JP6383427B2 - 縮合複素環化合物 - Google Patents

縮合複素環化合物 Download PDF

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JP6383427B2
JP6383427B2 JP2016550664A JP2016550664A JP6383427B2 JP 6383427 B2 JP6383427 B2 JP 6383427B2 JP 2016550664 A JP2016550664 A JP 2016550664A JP 2016550664 A JP2016550664 A JP 2016550664A JP 6383427 B2 JP6383427 B2 JP 6383427B2
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examples
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JP2017506627A (ja
JP2017506627A5 (enExample
Inventor
佐々木　実
佐々木　　実
佳子 掛川
佳子 掛川
史朗 菊地
史朗 菊地
善一 池田
善一 池田
西川　洋一
洋一 西川
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Takeda Pharmaceutical Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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  • Veterinary Medicine (AREA)
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  • Engineering & Computer Science (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
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  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Gynecology & Obstetrics (AREA)
JP2016550664A 2014-02-13 2015-02-12 縮合複素環化合物 Active JP6383427B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2014025832 2014-02-13
JP2014025832 2014-02-13
PCT/JP2015/000639 WO2015122187A1 (en) 2014-02-13 2015-02-12 Fused heterocyclic compound

Related Child Applications (1)

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JP2018146459A Division JP6529649B2 (ja) 2014-02-13 2018-08-03 縮合複素環化合物

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JP2017506627A JP2017506627A (ja) 2017-03-09
JP2017506627A5 JP2017506627A5 (enExample) 2018-03-08
JP6383427B2 true JP6383427B2 (ja) 2018-08-29

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US (2) US9346776B2 (enExample)
EP (1) EP3105213B1 (enExample)
JP (2) JP6383427B2 (enExample)
KR (1) KR102378454B1 (enExample)
CN (1) CN105980370B (enExample)
AR (1) AR099400A1 (enExample)
AU (1) AU2015216438B2 (enExample)
BR (1) BR112016018455B1 (enExample)
CA (1) CA2938191C (enExample)
CL (1) CL2016001911A1 (enExample)
CR (1) CR20160367A (enExample)
CY (1) CY1121534T1 (enExample)
DK (1) DK3105213T3 (enExample)
DO (1) DOP2016000206A (enExample)
EA (1) EA032201B1 (enExample)
EC (1) ECSP16067137A (enExample)
ES (1) ES2717113T3 (enExample)
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HU (1) HUE042709T2 (enExample)
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LT (1) LT3105213T (enExample)
MA (1) MA39246A1 (enExample)
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MY (1) MY173607A (enExample)
NZ (1) NZ722035A (enExample)
PE (1) PE20161243A1 (enExample)
PH (1) PH12016501582B1 (enExample)
PL (1) PL3105213T3 (enExample)
PT (1) PT3105213T (enExample)
RS (1) RS58498B1 (enExample)
SG (1) SG11201605654QA (enExample)
SI (1) SI3105213T1 (enExample)
SM (1) SMT201900175T1 (enExample)
TR (1) TR201903892T4 (enExample)
TW (1) TWI669297B (enExample)
UA (1) UA118280C2 (enExample)
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JPWO2016158788A1 (ja) * 2015-03-27 2018-01-25 武田薬品工業株式会社 縮合複素環化合物

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EP2975023B1 (en) * 2013-03-13 2018-05-30 Takeda Pharmaceutical Company Limited Guanidinobenzoic acid ester compound
US9428470B2 (en) 2014-02-13 2016-08-30 Takeda Pharmaceutical Company Limited Heterocyclic compound
PT3105218T (pt) 2014-02-13 2019-12-05 Incyte Corp Ciclopropilaminas como inibidores de lsd1
US9527835B2 (en) 2014-02-13 2016-12-27 Incyte Corporation Cyclopropylamines as LSD1 inhibitors
DK3105226T3 (da) 2014-02-13 2019-10-14 Incyte Corp Cyclopropylaminer som lsd1-inhibitorer
US9346776B2 (en) 2014-02-13 2016-05-24 Takeda Pharmaceutical Company Limited Fused heterocyclic compound
TW201613925A (en) 2014-07-10 2016-04-16 Incyte Corp Imidazopyrazines as LSD1 inhibitors
WO2016007722A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Triazolopyridines and triazolopyrazines as lsd1 inhibitors
TWI687419B (zh) 2014-07-10 2020-03-11 美商英塞特公司 作為ｌｓｄ１抑制劑之咪唑并吡啶及咪唑并吡嗪
JP2018080109A (ja) * 2015-03-16 2018-05-24 武田薬品工業株式会社 治療剤
EP3626720A1 (en) 2015-04-03 2020-03-25 Incyte Corporation Heterocyclic compounds as lsd1 inhibitors
KR102710120B1 (ko) 2015-08-12 2024-09-27 인사이트 홀딩스 코포레이션 Lsd1 저해제의 염
AU2018361589A1 (en) 2017-11-02 2020-06-04 Ube Corporation Double-headed protease inhibitor
EP3778577B1 (en) * 2018-05-09 2023-08-30 Lg Chem, Ltd. Novel compound exhibiting enteropeptidase inhibitory activity
JP6773938B2 (ja) * 2018-08-27 2020-10-21 株式会社スコヒアファーマ 安息香酸エステル化合物
US10968200B2 (en) 2018-08-31 2021-04-06 Incyte Corporation Salts of an LSD1 inhibitor and processes for preparing the same
US20220281866A1 (en) 2019-07-19 2022-09-08 Janssen Pharmaceutica Nv 5,8-disubstituted-[1,2,4]triazolo[1,5-a]pyridinyl and 5,8-disubstituted-imidazo[1,2-a]pyridine derivatives useful as inhibitors of enteropeptidase
JP7327788B2 (ja) * 2019-08-06 2023-08-16 学校法人福岡大学 糖化産物生成抑制剤及び医薬組成物
WO2021166899A1 (ja) * 2020-02-17 2021-08-26 宇部興産株式会社 インクレチン様物質と組み合わせて使用するための消化管プロテアーゼ阻害剤を含む薬剤
CN111544599B (zh) * 2020-07-10 2020-12-01 有术肌肤管理(深圳)有限公司 一种用于治疗痤疮的化合物及其用于制备药物或化妆品的用途
CN111803652B (zh) * 2020-08-04 2021-09-14 南通康是美生物科技有限公司 治疗痤疮的化合物在制备治疗痤疮的药物组合物或化妆品组合物中的用途
US12029718B2 (en) 2021-11-09 2024-07-09 Cct Sciences, Llc Process for production of essentially pure delta-9-tetrahydrocannabinol
WO2025115997A1 (ja) * 2023-12-01 2025-06-05 Ｅａファーマ株式会社 医薬組成物
WO2025115989A1 (ja) * 2023-12-01 2025-06-05 Ｅａファーマ株式会社 医薬組成物
WO2025211248A1 (ja) * 2024-04-04 2025-10-09 Ｅａファーマ株式会社 医薬組成物

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