1991-11-14 | 1999-11-09 | Digene Diagnostics, Inc. | Continuous amplification reaction |
| US5213960A (en) | 1992-03-09 | 1993-05-25 | Tanox Biosystems, Inc. | Methods for selecting low frequency antigen-specific single B lymphocytes |
| US5256542A (en) | 1992-03-09 | 1993-10-26 | Tanox Biosystems, Inc. | Selecting low frequency antigen-specific single B lymphocytes with correction for background noise |
| US5837447A (en) | 1992-04-15 | 1998-11-17 | Blood Center Research Foundation, Inc., The | Monitoring an immune response by analysis of amplified immunoglobulin or T-cell-receptor nucleic acid |
| US5498392A (en) | 1992-05-01 | 1996-03-12 | Trustees Of The University Of Pennsylvania | Mesoscale polynucleotide amplification device and method |
| US5587128A (en) | 1992-05-01 | 1996-12-24 | The Trustees Of The University Of Pennsylvania | Mesoscale polynucleotide amplification devices |
| US5981176A (en) | 1992-06-17 | 1999-11-09 | City Of Hope | Method of detecting and discriminating between nucleic acid sequences |
| US5925517A (en) | 1993-11-12 | 1999-07-20 | The Public Health Research Institute Of The City Of New York, Inc. | Detectably labeled dual conformation oligonucleotide probes, assays and kits |
| US6214613B1 (en) | 1993-12-03 | 2001-04-10 | Ashai Kasei Kogyo Kabushiki Kaisha | Expression screening vector |
| EP0753060A4 (en) | 1994-04-18 | 1999-11-24 | New York Society | PRESERVED T CELL RECEPTOR SEQUENCES |
| US6001229A (en) | 1994-08-01 | 1999-12-14 | Lockheed Martin Energy Systems, Inc. | Apparatus and method for performing microfluidic manipulations for chemical analysis |
| US6090592A (en) | 1994-08-03 | 2000-07-18 | Mosaic Technologies, Inc. | Method for performing amplification of nucleic acid on supports |
| FR2724182B1 (fr) | 1994-09-02 | 1996-12-13 | Pasteur Institut | Obtention d'un anticorps monoclonal recombinant a partir d'un anticorps monoclonal humain anti-rhesus d, sa production en cellules d'insecte, et ses utilisations |
| US5604097A (en) | 1994-10-13 | 1997-02-18 | Spectragen, Inc. | Methods for sorting polynucleotides using oligonucleotide tags |
| US5846719A (en) | 1994-10-13 | 1998-12-08 | Lynx Therapeutics, Inc. | Oligonucleotide tags for sorting and identification |
| US5776737A (en) | 1994-12-22 | 1998-07-07 | Visible Genetics Inc. | Method and composition for internal identification of samples |
| US6919434B1 (en) | 1995-02-20 | 2005-07-19 | Sankyo Co., Ltd. | Monoclonal antibodies that bind OCIF |
| US5698396A (en) | 1995-06-07 | 1997-12-16 | Ludwig Institute For Cancer Research | Method for identifying auto-immunoreactive substances from a subject |
| WO1997013868A1 (en) | 1995-10-11 | 1997-04-17 | Leonard Adleman | Large scale dna sequencing by position sensitive hybridization |
| WO1997013877A1 (en) | 1995-10-12 | 1997-04-17 | Lynx Therapeutics, Inc. | Measurement of gene expression profiles in toxicity determination |
| US6087096A (en) | 1995-11-13 | 2000-07-11 | Dau; Peter C. | Method of intrafamily fragment analysis of the T cell receptor α and β chain CDR3 regions |
| US5854033A (en) | 1995-11-21 | 1998-12-29 | Yale University | Rolling circle replication reporter systems |
| KR19990087749A (ko) | 1996-03-13 | 1999-12-27 | 시오노 요시히코 | 류마티스성 관절염에 특이적인 인간 티 세포 클론 |
| US6458530B1 (en) | 1996-04-04 | 2002-10-01 | Affymetrix Inc. | Selecting tag nucleic acids |
| US6300065B1 (en) | 1996-05-31 | 2001-10-09 | Board Of Trustees Of The University Of Illinois | Yeast cell surface display of proteins and uses thereof |
| US6699658B1 (en) | 1996-05-31 | 2004-03-02 | Board Of Trustees Of The University Of Illinois | Yeast cell surface display of proteins and uses thereof |
| EP0910668A4 (en) | 1996-06-03 | 2003-02-19 | Univ Alberta | METHOD FOR DETECTING REASSEMBLED DNA |
| EP1033411B1 (en) | 1996-06-04 | 2006-02-22 | University of Utah Research Foundation | Fluorescent donor-acceptor pair |
| AU3878697A (en) | 1996-06-20 | 1998-02-02 | Cornell Research Foundation Inc. | Identification of abnormalities in the expression of t and cell antigen receptors as indicators of disease diagnosis, prognosis and therapeutic predictors |
| US6074827A (en) | 1996-07-30 | 2000-06-13 | Aclara Biosciences, Inc. | Microfluidic method for nucleic acid purification and processing |
| DK0937251T3 (da) | 1996-09-06 | 2007-02-19 | Ortho Mcneil Pharm Inc | Oprensning af antigenspecifikke T-celler |
| US6255071B1 (en) | 1996-09-20 | 2001-07-03 | Cold Spring Harbor Laboratory | Mammalian viral vectors and their uses |
| WO1998015644A2 (en) | 1996-09-27 | 1998-04-16 | The Chinese University Of Hong Kong | Parallel polynucleotide sequencing method |
| US6136566A (en) | 1996-10-04 | 2000-10-24 | Lexicon Graphics Incorporated | Indexed library of cells containing genomic modifications and methods of making and utilizing the same |
| US6207371B1 (en) | 1996-10-04 | 2001-03-27 | Lexicon Genetics Incorporated | Indexed library of cells containing genomic modifications and methods of making and utilizing the same |
| US6228589B1 (en) | 1996-10-11 | 2001-05-08 | Lynx Therapeutics, Inc. | Measurement of gene expression profiles in toxicity determination |
| GB9626815D0 (en) | 1996-12-23 | 1997-02-12 | Cemu Bioteknik Ab | Method of sequencing DNA |
| GB9704444D0 (en) | 1997-03-04 | 1997-04-23 | Isis Innovation | Non-invasive prenatal diagnosis |
| JP2002503954A (ja) | 1997-04-01 | 2002-02-05 | グラクソ、グループ、リミテッド | 核酸増幅法 |
| US6143496A (en) | 1997-04-17 | 2000-11-07 | Cytonix Corporation | Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly |
| JP4298912B2 (ja) | 1997-07-07 | 2009-07-22 | メディカル リサーチ カウンシル | invitro選別法 |
| US6794499B2 (en) | 1997-09-12 | 2004-09-21 | Exiqon A/S | Oligonucleotide analogues |
| US7572582B2 (en) | 1997-09-12 | 2009-08-11 | Exiqon A/S | Oligonucleotide analogues |
| AU1517999A (en) | 1997-10-15 | 1999-05-03 | Aclara Biosciences, Inc. | Laminate microstructure device and method for making same |
| CA2307177C (en) | 1997-10-23 | 2004-06-29 | Exact Laboratories, Inc. | Methods for detecting contamination in molecular diagnostics using pcr |
| US7351578B2 (en) | 1999-12-10 | 2008-04-01 | Invitrogen Corp. | Use of multiple recombination sites with unique specificity in recombinational cloning |
| US6210910B1 (en) | 1998-03-02 | 2001-04-03 | Trustees Of Tufts College | Optical fiber biosensor array comprising cell populations confined to microcavities |
| DE19833738A1 (de) | 1998-07-27 | 2000-02-03 | Michael Giesing | Verfahren zur Isolierung von Krebszellen aus zellhaltigen Körperflüssigkeiten sowie Sets zur Durchführung dieses Verfahrens |
| US6787308B2 (en) | 1998-07-30 | 2004-09-07 | Solexa Ltd. | Arrayed biomolecules and their use in sequencing |
| DE19844931C1 (de) | 1998-09-30 | 2000-06-15 | Stefan Seeger | Verfahren zur DNS- oder RNS-Sequenzierung |
| AR021833A1 (es) | 1998-09-30 | 2002-08-07 | Applied Research Systems | Metodos de amplificacion y secuenciacion de acido nucleico |
| US6541608B1 (en) | 1999-02-23 | 2003-04-01 | Baylor College Of Medicine | T cell receptor Vβ-Dβ-Jβ sequence and methods for its detection |
| US6307024B1 (en) | 1999-03-09 | 2001-10-23 | Zymogenetics, Inc. | Cytokine zalpha11 Ligand |
| US6300070B1 (en) | 1999-06-04 | 2001-10-09 | Mosaic Technologies, Inc. | Solid phase methods for amplifying multiple nucleic acids |
| US6440706B1 (en) | 1999-08-02 | 2002-08-27 | Johns Hopkins University | Digital amplification |
| IL148079A0 (en) | 1999-08-24 | 2002-09-12 | Medarex Inc | Human ctla-4 antibodies and compositions containing the same |
| US20040209314A1 (en) | 1999-09-06 | 2004-10-21 | Institut National De La Sante Et De La Recherche Medicale France | Means for detection and purification of CD8+ T lymphocyte populations specific to peptides presented in the context of HLA |
| US6235483B1 (en) | 2000-01-31 | 2001-05-22 | Agilent Technologies, Inc. | Methods and kits for indirect labeling of nucleic acids |
| US7955794B2 (en) | 2000-09-21 | 2011-06-07 | Illumina, Inc. | Multiplex nucleic acid reactions |
| US20040121364A1 (en) * | 2000-02-07 | 2004-06-24 | Mark Chee | Multiplex nucleic acid reactions |
| WO2001075172A1 (en) | 2000-03-31 | 2001-10-11 | University Of Southern California | Epigenetic sequences for esophageal adenocarcinoma |
| AUPQ687600A0 (en) | 2000-04-13 | 2000-05-11 | Flinders Technologies Pty Ltd | A method of detection |
| US20030207300A1 (en) | 2000-04-28 | 2003-11-06 | Matray Tracy J. | Multiplex analytical platform using molecular tags |
| US6596492B2 (en) | 2000-07-11 | 2003-07-22 | Colorado State University Research Foundation | PCR materials and methods useful to detect canine and feline lymphoid malignancies |
| US7567870B1 (en) | 2000-07-31 | 2009-07-28 | Institute For Systems Biology | Multiparameter analysis for predictive medicine |
| EA013564B1 (ru) | 2000-08-03 | 2010-06-30 | Терапеутик Хьюман Поликлоналз Инк. | Гуманизированный иммуноглобулин и содержащая его фармацевтическая композиция |
| US6939451B2 (en) | 2000-09-19 | 2005-09-06 | Aclara Biosciences, Inc. | Microfluidic chip having integrated electrodes |
| DE60131903T2 (de) | 2000-10-24 | 2008-11-27 | The Board of Trustees of the Leland S. Stanford Junior University, Palo Alto | Direkte multiplex charakterisierung von genomischer dna |
| US6778724B2 (en) | 2000-11-28 | 2004-08-17 | The Regents Of The University Of California | Optical switching and sorting of biological samples and microparticles transported in a micro-fluidic device, including integrated bio-chip devices |
| US6947748B2 (en) | 2000-12-15 | 2005-09-20 | Adaptix, Inc. | OFDMA with adaptive subcarrier-cluster configuration and selective loading |
| JP2004525627A (ja) | 2001-02-20 | 2004-08-26 | ユニバーシティ・オブ・ジョージア・リサーチ・ファウンデイション・インコーポレイテッド | モノクローナル抗体の迅速な産生 |
| US6969597B2 (en) | 2001-02-21 | 2005-11-29 | Clontech Laboratories, Inc. | Nucleic acids encoding non aggregating fluorescent proteins and methods for using the same |
| US7265208B2 (en) | 2001-05-01 | 2007-09-04 | The Regents Of The University Of California | Fusion molecules and treatment of IgE-mediated allergic diseases |
| AU2002308331A1 (en) | 2001-05-24 | 2002-12-03 | Guard Inc. | Methods for selecting and producing animals having a predicted level of immune response |
| US20050260570A1 (en) | 2001-05-29 | 2005-11-24 | Mao Jen-I | Sequencing by proxy |
| US7026121B1 (en) | 2001-06-08 | 2006-04-11 | Expression Diagnostics, Inc. | Methods and compositions for diagnosing and monitoring transplant rejection |
| US6720144B1 (en) | 2001-06-21 | 2004-04-13 | Quest Diagnostics | Detection of clonal T-cell receptor-γ gene rearrangement by PCR/temporal temperature gradient gel electrophoresis (TTGE) |
| WO2003008624A2 (en) | 2001-07-15 | 2003-01-30 | Keck Graduate Institute | Nucleic acid amplification using nicking agents |
| WO2003020983A1 (en) | 2001-08-30 | 2003-03-13 | Virginia Commonwealth University | Allele specific pcr for genotyping |
| AU2002321581C1 (en) | 2001-08-31 | 2008-09-18 | Adaptimmune Limited | Soluble T cell receptor |
| US7432084B2 (en) | 2001-08-31 | 2008-10-07 | Rosetta Inpharmatics Llc | Methods for preparing nucleic acid samples |
| US7306906B2 (en) | 2001-09-19 | 2007-12-11 | Alexion Pharmaceuticals, Inc. | Engineered templates and their use in single primer amplification |
| CN1612936A (zh) | 2001-11-09 | 2005-05-04 | 苏尔斯精细医药公司 | 利用基因表达分布图识别、监控和治疗疾病以及鉴定生物学状态 |
| AU2002366098A1 (en) | 2001-11-19 | 2003-06-10 | Parallele Bioscience Inc | Multiplex pcr |
| GB2382137A (en) | 2001-11-20 | 2003-05-21 | Mats Gullberg | Nucleic acid enrichment |
| GB0128153D0 (en) | 2001-11-23 | 2002-01-16 | Bayer Ag | Profiling of the immune gene repertoire |
| WO2003052101A1 (en) | 2001-12-14 | 2003-06-26 | Rosetta Inpharmatics, Inc. | Sample tracking using molecular barcodes |
| GB0130267D0 (en) | 2001-12-19 | 2002-02-06 | Neutec Pharma Plc | Focussed antibody technology |
| WO2003059155A2 (en) | 2002-01-09 | 2003-07-24 | Maxx Genetech Co. Ltd | Method of detecting t-cell proliferation for diagnosis of diseases by gene array |
| US7323306B2 (en) * | 2002-04-01 | 2008-01-29 | Brookhaven Science Associates, Llc | Genome signature tags |
| US7157274B2 (en) | 2002-06-24 | 2007-01-02 | Cytonome, Inc. | Method and apparatus for sorting particles |
| WO2004046098A2 (en) | 2002-05-16 | 2004-06-03 | Vanderbilt University | Method for predicting autoimmune diseases |
| WO2004003820A2 (en) | 2002-07-01 | 2004-01-08 | Institut Pasteur | System, method, device, and computer program product for extraction, gathering, manipulation, and analysis of peak data from an automated sequencer |
| AU2003281336A1 (en) | 2002-07-03 | 2004-01-23 | Institute For Scientific Research, Inc. | Compositions and methods for the detection of human t cell receptor variable family gene expression |
| DE60334474D1 (de) | 2002-07-12 | 2010-11-18 | Univ Johns Hopkins | Reagenzien und verfahren zum eingriff in einzigartige klonotype lymphozyten-rezeptoren |
| WO2004009765A2 (en) | 2002-07-19 | 2004-01-29 | Althea Technologies, Inc. | Strategies for gene expression analysis |
| US7157228B2 (en) | 2002-09-09 | 2007-01-02 | Bioarray Solutions Ltd. | Genetic analysis and authentication |
| US7459273B2 (en) | 2002-10-04 | 2008-12-02 | Affymetrix, Inc. | Methods for genotyping selected polymorphism |
| DE60334471D1 (de) | 2002-10-11 | 2010-11-18 | Univ Erasmus | Primer für nukleinsäureamplifikation in pcr-basierten klonalitätsstudien |
| CA2501873A1 (en) | 2002-10-11 | 2004-04-22 | The Regents Of The University Of California | A method for diagnosis and prognosis of multiple sclerosis |
| WO2004044209A1 (en) | 2002-11-13 | 2004-05-27 | Monoquant Pty Ltd | A method of detection |
| DK1566635T3 (da) | 2002-11-14 | 2012-03-19 | Vivalis | Chip med array af mikrobrønde til påvisning af antigenspecifik lymfocyt, fremgangsmåde til påvisning af antigenspecifik lymfocyt og fremgangsmåde til kloning af antigenspecifik lymfocyt-antigenreceptorgen |
| EP1578954A4 (en) | 2002-12-11 | 2010-08-11 | Coley Pharm Group Inc | 5'-CPG NUCLEIC ACIDS AND USE METHOD |
| WO2004063706A2 (en) | 2003-01-08 | 2004-07-29 | Maxx Genetech Co., Ltd. | Method of detecting over-expression of t-cell receptor genes by real-time pcr |
| WO2005003375A2 (en) | 2003-01-29 | 2005-01-13 | 454 Corporation | Methods of amplifying and sequencing nucleic acids |
| GB0304068D0 (en) | 2003-02-22 | 2003-03-26 | Avidex Ltd | Substances |
| WO2004096985A2 (en) | 2003-04-24 | 2004-11-11 | Mayo Foundation For Medical Education And Research | Methods for assessing biologic diversity |
| AU2003902299A0 (en) | 2003-05-13 | 2003-05-29 | Flinders Medical Centre | A method of analysing a marker nucleic acid molecule |
| US20070105105A1 (en) | 2003-05-23 | 2007-05-10 | Mount Sinai School Of Medicine Of New York University | Surrogate cell gene expression signatures for evaluating the physical state of a subject |
| US20050010030A1 (en) | 2003-07-02 | 2005-01-13 | Zang Jingwu Z. | T cell receptor CDR3 sequence and methods for detecting and treating rheumatoid arthritis |
| EP1641809B2 (en) | 2003-07-05 | 2018-10-03 | The Johns Hopkins University | Method and compositions for detection and enumeration of genetic variations |
| TW200510723A (en) | 2003-07-15 | 2005-03-16 | Bioarray Solutions Ltd | Concurrent optimization in selection of primer and capture probe sets for nucleic acid analysis |
| US20060228350A1 (en) | 2003-08-18 | 2006-10-12 | Medimmune, Inc. | Framework-shuffling of antibodies |
| US20050048498A1 (en) | 2003-08-29 | 2005-03-03 | Applera Corporation | Compositions, methods, and kits for assembling probes |
| US7365179B2 (en) | 2003-09-09 | 2008-04-29 | Compass Genetics, Llc | Multiplexed analytical platform |
| TWI333977B (en) | 2003-09-18 | 2010-12-01 | Symphogen As | Method for linking sequences of interest |
| FR2863274B1 (fr) | 2003-12-05 | 2012-11-16 | Commissariat Energie Atomique | Procede d'evaluation quantitative d'un rearrangement ou d'une recombinaison genetique ciblee d'un individu et ses applications. |
| US20070238099A1 (en) | 2003-12-08 | 2007-10-11 | Cohen Irun R | Antigen Receptor Variable Region Typing |
| EP1544308B1 (en) | 2003-12-15 | 2009-01-28 | Institut Pasteur | Repertoire determination of a lymphocyte B population |
| US20070160994A1 (en) | 2003-12-15 | 2007-07-12 | Institut Pasteur | Repertoire determination of a lymphocyte b population |
| US20080166718A1 (en) | 2003-12-15 | 2008-07-10 | Institut Pasteur | Repertoire determination of a lymphocyte B population |
| CA2556981C (en) | 2004-02-18 | 2015-10-13 | The Trustees Of Boston University | Method for detecting and quantifying rare mutations or polymorphisms |
| US20060046258A1 (en) | 2004-02-27 | 2006-03-02 | Lapidus Stanley N | Applications of single molecule sequencing |
| WO2005084134A2 (en) | 2004-03-04 | 2005-09-15 | Dena Leshkowitz | Quantifying and profiling antibody and t cell receptor gene expression |
| JP4480423B2 (ja) | 2004-03-08 | 2010-06-16 | 独立行政法人科学技術振興機構 | 免疫細胞クローンの拡大の有無の判定方法 |
| DE102004016437A1 (de) | 2004-04-04 | 2005-10-20 | Oligene Gmbh | Verfahren zur Erkennung von Signaturen in komplexen Genexpressionsprofilen |
| WO2005111242A2 (en) | 2004-05-10 | 2005-11-24 | Parallele Bioscience, Inc. | Digital profiling of polynucleotide populations |
| WO2006076025A2 (en) | 2004-05-14 | 2006-07-20 | Amaox, Inc. | Immune cell biosensors and methods of using same |
| EP1598429A1 (en) | 2004-05-19 | 2005-11-23 | Amplion Ltd. | Detection of amplicon contamination during PCR exhibiting two different annealing temperatures |
| GB0412973D0 (en) | 2004-06-10 | 2004-07-14 | Celltech R&D Ltd | Identification of antibody producing cells |
| US20060020397A1 (en) | 2004-07-21 | 2006-01-26 | Kermani Bahram G | Methods for nucleic acid and polypeptide similarity search employing content addressable memories |
| WO2006014869A1 (en) | 2004-07-26 | 2006-02-09 | Parallele Bioscience, Inc. | Simultaneous analysis of multiple genomes |
| US20060094018A1 (en) | 2004-08-03 | 2006-05-04 | Bauer A R Jr | Discovery and a method for the early detection of pancreatic cancer and other disease conditions |
| US7820382B2 (en) | 2004-08-03 | 2010-10-26 | Bauer A Robert | Method for the early detection of breast cancer, lung cancer, pancreatic cancer and colon polyps, growths and cancers as well as other gastrointestinal disease conditions and the preoperative and postoperative monitoring of transplanted organs from the donor and in the recipient and their associated conditions related and unrelated to the organ transplantation |
| EP1773885B1 (en) | 2004-08-05 | 2010-04-21 | Genentech, Inc. | Humanized anti-cmet antagonists |
| US7915036B2 (en) | 2004-09-13 | 2011-03-29 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Compositions comprising T cell receptors and methods of use thereof |
| US7170050B2 (en) | 2004-09-17 | 2007-01-30 | Pacific Biosciences Of California, Inc. | Apparatus and methods for optical analysis of molecules |
| EP1812563B1 (en) | 2004-10-29 | 2013-04-10 | Benaroya Research Institute at Virginia Mason | Methods of generating antigen-specific cd4+cd25+ regulatory t cells, compositions and methods of use |
| US7966988B2 (en) | 2005-01-11 | 2011-06-28 | Exxonmobil Research And Engineering Company | Method for controlling soot induced lubricant viscosity increase |
| US8029783B2 (en) | 2005-02-02 | 2011-10-04 | Genentech, Inc. | DR5 antibodies and articles of manufacture containing same |
| FR2881436B1 (fr) | 2005-02-03 | 2007-04-27 | Commissariat Energie Atomique | Procede de determination de la diversite des lymphocytes t dans un echantillon biologique |
| US7393665B2 (en) | 2005-02-10 | 2008-07-01 | Population Genetics Technologies Ltd | Methods and compositions for tagging and identifying polynucleotides |
| BRPI0607753A2 (pt) | 2005-02-16 | 2009-10-06 | Wyeth Corp | método para prever um efeito clìnico em resposta a um tratamento de uma leucemia; método para prever um efeito clìnico de uma leucemia; método para selecionar um tratamento para um paciente com leucemia; método para o diagnóstico ou monitoramento de ocorrência, desenvolvimento, progressão ou tratamento de uma leucemia; arranjo para uso num método para prever um efeito clìnico para um paciente aml; arranjo para uso num método de diagnóstico de aml; meio legìvel por computador; kit para o prognóstico de aml |
| US7537894B2 (en) | 2005-03-02 | 2009-05-26 | The University Of Chicago | Methods and kits for monitoring Barrett's metaplasia |
| WO2006099164A2 (en) | 2005-03-10 | 2006-09-21 | Applera Corporation | Methods for multiplex amplification |
| WO2006099604A2 (en) | 2005-03-16 | 2006-09-21 | Compass Genetics, Llc | Methods and compositions for assay readouts on multiple analytical platforms |
| ES2404311T3 (es) | 2005-04-12 | 2013-05-27 | 454 Life Sciences Corporation | Métodos para determinar variantes de secuencias usando secuenciación ultraprofunda |
| WO2006116155A2 (en) | 2005-04-21 | 2006-11-02 | The Regents Of The University Of California | A method for diagnosis and prognosis of multiple sclerosis subtypes |
| US20060263789A1 (en) | 2005-05-19 | 2006-11-23 | Robert Kincaid | Unique identifiers for indicating properties associated with entities to which they are attached, and methods for using |
| US7208795B2 (en) | 2005-05-24 | 2007-04-24 | Atmel Corporation | Low-cost, low-voltage single-layer polycrystalline EEPROM memory cell integration into BiCMOS technology |
| US8426146B2 (en) | 2005-06-03 | 2013-04-23 | University of Pittsburgh—of the Commonwealth System of Higher Education | Multiparameteric method for assessing immune system status |
| JP5331476B2 (ja) * | 2005-06-15 | 2013-10-30 | カリダ・ジェノミックス・インコーポレイテッド | 遺伝子解析および化学解析用の単分子アレイ |
| WO2007008759A2 (en) | 2005-07-07 | 2007-01-18 | Hematologics, Inc. | Methods for detecting and confirming minimal disease in a cancer patient |
| US20070020640A1 (en) | 2005-07-21 | 2007-01-25 | Mccloskey Megan L | Molecular encoding of nucleic acid templates for PCR and other forms of sequence analysis |
| GB0521521D0 (en) | 2005-10-21 | 2005-11-30 | Medical Res Council | Diagnostic methods and kits |
| GB0522310D0 (en) | 2005-11-01 | 2005-12-07 | Solexa Ltd | Methods of preparing libraries of template polynucleotides |
| US20070105165A1 (en) | 2005-11-04 | 2007-05-10 | Charles Goolsby | Composite profiles of cell antigens and target signal transduction proteins for analysis and clinical management of hematologic cancers |
| US7375211B2 (en) | 2005-11-18 | 2008-05-20 | Kou Zhong C | Method for detection and quantification of T-cell receptor Vβ repertoire |
| US8137936B2 (en) | 2005-11-29 | 2012-03-20 | Macevicz Stephen C | Selected amplification of polynucleotides |
| WO2007087312A2 (en) | 2006-01-23 | 2007-08-02 | Population Genetics Technologies Ltd. | Molecular counting |
| EP1987162A4 (en) | 2006-01-23 | 2009-11-25 | Population Genetics Technologi | NUCLEIC ACID ANALYSIS ABOUT SEQUENCE TOKENS |
| SG170028A1 (en) | 2006-02-24 | 2011-04-29 | Callida Genomics Inc | High throughput genome sequencing on dna arrays |
| JP2009528828A (ja) | 2006-03-06 | 2009-08-13 | シムフォゲン・アクティーゼルスカブ | 消化器多核体ウイルス感染症の治療のための組み換えポリクローナル抗体 |
| ES2546848T3 (es) | 2006-03-10 | 2015-09-29 | Epigenomics Ag | Un método para identificar una muestra biológica para el análisis de la metilación |
| DK3239304T3 (da) | 2006-04-04 | 2020-10-26 | Keygene Nv | Højgennemløbsdetektering af molekylære markører baseret på AFLP og sekventering med højt gennemløb |
| EP2021460A4 (en) | 2006-05-11 | 2010-11-17 | Univ Maryland Biotech Inst | GENERAL METHOD FOR GENERATING IN VITRO HUMAN ANTIBODY RESPONSES |
| WO2007136518A2 (en) | 2006-05-17 | 2007-11-29 | Torrey Pines Institute For Molecular Studies | Treatment of autoimmune disorders |
| WO2007139584A2 (en) | 2006-05-25 | 2007-12-06 | Institute For Advanced Study | Methods for identifying sequence motifs, and applications thereof |
| US7833716B2 (en) | 2006-06-06 | 2010-11-16 | Gen-Probe Incorporated | Tagged oligonucleotides and their use in nucleic acid amplification methods |
| AU2007261114B2 (en) | 2006-06-12 | 2012-07-12 | Pacific Biosciences Of California, Inc. | Substrates for performing analytical reactions |
| EP2589668A1 (en) | 2006-06-14 | 2013-05-08 | Verinata Health, Inc | Rare cell analysis using sample splitting and DNA tags |
| US20100027896A1 (en) | 2006-06-28 | 2010-02-04 | Amir Geva | Automated application interaction using a virtual operator |
| CA2656525A1 (en) | 2006-06-30 | 2008-01-10 | Applera Corporation | Reversible terminator nucleotides and methods of use |
| WO2008108803A2 (en) | 2006-07-13 | 2008-09-12 | Amaox, Ltd. | Immune cell biosensors and methods of using same |
| US8394590B2 (en) | 2006-08-02 | 2013-03-12 | California Institute Of Technology | Capture agents and related methods and systems for detecting and/or sorting targets |
| US20080274904A1 (en) | 2006-08-10 | 2008-11-06 | Niall Anthony Gormley | Method of target enrichment |
| WO2008026927A2 (en) | 2006-08-30 | 2008-03-06 | Academisch Medisch Centrum | Process for displaying t- and b-cell receptor repertoires |
| WO2008039818A2 (en) | 2006-09-26 | 2008-04-03 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Modified t cell receptors and related materials and methods |
| WO2008039694A2 (en) | 2006-09-26 | 2008-04-03 | St. Jude Children's Research Hospital | Methods and compositions for monitoring t cell receptor diversity |
| JP5026047B2 (ja) | 2006-10-18 | 2012-09-12 | 株式会社膠原病研究所 | 自己免疫疾患の発症に関わる自己応答性t細胞またはt細胞受容体の同定方法、およびその利用 |
| US8148067B2 (en) | 2006-11-09 | 2012-04-03 | Xdx, Inc. | Methods for diagnosing and monitoring the status of systemic lupus erythematosus |
| US8262900B2 (en) | 2006-12-14 | 2012-09-11 | Life Technologies Corporation | Methods and apparatus for measuring analytes using large scale FET arrays |
| US7862999B2 (en) | 2007-01-17 | 2011-01-04 | Affymetrix, Inc. | Multiplex targeted amplification using flap nuclease |
| WO2008093098A2 (en) | 2007-02-02 | 2008-08-07 | Illumina Cambridge Limited | Methods for indexing samples and sequencing multiple nucleotide templates |
| PT2121920E (pt) | 2007-03-01 | 2011-10-03 | Symphogen As | Método de clonagem de anticorpos cognatos |
| WO2008147879A1 (en) | 2007-05-22 | 2008-12-04 | Ryan Golhar | Automated method and device for dna isolation, sequence determination, and identification |
| EP2164985A4 (en) | 2007-06-01 | 2014-05-14 | 454 Life Sciences Corp | SYSTEM AND METHOD FOR IDENTIFYING INDIVIDUAL SAMPLES FROM A MULTIPLEX MIXTURE |
| WO2009015296A1 (en) | 2007-07-24 | 2009-01-29 | The Regents Of The University Of California | Microfabricated dropley generator |
| JP2010534474A (ja) | 2007-07-26 | 2010-11-11 | パシフィック バイオサイエンシーズ オブ カリフォルニア, インコーポレイテッド | 分子冗長配列決定 |
| ITRM20070429A1 (it) | 2007-08-06 | 2009-02-07 | Uni Cattolica Del Sacro Cuor E | Mezzi per la diagnosi la prevenzione e la cura dell'artrite reumatoide. |
| WO2009021215A1 (en) | 2007-08-09 | 2009-02-12 | Celula, Inc. | Methods and devices for correlated, multi-parameter single cell measurements and recovery of remnant biological material |
| US8268564B2 (en) | 2007-09-26 | 2012-09-18 | President And Fellows Of Harvard College | Methods and applications for stitched DNA barcodes |
| US7960116B2 (en) | 2007-09-28 | 2011-06-14 | Pacific Biosciences Of California, Inc. | Nucleic acid sequencing methods and systems |
| US20100285984A1 (en) | 2007-09-28 | 2010-11-11 | Wettstein Peter J | Assessing t cell repertoires |
| MX2010005080A (es) | 2007-11-07 | 2010-07-28 | Genentech Inc | Metodos y composiciones para determinar la sensibilidad de linfoma de celula b al tratamiento con anticuerpos anti-cd40. |
| EP2060637A1 (en) | 2007-11-14 | 2009-05-20 | Koninklijke Philips Electronics N.V. | Means and methods for detection of nucleic acids |
| WO2009070767A2 (en) | 2007-11-28 | 2009-06-04 | Whitehead Institute For Biomedical Research | Systemic instigation systems to study tumor growth or metastasis |
| EP2062982A1 (fr) | 2007-11-26 | 2009-05-27 | ImmunID | Procédé d'étude de la diversité combinatoire V(D)J |
| CN101225441B (zh) | 2007-12-05 | 2010-12-01 | 浙江大学 | 一种检测克隆特异性t淋巴细胞tcr bv cdr3基因组成的方法 |
| US20100021894A1 (en) | 2007-12-20 | 2010-01-28 | Northwestern University | Nanoparticle-Based Colorimetric Detection Of Cysteine |
| US8621502B2 (en) | 2007-12-21 | 2013-12-31 | Microsoft Corporation | Obtaining user reactions to video |
| US7767400B2 (en) | 2008-02-03 | 2010-08-03 | Helicos Biosciences Corporation | Paired-end reads in sequencing by synthesis |
| WO2009100080A1 (en) | 2008-02-04 | 2009-08-13 | Life Technologies Corporation | Composition and method for sequencing nucleic acid |
| EP2088205A1 (en) | 2008-02-11 | 2009-08-12 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | PSMB10: A diagnosis marker and therapeutic target of chronic rejection. |
| EP2088432A1 (en) | 2008-02-11 | 2009-08-12 | MorphoSys AG | Methods for identification of an antibody or a target |
| JP2011516033A (ja) | 2008-02-28 | 2011-05-26 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | 急性骨髄性性白血病(aml)における細胞遺伝学および予後と関連するマイクロrnaシグネチャーおよびその使用 |
| US20110054009A1 (en) | 2008-02-28 | 2011-03-03 | The Ohio State University Research Foundation | MicroRNA-Based Methods and Compositions for the Diagnosis, Prognosis and Treatment of Prostate Related Disorders |
| US20090226975A1 (en) | 2008-03-10 | 2009-09-10 | Illumina, Inc. | Constant cluster seeding |
| TW200938840A (en) | 2008-03-12 | 2009-09-16 | Emo Biomedicine Corp | A method for in vitro study of immune modulation using pig blood cell |
| EP2100970B1 (en) | 2008-03-13 | 2017-05-10 | National Institute of Immunology | Ig genes specific oligonucleotides and uses thereof |
| MX2010010600A (es) | 2008-03-28 | 2011-03-30 | Pacific Biosciences California Inc | Composiciones y metodos para secuenciacion de acidos nucleicos. |
| EP2107040B1 (en) | 2008-03-31 | 2011-10-26 | Sony Deutschland Gmbh | A method of fabricating a membrane having a tapered pore |
| US9012148B2 (en) | 2008-04-16 | 2015-04-21 | Jian Han | Method for evaluating and comparing immunorepertoires |
| US8911948B2 (en) | 2008-04-30 | 2014-12-16 | Integrated Dna Technologies, Inc. | RNase H-based assays utilizing modified RNA monomers |
| US20120003225A1 (en) | 2008-05-09 | 2012-01-05 | Duke University | Autoantibodies in the detection and treatment of cancer |
| US9068181B2 (en) | 2008-05-23 | 2015-06-30 | The General Hospital Corporation | Microfluidic droplet encapsulation |
| DE102008025656B4 (de) | 2008-05-28 | 2016-07-28 | Genxpro Gmbh | Verfahren zur quantitativen Analyse von Nukleinsäuren, Marker dafür und deren Verwendung |
| DK2297333T3 (en) | 2008-05-30 | 2015-04-07 | Massachusetts Inst Technology | Method for spatial separation and for screening cells |
| WO2009151628A2 (en) | 2008-06-12 | 2009-12-17 | Gov't Of The Usa, As Represented By The Secretary, Department Of Health Human Services | Monitoring tcr-b to determine hiv therapy and disease progression |
| AP2011005546A0 (en) | 2008-06-25 | 2011-02-28 | Baylor Res Intitute | Blood transcriptional signature of mycobacterium tuberculosis infection. |
| US8394583B2 (en) | 2008-07-24 | 2013-03-12 | The Board Of Regents Of The University Of Texas System | VH4 codon signature for multiple sclerosis |
| EP3629022A1 (en) | 2008-07-25 | 2020-04-01 | Richard W. Wagner | Protein screening methods |
| US8586310B2 (en) | 2008-09-05 | 2013-11-19 | Washington University | Method for multiplexed nucleic acid patch polymerase chain reaction |
| US9156010B2 (en) | 2008-09-23 | 2015-10-13 | Bio-Rad Laboratories, Inc. | Droplet-based assay system |
| CA2738578C (en) | 2008-09-23 | 2021-05-04 | Quantalife, Inc. | Droplet-based assay system |
| US8699361B2 (en) | 2008-09-30 | 2014-04-15 | Qualcomm Incorporated | Out-of-synchronization handling method and apparatus |
| US8546128B2 (en) | 2008-10-22 | 2013-10-01 | Life Technologies Corporation | Fluidics system for sequential delivery of reagents |
| US20100137143A1 (en) | 2008-10-22 | 2010-06-03 | Ion Torrent Systems Incorporated | Methods and apparatus for measuring analytes |
| US9506119B2 (en) | 2008-11-07 | 2016-11-29 | Adaptive Biotechnologies Corp. | Method of sequence determination using sequence tags |
| US8628927B2 (en) | 2008-11-07 | 2014-01-14 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
| CN104195227B (zh) | 2008-11-07 | 2017-04-12 | 适应生物技术公司 | 通过序列分析监测状况的方法 |
| US8748103B2 (en) | 2008-11-07 | 2014-06-10 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
| US9528160B2 (en) | 2008-11-07 | 2016-12-27 | Adaptive Biotechnolgies Corp. | Rare clonotypes and uses thereof |
| US9365901B2 (en) | 2008-11-07 | 2016-06-14 | Adaptive Biotechnologies Corp. | Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia |
| US8691510B2 (en) | 2008-11-07 | 2014-04-08 | Sequenta, Inc. | Sequence analysis of complex amplicons |
| US20140234835A1 (en) | 2008-11-07 | 2014-08-21 | Sequenta, Inc. | Rare clonotypes and uses thereof |
| US9394567B2 (en) | 2008-11-07 | 2016-07-19 | Adaptive Biotechnologies Corporation | Detection and quantification of sample contamination in immune repertoire analysis |
| WO2010060051A2 (en) | 2008-11-21 | 2010-05-27 | Emory University | Systems biology approach predicts the immunogenicity of vaccines |
| US8367330B2 (en) | 2008-12-22 | 2013-02-05 | Quest Diagnostics Investments Incorporated | Methods for detecting TCR-gamma gene rearrangement |
| MX2011007030A (es) | 2008-12-30 | 2011-07-20 | Centocor Ortho Biotech Inc | Marcadores sericos que predicen la respuesta clinica a los anticuerpos anti-factor de necrosis tumoral alfa en pacientes con espondilitis anquilosante. |
| EP2387627B1 (en) | 2009-01-15 | 2016-03-30 | Adaptive Biotechnologies Corporation | Adaptive immunity profiling and methods for generation of monoclonal antibodies |
| AU2010206843B2 (en) | 2009-01-20 | 2015-01-29 | The Board Of Trustees Of The Leland Stanford Junior University | Single cell gene expression for diagnosis, prognosis and identification of drug targets |
| US20100323348A1 (en) | 2009-01-31 | 2010-12-23 | The Regents Of The University Of Colorado, A Body Corporate | Methods and Compositions for Using Error-Detecting and/or Error-Correcting Barcodes in Nucleic Acid Amplification Process |
| US8574835B2 (en) | 2009-05-29 | 2013-11-05 | Life Technologies Corporation | Scaffolded nucleic acid polymer particles and methods of making and using |
| US8673627B2 (en) | 2009-05-29 | 2014-03-18 | Life Technologies Corporation | Apparatus and methods for performing electrochemical reactions |
| CN102459643B (zh) | 2009-06-25 | 2016-06-01 | 弗雷德哈钦森癌症研究中心 | 检测获得性免疫的方法 |
| US8497071B2 (en) | 2009-06-29 | 2013-07-30 | California Institute Of Technology | Isolation of unknown rearranged T-cell receptors from single cells |
| EP2462236B1 (en) | 2009-07-17 | 2016-03-09 | Brown University | Detection of short rna sequences |
| US8467973B2 (en) | 2009-07-28 | 2013-06-18 | Promising Future, Llc | Pairing processes for preparing alloreactive cytotoxic T cells |
| EP2480683B1 (en) | 2009-09-22 | 2017-11-29 | Roche Diagnostics GmbH | Determination of kir haplotypes by amplification of exons |
| GB0917094D0 (en) | 2009-09-29 | 2009-11-11 | Ucl Biomedica Plc | T-cell receptor |
| US9043160B1 (en) | 2009-11-09 | 2015-05-26 | Sequenta, Inc. | Method of determining clonotypes and clonotype profiles |
| US8835358B2 (en) | 2009-12-15 | 2014-09-16 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse labels |
| US9315857B2 (en) | 2009-12-15 | 2016-04-19 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse label-tags |
| US8545248B2 (en) | 2010-01-07 | 2013-10-01 | Life Technologies Corporation | System to control fluid flow based on a leak detected by a sensor |
| KR101323827B1 (ko) | 2010-01-08 | 2013-10-31 | 키스트 유럽 에프게엠베하 | 강직성척추염 진단용 프라이머 및 이를 이용한 강직성 척추염 진단 방법 |
| GB201000375D0 (en) | 2010-01-09 | 2010-02-24 | Univ Cardiff | T Cell clonotypes |
| WO2011106738A2 (en) | 2010-02-25 | 2011-09-01 | Fred Hutchinson Cancer Research Center | Use of tcr clonotypes as biomarkers for disease |
| EP2367000A1 (en) | 2010-03-04 | 2011-09-21 | Charité Universitätsmedizin Berlin | High throughput analysis of T-cell receptor repertoires |
| EP4219759A3 (en) | 2010-05-06 | 2023-09-06 | Adaptive Biotechnologies Corporation | Monitoring health and disease status using clonotype profiles |
| WO2011140433A2 (en) | 2010-05-07 | 2011-11-10 | The Board Of Trustees Of The Leland Stanford Junior University | Measurement and comparison of immune diversity by high-throughput sequencing |
| US20130123120A1 (en) | 2010-05-18 | 2013-05-16 | Natera, Inc. | Highly Multiplex PCR Methods and Compositions |
| EP2952590B1 (en) | 2010-06-11 | 2017-07-26 | Life Technologies Corporation | Alternative nucleotide flows in sequencing-by-synthesis methods |
| CN103069006A (zh) | 2010-07-23 | 2013-04-24 | 艾索特里克斯遗传实验室有限责任公司 | 区别表达的胚胎或母源基因组区的鉴定及其用途 |
| EP2601521B1 (en) | 2010-08-06 | 2018-05-02 | Ludwig-Maximilians-Universität München | Identification of t cell target antigens |
| WO2012027503A2 (en) | 2010-08-24 | 2012-03-01 | Fred Hutchinson Cancer Research Center | Method of measuring adaptive immunity |
| ES2635335T3 (es) | 2010-09-20 | 2017-10-03 | Biontech Cell & Gene Therapies Gmbh | Receptores de células T específicos de antígeno y epítopos de células T |
| CA2811185C (en) | 2010-09-21 | 2020-09-22 | Population Genetics Technologies Ltd. | Increasing confidence of allele calls with molecular counting |
| WO2012045012A2 (en) | 2010-09-30 | 2012-04-05 | Raindance Technologies, Inc. | Sandwich assays in droplets |
| EP2625320B1 (en) | 2010-10-08 | 2019-03-27 | President and Fellows of Harvard College | High-throughput single cell barcoding |
| EP2625295B1 (en) | 2010-10-08 | 2019-03-13 | President and Fellows of Harvard College | High-throughput immune sequencing |
| EP2633069B1 (en) | 2010-10-26 | 2015-07-01 | Illumina, Inc. | Sequencing methods |
| CA2821299C (en) | 2010-11-05 | 2019-02-12 | Frank J. Steemers | Linking sequence reads using paired code tags |
| WO2012083069A2 (en) | 2010-12-15 | 2012-06-21 | The Board Of Trustees Of The Leland Stanford Junior University | Measurement and monitoring of cell clonality |
| WO2012083225A2 (en) | 2010-12-16 | 2012-06-21 | Gigagen, Inc. | System and methods for massively parallel analysis of nycleic acids in single cells |
| WO2012118555A1 (en) | 2010-12-29 | 2012-09-07 | Life Technologies Corporation | Time-warped background signal for sequencing-by-synthesis operations |
| WO2012092455A2 (en) | 2010-12-30 | 2012-07-05 | Life Technologies Corporation | Models for analyzing data from sequencing-by-synthesis operations |
| EP3736281A1 (en) | 2011-02-18 | 2020-11-11 | Bio-Rad Laboratories, Inc. | Compositions and methods for molecular labeling |
| KR20190107761A (ko) | 2011-03-09 | 2019-09-20 | 셀 시그널링 테크놀러지, 인크. | 모노클로날 항체를 생성하는 방법 및 시약 |
| US8759036B2 (en) | 2011-03-21 | 2014-06-24 | Affymetrix, Inc. | Methods for synthesizing pools of probes |
| ES2625288T3 (es) | 2011-04-15 | 2017-07-19 | The Johns Hopkins University | Sistema de secuenciación segura |
| PT3415619T (pt) | 2011-04-28 | 2021-03-22 | Univ Leland Stanford Junior | Identificação de polinucleótidos associados a uma amostra |
| HRP20211595T1 (hr) | 2011-05-24 | 2022-01-21 | BioNTech SE | Individualizirana cjepiva protiv raka |
| US9834766B2 (en) | 2011-09-02 | 2017-12-05 | Atreca, Inc. | DNA barcodes for multiplexed sequencing |
| WO2013036459A2 (en) | 2011-09-09 | 2013-03-14 | Sequenta, Inc. | Sequence-based measures of immune response |
| US10385475B2 (en) | 2011-09-12 | 2019-08-20 | Adaptive Biotechnologies Corp. | Random array sequencing of low-complexity libraries |
| WO2013055595A1 (en) | 2011-10-11 | 2013-04-18 | Sequenta, Inc. | Determining responsiveness of autoimmune patients to dmard treatment |
| EP2768982A4 (en) | 2011-10-21 | 2015-06-03 | Adaptive Biotechnologies Corp | QUANTIFICATION OF ADAPTIVE IMMUNOCELL GENOMES IN A COMPLEX MIX OF CELLS |
| US20130137108A1 (en) | 2011-10-25 | 2013-05-30 | Anubhav Tripathi | Magnetic bead separation apparatus and method |
| EP2773773B1 (en) | 2011-11-04 | 2017-01-11 | Adaptive Biotechnologies Corporation | T-cell receptor clonotypes shared among ankylosing spondylitis patients |
| WO2013085855A1 (en) | 2011-12-05 | 2013-06-13 | Sequenta, Inc. | Clonotypes as biometric specimen tags |
| US9824179B2 (en) | 2011-12-09 | 2017-11-21 | Adaptive Biotechnologies Corp. | Diagnosis of lymphoid malignancies and minimal residual disease detection |
| US20140342360A1 (en) | 2011-12-09 | 2014-11-20 | Sequenta, Inc. | Method of measuring immune activation |
| WO2013090390A2 (en) | 2011-12-13 | 2013-06-20 | Sequenta, Inc. | Method of measuring immune activation |
| US9499865B2 (en) | 2011-12-13 | 2016-11-22 | Adaptive Biotechnologies Corp. | Detection and measurement of tissue-infiltrating lymphocytes |
| WO2013096480A2 (en) | 2011-12-20 | 2013-06-27 | Sequenta, Inc. | Monitoring transformation of follicular lymphoma to diffuse large b-cell lymphoma by immune repertoire analysis |
| WO2013112655A1 (en) | 2012-01-24 | 2013-08-01 | Gigagen, Inc. | Method for correction of bias in multiplexed amplification |
| EP3367099B1 (en) | 2012-02-09 | 2021-05-26 | Memed Diagnostics Ltd. | Signatures and determinants for diagnosing infections and methods of use thereof |
| DK2814959T3 (en) * | 2012-02-17 | 2018-04-23 | Hutchinson Fred Cancer Res | COMPOSITIONS AND PROCEDURES FOR EXACTLY IDENTIFYING MUTATIONS |
| EP2820174B1 (en) | 2012-02-27 | 2019-12-25 | The University of North Carolina at Chapel Hill | Methods and uses for molecular tags |
| WO2013131074A1 (en) | 2012-03-02 | 2013-09-06 | Diogenix, Inc. | Methods and reagents for evaluating autoimmune disease and determining antibody repertoire |
| US20150038346A1 (en) | 2012-03-05 | 2015-02-05 | Sequenta, Inc. | Monitoring immune responsiveness to cancer vaccination |
| DK2823060T3 (en) | 2012-03-05 | 2018-05-28 | Adaptive Biotechnologies Corp | Determination of associated immune receptor chains from frequency-matched subunits |
| WO2013134302A1 (en) | 2012-03-05 | 2013-09-12 | Sequenta, Inc. | Monitoring immune responsiveness to cancer vaccination |
| US9862995B2 (en) | 2012-03-13 | 2018-01-09 | Abhijit Ajit Patel | Measurement of nucleic acid variants using highly-multiplexed error-suppressed deep sequencing |
| SG11201406538VA (en) | 2012-04-13 | 2014-11-27 | Sequenta Inc | Detection and quantitation of sample contamination in immune repertoire analysis |
| WO2013158936A1 (en) | 2012-04-20 | 2013-10-24 | Sequenta, Inc | Monitoring immunoglobulin heavy chain evolution in b-cell acute lymphoblastic leukemia |
| CN111876409A (zh) | 2012-04-24 | 2020-11-03 | Gen9股份有限公司 | 在体外克隆中分选核酸和多重制备物的方法 |
| CA2872468C (en) | 2012-05-08 | 2020-10-27 | Adaptive Biotechnologies Corporation | Compositions and methods for measuring and calibrating amplification bias in multiplexed pcr reactions |
| WO2013181428A2 (en) | 2012-05-31 | 2013-12-05 | Sequenta, Inc. | Predicting relapse of chronic lymphocytic leukemia patients treated by allogeneic stem cell transplantation |
| US20130324422A1 (en) | 2012-06-04 | 2013-12-05 | Sequenta, Inc. | Detecting disease-correlated clonotypes from fixed samples |
| SG11201407888RA (en) | 2012-06-11 | 2014-12-30 | Sequenta Inc | Method of sequence determination using sequence tags |
| SG11201408128WA (en) | 2012-06-15 | 2015-01-29 | Adaptive Biotechnologies Corp | Uniquely tagged rearranged adaptive immune receptor genes in a complex gene set |
| US20150154352A1 (en) | 2012-06-21 | 2015-06-04 | Gigagen, Inc. | System and Methods for Genetic Analysis of Mixed Cell Populations |
| EP2877604A1 (en) | 2012-07-24 | 2015-06-03 | Sequenta, Inc. | Single cell analysis using sequence tags |
| WO2014026031A1 (en) | 2012-08-10 | 2014-02-13 | Sequenta, Inc. | High sensitivity mutation detection using sequence tags |
| US20140065629A1 (en) | 2012-08-29 | 2014-03-06 | Israel Barken | Methods of treating diseases |
| DE112013004650T5 (de) | 2012-09-24 | 2015-06-18 | Cb Biotechnologies, Inc. | Multiplexpyrosequenzierung unter Verwendung nichtinterferierender, rauschbeendender Polynukleotididentifikationstags |
| US10150996B2 (en) | 2012-10-19 | 2018-12-11 | Adaptive Biotechnologies Corp. | Quantification of adaptive immune cell genomes in a complex mixture of cells |
| WO2014062945A1 (en) | 2012-10-19 | 2014-04-24 | Sequenta, Inc. | Monitoring clonotypes of plasma cell proliferative disorders in peripheral blood |
| CA2888520A1 (en) | 2012-10-19 | 2014-04-24 | Sequenta, Inc. | Monitoring diffuse large b-cell lymphoma from peripheral blood samples |
| CA2888524A1 (en) | 2012-10-22 | 2014-05-01 | Sequenta, Inc. | Monitoring mantle cell lymphoma clonotypes in peripheral blood after immunotransplant |
| JP6513035B2 (ja) | 2013-02-22 | 2019-05-15 | アダプティヴ バイオテクノロジーズ コーポレーション | 希少クロノタイプおよびその用途 |
| US20140255944A1 (en) | 2013-03-08 | 2014-09-11 | Sequenta, Inc. | Monitoring treatment-resistant clones in lymphoid and myeloid neoplasms by relative levels of evolved clonotypes |
| US20140255929A1 (en) | 2013-03-11 | 2014-09-11 | Sequenta, Inc. | Mosaic tags for labeling templates in large-scale amplifications |
| CA2906218A1 (en) | 2013-03-15 | 2014-09-18 | Adaptive Biotechnologies Corporation | Uniquely tagged rearranged adaptive immune receptor genes in a complex gene set |
| US9708657B2 (en) | 2013-07-01 | 2017-07-18 | Adaptive Biotechnologies Corp. | Method for generating clonotype profiles using sequence tags |
| US20160186260A1 (en) | 2013-07-26 | 2016-06-30 | Sequenta, Llc | Cancer vaccination with antigen evolution |
| US20160258025A1 (en) | 2013-10-18 | 2016-09-08 | The Regents Of The University Of California | Predicting patient responsiveness to immune checkpoint inhibitors |
| EP3092318A4 (en) | 2014-01-10 | 2017-08-16 | Adaptive Biotechnologies Corp. | Methods for defining and predicting immune response to allograft |
| US20150218656A1 (en) | 2014-02-03 | 2015-08-06 | Adaptive Biotechnologies Corp. | Methods for detection and diagnosis of a lymphoid malignancy using high throughput sequencing |
| WO2015134787A2 (en) | 2014-03-05 | 2015-09-11 | Adaptive Biotechnologies Corporation | Methods using randomer-containing synthetic molecules |
| US10066265B2 (en) | 2014-04-01 | 2018-09-04 | Adaptive Biotechnologies Corp. | Determining antigen-specific t-cells |
| CA2966201A1 (en) | 2014-10-29 | 2016-05-06 | Adaptive Biotechnologies Corp. | Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples |
| US10246701B2 (en) | 2014-11-14 | 2019-04-02 | Adaptive Biotechnologies Corp. | Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture |
| CA2976580A1 (en) | 2015-02-24 | 2016-09-01 | Adaptive Biotechnologies Corp. | Methods for diagnosing infectious disease and determining hla status using immune repertoire sequencing |
| AU2016242967B2 (en) | 2015-04-01 | 2021-07-01 | Adaptive Biotechnologies Corp. | Method of identifying human compatible T cell receptors specific for an antigenic target |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2023511200A (ja) * | 2020-01-22 | 2023-03-16 | ライフ テクノロジーズ コーポレーション | 自己免疫疾患および免疫不全疾患における免疫レパートリーバイオマーカー |
| JP7787078B2 (ja) | 2020-01-22 | 2025-12-16 | ライフ テクノロジーズ コーポレーション | 自己免疫疾患および免疫不全疾患における免疫レパートリーバイオマーカー |
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